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Induratio penis plastica

MedGen UID:
10629
Concept ID:
C0030848
Disease or Syndrome
Synonyms: Penile curvature; Penile Induration; Peyronie disease
SNOMED CT: Peyronies disease (1335005); Induratio penis plastica (1335005); Peyronie's disease (1335005); Penile fibromatosis (1335005); Fibrous cavernositis (1335005); Plastic induration of penis (1335005); Penile plaque (1335005)
 
Monarch Initiative: MONDO:0008231
OMIM®: 171000
Orphanet: ORPHA2870

Definition

Fibromatosis arising from the soft tissues of the penis. It is characterized by the presence of spindle-shaped fibroblasts, and an infiltrative growth pattern. It causes the penis to bend when it becomes erect. [from NCI]

Clinical features

From HPO
Abnormality of the genitourinary system
MedGen UID:
52948
Concept ID:
C0042063
Congenital Abnormality
The presence of any abnormality of the genitourinary system.
Contracture of palmar fascia
MedGen UID:
41672
Concept ID:
C0013312
Disease or Syndrome
Dupuytren contracture is the most common heritable disorder of connective tissue. It is a disease of the soft tissues of the palm and fingers characterized by a progressive thickening and shortening of the fascial structures that normally provide support to the glabrous skin of the palm. Although it can also be a sporadic disorder, the inherited form is most frequently observed among people of Nordic descent. There is a male: female ratio of greater than 3:1 (Hu et al., 2005). Dupuytren contracture has been associated with multiple fibroproliferative conditions, including Peyronie disease (171000), knuckle pads (149100), congenital generalized fibromatosis (228550), juvenile fibromatosis (228600), and frozen shoulder, suggesting a common underlying defect in wound repair (Hu et al., 2005).
Abnormality of the skeletal system
MedGen UID:
867418
Concept ID:
C4021790
Anatomical Abnormality
An abnormality of the skeletal system.

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInduratio penis plastica

Professional guidelines

PubMed

Colombo F, Franceschelli A, Gentile G, Droghetti M, Fiorillo A, Palmisano F
Urologia 2021 May;88(2):79-89. Epub 2021 Mar 30 doi: 10.1177/03915603211005326. PMID: 33781136
Seegenschmiedt MH, Micke O, Niewald M, Mücke R, Eich HT, Kriz J, Heyd R; German Cooperative Group on Radiotherapy of Benign Diseases (GCG-BD)
Strahlenther Onkol 2015 Jul;191(7):541-8. Epub 2015 Mar 10 doi: 10.1007/s00066-015-0818-2. PMID: 25753848
Byström J, Johansson B, Edsmyr F, Körlof B, Nylén B
Scand J Urol Nephrol 1972;6(1):1-5. doi: 10.3109/00365597209132070. PMID: 5057616

Recent clinical studies

Etiology

Capogrosso P, Pozzi E, Russo GI, Hatzichristodoulou G, Cocci A, Falcone M, Martinez-Salamanca JI, Fernández-Pascual E, Candela L, Schifano N, Dehò F, Salonia A; European Association of Urology–Young Academic Urologists Sexual and Reproductive Working Group
J Sex Med 2023 Dec 22;21(1):54-58. doi: 10.1093/jsxmed/qdad145. PMID: 37973410
Seegenschmiedt MH, Micke O, Niewald M, Mücke R, Eich HT, Kriz J, Heyd R; German Cooperative Group on Radiotherapy of Benign Diseases (GCG-BD)
Strahlenther Onkol 2015 Jul;191(7):541-8. Epub 2015 Mar 10 doi: 10.1007/s00066-015-0818-2. PMID: 25753848
Silvani M, Pecoraro S, Zucchi A
Arch Ital Urol Androl 2012 Jun;84(2):84-8. PMID: 22908777
Seveso M, Taverna G, Giusti G, Benetti A, Maugeri O, Piccinelli A, Graziotti P
Arch Ital Urol Androl 2010 Sep;82(3):164-6. PMID: 21121435
Koren H, Alth G, Schenk GM, Jindra RH
Urol Res 1996;24(4):245-8. doi: 10.1007/BF00295900. PMID: 8873384

