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Hand-foot syndrome

MedGen UID:
107497
•Concept ID:
C0549410
•
Disease or Syndrome
Synonyms: Acral Erythema, Chemotherapy-Induced; Acral Erythemas, Chemotherapy-Induced; Chemotherapy Induced Acral Erythema; Chemotherapy Induced Palmoplantar Erythrodysesthesia; Chemotherapy-Induced Acral Erythema; Chemotherapy-Induced Acral Erythemas; Chemotherapy-Induced Palmoplantar Erythrodysesthesia; Chemotherapy-Induced Palmoplantar Erythrodysesthesias; Hand Foot Syndrome; Hand-Foot Syndrome; Hand-Foot Syndromes; Palmoplantar Erythrodysesthesia, Chemotherapy-Induced; Palmoplantar Erythrodysesthesias, Chemotherapy-Induced; Syndrome, Hand-Foot; Syndromes, Hand-Foot
 
Monarch Initiative: MONDO:0700048

Definition

A condition characterized by redness, pain, swelling, and tingling in the palms of the hands or the soles of the feet. It may appear as a side effect to chemotherapy agents. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHand-foot syndrome

Professional guidelines

PubMed

Prophylactic strategies for hand-foot syndrome/skin reaction associated with systemic cancer treatment: a meta-analysis of randomized controlled trials.
Pandy JGP, Franco PIG, Li RK
Support Care Cancer 2022 Nov;30(11):8655-8666. Epub 2022 Jun 2 doi: 10.1007/s00520-022-07175-3. PMID: 35655045
Drug-Induced Itch Management.
Ebata T
Curr Probl Dermatol 2016;50:155-63. Epub 2016 Aug 23 doi: 10.1159/000446084. PMID: 27578085
Chemotherapy-induced hand-foot syndrome and nail changes: a review of clinical presentation, etiology, pathogenesis, and management.
Miller KK, Gorcey L, McLellan BN
J Am Acad Dermatol 2014 Oct;71(4):787-94. Epub 2014 May 1 doi: 10.1016/j.jaad.2014.03.019. PMID: 24795111

Recent clinical studies

Etiology

Hand-foot syndrome induced by chemotherapy drug: Case series study and literature review.
Zaiem A, Hammamia SB, Aouinti I, Charfi O, Ladhari W, Kastalli S, Aidli SE, Lakhoua G
Indian J Pharmacol 2022 May-Jun;54(3):208-215. doi: 10.4103/ijp.ijp_175_21. PMID: 35848692Free PMC Article
Prophylactic strategies for hand-foot syndrome/skin reaction associated with systemic cancer treatment: a meta-analysis of randomized controlled trials.
Pandy JGP, Franco PIG, Li RK
Support Care Cancer 2022 Nov;30(11):8655-8666. Epub 2022 Jun 2 doi: 10.1007/s00520-022-07175-3. PMID: 35655045
Adjuvant Capecitabine for Breast Cancer after Preoperative Chemotherapy.
Masuda N, Lee SJ, Ohtani S, Im YH, Lee ES, Yokota I, Kuroi K, Im SA, Park BW, Kim SB, Yanagita Y, Ohno S, Takao S, Aogi K, Iwata H, Jeong J, Kim A, Park KH, Sasano H, Ohashi Y, Toi M
N Engl J Med 2017 Jun 1;376(22):2147-2159. doi: 10.1056/NEJMoa1612645. PMID: 28564564
Topical Retinoids: Therapeutic Mechanisms in the Treatment of Photodamaged Skin.
Riahi RR, Bush AE, Cohen PR
Am J Clin Dermatol 2016 Jun;17(3):265-76. doi: 10.1007/s40257-016-0185-5. PMID: 26969582
Chemotherapy-induced hand-foot syndrome and nail changes: a review of clinical presentation, etiology, pathogenesis, and management.
Miller KK, Gorcey L, McLellan BN
J Am Acad Dermatol 2014 Oct;71(4):787-94. Epub 2014 May 1 doi: 10.1016/j.jaad.2014.03.019. PMID: 24795111

