U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ocular melanoma

MedGen UID:
107846
•Concept ID:
C0558356
•
Neoplastic Process
Synonyms: Eye Melanoma; eye melanoma; eye melanoma (disease); eyeball of camera-type eye melanoma; eyeball of camera-type eye melanoma (disease); Malignant melanoma of eye; melanoma (disease) of eyeball of camera-type eye; Melanoma of Eye; melanoma of eye; Melanoma of the Eye; melanoma of the eye; MM (malignant melanoma) of eye; Ocular Melanoma; ocular melanoma; OM
SNOMED CT: Malignant melanoma of eye (274087000); Ocular melanoma (274087000); MM (malignant melanoma) of eye (274087000)
 
Monarch Initiative: MONDO:0006325

Definition

A melanoma that arises from the structures of the eye or ocular adnexa. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOcular melanoma

Professional guidelines

PubMed

Uveal melanoma: From diagnosis to treatment and the science in between.
Chattopadhyay C, Kim DW, Gombos DS, Oba J, Qin Y, Williams MD, Esmaeli B, Grimm EA, Wargo JA, Woodman SE, Patel SP
Cancer 2016 Aug 1;122(15):2299-312. Epub 2016 Mar 15 doi: 10.1002/cncr.29727. PMID: 26991400Free PMC Article
Clinical Management of Uveal and Conjunctival Melanoma.
Blum ES, Yang J, Komatsubara KM, Carvajal RD
Oncology (Williston Park) 2016 Jan;30(1):29-32, 34-43, 48. PMID: 26791842
Melanoma susceptibility genes and risk assessment.
Marzuka-Alcalá A, Gabree MJ, Tsao H
Methods Mol Biol 2014;1102:381-93. doi: 10.1007/978-1-62703-727-3_20. PMID: 24258989

Recent clinical studies

Etiology

Immunotherapy and radiotherapy in melanoma: a multidisciplinary comprehensive review.
Tagliaferri L, Lancellotta V, Fionda B, Mangoni M, Casà C, Di Stefani A, Pagliara MM, D'Aviero A, Schinzari G, Chiesa S, Mazzarella C, Manfrida S, Colloca GF, Marazzi F, Morganti AG, Blasi MA, Peris K, Tortora G, Valentini V
Hum Vaccin Immunother 2022 May 31;18(3):1903827. Epub 2021 Apr 13 doi: 10.1080/21645515.2021.1903827. PMID: 33847208Free PMC Article
Extracutaneous Melanoma.
Carvajal R, Maniar R
Hematol Oncol Clin North Am 2021 Feb;35(1):85-98. Epub 2020 Oct 26 doi: 10.1016/j.hoc.2020.09.004. PMID: 33759775
Pembrolizumab versus ipilimumab for advanced melanoma: final overall survival results of a multicentre, randomised, open-label phase 3 study (KEYNOTE-006).
Schachter J, Ribas A, Long GV, Arance A, Grob JJ, Mortier L, Daud A, Carlino MS, McNeil C, Lotem M, Larkin J, Lorigan P, Neyns B, Blank C, Petrella TM, Hamid O, Zhou H, Ebbinghaus S, Ibrahim N, Robert C
Lancet 2017 Oct 21;390(10105):1853-1862. Epub 2017 Aug 16 doi: 10.1016/S0140-6736(17)31601-X. PMID: 28822576
Uveal melanoma: From diagnosis to treatment and the science in between.
Chattopadhyay C, Kim DW, Gombos DS, Oba J, Qin Y, Williams MD, Esmaeli B, Grimm EA, Wargo JA, Woodman SE, Patel SP
Cancer 2016 Aug 1;122(15):2299-312. Epub 2016 Mar 15 doi: 10.1002/cncr.29727. PMID: 26991400Free PMC Article
Ocular melanoma.
Laver NV, McLaughlin ME, Duker JS
Arch Pathol Lab Med 2010 Dec;134(12):1778-84. doi: 10.5858/2009-0441-RAR.1. PMID: 21128775

