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Allergy to penicillin

MedGen UID:
10626
•Concept ID:
C0030824
•
Disease or Syndrome
Synonyms: Penicillin allergy; Penicillin Allergy
SNOMED CT: Penicillin allergy (91936005); Allergy to penicillin (91936005)

Definition

An allergy to Penicillin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAllergy to penicillin

Professional guidelines

PubMed

Penicillin Allergy: Mechanisms, Diagnosis, and Management.
Green EA, Fogarty K, Ishmael FT
Prim Care 2023 Jun;50(2):221-235. Epub 2023 Feb 26 doi: 10.1016/j.pop.2022.11.002. PMID: 37105603
Evaluation and Management of Penicillin Allergy: A Review.
Shenoy ES, Macy E, Rowe T, Blumenthal KG
JAMA 2019 Jan 15;321(2):188-199. doi: 10.1001/jama.2018.19283. PMID: 30644987
Epidemiology, clinical impacts and current clinical management of Helicobacter pylori infection.
Mitchell H, Katelaris P
Med J Aust 2016 Jun 6;204(10):376-80. doi: 10.5694/mja16.00104. PMID: 27256648

Recent clinical studies

Etiology

Allergy to penicillin and betalactam antibiotics.
Felix MMR, Aun MV, Menezes UP, Queiroz GRES, Rodrigues AT, D'Onofrio-Silva AC, Perelló MI, Camelo-Nunes IC, Malaman MF
Einstein (Sao Paulo) 2021;19:eMD5703. Epub 2021 Apr 26 doi: 10.31744/einstein_journal/2021MD5703. PMID: 33909756Free PMC Article
Update on penicillin allergy delabeling.
Shaker M, McWilliams S, Greenhawt M
Curr Opin Pediatr 2020 Apr;32(2):321-327. doi: 10.1097/MOP.0000000000000879. PMID: 32068593
Evaluation and Management of Penicillin Allergy: A Review.
Shenoy ES, Macy E, Rowe T, Blumenthal KG
JAMA 2019 Jan 15;321(2):188-199. doi: 10.1001/jama.2018.19283. PMID: 30644987
Overview of penicillin allergy.
Chang C, Mahmood MM, Teuber SS, Gershwin ME
Clin Rev Allergy Immunol 2012 Aug;43(1-2):84-97. doi: 10.1007/s12016-011-8279-6. PMID: 21789743
Cephalosporin allergy.
Madaan A, Li JT
Immunol Allergy Clin North Am 2004 Aug;24(3):463-76, vi-vii. doi: 10.1016/j.iac.2004.03.009. PMID: 15242721

Diagnosis

Penicillin Allergy: Mechanisms, Diagnosis, and Management.
Green EA, Fogarty K, Ishmael FT
Prim Care 2023 Jun;50(2):221-235. Epub 2023 Feb 26 doi: 10.1016/j.pop.2022.11.002. PMID: 37105603
Evaluation and Management of Penicillin Allergy: A Review.
Shenoy ES, Macy E, Rowe T, Blumenthal KG
JAMA 2019 Jan 15;321(2):188-199. doi: 10.1001/jama.2018.19283. PMID: 30644987
Rhinosinusitis.
DeCastro A, Mims L, Hueston WJ
Prim Care 2014 Mar;41(1):47-61. doi: 10.1016/j.pop.2013.10.006. PMID: 24439880
Cephalosporin allergy.
Madaan A, Li JT
Immunol Allergy Clin North Am 2004 Aug;24(3):463-76, vi-vii. doi: 10.1016/j.iac.2004.03.009. PMID: 15242721
Allergy to penicillin.
Beeley L
Br Med J (Clin Res Ed) 1984 Feb 18;288(6416):511-2. doi: 10.1136/bmj.288.6416.511-a. PMID: 6421358Free PMC Article

Therapy

Penicillin Allergy: Mechanisms, Diagnosis, and Management.
Green EA, Fogarty K, Ishmael FT
Prim Care 2023 Jun;50(2):221-235. Epub 2023 Feb 26 doi: 10.1016/j.pop.2022.11.002. PMID: 37105603
Evaluation and Management of Penicillin Allergy: A Review.
Shenoy ES, Macy E, Rowe T, Blumenthal KG
JAMA 2019 Jan 15;321(2):188-199. doi: 10.1001/jama.2018.19283. PMID: 30644987
Rhinosinusitis.
DeCastro A, Mims L, Hueston WJ
Prim Care 2014 Mar;41(1):47-61. doi: 10.1016/j.pop.2013.10.006. PMID: 24439880
Cephalosporin allergy.
Madaan A, Li JT
Immunol Allergy Clin North Am 2004 Aug;24(3):463-76, vi-vii. doi: 10.1016/j.iac.2004.03.009. PMID: 15242721
Allergy to penicillin.
Beeley L
Br Med J (Clin Res Ed) 1984 Feb 18;288(6416):511-2. doi: 10.1136/bmj.288.6416.511-a. PMID: 6421358Free PMC Article

