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Skin pilomatrix carcinoma

MedGen UID:
108439
Concept ID:
C0585475
Neoplastic Process
Synonyms: Calcified epithelial carcinoma of Malherbe; calcified epithelial carcinoma of Malherbe; Calcifying epitheliocarcinoma; calcifying epitheliocarcinoma; Invasive Pilomatrixoma; invasive pilomatrixoma; Malignant pilomatricoma; malignant pilomatricoma; Malignant pilomatrixoma; Matrical Carcinoma; Matrical carcinoma; matrical carcinoma; Pilomatrical Carcinoma; Pilomatrical carcinoma; Pilomatricoma, malignant; pilomatricoma, malignant; Pilomatrix carcinoma; Pilomatrix Carcinoma; pilomatrix carcinoma; Pilomatrix carcinoma of skin; Pilomatrix Carcinoma of Skin; pilomatrix carcinoma of skin; Pilomatrix Carcinoma of the Skin; pilomatrix carcinoma of the skin; Pilomatrix Skin Carcinoma; pilomatrix skin carcinoma; Pilomatrixoma, malignant; skin pilomatrix carcinoma; Trichomatrical carcinoma
SNOMED CT: Malignant pilomatrixoma (24762001); Pilomatricoma, malignant (24762001); Matrical carcinoma (24762001); Pilomatrix carcinoma (24762001); Pilomatrixoma, malignant (24762001); Pilomatrix carcinoma of skin (307610008)
 
Monarch Initiative: MONDO:0003414
Orphanet: ORPHA499182

Definition

A rare skin tumor characterized by an asymptomatic, solitary, often ulcerated nodule most commonly located in the face, involving the deep dermis, subcutaneous tissue, and skeletal muscle and fascia. Histopathologically, the lesion is composed of aggregates of atypical basaloid cells with numerous mitoses. Typical features include shadow cells, keratin cysts, and trichohyalin and keratohyalin granules. The tumor is locally aggressive and shows a tendency to recur after incomplete excision. Regional lymph node or visceral metastasis has been reported. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSkin pilomatrix carcinoma

Professional guidelines

PubMed

Wierzbicka M, Kraiński P, Bartochowska A
Curr Opin Otolaryngol Head Neck Surg 2023 Apr 1;31(2):134-145. Epub 2023 Jan 24 doi: 10.1097/MOO.0000000000000872. PMID: 36912226
Sia PI, Figueira E, Allende A, Selva D
Orbit 2016 Jun;35(3):144-56. Epub 2016 May 12 doi: 10.1080/01676830.2016.1176048. PMID: 27171562

Recent clinical studies

Etiology

Naveed H, Yaqoob N, Muhammad S, Aftab K, Raza MR
J Ayub Med Coll Abbottabad 2022 Oct-Dec;34(Suppl 1)(4):S1046-S1049. doi: 10.55519/JAMC-04-S4-10675. PMID: 36550674
Abed K, Stopa Z, Siewert-Gutowska M
Medicine (Baltimore) 2018 Jan;97(4):e9645. doi: 10.1097/MD.0000000000009645. PMID: 29369180Free PMC Article
Herrmann JL, Allan A, Trapp KM, Morgan MB
J Am Acad Dermatol 2014 Jul;71(1):38-43.e2. Epub 2014 Apr 13 doi: 10.1016/j.jaad.2014.02.042. PMID: 24739254
Yadia S, Randazzo CG, Malik S, Gressen E, Chasky M, Kenyon LC, Ratliff JK
J Spinal Cord Med 2010;33(3):272-7. doi: 10.1080/10790268.2010.11689707. PMID: 20737803Free PMC Article
Sau P, Lupton GP, Graham JH
Cancer 1993 Apr 15;71(8):2491-8. doi: 10.1002/1097-0142(19930415)71:8<2491::aid-cncr2820710811>3.0.co;2-i. PMID: 8453573

