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Malignant superior sulcus neoplasm

MedGen UID:
107810
•Concept ID:
C0549471
•
Neoplastic Process
Synonyms: Pancoast Tumor; Tumor, Pancoast
SNOMED CT: Superior sulcus tumor (254638002); Pancoast tumor (254638002)
 
Monarch Initiative: MONDO:0006883

Definition

A malignant neoplasm originating from the apical lung. Most malignant superior sulcus neoplasms are bronchogenic carcinomas. This tumor may be associated with Pancoast syndrome. It is also known as Pancoast tumor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant superior sulcus neoplasm

Professional guidelines

PubMed

Management of Lung Cancer Invading the Superior Sulcus.
Kratz JR, Woodard G, Jablons DM
Thorac Surg Clin 2017 May;27(2):149-157. doi: 10.1016/j.thorsurg.2017.01.008. PMID: 28363369
Management of locally advanced pancoast (superior sulcus) tumors with spine involvement.
Setzer M, Robinson LA, Vrionis FD
Cancer Control 2014 Apr;21(2):158-67. doi: 10.1177/107327481402100209. PMID: 24667403
Cubital tunnel syndrome - a review and management guidelines.
Assmus H, Antoniadis G, Bischoff C, Hoffmann R, Martini AK, Preissler P, Scheglmann K, Schwerdtfeger K, Wessels KD, Wüstner-Hofmann M
Cent Eur Neurosurg 2011 May;72(2):90-8. Epub 2011 May 4 doi: 10.1055/s-0031-1271800. PMID: 21547883

Recent clinical studies

Etiology

Surgical Treatment of Superior Sulcus Tumors: A 15-Year Single-center Experience.
Solli P, Casiraghi M, Brambilla D, Maisonneuve P, Spaggiari L
Semin Thorac Cardiovasc Surg 2017 Spring;29(1):79-88. Epub 2017 Feb 22 doi: 10.1053/j.semtcvs.2017.01.010. PMID: 28684003
Pancoast tumor: a modern perspective on an old problem.
Glassman LR, Hyman K
Curr Opin Pulm Med 2013 Jul;19(4):340-3. doi: 10.1097/MCP.0b013e3283621b31. PMID: 23702478
Cubital tunnel syndrome - a review and management guidelines.
Assmus H, Antoniadis G, Bischoff C, Hoffmann R, Martini AK, Preissler P, Scheglmann K, Schwerdtfeger K, Wessels KD, Wüstner-Hofmann M
Cent Eur Neurosurg 2011 May;72(2):90-8. Epub 2011 May 4 doi: 10.1055/s-0031-1271800. PMID: 21547883
Resection of superior sulcus carcinomas (anterior approach).
Macchiarini P
Thorac Surg Clin 2004 May;14(2):229-40. doi: 10.1016/S1547-4127(04)00008-8. PMID: 15382299
Surgical treatment of superior sulcus tumors: results and prognostic factors.
Alifano M, D'Aiuto M, Magdeleinat P, Poupardin E, Chafik A, Strano S, Regnard JF
Chest 2003 Sep;124(3):996-1003. doi: 10.1378/chest.124.3.996. PMID: 12970029

Diagnosis

Pancoast tumour: current therapeutic options.
Palumbo VD, Fazzotta S, Fatica F, D'Orazio B, Caronia FP, Cajozzo M, Damiano G, Maffongelli A, Cudia BM, Messina M, Lo Monte AI
Clin Ter 2019 Jul-Aug;170(4):e291-e294. doi: 10.7417/CT.2019.2150. PMID: 31304518
Diagnosing and treating pancoast tumors.
Zarogoulidis K, Porpodis K, Domvri K, Eleftheriadou E, Ioannidou D, Zarogoulidis P
Expert Rev Respir Med 2016 Dec;10(12):1255-1258. Epub 2016 Oct 27 doi: 10.1080/17476348.2017.1246964. PMID: 27786592
Differential diagnosis of cervical radiculopathy and superior pulmonary sulcus tumor.
Gu R, Kang MY, Gao ZL, Zhao JW, Wang JC
Chin Med J (Engl) 2012 Aug;125(15):2755-7. PMID: 22931987
Cubital tunnel syndrome - a review and management guidelines.
Assmus H, Antoniadis G, Bischoff C, Hoffmann R, Martini AK, Preissler P, Scheglmann K, Schwerdtfeger K, Wessels KD, Wüstner-Hofmann M
Cent Eur Neurosurg 2011 May;72(2):90-8. Epub 2011 May 4 doi: 10.1055/s-0031-1271800. PMID: 21547883
Superior sulcus tumors.
Wright CD, Mathisen DJ
Curr Treat Options Oncol 2001 Feb;2(1):43-9. doi: 10.1007/s11864-001-0015-7. PMID: 12057139

