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Lhermitte sign

MedGen UID:
108397
•Concept ID:
C0576702
•
Finding
Synonym: Lhermitte's sign
SNOMED CT: Lhermitte's phenomenon (299950000); Barber chair sign (299950000); Barber's chair sign (299950000)
 
HPO: HP:0032504

Definition

An electric shock-like sensation that occurs on flexion of the neck. This sensation radiates down the spine, often into the legs, arms, and sometimes to the trunk. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLhermitte sign

Professional guidelines

PubMed

Multiple Sclerosis: A Primary Care Perspective.
Saguil A, Farnell Iv EA, Jordan TS
Am Fam Physician 2022 Aug;106(2):173-183. PMID: 35977131
Multiple sclerosis: a primary care perspective.
Saguil A, Kane S, Farnell E
Am Fam Physician 2014 Nov 1;90(9):644-52. PMID: 25368924
Lhermitte sign and myelopathy after irradiation of the cervical spinal cord in radiotherapy treatment of head and neck cancer.
Mul VE, de Jong JM, Murrer LH, van den Ende PL, Houben RM, Lacko M, Lambin P, Baumert BG
Strahlenther Onkol 2012 Jan;188(1):71-6. Epub 2011 Dec 23 doi: 10.1007/s00066-011-0010-2. PMID: 22194023

Recent clinical studies

Etiology

Pain Characteristics and Associations with Quality of Life in Patients with Multiple Sclerosis in Lithuania.
Veličkaitė G, Jucevičiūtė N, Balnytė R, Laucius O, Vaitkus A
Medicina (Kaunas) 2020 Nov 8;56(11) doi: 10.3390/medicina56110596. PMID: 33171619Free PMC Article
Prevalence and natural history of pain in adults with multiple sclerosis: systematic review and meta-analysis.
Foley PL, Vesterinen HM, Laird BJ, Sena ES, Colvin LA, Chandran S, MacLeod MR, Fallon MT
Pain 2013 May;154(5):632-642. Epub 2012 Dec 14 doi: 10.1016/j.pain.2012.12.002. PMID: 23318126
Lhermitte sign after chemo-IMRT of head-and-neck cancer: incidence, doses, and potential mechanisms.
Pak D, Vineberg K, Feng F, Ten Haken RK, Eisbruch A
Int J Radiat Oncol Biol Phys 2012 Aug 1;83(5):1528-33. Epub 2012 Jan 26 doi: 10.1016/j.ijrobp.2011.10.052. PMID: 22284690Free PMC Article
Lhermitte sign and myelopathy after irradiation of the cervical spinal cord in radiotherapy treatment of head and neck cancer.
Mul VE, de Jong JM, Murrer LH, van den Ende PL, Houben RM, Lacko M, Lambin P, Baumert BG
Strahlenther Onkol 2012 Jan;188(1):71-6. Epub 2011 Dec 23 doi: 10.1007/s00066-011-0010-2. PMID: 22194023
Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD.
Nutt JG, Burchiel KJ, Comella CL, Jankovic J, Lang AE, Laws ER Jr, Lozano AM, Penn RD, Simpson RK Jr, Stacy M, Wooten GF; ICV GDNF Study Group. Implanted intracerebroventricular. Glial cell line-derived neurotrophic factor
Neurology 2003 Jan 14;60(1):69-73. doi: 10.1212/wnl.60.1.69. PMID: 12525720

Diagnosis

Degenerative Cervical Myelopathy: A Concept Review and Clinical Approach.
Gallagher DO, Taghlabi KM, Bondar K, Saifi C
Clin Spine Surg 2024 Feb 1;37(1):1-8. Epub 2023 Jun 19 doi: 10.1097/BSD.0000000000001463. PMID: 38285428
Multiple Sclerosis: A Primary Care Perspective.
Saguil A, Farnell Iv EA, Jordan TS
Am Fam Physician 2022 Aug;106(2):173-183. PMID: 35977131
Multiple sclerosis: a primary care perspective.
Saguil A, Kane S, Farnell E
Am Fam Physician 2014 Nov 1;90(9):644-52. PMID: 25368924
Unusual symptoms and syndromes in multiple sclerosis.
Rae-Grant AD
Continuum (Minneap Minn) 2013 Aug;19(4 Multiple Sclerosis):992-1006. doi: 10.1212/01.CON.0000433287.30715.07. PMID: 23917097
A pragmatic neurological screen for patients with suspected cord compressive myelopathy.
Cook CE, Hegedus E, Pietrobon R, Goode A
Phys Ther 2007 Sep;87(9):1233-42. Epub 2007 Jul 17 doi: 10.2522/ptj.20060150. PMID: 17636158

