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Esophageal dysplasia

MedGen UID:
108322
Concept ID:
C0586354
Disease or Syndrome
Synonyms: Esophageal Dysplasia; Esophageal Intraepithelial Neoplasia; Intraepithelial Neoplasia of Esophagus; Intraepithelial Neoplasia of the Esophagus
SNOMED CT: Esophageal dysplasia (308857008)

Definition

A lesion that is characterized by architectural and cytologic abnormalities of the esophageal epithelium, and carries a predisposition for progression to invasive carcinoma. Intraepithelial neoplasia (dysplasia) of the esophagus is graded as low or high grade. In this two-tier system, severe dysplasia and carcinoma in situ are included under the rubric of high grade intraepithelial neoplasia and may have the same clinical implications. (WHO, 2000) [from NCI]

Professional guidelines

PubMed

van Munster SN, Nieuwenhuis E, Bisschops R, Willekens H, Weusten BLAM, Herrero LA, Bogte A, Alkhalaf A, Schenk EBE, Schoon EJ, Curvers W, Koch AD, de Jonge PJF, Tang TJ, Nagengast WB, Westerhof J, Houben MHMG, Bergman JJGHM, Pouw RE
Clin Gastroenterol Hepatol 2022 Nov;20(11):2495-2504.e5. Epub 2022 Mar 12 doi: 10.1016/j.cgh.2022.02.057. PMID: 35292379
Tyselskyi V, Poylin V, Tkachuk O, Kebkalo A
Pol Przegl Chir 2021 May 14;93(5):1-5. doi: 10.5604/01.3001.0014.8863. PMID: 34552027
Halsey KD, Greenwald BD
Gastrointest Endosc Clin N Am 2010 Jan;20(1):75-87, vi-vii. doi: 10.1016/j.giec.2009.07.009. PMID: 19951795

Recent clinical studies

Etiology

Syed T, Doshi A, Guleria S, Syed S, Shah T
Dig Dis Sci 2020 Dec;65(12):3448-3455. Epub 2020 Oct 15 doi: 10.1007/s10620-020-06643-2. PMID: 33057945Free PMC Article
Chlumská A, Mukenšnabl P, Waloschek T, Zámečník M
Cesk Patol 2018 Summer;54(2):81-85. PMID: 30441967
Triadafilopoulos G, Akiyama J
Expert Rev Gastroenterol Hepatol 2016;10(5):605-13. Epub 2016 Feb 6 doi: 10.1586/17474124.2016.1140037. PMID: 26753504
Shahid MW, Wallace MB
Gastrointest Endosc Clin N Am 2010 Jan;20(1):11-24, v. doi: 10.1016/j.giec.2009.08.006. PMID: 19951791
Bonino JA, Sharma P
Curr Opin Gastroenterol 2005 Jul;21(4):461-5. PMID: 15930989

Diagnosis

Li M, Kong J, Wang L, Yan H, Liang W, Wang N, Zhao J
World J Surg Oncol 2022 May 12;20(1):155. doi: 10.1186/s12957-022-02612-3. PMID: 35549728Free PMC Article
Syed T, Doshi A, Guleria S, Syed S, Shah T
Dig Dis Sci 2020 Dec;65(12):3448-3455. Epub 2020 Oct 15 doi: 10.1007/s10620-020-06643-2. PMID: 33057945Free PMC Article
Chlumská A, Mukenšnabl P, Waloschek T, Zámečník M
Cesk Patol 2018 Summer;54(2):81-85. PMID: 30441967
Triadafilopoulos G, Akiyama J
Expert Rev Gastroenterol Hepatol 2016;10(5):605-13. Epub 2016 Feb 6 doi: 10.1586/17474124.2016.1140037. PMID: 26753504
Shahid MW, Wallace MB
Gastrointest Endosc Clin N Am 2010 Jan;20(1):11-24, v. doi: 10.1016/j.giec.2009.08.006. PMID: 19951791