Therapy

Pancoast tumor: a modern perspective on an old problem.
Glassman LR, Hyman K
Curr Opin Pulm Med 2013 Jul;19(4):340-3. doi: 10.1097/MCP.0b013e3283621b31. PMID: 23702478
Cubital tunnel syndrome - a review and management guidelines.
Assmus H, Antoniadis G, Bischoff C, Hoffmann R, Martini AK, Preissler P, Scheglmann K, Schwerdtfeger K, Wessels KD, Wüstner-Hofmann M
Cent Eur Neurosurg 2011 May;72(2):90-8. Epub 2011 May 4 doi: 10.1055/s-0031-1271800. PMID: 21547883
Pancoast (superior sulcus) neoplasms.
Kraut MJ, Vallières E, Thomas CR Jr
Curr Probl Cancer 2003 Mar-Apr;27(2):81-104. doi: 10.1016/s0147-0272(03)00018-7. PMID: 12717414
Superior sulcus tumors.
Wright CD, Mathisen DJ
Curr Treat Options Oncol 2001 Feb;2(1):43-9. doi: 10.1007/s11864-001-0015-7. PMID: 12057139
Pancoast tumors.
Vallières E, Karmy-Jones R, Mulligan MS, Wood DE
Curr Probl Surg 2001 May;38(5):293-376. doi: 10.1067/msg.2001.113528. PMID: 11332249

Prognosis

Harlequin sign in Pancoast tumor.
Kumar R, Bhandari S, Kloecker GH
Curr Probl Cancer 2020 Apr;44(2):100506. Epub 2019 Nov 1 doi: 10.1016/j.currproblcancer.2019.100506. PMID: 31732238
Cubital tunnel syndrome - a review and management guidelines.
Assmus H, Antoniadis G, Bischoff C, Hoffmann R, Martini AK, Preissler P, Scheglmann K, Schwerdtfeger K, Wessels KD, Wüstner-Hofmann M
Cent Eur Neurosurg 2011 May;72(2):90-8. Epub 2011 May 4 doi: 10.1055/s-0031-1271800. PMID: 21547883
Superior sulcus tumors and Pancoast's syndrome.
Jett JR
Lung Cancer 2003 Dec;42 Suppl 2:S17-21. doi: 10.1016/j.lungcan.2003.08.006. PMID: 14644531
Pancoast tumors.
Vallières E, Karmy-Jones R, Mulligan MS, Wood DE
Curr Probl Surg 2001 May;38(5):293-376. doi: 10.1067/msg.2001.113528. PMID: 11332249
Pancoast (superior sulcus) tumors.
Detterbeck FC
Ann Thorac Surg 1997 Jun;63(6):1810-8. doi: 10.1016/s0003-4975(97)00360-3. PMID: 9205202

Clinical prediction guides

Influence of anterior tumor location on survival after resection of lung cancer invading the thoracic inlet (Pancoast tumors).
Tsitsias T, Yasufuku K, Pierre A, Leighl N, Cho J, Waddell TK, Darling G, Cypel M, Donahoe L, Yeung J, Keshavjee S, de Perrot M
J Thorac Cardiovasc Surg 2023 May;165(5):1710-1719.e3. Epub 2022 Nov 2 doi: 10.1016/j.jtcvs.2022.10.033. PMID: 36481062
Horner's syndrome and epidural anesthesia in labor and cesarean section.
Vogiatzaki T, Tsikouras P, Tsoleridis T, Bachar M, Christofis C, Liberis A, Galazios G
Clin Exp Obstet Gynecol 2017;44(3):337-340. PMID: 29949268
Surgical Treatment of Superior Sulcus Tumors: A 15-Year Single-center Experience.
Solli P, Casiraghi M, Brambilla D, Maisonneuve P, Spaggiari L
Semin Thorac Cardiovasc Surg 2017 Spring;29(1):79-88. Epub 2017 Feb 22 doi: 10.1053/j.semtcvs.2017.01.010. PMID: 28684003
Hybrid video-assisted and limited open (VALO) resection of superior sulcus tumors.
Nun AB, Simansky D, Rokah M, Zeitlin N, Avi RB, Soudack M, Golan N, Apel S, Bar J, Yelin A
Surg Today 2016 Jun;46(6):686-90. Epub 2015 Jul 22 doi: 10.1007/s00595-015-1225-0. PMID: 26198898
Eponyms in cardiothoracic radiology: Part I. Neoplasms.
Mohammed TL, Saettele MR, Saettele T, Patel V, Kanne JP
Curr Probl Diagn Radiol 2014 Mar-Apr;43(2):91-8. doi: 10.1067/j.cpradiol.2013.12.003. PMID: 24629662

Recent systematic reviews

Management of locally advanced pancoast (superior sulcus) tumors with spine involvement.
Setzer M, Robinson LA, Vrionis FD
Cancer Control 2014 Apr;21(2):158-67. doi: 10.1177/107327481402100209. PMID: 24667403

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