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Peliosis hepatis

MedGen UID:
10618
•Concept ID:
C0030781
•
Disease or Syndrome
Synonyms: Hepatis, Peliosis; Peliosis Hepatis
SNOMED CT: PH - Peliosis hepatis (58008004); Peliosis hepatis (58008004); Hepatic peliosis (58008004)
 
Monarch Initiative: MONDO:0004717

Definition

A vascular disease of the liver characterized by the occurrence of multiple blood-filled cysts or cavities. The cysts are lined with endothelial cells; the cavities lined with hepatic parenchymal cells (hepatocytes). Peliosis hepatis has been associated with use of anabolic steroids (anabolic agents) and certain drugs. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPeliosis hepatis

Professional guidelines

PubMed

Spontaneous hepatic haemorrhage: a review of pathogenesis, aetiology and treatment.
Srinivasa S, Lee WG, Aldameh A, Koea JB
HPB (Oxford) 2015 Oct;17(10):872-80. Epub 2015 Aug 7 doi: 10.1111/hpb.12474. PMID: 26252245Free PMC Article
Pathogenicity and treatment of Bartonella infections.
Angelakis E, Raoult D
Int J Antimicrob Agents 2014 Jul;44(1):16-25. Epub 2014 May 9 doi: 10.1016/j.ijantimicag.2014.04.006. PMID: 24933445
Bartonella infection: treatment and drug resistance.
Biswas S, Rolain JM
Future Microbiol 2010 Nov;5(11):1719-31. doi: 10.2217/fmb.10.133. PMID: 21133691

Recent clinical studies

Etiology

Anabolic androgenic steroid-induced liver injury: An update.
Petrovic A, Vukadin S, Sikora R, Bojanic K, Smolic R, Plavec D, Wu GY, Smolic M
World J Gastroenterol 2022 Jul 14;28(26):3071-3080. doi: 10.3748/wjg.v28.i26.3071. PMID: 36051334Free PMC Article
Hepatotoxicity associated with illicit use of anabolic androgenic steroids in doping.
Solimini R, Rotolo MC, Mastrobattista L, Mortali C, Minutillo A, Pichini S, Pacifici R, Palmi I
Eur Rev Med Pharmacol Sci 2017 Mar;21(1 Suppl):7-16. PMID: 28379599
Peliosis hepatis: Personal experience and literature review.
Crocetti D, Palmieri A, Pedullà G, Pasta V, D'Orazi V, Grazi GL
World J Gastroenterol 2015 Dec 14;21(46):13188-94. doi: 10.3748/wjg.v21.i46.13188. PMID: 26675327Free PMC Article
Bartonellosis.
Maguiña C, Guerra H, Ventosilla P
Clin Dermatol 2009 May-Jun;27(3):271-80. doi: 10.1016/j.clindermatol.2008.10.006. PMID: 19362689
Vascular liver diseases.
DeLeve LD
Curr Gastroenterol Rep 2003 Feb;5(1):63-70. doi: 10.1007/s11894-003-0011-0. PMID: 12530950

Diagnosis

A Comprehensive Approach to Hepatic Vascular Disease.
Elsayes KM, Shaaban AM, Rothan SM, Javadi S, Madrazo BL, Castillo RP, Casillas VJ, Menias CO
Radiographics 2017 May-Jun;37(3):813-836. Epub 2017 Apr 21 doi: 10.1148/rg.2017160161. PMID: 28430541
Bartonellosis.
Maguiña C, Guerra H, Ventosilla P
Clin Dermatol 2009 May-Jun;27(3):271-80. doi: 10.1016/j.clindermatol.2008.10.006. PMID: 19362689
Pathology of peliosis.
Tsokos M, Erbersdobler A
Forensic Sci Int 2005 Apr 20;149(1):25-33. doi: 10.1016/j.forsciint.2004.05.010. PMID: 15734106
Vascular liver diseases.
DeLeve LD
Curr Gastroenterol Rep 2003 Feb;5(1):63-70. doi: 10.1007/s11894-003-0011-0. PMID: 12530950
Drug-induced liver disease.
Zimmerman HJ
Drugs 1978 Jul;16(1):25-45. doi: 10.2165/00003495-197816010-00002. PMID: 352664