Therapy

Fan JH, Sun WY, Yang H, Wang XK, Abnet CC, Qiao YL
Cancer 2023 Aug 1;129(15):2360-2372. Epub 2023 May 27 doi: 10.1002/cncr.34761. PMID: 37243894
Yeh CC, Chen CC, Chen CC, Han ML, Wu JF, Wang HP, Wu MS, Tseng PH
J Gastroenterol Hepatol 2023 Aug;38(8):1307-1315. Epub 2023 Apr 20 doi: 10.1111/jgh.16192. PMID: 37078564
Syed T, Doshi A, Guleria S, Syed S, Shah T
Dig Dis Sci 2020 Dec;65(12):3448-3455. Epub 2020 Oct 15 doi: 10.1007/s10620-020-06643-2. PMID: 33057945Free PMC Article
Münch NS, Fang HY, Ingermann J, Maurer HC, Anand A, Kellner V, Sahm V, Wiethaler M, Baumeister T, Wein F, Einwächter H, Bolze F, Klingenspor M, Haller D, Kavanagh M, Lysaght J, Friedman R, Dannenberg AJ, Pollak M, Holt PR, Muthupalani S, Fox JG, Whary MT, Lee Y, Ren TY, Elliot R, Fitzgerald R, Steiger K, Schmid RM, Wang TC, Quante M
Gastroenterology 2019 Aug;157(2):492-506.e2. Epub 2019 Apr 15 doi: 10.1053/j.gastro.2019.04.013. PMID: 30998992Free PMC Article
Stoner GD, Wang LS, Chen T
Toxicol Appl Pharmacol 2007 Nov 1;224(3):337-49. Epub 2007 Mar 15 doi: 10.1016/j.taap.2007.01.030. PMID: 17475300Free PMC Article

Prognosis

Li M, Kong J, Wang L, Yan H, Liang W, Wang N, Zhao J
World J Surg Oncol 2022 May 12;20(1):155. doi: 10.1186/s12957-022-02612-3. PMID: 35549728Free PMC Article
Beuque M, Martin-Lorenzo M, Balluff B, Woodruff HC, Lucas M, de Bruin DM, van Timmeren JE, Boer OJ, Heeren RM, Meijer SL, Lambin P
Comput Biol Med 2021 Nov;138:104918. Epub 2021 Oct 4 doi: 10.1016/j.compbiomed.2021.104918. PMID: 34638018
Chlumská A, Mukenšnabl P, Waloschek T, Zámečník M
Cesk Patol 2018 Summer;54(2):81-85. PMID: 30441967
Triadafilopoulos G, Akiyama J
Expert Rev Gastroenterol Hepatol 2016;10(5):605-13. Epub 2016 Feb 6 doi: 10.1586/17474124.2016.1140037. PMID: 26753504
Findlay JM, Middleton MR, Tomlinson I
Dig Dis Sci 2016 Jan;61(1):25-38. Epub 2015 Oct 7 doi: 10.1007/s10620-015-3884-5. PMID: 26445852Free PMC Article

Clinical prediction guides

Yeh CC, Chen CC, Chen CC, Han ML, Wu JF, Wang HP, Wu MS, Tseng PH
J Gastroenterol Hepatol 2023 Aug;38(8):1307-1315. Epub 2023 Apr 20 doi: 10.1111/jgh.16192. PMID: 37078564
Li M, Kong J, Wang L, Yan H, Liang W, Wang N, Zhao J
World J Surg Oncol 2022 May 12;20(1):155. doi: 10.1186/s12957-022-02612-3. PMID: 35549728Free PMC Article
Münch NS, Fang HY, Ingermann J, Maurer HC, Anand A, Kellner V, Sahm V, Wiethaler M, Baumeister T, Wein F, Einwächter H, Bolze F, Klingenspor M, Haller D, Kavanagh M, Lysaght J, Friedman R, Dannenberg AJ, Pollak M, Holt PR, Muthupalani S, Fox JG, Whary MT, Lee Y, Ren TY, Elliot R, Fitzgerald R, Steiger K, Schmid RM, Wang TC, Quante M
Gastroenterology 2019 Aug;157(2):492-506.e2. Epub 2019 Apr 15 doi: 10.1053/j.gastro.2019.04.013. PMID: 30998992Free PMC Article
Triadafilopoulos G, Akiyama J
Expert Rev Gastroenterol Hepatol 2016;10(5):605-13. Epub 2016 Feb 6 doi: 10.1586/17474124.2016.1140037. PMID: 26753504
Findlay JM, Middleton MR, Tomlinson I
Dig Dis Sci 2016 Jan;61(1):25-38. Epub 2015 Oct 7 doi: 10.1007/s10620-015-3884-5. PMID: 26445852Free PMC Article

Recent systematic reviews

Findlay JM, Middleton MR, Tomlinson I
Dig Dis Sci 2016 Jan;61(1):25-38. Epub 2015 Oct 7 doi: 10.1007/s10620-015-3884-5. PMID: 26445852Free PMC Article

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