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Malignant glioma

MedGen UID:
107826
•Concept ID:
C0555198
•
Neoplastic Process
Synonyms: Glioma, Malignant; Gliomas, Malignant; Malignant Glioma; Malignant Gliomas
SNOMED CT: Glioma, malignant (74532006); Malignant glioma (74532006)
 
Monarch Initiative: MONDO:0100342

Definition

A grade 3 or grade 4 glioma arising from the central nervous system. This category includes glioblastoma, anaplastic astrocytoma, anaplastic ependymoma, anaplastic oligodendroglioma, and anaplastic oligoastrocytoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Malignant glioma

Professional guidelines

PubMed

Tumor Treating Fields in the Management of Patients with Malignant Gliomas.
Ghiaseddin AP, Shin D, Melnick K, Tran DD
Curr Treat Options Oncol 2020 Jul 30;21(9):76. doi: 10.1007/s11864-020-00773-5. PMID: 32734509Free PMC Article
ESTRO-ACROP guideline "target delineation of glioblastomas".
Niyazi M, Brada M, Chalmers AJ, Combs SE, Erridge SC, Fiorentino A, Grosu AL, Lagerwaard FJ, Minniti G, Mirimanoff RO, Ricardi U, Short SC, Weber DC, Belka C
Radiother Oncol 2016 Jan;118(1):35-42. Epub 2016 Jan 6 doi: 10.1016/j.radonc.2015.12.003. PMID: 26777122
Management of malignant glioma--quo vadis?
Stupp R, Hottinger AF
Onkologie 2008 Jun;31(6):300-2. Epub 2008 May 27 doi: 10.1159/000134024. PMID: 18547969

Recent clinical studies

Etiology

Gospel of malignant Glioma: Oncolytic virus therapy.
Li J, Meng Q, Zhou X, Zhao H, Wang K, Niu H, Wang Y
Gene 2022 Apr 15;818:146217. Epub 2022 Jan 28 doi: 10.1016/j.gene.2022.146217. PMID: 35093451
Origin of Gliomas.
Cahill D, Turcan S
Semin Neurol 2018 Feb;38(1):5-10. Epub 2018 Mar 16 doi: 10.1055/s-0037-1620238. PMID: 29548046
Phase I Study of DNX-2401 (Delta-24-RGD) Oncolytic Adenovirus: Replication and Immunotherapeutic Effects in Recurrent Malignant Glioma.
Lang FF, Conrad C, Gomez-Manzano C, Yung WKA, Sawaya R, Weinberg JS, Prabhu SS, Rao G, Fuller GN, Aldape KD, Gumin J, Vence LM, Wistuba I, Rodriguez-Canales J, Villalobos PA, Dirven CMF, Tejada S, Valle RD, Alonso MM, Ewald B, Peterkin JJ, Tufaro F, Fueyo J
J Clin Oncol 2018 May 10;36(14):1419-1427. Epub 2018 Feb 12 doi: 10.1200/JCO.2017.75.8219. PMID: 29432077Free PMC Article
Glioblastoma and other malignant gliomas: a clinical review.
Omuro A, DeAngelis LM
JAMA 2013 Nov 6;310(17):1842-50. doi: 10.1001/jama.2013.280319. PMID: 24193082
Brain tumors.
Blomgren H
Acta Oncol 1996;35 Suppl 7:16-21. doi: 10.3109/02841869609101660. PMID: 9154092

Diagnosis

Malignant Glioma.
Wang LM, Englander ZK, Miller ML, Bruce JN
Adv Exp Med Biol 2023;1405:1-30. doi: 10.1007/978-3-031-23705-8_1. PMID: 37452933
5-Aminolevulinic Acid Imaging of Malignant Glioma.
Li G, Rodrigues A, Kim L, Garcia C, Jain S, Zhang M, Hayden-Gephart M
Surg Oncol Clin N Am 2022 Oct;31(4):581-593. Epub 2022 Sep 26 doi: 10.1016/j.soc.2022.06.002. PMID: 36243495
Sequential fate-switches in stem-like cells drive the tumorigenic trajectory from human neural stem cells to malignant glioma.
Wang X, Zhou R, Xiong Y, Zhou L, Yan X, Wang M, Li F, Xie C, Zhang Y, Huang Z, Ding C, Shi K, Li W, Liu Y, Cao Z, Zhang ZN, Zhou S, Chen C, Zhang Y, Chen L, Wang Y
Cell Res 2021 Jun;31(6):684-702. Epub 2021 Jan 4 doi: 10.1038/s41422-020-00451-z. PMID: 33390587Free PMC Article
Anaplastic astrocytoma.
Grimm SA, Chamberlain MC
CNS Oncol 2016 Jul;5(3):145-57. Epub 2016 May 27 doi: 10.2217/cns-2016-0002. PMID: 27230974Free PMC Article
Glioblastoma and other malignant gliomas: a clinical review.
Omuro A, DeAngelis LM
JAMA 2013 Nov 6;310(17):1842-50. doi: 10.1001/jama.2013.280319. PMID: 24193082

