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Pain of lymph node

MedGen UID:
107911
•Concept ID:
C0578050
•
Sign or Symptom
Synonyms: Lymph Node Pain; Painful lymph node
SNOMED CT: Painful lymph node (301360004); Pain of lymph node (301360004)

Definition

A painful sensation in a lymph node. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPain of lymph node

Professional guidelines

PubMed

Clinical Practice Guideline: Sore Throat.
Krüger K, Töpfner N, Berner R, Windfuhr J, Oltrogge JH; Guideline group
Dtsch Arztebl Int 2021 Mar 19;118(11):188-94. doi: 10.3238/arztebl.m2021.0121. PMID: 33602392Free PMC Article
Chronic fatigue syndrome: diagnosis and treatment.
Yancey JR, Thomas SM
Am Fam Physician 2012 Oct 15;86(8):741-6. PMID: 23062157
Treatment of breast cancer.
Maughan KL, Lutterbie MA, Ham PS
Am Fam Physician 2010 Jun 1;81(11):1339-46. PMID: 20521754

Recent clinical studies

Etiology

Preoperative Paravertebral Block and Chronic Pain after Breast Cancer Surgery: A Double-blind Randomized Trial.
Albi-Feldzer A, Dureau S, Ghimouz A, Raft J, Soubirou JL, Gayraud G, Jayr C
Anesthesiology 2021 Dec 1;135(6):1091-1103. doi: 10.1097/ALN.0000000000003989. PMID: 34618889
Hypofractionated Versus Standard Fractionated Radiotherapy in Patients With Early Breast Cancer or Ductal Carcinoma In Situ in a Randomized Phase III Trial: The DBCG HYPO Trial.
Offersen BV, Alsner J, Nielsen HM, Jakobsen EH, Nielsen MH, Krause M, Stenbygaard L, Mjaaland I, Schreiber A, Kasti UM, Overgaard J; Danish Breast Cancer Group Radiation Therapy Committee
J Clin Oncol 2020 Nov 1;38(31):3615-3625. Epub 2020 Sep 10 doi: 10.1200/JCO.20.01363. PMID: 32910709
Effects of a physical therapy program combined with manual lymphatic drainage on shoulder function, quality of life, lymphedema incidence, and pain in breast cancer patients with axillary web syndrome following axillary dissection.
Cho Y, Do J, Jung S, Kwon O, Jeon JY
Support Care Cancer 2016 May;24(5):2047-2057. Epub 2015 Nov 5 doi: 10.1007/s00520-015-3005-1. PMID: 26542271
Adjuvant lymph-node field radiotherapy versus observation only in patients with melanoma at high risk of further lymph-node field relapse after lymphadenectomy (ANZMTG 01.02/TROG 02.01): 6-year follow-up of a phase 3, randomised controlled trial.
Henderson MA, Burmeister BH, Ainslie J, Fisher R, Di Iulio J, Smithers BM, Hong A, Shannon K, Scolyer RA, Carruthers S, Coventry BJ, Babington S, Duprat J, Hoekstra HJ, Thompson JF
Lancet Oncol 2015 Sep;16(9):1049-1060. Epub 2015 Jul 20 doi: 10.1016/S1470-2045(15)00187-4. PMID: 26206146
Stereotactic ablative radiotherapy versus lobectomy for operable stage I non-small-cell lung cancer: a pooled analysis of two randomised trials.
Chang JY, Senan S, Paul MA, Mehran RJ, Louie AV, Balter P, Groen HJ, McRae SE, Widder J, Feng L, van den Borne BE, Munsell MF, Hurkmans C, Berry DA, van Werkhoven E, Kresl JJ, Dingemans AM, Dawood O, Haasbeek CJ, Carpenter LS, De Jaeger K, Komaki R, Slotman BJ, Smit EF, Roth JA
Lancet Oncol 2015 Jun;16(6):630-7. Epub 2015 May 13 doi: 10.1016/S1470-2045(15)70168-3. PMID: 25981812Free PMC Article