Diagnosis

Extracutaneous Melanoma.
Carvajal R, Maniar R
Hematol Oncol Clin North Am 2021 Feb;35(1):85-98. Epub 2020 Oct 26 doi: 10.1016/j.hoc.2020.09.004. PMID: 33759775
BRCA1-associated protein (BAP1)-inactivated melanocytic tumors.
Zhang AJ, Rush PS, Tsao H, Duncan LM
J Cutan Pathol 2019 Dec;46(12):965-972. Epub 2019 Jul 11 doi: 10.1111/cup.13530. PMID: 31233225
Uveal melanoma: From diagnosis to treatment and the science in between.
Chattopadhyay C, Kim DW, Gombos DS, Oba J, Qin Y, Williams MD, Esmaeli B, Grimm EA, Wargo JA, Woodman SE, Patel SP
Cancer 2016 Aug 1;122(15):2299-312. Epub 2016 Mar 15 doi: 10.1002/cncr.29727. PMID: 26991400Free PMC Article
Ocular melanoma.
Laver NV, McLaughlin ME, Duker JS
Arch Pathol Lab Med 2010 Dec;134(12):1778-84. doi: 10.5858/2009-0441-RAR.1. PMID: 21128775
Ocular melanoma.
Char DH
Surg Clin North Am 2003 Apr;83(2):253-74, vii. doi: 10.1016/S0039-6109(02)00098-1. PMID: 12744609

Therapy

Genetic prognostication in uveal melanoma.
Dogrusöz M, Jager MJ
Acta Ophthalmol 2018 Jun;96(4):331-347. Epub 2017 Nov 4 doi: 10.1111/aos.13580. PMID: 29105334
Pembrolizumab versus ipilimumab for advanced melanoma: final overall survival results of a multicentre, randomised, open-label phase 3 study (KEYNOTE-006).
Schachter J, Ribas A, Long GV, Arance A, Grob JJ, Mortier L, Daud A, Carlino MS, McNeil C, Lotem M, Larkin J, Lorigan P, Neyns B, Blank C, Petrella TM, Hamid O, Zhou H, Ebbinghaus S, Ibrahim N, Robert C
Lancet 2017 Oct 21;390(10105):1853-1862. Epub 2017 Aug 16 doi: 10.1016/S0140-6736(17)31601-X. PMID: 28822576
Sorafenib in melanoma.
Mangana J, Levesque MP, Karpova MB, Dummer R
Expert Opin Investig Drugs 2012 Apr;21(4):557-68. Epub 2012 Mar 7 doi: 10.1517/13543784.2012.665872. PMID: 22394203
Uveal melanoma.
Spagnolo F, Caltabiano G, Queirolo P
Cancer Treat Rev 2012 Aug;38(5):549-53. Epub 2012 Jan 24 doi: 10.1016/j.ctrv.2012.01.002. PMID: 22270078
Enucleation.
Moshfeghi DM, Moshfeghi AA, Finger PT
Surv Ophthalmol 2000 Jan-Feb;44(4):277-301. doi: 10.1016/s0039-6257(99)00112-5. PMID: 10667436