Therapy

Neural stem cell delivery of an oncolytic adenovirus in newly diagnosed malignant glioma: a first-in-human, phase 1, dose-escalation trial.
Fares J, Ahmed AU, Ulasov IV, Sonabend AM, Miska J, Lee-Chang C, Balyasnikova IV, Chandler JP, Portnow J, Tate MC, Kumthekar P, Lukas RV, Grimm SA, Adams AK, Hébert CD, Strong TV, Amidei C, Arrieta VA, Zannikou M, Horbinski C, Zhang H, Burdett KB, Curiel DT, Sachdev S, Aboody KS, Stupp R, Lesniak MS
Lancet Oncol 2021 Aug;22(8):1103-1114. Epub 2021 Jun 29 doi: 10.1016/S1470-2045(21)00245-X. PMID: 34214495Free PMC Article
Tumor Treating Fields in the Management of Patients with Malignant Gliomas.
Ghiaseddin AP, Shin D, Melnick K, Tran DD
Curr Treat Options Oncol 2020 Jul 30;21(9):76. doi: 10.1007/s11864-020-00773-5. PMID: 32734509Free PMC Article
Phase I Study of DNX-2401 (Delta-24-RGD) Oncolytic Adenovirus: Replication and Immunotherapeutic Effects in Recurrent Malignant Glioma.
Lang FF, Conrad C, Gomez-Manzano C, Yung WKA, Sawaya R, Weinberg JS, Prabhu SS, Rao G, Fuller GN, Aldape KD, Gumin J, Vence LM, Wistuba I, Rodriguez-Canales J, Villalobos PA, Dirven CMF, Tejada S, Valle RD, Alonso MM, Ewald B, Peterkin JJ, Tufaro F, Fueyo J
J Clin Oncol 2018 May 10;36(14):1419-1427. Epub 2018 Feb 12 doi: 10.1200/JCO.2017.75.8219. PMID: 29432077Free PMC Article
Anaplastic astrocytoma.
Grimm SA, Chamberlain MC
CNS Oncol 2016 Jul;5(3):145-57. Epub 2016 May 27 doi: 10.2217/cns-2016-0002. PMID: 27230974Free PMC Article
Peptide vaccine.
Izumoto S
Adv Exp Med Biol 2012;746:166-77. doi: 10.1007/978-1-4614-3146-6_13. PMID: 22639167

Prognosis

Malignant Glioma.
Wang LM, Englander ZK, Miller ML, Bruce JN
Adv Exp Med Biol 2023;1405:1-30. doi: 10.1007/978-3-031-23705-8_1. PMID: 37452933
Multidomain and long-term cognitive evaluation in malignant glioma patients.
Tanzilli A, Pace A, Prosperini L, Oppido PA, Telera S, Rasile F, Farneti A, Marucci L, Villani V
Future Oncol 2022 May;18(15):1839-1848. Epub 2022 Feb 24 doi: 10.2217/fon-2021-0963. PMID: 35196869
Recurrent Glioblastoma Treated with Recombinant Poliovirus.
Desjardins A, Gromeier M, Herndon JE 2nd, Beaubier N, Bolognesi DP, Friedman AH, Friedman HS, McSherry F, Muscat AM, Nair S, Peters KB, Randazzo D, Sampson JH, Vlahovic G, Harrison WT, McLendon RE, Ashley D, Bigner DD
N Engl J Med 2018 Jul 12;379(2):150-161. Epub 2018 Jun 26 doi: 10.1056/NEJMoa1716435. PMID: 29943666Free PMC Article
Phase I Study of DNX-2401 (Delta-24-RGD) Oncolytic Adenovirus: Replication and Immunotherapeutic Effects in Recurrent Malignant Glioma.
Lang FF, Conrad C, Gomez-Manzano C, Yung WKA, Sawaya R, Weinberg JS, Prabhu SS, Rao G, Fuller GN, Aldape KD, Gumin J, Vence LM, Wistuba I, Rodriguez-Canales J, Villalobos PA, Dirven CMF, Tejada S, Valle RD, Alonso MM, Ewald B, Peterkin JJ, Tufaro F, Fueyo J
J Clin Oncol 2018 May 10;36(14):1419-1427. Epub 2018 Feb 12 doi: 10.1200/JCO.2017.75.8219. PMID: 29432077Free PMC Article
Adult brainstem gliomas.
Reyes-Botero G, Mokhtari K, Martin-Duverneuil N, Delattre JY, Laigle-Donadey F
Oncologist 2012;17(3):388-97. Epub 2012 Mar 1 doi: 10.1634/theoncologist.2011-0335. PMID: 22382458Free PMC Article