Diagnosis

Ultrasound and clinicopathological characteristics of breast cancer for predicting axillary lymph node metastasis.
Bai X, Wang Y, Song R, Li S, Song Y, Wang H, Tong X, Wei W, Ruan L, Zhao Q
Clin Hemorheol Microcirc 2023;85(2):147-162. doi: 10.3233/CH-231777. PMID: 37694357Free PMC Article
Surgical Treatment and Rehabilitation Strategies for Upper and Lower Extremity Lymphedema: A Comprehensive Review.
de Sire A, Losco L, Lippi L, Spadoni D, Kaciulyte J, Sert G, Ciamarra P, Marcasciano M, Cuomo R, Bolletta A, Invernizzi M, Cigna E
Medicina (Kaunas) 2022 Jul 19;58(7) doi: 10.3390/medicina58070954. PMID: 35888673Free PMC Article
Primary lymph node gastrinoma: a case report and review of the literature.
Cavalcanti E, Stasi E, Coletta S, Lorusso D, Rinaldi CM, Armentano R
World J Surg Oncol 2020 Apr 28;18(1):80. doi: 10.1186/s12957-020-01860-5. PMID: 32345299Free PMC Article
Review of axillary web syndrome: What the radiologist should know.
Mullen LA, Harvey SC
Eur J Radiol 2019 Apr;113:66-73. Epub 2019 Feb 4 doi: 10.1016/j.ejrad.2019.02.001. PMID: 30927961
Acute Nonspecific Mesenteric Lymphadenitis: More Than "No Need for Surgery".
Helbling R, Conficconi E, Wyttenbach M, Benetti C, Simonetti GD, Bianchetti MG, Hamitaga F, Lava SA, Fossali EF, Milani GP
Biomed Res Int 2017;2017:9784565. Epub 2017 Feb 2 doi: 10.1155/2017/9784565. PMID: 28261620Free PMC Article

Therapy

Surgical Treatment and Rehabilitation Strategies for Upper and Lower Extremity Lymphedema: A Comprehensive Review.
de Sire A, Losco L, Lippi L, Spadoni D, Kaciulyte J, Sert G, Ciamarra P, Marcasciano M, Cuomo R, Bolletta A, Invernizzi M, Cigna E
Medicina (Kaunas) 2022 Jul 19;58(7) doi: 10.3390/medicina58070954. PMID: 35888673Free PMC Article
Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults.
Cope AL, Francis N, Wood F, Chestnutt IG
Cochrane Database Syst Rev 2018 Sep 27;9(9):CD010136. doi: 10.1002/14651858.CD010136.pub3. PMID: 30259968Free PMC Article
Acute Nonspecific Mesenteric Lymphadenitis: More Than "No Need for Surgery".
Helbling R, Conficconi E, Wyttenbach M, Benetti C, Simonetti GD, Bianchetti MG, Hamitaga F, Lava SA, Fossali EF, Milani GP
Biomed Res Int 2017;2017:9784565. Epub 2017 Feb 2 doi: 10.1155/2017/9784565. PMID: 28261620Free PMC Article
Effects of a physical therapy program combined with manual lymphatic drainage on shoulder function, quality of life, lymphedema incidence, and pain in breast cancer patients with axillary web syndrome following axillary dissection.
Cho Y, Do J, Jung S, Kwon O, Jeon JY
Support Care Cancer 2016 May;24(5):2047-2057. Epub 2015 Nov 5 doi: 10.1007/s00520-015-3005-1. PMID: 26542271
Treatment of breast cancer.
Maughan KL, Lutterbie MA, Ham PS
Am Fam Physician 2010 Jun 1;81(11):1339-46. PMID: 20521754

Prognosis

Hypofractionated Versus Standard Fractionated Radiotherapy in Patients With Early Breast Cancer or Ductal Carcinoma In Situ in a Randomized Phase III Trial: The DBCG HYPO Trial.
Offersen BV, Alsner J, Nielsen HM, Jakobsen EH, Nielsen MH, Krause M, Stenbygaard L, Mjaaland I, Schreiber A, Kasti UM, Overgaard J; Danish Breast Cancer Group Radiation Therapy Committee
J Clin Oncol 2020 Nov 1;38(31):3615-3625. Epub 2020 Sep 10 doi: 10.1200/JCO.20.01363. PMID: 32910709
Effects of a physical therapy program combined with manual lymphatic drainage on shoulder function, quality of life, lymphedema incidence, and pain in breast cancer patients with axillary web syndrome following axillary dissection.
Cho Y, Do J, Jung S, Kwon O, Jeon JY
Support Care Cancer 2016 May;24(5):2047-2057. Epub 2015 Nov 5 doi: 10.1007/s00520-015-3005-1. PMID: 26542271
Adjuvant lymph-node field radiotherapy versus observation only in patients with melanoma at high risk of further lymph-node field relapse after lymphadenectomy (ANZMTG 01.02/TROG 02.01): 6-year follow-up of a phase 3, randomised controlled trial.
Henderson MA, Burmeister BH, Ainslie J, Fisher R, Di Iulio J, Smithers BM, Hong A, Shannon K, Scolyer RA, Carruthers S, Coventry BJ, Babington S, Duprat J, Hoekstra HJ, Thompson JF
Lancet Oncol 2015 Sep;16(9):1049-1060. Epub 2015 Jul 20 doi: 10.1016/S1470-2045(15)00187-4. PMID: 26206146
Treatment of breast cancer.
Maughan KL, Lutterbie MA, Ham PS
Am Fam Physician 2010 Jun 1;81(11):1339-46. PMID: 20521754
Testicular cancer.
Kinkade S
Am Fam Physician 1999 May 1;59(9):2539-44, 2549-50. PMID: 10323360