Diagnosis

Apatinib as second-line or later therapy in patients with advanced hepatocellular carcinoma (AHELP): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial.
Qin S, Li Q, Gu S, Chen X, Lin L, Wang Z, Xu A, Chen X, Zhou C, Ren Z, Yang L, Xu L, Bai Y, Chen L, Li J, Pan H, Cao B, Fang W, Wu W, Wang G, Cheng Y, Yu Z, Zhu X, Jiang D, Lu Y, Wang H, Xu J, Bai L, Liu Y, Lin H, Wu C, Zhang Y, Yan P, Jin C, Zou J
Lancet Gastroenterol Hepatol 2021 Jul;6(7):559-568. Epub 2021 May 8 doi: 10.1016/S2468-1253(21)00109-6. PMID: 33971141
Capecitabine compared with observation in resected biliary tract cancer (BILCAP): a randomised, controlled, multicentre, phase 3 study.
Primrose JN, Fox RP, Palmer DH, Malik HZ, Prasad R, Mirza D, Anthony A, Corrie P, Falk S, Finch-Jones M, Wasan H, Ross P, Wall L, Wadsley J, Evans JTR, Stocken D, Praseedom R, Ma YT, Davidson B, Neoptolemos JP, Iveson T, Raftery J, Zhu S, Cunningham D, Garden OJ, Stubbs C, Valle JW, Bridgewater J; BILCAP study group
Lancet Oncol 2019 May;20(5):663-673. Epub 2019 Mar 25 doi: 10.1016/S1470-2045(18)30915-X. PMID: 30922733
Predictors of Hand-Foot Syndrome and Pyridoxine for Prevention of Capecitabine-Induced Hand-Foot Syndrome: A Randomized Clinical Trial.
Yap YS, Kwok LL, Syn N, Chay WY, Chia JWK, Tham CK, Wong NS, Lo SK, Dent RA, Tan S, Mok ZY, Koh KX, Toh HC, Koo WH, Loh M, Ng RCH, Choo SP, Soong RCT
JAMA Oncol 2017 Nov 1;3(11):1538-1545. doi: 10.1001/jamaoncol.2017.1269. PMID: 28715540Free PMC Article
SWOG S0809: A Phase II Intergroup Trial of Adjuvant Capecitabine and Gemcitabine Followed by Radiotherapy and Concurrent Capecitabine in Extrahepatic Cholangiocarcinoma and Gallbladder Carcinoma.
Ben-Josef E, Guthrie KA, El-Khoueiry AB, Corless CL, Zalupski MM, Lowy AM, Thomas CR Jr, Alberts SR, Dawson LA, Micetich KC, Thomas MB, Siegel AB, Blanke CD
J Clin Oncol 2015 Aug 20;33(24):2617-22. Epub 2015 May 11 doi: 10.1200/JCO.2014.60.2219. PMID: 25964250Free PMC Article
Capecitabine and hand-foot syndrome.
Saif MW
Expert Opin Drug Saf 2011 Mar;10(2):159-69. Epub 2010 Dec 22 doi: 10.1517/14740338.2011.546342. PMID: 21174613

Therapy

Prophylactic strategies for hand-foot syndrome/skin reaction associated with systemic cancer treatment: a meta-analysis of randomized controlled trials.
Pandy JGP, Franco PIG, Li RK
Support Care Cancer 2022 Nov;30(11):8655-8666. Epub 2022 Jun 2 doi: 10.1007/s00520-022-07175-3. PMID: 35655045
Effect of Capecitabine Maintenance Therapy Using Lower Dosage and Higher Frequency vs Observation on Disease-Free Survival Among Patients With Early-Stage Triple-Negative Breast Cancer Who Had Received Standard Treatment: The SYSUCC-001 Randomized Clinical Trial.
Wang X, Wang SS, Huang H, Cai L, Zhao L, Peng RJ, Lin Y, Tang J, Zeng J, Zhang LH, Ke YL, Wang XM, Liu XM, Chen QJ, Zhang AQ, Xu F, Bi XW, Huang JJ, Li JB, Pang DM, Xue C, Shi YX, He ZY, Lin HX, An X, Xia W, Cao Y, Guo Y, Su YH, Hua X, Wang XY, Hong RX, Jiang KK, Song CG, Huang ZZ, Shi W, Zhong YY, Yuan ZY; South China Breast Cancer Group (SCBCG)
JAMA 2021 Jan 5;325(1):50-58. doi: 10.1001/jama.2020.23370. PMID: 33300950Free PMC Article
Adjuvant Capecitabine for Breast Cancer after Preoperative Chemotherapy.
Masuda N, Lee SJ, Ohtani S, Im YH, Lee ES, Yokota I, Kuroi K, Im SA, Park BW, Kim SB, Yanagita Y, Ohno S, Takao S, Aogi K, Iwata H, Jeong J, Kim A, Park KH, Sasano H, Ohashi Y, Toi M
N Engl J Med 2017 Jun 1;376(22):2147-2159. doi: 10.1056/NEJMoa1612645. PMID: 28564564
Possible Pathways of Capecitabine-Induced Hand-Foot Syndrome.
Lou Y, Wang Q, Zheng J, Hu H, Liu L, Hong D, Zeng S
Chem Res Toxicol 2016 Oct 17;29(10):1591-1601. Epub 2016 Sep 28 doi: 10.1021/acs.chemrestox.6b00215. PMID: 27631426
Chemotherapy-induced hand-foot syndrome and nail changes: a review of clinical presentation, etiology, pathogenesis, and management.
Miller KK, Gorcey L, McLellan BN
J Am Acad Dermatol 2014 Oct;71(4):787-94. Epub 2014 May 1 doi: 10.1016/j.jaad.2014.03.019. PMID: 24795111