Prognosis

Is Penicillin Allergy a Risk Factor for Surgical Site Infection After Oral and Maxillofacial Surgery?
Roistacher DM, Heller JA, Ferraro NF, August M
J Oral Maxillofac Surg 2022 Jan;80(1):93-100. Epub 2021 Aug 19 doi: 10.1016/j.joms.2021.08.147. PMID: 34547269
A Closer Look at Penicillin Allergy History: Systematic Review and Meta-Analysis of Tolerance to Drug Challenge.
DesBiens M, Scalia P, Ravikumar S, Glick A, Newton H, Erinne O, Riblet N
Am J Med 2020 Apr;133(4):452-462.e4. Epub 2019 Oct 21 doi: 10.1016/j.amjmed.2019.09.017. PMID: 31647915
Penicillin Allergy Evaluation: A Prospective, Multicenter, Open-Label Evaluation of a Comprehensive Penicillin Skin Test Kit.
Solensky R, Jacobs J, Lester M, Lieberman P, McCafferty F, Nilsson T, Park M, Schwarz G, Soong W, Wagelie-Steffen A, Wedner HJ, Weiss M, Windom H, Tonascia J, Yates KP, Mendelson LM, Wolfe J, Adkinson NF
J Allergy Clin Immunol Pract 2019 Jul-Aug;7(6):1876-1885.e3. Epub 2019 Mar 13 doi: 10.1016/j.jaip.2019.02.040. PMID: 30878711
Evaluation and Management of Penicillin Allergy: A Review.
Shenoy ES, Macy E, Rowe T, Blumenthal KG
JAMA 2019 Jan 15;321(2):188-199. doi: 10.1001/jama.2018.19283. PMID: 30644987
Adverse drug reactions of Shuanghuanglian injection: a systematic review of public literatures.
Wang L, Cheng L, Yuan Q, Cui X, Shang H, Zhang B, Li Y
J Evid Based Med 2010 Feb;3(1):18-26. Epub 2010 Feb 17 doi: 10.1111/j.1756-5391.2010.01067.x. PMID: 21349036

Clinical prediction guides

Is Penicillin Allergy a Risk Factor for Surgical Site Infection After Oral and Maxillofacial Surgery?
Roistacher DM, Heller JA, Ferraro NF, August M
J Oral Maxillofac Surg 2022 Jan;80(1):93-100. Epub 2021 Aug 19 doi: 10.1016/j.joms.2021.08.147. PMID: 34547269
Self-reported beta-lactam intolerance: not a class effect, dangerous to patients, and rarely allergy.
Vyles D, Macy E
Expert Rev Anti Infect Ther 2019 Jun;17(6):429-435. Epub 2019 May 15 doi: 10.1080/14787210.2019.1617132. PMID: 31067139
Evaluation and Management of Penicillin Allergy: A Review.
Shenoy ES, Macy E, Rowe T, Blumenthal KG
JAMA 2019 Jan 15;321(2):188-199. doi: 10.1001/jama.2018.19283. PMID: 30644987
Overview of penicillin allergy.
Chang C, Mahmood MM, Teuber SS, Gershwin ME
Clin Rev Allergy Immunol 2012 Aug;43(1-2):84-97. doi: 10.1007/s12016-011-8279-6. PMID: 21789743
Vancomycin-induced leukocytoclastic vasculitis.
Felix-Getzik E, Sylvia LM
Pharmacotherapy 2009 Jul;29(7):846-51. doi: 10.1592/phco.29.7.846. PMID: 19558258

Recent systematic reviews

Self-reported allergy to penicillin and clindamycin administration may be risk factors for dental implant failure: A systematic review, meta-analysis and delabeling protocol.
Edibam NR, Lorenzo-Pouso AI, Caponio VCA
Clin Oral Implants Res 2023 Jul;34(7):651-661. Epub 2023 Apr 27 doi: 10.1111/clr.14073. PMID: 37102260
Antibiotic desensitization as a potential tool in antimicrobial stewardship programs: retrospective data analysis and systematic literature review.
Rodríguez-Alarcón A, Barceló-Vidal J, Echeverría-Esnal D, Sorli L, Güerri-Fernández R, Ramis Fernández SM, Benitez-Cano A, Sendra E, López Montesinos I, Membrilla-Fernández E, Ferrández O, Adalia R, Horcajada JP, Escolano F, Gómez-Zorrilla S, Grau S; , on behalf of PROA-PSMAR group.
Expert Rev Anti Infect Ther 2022 Nov;20(11):1491-1500. Epub 2022 Sep 12 doi: 10.1080/14787210.2022.2122443. PMID: 36069242
A Closer Look at Penicillin Allergy History: Systematic Review and Meta-Analysis of Tolerance to Drug Challenge.
DesBiens M, Scalia P, Ravikumar S, Glick A, Newton H, Erinne O, Riblet N
Am J Med 2020 Apr;133(4):452-462.e4. Epub 2019 Oct 21 doi: 10.1016/j.amjmed.2019.09.017. PMID: 31647915
Adverse events to Houttuynia injection: A systematic review.
Wang L, Cui X, Cheng L, Yuan Q, Li T, Li Y, Deng S, Shang H, Bian Z
J Evid Based Med 2010 Aug;3(3):168-76. doi: 10.1111/j.1756-5391.2010.01091.x. PMID: 21349062
Adverse drug reactions of Shuanghuanglian injection: a systematic review of public literatures.
Wang L, Cheng L, Yuan Q, Cui X, Shang H, Zhang B, Li Y
J Evid Based Med 2010 Feb;3(1):18-26. Epub 2010 Feb 17 doi: 10.1111/j.1756-5391.2010.01067.x. PMID: 21349036

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