Prognosis

Histone lactylation drives oncogenesis by facilitating m(6)A reader protein YTHDF2 expression in ocular melanoma.
Yu J, Chai P, Xie M, Ge S, Ruan J, Fan X, Jia R
Genome Biol 2021 Mar 16;22(1):85. doi: 10.1186/s13059-021-02308-z. PMID: 33726814Free PMC Article
Genetics of metastasis: melanoma and other cancers.
Turner N, Ware O, Bosenberg M
Clin Exp Metastasis 2018 Aug;35(5-6):379-391. Epub 2018 May 2 doi: 10.1007/s10585-018-9893-y. PMID: 29722002
Uveal melanoma: From diagnosis to treatment and the science in between.
Chattopadhyay C, Kim DW, Gombos DS, Oba J, Qin Y, Williams MD, Esmaeli B, Grimm EA, Wargo JA, Woodman SE, Patel SP
Cancer 2016 Aug 1;122(15):2299-312. Epub 2016 Mar 15 doi: 10.1002/cncr.29727. PMID: 26991400Free PMC Article
Ocular melanoma.
Laver NV, McLaughlin ME, Duker JS
Arch Pathol Lab Med 2010 Dec;134(12):1778-84. doi: 10.5858/2009-0441-RAR.1. PMID: 21128775
Health risks.
Longstreth J, de Gruijl FR, Kripke ML, Abseck S, Arnold F, Slaper HI, Velders G, Takizawa Y, van der Leun JC
J Photochem Photobiol B 1998 Oct;46(1-3):20-39. doi: 10.1016/s1011-1344(98)00183-3. PMID: 9894351

Clinical prediction guides

Incidence and survival of ocular melanoma in National Cancer Registry of Poland in 2010-2017.
Nowak MS, Romanowska-Dixon B, Grabska-Liberek I, Żurek M
Adv Clin Exp Med 2022 Jun;31(6):615-621. doi: 10.17219/acem/146581. PMID: 35349230
Clinical features and survival outcomes of ocular melanoma in a multi-ethnic Asian cohort.
Tan LLY, Hong J, Goh WL, Chang EWY, Yang VS, Poon E, Somasundaram N, Farid M, Chan ASY, Chan JY
Sci Rep 2020 Oct 1;10(1):16367. doi: 10.1038/s41598-020-73534-x. PMID: 33004998Free PMC Article
Clinical spectrum, treatment and outcomes of uveal melanoma in a tertiary centre.
Wong W, Sundar G, Chee C, Zhao PS, Rajagopalan R, Gopal L
Singapore Med J 2019 Sep;60(9):474-478. Epub 2019 Jun 14 doi: 10.11622/smedj.2019054. PMID: 31197380Free PMC Article
Hepatic Perfusion Therapy.
Rajeev R, Gamblin TC, Turaga KK
Surg Clin North Am 2016 Apr;96(2):357-68. doi: 10.1016/j.suc.2015.12.005. PMID: 27017869
Metastatic melanoma to the liver: a contemporary and comprehensive review of surgical, systemic, and regional therapeutic options.
Agarwala SS, Eggermont AM, O'Day S, Zager JS
Cancer 2014 Mar 15;120(6):781-9. Epub 2013 Dec 2 doi: 10.1002/cncr.28480. PMID: 24301420

Recent systematic reviews

Systemic and liver-directed therapies in metastatic uveal melanoma: state-of-the-art and novel perspectives.
Comito F, Marchese PV, Ricci AD, Tober N, Peterle C, Sperandi F, Melotti B
Future Oncol 2021 Nov;17(33):4583-4606. Epub 2021 Aug 25 doi: 10.2217/fon-2021-0318. PMID: 34431316
Meta-analysis on the utility of radiotherapy for the treatment of Ocular Melanoma.
Messineo D, Barile G, Morrone S, La Torre G, Turchetti P, Accetta L, Trovato Battagliola E, Agostinelli E, Pacella F
Clin Ter 2020 Jan-Feb;170(1):e89-e98. doi: 10.7417/CT.2020.2195. PMID: 31916427
How to MEK the best of uveal melanoma: A systematic review on the efficacy and safety of MEK inhibitors in metastatic or unresectable uveal melanoma.
Steeb T, Wessely A, Ruzicka T, Heppt MV, Berking C
Eur J Cancer 2018 Nov;103:41-51. Epub 2018 Sep 8 doi: 10.1016/j.ejca.2018.08.005. PMID: 30205280
Sorafenib in melanoma.
Mangana J, Levesque MP, Karpova MB, Dummer R
Expert Opin Investig Drugs 2012 Apr;21(4):557-68. Epub 2012 Mar 7 doi: 10.1517/13543784.2012.665872. PMID: 22394203

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...