Prognosis

Hand-foot syndrome induced by chemotherapy drug: Case series study and literature review.
Zaiem A, Hammamia SB, Aouinti I, Charfi O, Ladhari W, Kastalli S, Aidli SE, Lakhoua G
Indian J Pharmacol 2022 May-Jun;54(3):208-215. doi: 10.4103/ijp.ijp_175_21. PMID: 35848692Free PMC Article
Pyrotinib plus capecitabine versus lapatinib plus capecitabine for the treatment of HER2-positive metastatic breast cancer (PHOEBE): a multicentre, open-label, randomised, controlled, phase 3 trial.
Xu B, Yan M, Ma F, Hu X, Feng J, Ouyang Q, Tong Z, Li H, Zhang Q, Sun T, Wang X, Yin Y, Cheng Y, Li W, Gu Y, Chen Q, Liu J, Cheng J, Geng C, Qin S, Wang S, Lu J, Shen K, Liu Q, Wang X, Wang H, Luo T, Yang J, Wu Y, Yu Z, Zhu X, Chen C, Zou J; PHOEBE Investigators
Lancet Oncol 2021 Mar;22(3):351-360. Epub 2021 Feb 11 doi: 10.1016/S1470-2045(20)30702-6. PMID: 33581774
Effect of Capecitabine Maintenance Therapy Using Lower Dosage and Higher Frequency vs Observation on Disease-Free Survival Among Patients With Early-Stage Triple-Negative Breast Cancer Who Had Received Standard Treatment: The SYSUCC-001 Randomized Clinical Trial.
Wang X, Wang SS, Huang H, Cai L, Zhao L, Peng RJ, Lin Y, Tang J, Zeng J, Zhang LH, Ke YL, Wang XM, Liu XM, Chen QJ, Zhang AQ, Xu F, Bi XW, Huang JJ, Li JB, Pang DM, Xue C, Shi YX, He ZY, Lin HX, An X, Xia W, Cao Y, Guo Y, Su YH, Hua X, Wang XY, Hong RX, Jiang KK, Song CG, Huang ZZ, Shi W, Zhong YY, Yuan ZY; South China Breast Cancer Group (SCBCG)
JAMA 2021 Jan 5;325(1):50-58. doi: 10.1001/jama.2020.23370. PMID: 33300950Free PMC Article
Adjuvant Capecitabine for Breast Cancer after Preoperative Chemotherapy.
Masuda N, Lee SJ, Ohtani S, Im YH, Lee ES, Yokota I, Kuroi K, Im SA, Park BW, Kim SB, Yanagita Y, Ohno S, Takao S, Aogi K, Iwata H, Jeong J, Kim A, Park KH, Sasano H, Ohashi Y, Toi M
N Engl J Med 2017 Jun 1;376(22):2147-2159. doi: 10.1056/NEJMoa1612645. PMID: 28564564
Chemotherapy-induced hand-foot syndrome and nail changes: a review of clinical presentation, etiology, pathogenesis, and management.
Miller KK, Gorcey L, McLellan BN
J Am Acad Dermatol 2014 Oct;71(4):787-94. Epub 2014 May 1 doi: 10.1016/j.jaad.2014.03.019. PMID: 24795111