Diagnosis

Seveso M, Taverna G, Giusti G, Benetti A, Maugeri O, Piccinelli A, Graziotti P
Arch Ital Urol Androl 2010 Sep;82(3):164-6. PMID: 21121435
Fornara P, Gerbershagen HP
World J Urol 2004 Nov;22(5):365-7. Epub 2004 Jul 28 doi: 10.1007/s00345-004-0424-x. PMID: 15672280
Wunderlich H, Werner W, Schubert J
Urol Int 1998;60(2):97-100. doi: 10.1159/000030219. PMID: 9563147
Schneider HJ, Rugendorff EW, Röhrborn C
Int Urol Nephrol 1985;17(3):235-44. doi: 10.1007/BF02085410. PMID: 4086238
Byström J, Rubio C
Scand J Urol Nephrol 1976;10(1):12-20. doi: 10.3109/00365597609179648. PMID: 1273527

Therapy

Longo L, Longo D
Photobiomodul Photomed Laser Surg 2022 Apr;40(4):287-291. Epub 2021 Dec 23 doi: 10.1089/photob.2021.0102. PMID: 34941426
Mirone V, Imbimbo C, Palmieri A, Fusco F
Eur Urol 1999 Oct;36(4):327-30. doi: 10.1159/000020013. PMID: 10473993
Koren H, Alth G, Schenk GM, Jindra RH
Urol Res 1996;24(4):245-8. doi: 10.1007/BF00295900. PMID: 8873384
Schneider HJ, Rugendorff EW, Röhrborn C
Int Urol Nephrol 1985;17(3):235-44. doi: 10.1007/BF02085410. PMID: 4086238
Byström J, Johansson B, Edsmyr F, Körlof B, Nylén B
Scand J Urol Nephrol 1972;6(1):1-5. doi: 10.3109/00365597209132070. PMID: 5057616

Prognosis

De Rose AF, Mantica G, Maffezzini M, Terrone C
Arch Esp Urol 2019 May;72(4):415-421. PMID: 31070138
Silvani M, Pecoraro S, Zucchi A
Arch Ital Urol Androl 2012 Jun;84(2):84-8. PMID: 22908777
Seveso M, Taverna G, Giusti G, Benetti A, Maugeri O, Piccinelli A, Graziotti P
Arch Ital Urol Androl 2010 Sep;82(3):164-6. PMID: 21121435
Wunderlich H, Werner W, Schubert J
Urol Int 1998;60(2):97-100. doi: 10.1159/000030219. PMID: 9563147
Byström J, Alfthan O, Johansson B, Körlof B
Scand J Plast Reconstr Surg 1973;7(2):137-40. doi: 10.3109/02844317309056423. PMID: 4782119

Clinical prediction guides

Capogrosso P, Pozzi E, Russo GI, Hatzichristodoulou G, Cocci A, Falcone M, Martinez-Salamanca JI, Fernández-Pascual E, Candela L, Schifano N, Dehò F, Salonia A; European Association of Urology–Young Academic Urologists Sexual and Reproductive Working Group
J Sex Med 2023 Dec 22;21(1):54-58. doi: 10.1093/jsxmed/qdad145. PMID: 37973410
Silvani M, Pecoraro S, Zucchi A
Arch Ital Urol Androl 2012 Jun;84(2):84-8. PMID: 22908777
Koren H, Alth G, Schenk GM, Jindra RH
Urol Res 1996;24(4):245-8. doi: 10.1007/BF00295900. PMID: 8873384
Klevmark B, Andersen M, Schultz A, Talseth T
Br J Urol 1994 Oct;74(4):501-6. doi: 10.1111/j.1464-410x.1994.tb00431.x. PMID: 7820431
Byström J, Rubio C
Scand J Urol Nephrol 1976;10(1):12-20. doi: 10.3109/00365597609179648. PMID: 1273527

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