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Paraproteinemia

MedGen UID:
10577
Concept ID:
C0030489
Disease or Syndrome
Synonyms: Paraimmunoglobulinemia; Paraimmunoglobulinemias; Paraproteinemias
SNOMED CT: Paraproteinemia (35601003)
 
HPO: HP:0031047

Definition

An abnormal immunoglobulin or part of an Ig (light chain) in the circulation. Paraproteins are typically produced by a clonal population of B-cell derived plasma cells. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVParaproteinemia

Conditions with this feature

Multiple myeloma
MedGen UID:
10122
Concept ID:
C0026764
Neoplastic Process
Multiple myeloma is a neoplastic plasma cell disorder characterized by clonal proliferation of malignant plasma cells in the bone marrow microenvironment, monoclonal protein in the blood or urine, and associated organ dysfunction (Palumbo and Anderson, 2011).

Professional guidelines

PubMed

Khouri J, Nakashima M, Wong S
JAMA Oncol 2021 Sep 1;7(9):1383-1391. doi: 10.1001/jamaoncol.2021.0586. PMID: 34081097
Castillo JJ, Treon SP
Leukemia 2019 Nov;33(11):2555-2562. Epub 2019 Oct 7 doi: 10.1038/s41375-019-0592-8. PMID: 31591468
Miguel D, Lukacs J, Illing T, Elsner P
J Eur Acad Dermatol Venereol 2017 Feb;31(2):221-235. Epub 2016 Jul 19 doi: 10.1111/jdv.13786. PMID: 27436448

Recent clinical studies

Etiology

Hoffmann JHO, Enk AH
J Dtsch Dermatol Ges 2020 Dec;18(12):1449-1467. doi: 10.1111/ddg.14319. PMID: 33373143
Raheja D, Specht C, Simmons Z
Muscle Nerve 2015 Jan;51(1):1-13. Epub 2014 Nov 22 doi: 10.1002/mus.24471. PMID: 25288371
Mansour AM, Arevalo JF, Badal J, Moorthy RS, Shah GK, Zegarra H, Pulido JS, Charbaji A, Amselem L, Lavaque AJ, Casella A, Ahmad B, Paschall JG, Caimi A, Staurenghi G
Ophthalmology 2014 Oct;121(10):1925-32. Epub 2014 Jun 18 doi: 10.1016/j.ophtha.2014.04.007. PMID: 24950591
Pomann JJ, Rudner EJ
Int J Dermatol 2003 Jan;42(1):31-5. doi: 10.1046/j.1365-4362.2003.01565.x. PMID: 12581140
Ringel E, Moschella S
Arch Dermatol 1985 Dec;121(12):1531-41. PMID: 2998286

Diagnosis

Koike H, Katsuno M
Neurol Sci 2021 Nov;42(11):4489-4501. Epub 2021 Sep 16 doi: 10.1007/s10072-021-05583-7. PMID: 34529193
Khouri J, Nakashima M, Wong S
JAMA Oncol 2021 Sep 1;7(9):1383-1391. doi: 10.1001/jamaoncol.2021.0586. PMID: 34081097
Hoffmann JHO, Enk AH
J Dtsch Dermatol Ges 2020 Dec;18(12):1449-1467. doi: 10.1111/ddg.14319. PMID: 33373143
Bhadada SK, Dhaliwal R, Dhiman V, Rao SD
Calcif Tissue Int 2019 May;104(5):561-569. Epub 2019 May 8 doi: 10.1007/s00223-019-00547-8. PMID: 31069441
Raheja D, Specht C, Simmons Z
Muscle Nerve 2015 Jan;51(1):1-13. Epub 2014 Nov 22 doi: 10.1002/mus.24471. PMID: 25288371