Clinical prediction guides

Comprehensive transcriptomic characterization reveals core genes and module associated with immunological changes via 1619 samples of brain glioma.
Zhang Y, Ma W, Fan W, Ren C, Xu J, Zeng F, Bao Z, Jiang T, Zhao Z
Cell Death Dis 2021 Dec 8;12(12):1140. doi: 10.1038/s41419-021-04427-8. PMID: 34880206Free PMC Article
The Evolving Role of CD8(+)CD28(-) Immunosenescent T Cells in Cancer Immunology.
Huff WX, Kwon JH, Henriquez M, Fetcko K, Dey M
Int J Mol Sci 2019 Jun 8;20(11) doi: 10.3390/ijms20112810. PMID: 31181772Free PMC Article
Recurrent Glioblastoma Treated with Recombinant Poliovirus.
Desjardins A, Gromeier M, Herndon JE 2nd, Beaubier N, Bolognesi DP, Friedman AH, Friedman HS, McSherry F, Muscat AM, Nair S, Peters KB, Randazzo D, Sampson JH, Vlahovic G, Harrison WT, McLendon RE, Ashley D, Bigner DD
N Engl J Med 2018 Jul 12;379(2):150-161. Epub 2018 Jun 26 doi: 10.1056/NEJMoa1716435. PMID: 29943666Free PMC Article
The Neurologic Assessment in Neuro-Oncology (NANO) scale: a tool to assess neurologic function for integration into the Response Assessment in Neuro-Oncology (RANO) criteria.
Nayak L, DeAngelis LM, Brandes AA, Peereboom DM, Galanis E, Lin NU, Soffietti R, Macdonald DR, Chamberlain M, Perry J, Jaeckle K, Mehta M, Stupp R, Muzikansky A, Pentsova E, Cloughesy T, Iwamoto FM, Tonn JC, Vogelbaum MA, Wen PY, van den Bent MJ, Reardon DA
Neuro Oncol 2017 May 1;19(5):625-635. doi: 10.1093/neuonc/nox029. PMID: 28453751Free PMC Article
Immunostimulatory oligonucleotides.
Bodera P
Recent Pat Inflamm Allergy Drug Discov 2011 Jan;5(1):87-93. doi: 10.2174/187221311794474856. PMID: 21158735

Recent systematic reviews

Telomerase inhibition in malignant gliomas: a systematic review.
D'Alessandris QG, Battistelli M, Pennisi G, Offi M, Martini M, Cenci T, Falchetti ML, Lauretti L, Olivi A, Pallini R, Montano N
Expert Rev Mol Med 2023 Mar 15;25:e10. doi: 10.1017/erm.2023.6. PMID: 36919343
Role of ketogenic metabolic therapy in malignant glioma: A systematic review.
Winter SF, Loebel F, Dietrich J
Crit Rev Oncol Hematol 2017 Apr;112:41-58. Epub 2017 Feb 20 doi: 10.1016/j.critrevonc.2017.02.016. PMID: 28325264
Chemotherapy for Adults with Malignant Glioma: A Systematic Review and Network Meta-Analysis.
Wang W, Shi G, Ma B, Hao X, Dong X, Zhang B
Turk Neurosurg 2017;27(2):174-181. doi: 10.5137/1019-5149.JTN.15462-15.0. PMID: 27337236
Prognostic awareness and communication of prognostic information in malignant glioma: a systematic review.
Diamond EL, Corner GW, De Rosa A, Breitbart W, Applebaum AJ
J Neurooncol 2014 Sep;119(2):227-34. Epub 2014 May 30 doi: 10.1007/s11060-014-1487-1. PMID: 24874468Free PMC Article
Adjuvant chemotherapy for adults with malignant glioma: a systematic review.
Perry J, Laperriere N, Zuraw L, Chambers A, Spithoff K, Cairncross JG; Neuro-oncology Disease Site Group; Cancer Care Ontario Program in Evidence-Based Care
Can J Neurol Sci 2007 Nov;34(4):402-10. doi: 10.1017/s0317167100007265. PMID: 18062446

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