Therapy

Oxaliplatin-induced Lhermitte sign. A case report and review of literature.
Amaraneni A, Seth A, Itawi EA, Chandana SR
Clin Colorectal Cancer 2014 Dec;13(4):257-9. Epub 2014 Sep 21 doi: 10.1016/j.clcc.2014.09.006. PMID: 25442817
Multiple sclerosis: a primary care perspective.
Saguil A, Kane S, Farnell E
Am Fam Physician 2014 Nov 1;90(9):644-52. PMID: 25368924
Lhermitte sign after chemo-IMRT of head-and-neck cancer: incidence, doses, and potential mechanisms.
Pak D, Vineberg K, Feng F, Ten Haken RK, Eisbruch A
Int J Radiat Oncol Biol Phys 2012 Aug 1;83(5):1528-33. Epub 2012 Jan 26 doi: 10.1016/j.ijrobp.2011.10.052. PMID: 22284690Free PMC Article
Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD.
Nutt JG, Burchiel KJ, Comella CL, Jankovic J, Lang AE, Laws ER Jr, Lozano AM, Penn RD, Simpson RK Jr, Stacy M, Wooten GF; ICV GDNF Study Group. Implanted intracerebroventricular. Glial cell line-derived neurotrophic factor
Neurology 2003 Jan 14;60(1):69-73. doi: 10.1212/wnl.60.1.69. PMID: 12525720
Neuropathy following abuse of nitrous oxide.
Layzer RB, Fishman RA, Schafer JA
Neurology 1978 May;28(5):504-6. doi: 10.1212/wnl.28.5.504. PMID: 205816

Prognosis

Degenerative Cervical Myelopathy: A Concept Review and Clinical Approach.
Gallagher DO, Taghlabi KM, Bondar K, Saifi C
Clin Spine Surg 2024 Feb 1;37(1):1-8. Epub 2023 Jun 19 doi: 10.1097/BSD.0000000000001463. PMID: 38285428
Oxaliplatin-induced Lhermitte sign. A case report and review of literature.
Amaraneni A, Seth A, Itawi EA, Chandana SR
Clin Colorectal Cancer 2014 Dec;13(4):257-9. Epub 2014 Sep 21 doi: 10.1016/j.clcc.2014.09.006. PMID: 25442817
Prevalence and natural history of pain in adults with multiple sclerosis: systematic review and meta-analysis.
Foley PL, Vesterinen HM, Laird BJ, Sena ES, Colvin LA, Chandran S, MacLeod MR, Fallon MT
Pain 2013 May;154(5):632-642. Epub 2012 Dec 14 doi: 10.1016/j.pain.2012.12.002. PMID: 23318126
Lhermitte sign after chemo-IMRT of head-and-neck cancer: incidence, doses, and potential mechanisms.
Pak D, Vineberg K, Feng F, Ten Haken RK, Eisbruch A
Int J Radiat Oncol Biol Phys 2012 Aug 1;83(5):1528-33. Epub 2012 Jan 26 doi: 10.1016/j.ijrobp.2011.10.052. PMID: 22284690Free PMC Article
Lhermitte sign and myelopathy after irradiation of the cervical spinal cord in radiotherapy treatment of head and neck cancer.
Mul VE, de Jong JM, Murrer LH, van den Ende PL, Houben RM, Lacko M, Lambin P, Baumert BG
Strahlenther Onkol 2012 Jan;188(1):71-6. Epub 2011 Dec 23 doi: 10.1007/s00066-011-0010-2. PMID: 22194023

Clinical prediction guides

Degenerative Cervical Myelopathy: A Concept Review and Clinical Approach.
Gallagher DO, Taghlabi KM, Bondar K, Saifi C
Clin Spine Surg 2024 Feb 1;37(1):1-8. Epub 2023 Jun 19 doi: 10.1097/BSD.0000000000001463. PMID: 38285428
Pain Characteristics and Associations with Quality of Life in Patients with Multiple Sclerosis in Lithuania.
Veličkaitė G, Jucevičiūtė N, Balnytė R, Laucius O, Vaitkus A
Medicina (Kaunas) 2020 Nov 8;56(11) doi: 10.3390/medicina56110596. PMID: 33171619Free PMC Article
Lhermitte sign after chemo-IMRT of head-and-neck cancer: incidence, doses, and potential mechanisms.
Pak D, Vineberg K, Feng F, Ten Haken RK, Eisbruch A
Int J Radiat Oncol Biol Phys 2012 Aug 1;83(5):1528-33. Epub 2012 Jan 26 doi: 10.1016/j.ijrobp.2011.10.052. PMID: 22284690Free PMC Article
Lhermitte sign and myelopathy after irradiation of the cervical spinal cord in radiotherapy treatment of head and neck cancer.
Mul VE, de Jong JM, Murrer LH, van den Ende PL, Houben RM, Lacko M, Lambin P, Baumert BG
Strahlenther Onkol 2012 Jan;188(1):71-6. Epub 2011 Dec 23 doi: 10.1007/s00066-011-0010-2. PMID: 22194023
Lhermitte sign and urinary retention: atypical presentation of oxaliplatin neurotoxicity in four patients.
Taieb S, Trillet-Lenoir V, Rambaud L, Descos L, Freyer G
Cancer 2002 May 1;94(9):2434-40. doi: 10.1002/cncr.10500. PMID: 12015768

Recent systematic reviews

Prevalence and natural history of pain in adults with multiple sclerosis: systematic review and meta-analysis.
Foley PL, Vesterinen HM, Laird BJ, Sena ES, Colvin LA, Chandran S, MacLeod MR, Fallon MT
Pain 2013 May;154(5):632-642. Epub 2012 Dec 14 doi: 10.1016/j.pain.2012.12.002. PMID: 23318126

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