Clinical prediction guides

Preoperative Paravertebral Block and Chronic Pain after Breast Cancer Surgery: A Double-blind Randomized Trial.
Albi-Feldzer A, Dureau S, Ghimouz A, Raft J, Soubirou JL, Gayraud G, Jayr C
Anesthesiology 2021 Dec 1;135(6):1091-1103. doi: 10.1097/ALN.0000000000003989. PMID: 34618889
Clinical Practice Guideline: Sore Throat.
Krüger K, Töpfner N, Berner R, Windfuhr J, Oltrogge JH; Guideline group
Dtsch Arztebl Int 2021 Mar 19;118(11):188-94. doi: 10.3238/arztebl.m2021.0121. PMID: 33602392Free PMC Article
Cytoreduction for colorectal metastases: liver, lung, peritoneum, lymph nodes, bone, brain. When does it palliate, prolong survival, and potentially cure?
Stewart CL, Warner S, Ito K, Raoof M, Wu GX, Kessler J, Kim JY, Fong Y
Curr Probl Surg 2018 Sep;55(9):330-379. Epub 2018 Oct 4 doi: 10.1067/j.cpsurg.2018.08.004. PMID: 30526930Free PMC Article
Effects of a physical therapy program combined with manual lymphatic drainage on shoulder function, quality of life, lymphedema incidence, and pain in breast cancer patients with axillary web syndrome following axillary dissection.
Cho Y, Do J, Jung S, Kwon O, Jeon JY
Support Care Cancer 2016 May;24(5):2047-2057. Epub 2015 Nov 5 doi: 10.1007/s00520-015-3005-1. PMID: 26542271
Adjuvant lymph-node field radiotherapy versus observation only in patients with melanoma at high risk of further lymph-node field relapse after lymphadenectomy (ANZMTG 01.02/TROG 02.01): 6-year follow-up of a phase 3, randomised controlled trial.
Henderson MA, Burmeister BH, Ainslie J, Fisher R, Di Iulio J, Smithers BM, Hong A, Shannon K, Scolyer RA, Carruthers S, Coventry BJ, Babington S, Duprat J, Hoekstra HJ, Thompson JF
Lancet Oncol 2015 Sep;16(9):1049-1060. Epub 2015 Jul 20 doi: 10.1016/S1470-2045(15)00187-4. PMID: 26206146

Recent systematic reviews

Current evidence on diagnosis and treatment of parotid gland lymphomas: a systematic review.
Di Santo D, Bramati C, Festa BM, Pace GM, Comini LV, Luparello P, Cascardi E, Galizia D, Galli A, De Virgilio A, Giordano L, Bondi S
Eur Arch Otorhinolaryngol 2023 Dec;280(12):5219-5227. Epub 2023 Aug 28 doi: 10.1007/s00405-023-08206-3. PMID: 37638999
Transoral endoscopic thyroidectomy vestibular approach as a safe and feasible alternative to open thyroidectomy: a systematic review and meta-analysis.
Oh MY, Chai YJ, Yu HW, Kim SJ, Choi JY, Lee KE
Int J Surg 2023 Aug 1;109(8):2467-2477. doi: 10.1097/JS9.0000000000000444. PMID: 37161554Free PMC Article
Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults.
Cope AL, Francis N, Wood F, Chestnutt IG
Cochrane Database Syst Rev 2018 Sep 27;9(9):CD010136. doi: 10.1002/14651858.CD010136.pub3. PMID: 30259968Free PMC Article
Risk factors of pain in breast cancer survivors: a systematic review and meta-analysis.
Leysen L, Beckwée D, Nijs J, Pas R, Bilterys T, Vermeir S, Adriaenssens N
Support Care Cancer 2017 Dec;25(12):3607-3643. Epub 2017 Aug 10 doi: 10.1007/s00520-017-3824-3. PMID: 28799015
Clinical characteristics and prognosis of primary leiomyosarcoma of the pancreas: a systematic review.
Xu J, Zhang T, Wang T, You L, Zhao Y
World J Surg Oncol 2013 Nov 12;11:290. doi: 10.1186/1477-7819-11-290. PMID: 24219646Free PMC Article

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