Therapy

Anabolic androgenic steroid-induced liver injury: An update.
Petrovic A, Vukadin S, Sikora R, Bojanic K, Smolic R, Plavec D, Wu GY, Smolic M
World J Gastroenterol 2022 Jul 14;28(26):3071-3080. doi: 10.3748/wjg.v28.i26.3071. PMID: 36051334Free PMC Article
Hepatic disorders associated with exogenous sex steroids: MR imaging findings.
Hui CL, Lee ZJ
Abdom Radiol (NY) 2019 Jul;44(7):2436-2447. doi: 10.1007/s00261-019-01941-4. PMID: 30955069
Hepatotoxicity associated with illicit use of anabolic androgenic steroids in doping.
Solimini R, Rotolo MC, Mastrobattista L, Mortali C, Minutillo A, Pichini S, Pacifici R, Palmi I
Eur Rev Med Pharmacol Sci 2017 Mar;21(1 Suppl):7-16. PMID: 28379599
Pathogenicity and treatment of Bartonella infections.
Angelakis E, Raoult D
Int J Antimicrob Agents 2014 Jul;44(1):16-25. Epub 2014 May 9 doi: 10.1016/j.ijantimicag.2014.04.006. PMID: 24933445
Bartonella infection: treatment and drug resistance.
Biswas S, Rolain JM
Future Microbiol 2010 Nov;5(11):1719-31. doi: 10.2217/fmb.10.133. PMID: 21133691

Prognosis

Peliosis hepatis: Personal experience and literature review.
Crocetti D, Palmieri A, Pedullà G, Pasta V, D'Orazi V, Grazi GL
World J Gastroenterol 2015 Dec 14;21(46):13188-94. doi: 10.3748/wjg.v21.i46.13188. PMID: 26675327Free PMC Article
Sex hormonal preparations and the liver.
Dourakis SP, Tolis G
Eur J Contracept Reprod Health Care 1998 Mar;3(1):7-16. doi: 10.3109/13625189809167479. PMID: 9678067
Impact and evolution of peliosis hepatis in renal transplant recipients.
Cavalcanti R, Pol S, Carnot F, Campos H, Degott C, Driss F, Legendre C, Kreis H
Transplantation 1994 Aug 15;58(3):315-6. PMID: 8053054
Transjugular liver biopsy.
McAfee JH, Keeffe EB, Lee RG, Rösch J
Hepatology 1992 Apr;15(4):726-32. doi: 10.1002/hep.1840150429. PMID: 1551649
Drug-induced liver disease.
Zimmerman HJ
Drugs 1978 Jul;16(1):25-45. doi: 10.2165/00003495-197816010-00002. PMID: 352664

Clinical prediction guides

MRI of Peliosis Hepatis: A Case Series Presentation With a 2022 Systematic Literature Update.
Calistri L, Nardi C, Rastrelli V, Maraghelli D, Grazioli L, Messerini L, Colagrande S
J Magn Reson Imaging 2023 Nov;58(5):1386-1405. Epub 2023 Mar 29 doi: 10.1002/jmri.28673. PMID: 36988385
Anabolic androgenic steroid-induced hepatotoxicity.
Bond P, Llewellyn W, Van Mol P
Med Hypotheses 2016 Aug;93:150-3. Epub 2016 Jun 5 doi: 10.1016/j.mehy.2016.06.004. PMID: 27372877
Peliosis hepatis: Personal experience and literature review.
Crocetti D, Palmieri A, Pedullà G, Pasta V, D'Orazi V, Grazi GL
World J Gastroenterol 2015 Dec 14;21(46):13188-94. doi: 10.3748/wjg.v21.i46.13188. PMID: 26675327Free PMC Article
Bartonella infection in animals: carriership, reservoir potential, pathogenicity, and zoonotic potential for human infection.
Breitschwerdt EB, Kordick DL
Clin Microbiol Rev 2000 Jul;13(3):428-38. doi: 10.1128/CMR.13.3.428. PMID: 10885985Free PMC Article
Drug-induced liver disease.
Zimmerman HJ
Drugs 1978 Jul;16(1):25-45. doi: 10.2165/00003495-197816010-00002. PMID: 352664

Recent systematic reviews

MRI of Peliosis Hepatis: A Case Series Presentation With a 2022 Systematic Literature Update.
Calistri L, Nardi C, Rastrelli V, Maraghelli D, Grazioli L, Messerini L, Colagrande S
J Magn Reson Imaging 2023 Nov;58(5):1386-1405. Epub 2023 Mar 29 doi: 10.1002/jmri.28673. PMID: 36988385
Thiopurine-induced liver injury in patients with inflammatory bowel disease: a systematic review.
Gisbert JP, González-Lama Y, Maté J
Am J Gastroenterol 2007 Jul;102(7):1518-27. Epub 2007 Mar 27 doi: 10.1111/j.1572-0241.2007.01187.x. PMID: 17391318

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