Diagnosis

Toffoli L, Bazzacco G, Conforti C, Guarneri C, Giuffrida R, Zelin E, di Meo N, Zalaudek I
Curr Oncol 2023 Jan 19;30(2):1426-1438. doi: 10.3390/curroncol30020109. PMID: 36826070Free PMC Article
Kamil ZS, Sachdeva M, Kwapis J, Ghazarian D
Cutis 2021 Oct;108(4):E24-E28. doi: 10.12788/cutis.0393. PMID: 34847012
Sia PI, Figueira E, Allende A, Selva D
Orbit 2016 Jun;35(3):144-56. Epub 2016 May 12 doi: 10.1080/01676830.2016.1176048. PMID: 27171562
Goodwin CR, Sankey EW, Liu A, Elder BD, Kosztowski T, Lo SF, Fisher CG, Clarke MJ, Gokaslan ZL, Sciubba DM
J Neurosurg Spine 2016 May;24(5):837-49. Epub 2015 Nov 6 doi: 10.3171/2015.4.SPINE15239. PMID: 26544595
Sorin T, Eluecque H, Gauchotte G, De Runz A, Chassagne JF, Mansuy L, Gisquet H, Simon E
Ann Chir Plast Esthet 2015 Jun;60(3):242-6. Epub 2014 Jul 10 doi: 10.1016/j.anplas.2014.06.005. PMID: 25017713

Therapy

Kanitakis J, Ducroux E, Hoelt P, Cahen R, Jullien D
Am J Dermatopathol 2018 Aug;40(8):e115-e118. doi: 10.1097/DAD.0000000000001146. PMID: 29863570

Prognosis

Wierzbicka M, Kraiński P, Bartochowska A
Curr Opin Otolaryngol Head Neck Surg 2023 Apr 1;31(2):134-145. Epub 2023 Jan 24 doi: 10.1097/MOO.0000000000000872. PMID: 36912226
Goodwin CR, Sankey EW, Liu A, Elder BD, Kosztowski T, Lo SF, Fisher CG, Clarke MJ, Gokaslan ZL, Sciubba DM
J Neurosurg Spine 2016 May;24(5):837-49. Epub 2015 Nov 6 doi: 10.3171/2015.4.SPINE15239. PMID: 26544595
Herrmann JL, Allan A, Trapp KM, Morgan MB
J Am Acad Dermatol 2014 Jul;71(1):38-43.e2. Epub 2014 Apr 13 doi: 10.1016/j.jaad.2014.02.042. PMID: 24739254
Bremnes RM, Kvamme JM, Stalsberg H, Jacobsen EA
Eur J Cancer 1999 Mar;35(3):433-7. doi: 10.1016/s0959-8049(98)00299-8. PMID: 10448295
Sau P, Lupton GP, Graham JH
Cancer 1993 Apr 15;71(8):2491-8. doi: 10.1002/1097-0142(19930415)71:8<2491::aid-cncr2820710811>3.0.co;2-i. PMID: 8453573

Clinical prediction guides

Toffoli L, Bazzacco G, Conforti C, Guarneri C, Giuffrida R, Zelin E, di Meo N, Zalaudek I
Curr Oncol 2023 Jan 19;30(2):1426-1438. doi: 10.3390/curroncol30020109. PMID: 36826070Free PMC Article
Goodwin CR, Sankey EW, Liu A, Elder BD, Kosztowski T, Lo SF, Fisher CG, Clarke MJ, Gokaslan ZL, Sciubba DM
J Neurosurg Spine 2016 May;24(5):837-49. Epub 2015 Nov 6 doi: 10.3171/2015.4.SPINE15239. PMID: 26544595
Sorin T, Eluecque H, Gauchotte G, De Runz A, Chassagne JF, Mansuy L, Gisquet H, Simon E
Ann Chir Plast Esthet 2015 Jun;60(3):242-6. Epub 2014 Jul 10 doi: 10.1016/j.anplas.2014.06.005. PMID: 25017713
Herrmann JL, Allan A, Trapp KM, Morgan MB
J Am Acad Dermatol 2014 Jul;71(1):38-43.e2. Epub 2014 Apr 13 doi: 10.1016/j.jaad.2014.02.042. PMID: 24739254
Hardisson D, Linares MD, Cuevas-Santos J, Contreras F
Am J Dermatopathol 2001 Oct;23(5):394-401. doi: 10.1097/00000372-200110000-00002. PMID: 11801770

Recent systematic reviews

Panda SK, Sahoo PK, Agarwala SK, Houghton TT, Sankar KV, Mohanty P
J Cancer Res Ther 2023 Jul-Sep;19(5):1098-1102. doi: 10.4103/jcrt.jcrt_720_21. PMID: 37787269
Goodwin CR, Sankey EW, Liu A, Elder BD, Kosztowski T, Lo SF, Fisher CG, Clarke MJ, Gokaslan ZL, Sciubba DM
J Neurosurg Spine 2016 May;24(5):837-49. Epub 2015 Nov 6 doi: 10.3171/2015.4.SPINE15239. PMID: 26544595

Supplemental Content

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