Clinical prediction guides

Predicting Response to Anthracyclines in Ovarian Cancer.
Ferrero A, Borghese M, Restaino S, Puppo A, Vizzielli G, Biglia N
Int J Environ Res Public Health 2022 Apr 2;19(7) doi: 10.3390/ijerph19074260. PMID: 35409939Free PMC Article
Metronomic capecitabine as adjuvant therapy in locoregionally advanced nasopharyngeal carcinoma: a multicentre, open-label, parallel-group, randomised, controlled, phase 3 trial.
Chen YP, Liu X, Zhou Q, Yang KY, Jin F, Zhu XD, Shi M, Hu GQ, Hu WH, Sun Y, Wu HF, Wu H, Lin Q, Wang H, Tian Y, Zhang N, Wang XC, Shen LF, Liu ZZ, Huang J, Luo XL, Li L, Zang J, Mei Q, Zheng BM, Yue D, Xu J, Wu SG, Shi YX, Mao YP, Chen L, Li WF, Zhou GQ, Sun R, Guo R, Zhang Y, Xu C, Lv JW, Guo Y, Feng HX, Tang LL, Xie FY, Sun Y, Ma J
Lancet 2021 Jul 24;398(10297):303-313. Epub 2021 Jun 7 doi: 10.1016/S0140-6736(21)01123-5. PMID: 34111416
Pegylated liposomal doxorubicin in patients with epithelial ovarian cancer.
Yuan Z, Zhang Y, Cao D, Shen K, Li Q, Zhang G, Wu X, Cui M, Yue Y, Cheng W, Wang L, Qu P, Tao G, Hou J, Sun L, Meng Y, Li G, Li C, Shi H, Chen Y
J Ovarian Res 2021 Jan 11;14(1):12. doi: 10.1186/s13048-020-00736-2. PMID: 33423683Free PMC Article
Effect of Capecitabine Maintenance Therapy Using Lower Dosage and Higher Frequency vs Observation on Disease-Free Survival Among Patients With Early-Stage Triple-Negative Breast Cancer Who Had Received Standard Treatment: The SYSUCC-001 Randomized Clinical Trial.
Wang X, Wang SS, Huang H, Cai L, Zhao L, Peng RJ, Lin Y, Tang J, Zeng J, Zhang LH, Ke YL, Wang XM, Liu XM, Chen QJ, Zhang AQ, Xu F, Bi XW, Huang JJ, Li JB, Pang DM, Xue C, Shi YX, He ZY, Lin HX, An X, Xia W, Cao Y, Guo Y, Su YH, Hua X, Wang XY, Hong RX, Jiang KK, Song CG, Huang ZZ, Shi W, Zhong YY, Yuan ZY; South China Breast Cancer Group (SCBCG)
JAMA 2021 Jan 5;325(1):50-58. doi: 10.1001/jama.2020.23370. PMID: 33300950Free PMC Article
Predictors of Hand-Foot Syndrome and Pyridoxine for Prevention of Capecitabine-Induced Hand-Foot Syndrome: A Randomized Clinical Trial.
Yap YS, Kwok LL, Syn N, Chay WY, Chia JWK, Tham CK, Wong NS, Lo SK, Dent RA, Tan S, Mok ZY, Koh KX, Toh HC, Koo WH, Loh M, Ng RCH, Choo SP, Soong RCT
JAMA Oncol 2017 Nov 1;3(11):1538-1545. doi: 10.1001/jamaoncol.2017.1269. PMID: 28715540Free PMC Article

Recent systematic reviews

Prevalence of hand-foot syndrome following chemotherapy for colorectal cancer: a systematic review and meta-analysis.
Huang J, Ye S, Feng S, Zheng M, Zhong M
Int J Colorectal Dis 2023 Mar 6;38(1):61. doi: 10.1007/s00384-023-04345-5. PMID: 36872385
Association of Apatinib and Breast Cancer: A systematic review and meta-analysis.
Wang H, Su W, Lowe S, Zhou Z, Bentley R, Zhou Q, Cheng C, Guo X, Song Q, Liang Q, Li N, Liang M, Zhu Y, Sun C
Surg Oncol 2022 Sep;44:101818. Epub 2022 Jul 19 doi: 10.1016/j.suronc.2022.101818. PMID: 35930900
Herbal medicine for hand-foot syndrome induced by fluoropyrimidines: A systematic review and meta-analysis.
Deng B, Sun W
Phytother Res 2018 Jul;32(7):1211-1228. Epub 2018 Apr 16 doi: 10.1002/ptr.6068. PMID: 29682836
Prevention strategies for chemotherapy-induced hand-foot syndrome: a systematic review and meta-analysis of prospective randomised trials.
Macedo LT, Lima JP, dos Santos LV, Sasse AD
Support Care Cancer 2014 Jun;22(6):1585-93. Epub 2014 Jan 26 doi: 10.1007/s00520-014-2129-z. PMID: 24463616
Pyridoxine for prevention of hand-foot syndrome caused by chemotherapy: a systematic review.
Chen M, Zhang L, Wang Q, Shen J
PLoS One 2013;8(8):e72245. Epub 2013 Aug 20 doi: 10.1371/journal.pone.0072245. PMID: 23977264Free PMC Article

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