Therapy

Castillo JJ, Treon SP
Leukemia 2019 Nov;33(11):2555-2562. Epub 2019 Oct 7 doi: 10.1038/s41375-019-0592-8. PMID: 31591468
Bhadada SK, Dhaliwal R, Dhiman V, Rao SD
Calcif Tissue Int 2019 May;104(5):561-569. Epub 2019 May 8 doi: 10.1007/s00223-019-00547-8. PMID: 31069441
Miguel D, Lukacs J, Illing T, Elsner P
J Eur Acad Dermatol Venereol 2017 Feb;31(2):221-235. Epub 2016 Jul 19 doi: 10.1111/jdv.13786. PMID: 27436448
Zangari M, Zhan F, Tricot G
Curr Opin Support Palliat Care 2010 Sep;4(3):195-9. doi: 10.1097/SPC.0b013e32833d3011. PMID: 20657285
Korbet SM, Schwartz MM, Rosenberg BF, Sibley RK, Lewis EJ
Medicine (Baltimore) 1985 Jul;64(4):228-43. doi: 10.1097/00005792-198507000-00004. PMID: 4010500

Prognosis

Khouri J, Nakashima M, Wong S
JAMA Oncol 2021 Sep 1;7(9):1383-1391. doi: 10.1001/jamaoncol.2021.0586. PMID: 34081097
Hoffmann JHO, Enk AH
J Dtsch Dermatol Ges 2020 Dec;18(12):1449-1467. doi: 10.1111/ddg.14319. PMID: 33373143
Bhadada SK, Dhaliwal R, Dhiman V, Rao SD
Calcif Tissue Int 2019 May;104(5):561-569. Epub 2019 May 8 doi: 10.1007/s00223-019-00547-8. PMID: 31069441
Pomann JJ, Rudner EJ
Int J Dermatol 2003 Jan;42(1):31-5. doi: 10.1046/j.1365-4362.2003.01565.x. PMID: 12581140
Korbet SM, Schwartz MM, Lewis EJ
Am J Kidney Dis 1991 Mar;17(3):247-57. doi: 10.1016/s0272-6386(12)80469-0. PMID: 1996564

Clinical prediction guides

Khouri J, Nakashima M, Wong S
JAMA Oncol 2021 Sep 1;7(9):1383-1391. doi: 10.1001/jamaoncol.2021.0586. PMID: 34081097
Bhadada SK, Dhaliwal R, Dhiman V, Rao SD
Calcif Tissue Int 2019 May;104(5):561-569. Epub 2019 May 8 doi: 10.1007/s00223-019-00547-8. PMID: 31069441
Mansour AM, Arevalo JF, Badal J, Moorthy RS, Shah GK, Zegarra H, Pulido JS, Charbaji A, Amselem L, Lavaque AJ, Casella A, Ahmad B, Paschall JG, Caimi A, Staurenghi G
Ophthalmology 2014 Oct;121(10):1925-32. Epub 2014 Jun 18 doi: 10.1016/j.ophtha.2014.04.007. PMID: 24950591
Vitolo U, Ferreri AJ, Montoto S
Crit Rev Oncol Hematol 2008 Aug;67(2):172-85. Epub 2008 May 21 doi: 10.1016/j.critrevonc.2008.03.008. PMID: 18499469
Fernández-Herrera J, Pedraz J
Semin Cutan Med Surg 2007 Jun;26(2):108-13. doi: 10.1016/j.sder.2007.02.008. PMID: 17544963

Recent systematic reviews

Nelson CA, Zhong CS, Hashemi DA, Ashchyan HJ, Brown-Joel Z, Noe MH, Imadojemu S, Micheletti RG, Vleugels RA, Wanat KA, Rosenbach M, Mostaghimi A
JAMA Dermatol 2020 Mar 1;156(3):270-279. doi: 10.1001/jamadermatol.2019.4221. PMID: 31940000Free PMC Article
Miguel D, Lukacs J, Illing T, Elsner P
J Eur Acad Dermatol Venereol 2017 Feb;31(2):221-235. Epub 2016 Jul 19 doi: 10.1111/jdv.13786. PMID: 27436448
Wadhera RK, Rajkumar SV
Mayo Clin Proc 2010 Oct;85(10):933-42. Epub 2010 Aug 16 doi: 10.4065/mcp.2010.0337. PMID: 20713974Free PMC Article

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