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Prostate carcinoma

MedGen UID:
108657
Concept ID:
C0600139
Neoplastic Process
Synonyms: CA - Carcinoma of prostate; Cancer of Prostate; Cancer of the Prostate; Carcinoma of prostate; Carcinoma of Prostate; carcinoma of prostate; carcinoma of prostate gland; Carcinoma of the Prostate; carcinoma of the prostate; Prostate cancer; Prostate Cancer; Prostate Carcinoma; prostate carcinoma; prostate gland carcinoma
SNOMED CT: Prostate cancer (254900004); Carcinoma of prostate (254900004); CA - Carcinoma of prostate (254900004); Prostate carcinoma (254900004)
 
Monarch Initiative: MONDO:0005159

Definition

One of the most common malignant tumors afflicting men. The majority of carcinomas arise in the peripheral zone and a minority occur in the central or the transitional zone of the prostate gland. Grossly, prostatic carcinomas appear as ill-defined yellow areas of discoloration in the prostate gland lobes. Adenocarcinomas represent the overwhelming majority of prostatic carcinomas. Prostatic-specific antigen (PSA) serum test is widely used as a screening test for the early detection of prostatic carcinoma. Treatment options include radical prostatectomy, radiation therapy, androgen ablation and cryotherapy. Watchful waiting or surveillance alone is an option for older patients with low-grade or low-stage disease. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProstate carcinoma

Professional guidelines

PubMed

Ranasinghe W, Shapiro DD, Zhang M, Bathala T, Navone N, Thompson TC, Broom B, Aparicio A, Tu SM, Tang C, Davis JW, Pisters L, Chapin BF
Nat Rev Urol 2021 Jun;18(6):337-358. Epub 2021 Apr 6 doi: 10.1038/s41585-021-00447-3. PMID: 33824525
Groeben C, Wirth MP
Med Monatsschr Pharm 2017 May;40(5):192-201. PMID: 29950285
Arista-Nasr J, Martínez-Benítez B, Aguilar-Ayala EL, Aleman-Sanchez CN, Bornstein-Quevedo L, Albores-Saavedra J
Ann Diagn Pathol 2015 Aug;19(4):253-60. Epub 2015 May 22 doi: 10.1016/j.anndiagpath.2015.04.009. PMID: 26101154

Recent clinical studies

Etiology

Guo Z, Lu X, Yang F, Qin L, Yang N, Cai P, Han C, Wu J, Wang H
Comput Math Methods Med 2022;2022:1784791. Epub 2022 Aug 30 doi: 10.1155/2022/1784791. PMID: 36081431Free PMC Article
Fervaha G, Izard JP, Tripp DA, Rajan S, Leong DP, Siemens DR
Urol Oncol 2019 Apr;37(4):282-288. Epub 2019 Jan 7 doi: 10.1016/j.urolonc.2018.12.020. PMID: 30630735
Montironi R, Zhou M, Magi-Galluzzi C, Epstein JI
Eur Urol Oncol 2018 May;1(1):21-28. Epub 2018 May 15 doi: 10.1016/j.euo.2018.03.013. PMID: 31100224
Yu J, Fulcher AS, Turner MA, Cockrell CH, Cote EP, Wallace TJ
Br J Radiol 2014 May;87(1037):20130659. Epub 2014 Mar 20 doi: 10.1259/bjr.20130659. PMID: 24646125Free PMC Article
Rhoden EL, Averbeck MA
Curr Urol Rep 2009 Nov;10(6):453-9. doi: 10.1007/s11934-009-0072-1. PMID: 19863857

Diagnosis

Pokhrel A, Heravi O, Enayati L, Nelson R, Mooppan U, Wu R, Wang JC
Discov Med 2023 Oct;35(178):664-672. doi: 10.24976/Discov.Med.202335178.65. PMID: 37811608
Szentirmai E, Giannico GA
Pathologica 2020 Mar;112(1):17-24. doi: 10.32074/1591-951X-5-20. PMID: 32202536Free PMC Article
Montironi R, Zhou M, Magi-Galluzzi C, Epstein JI
Eur Urol Oncol 2018 May;1(1):21-28. Epub 2018 May 15 doi: 10.1016/j.euo.2018.03.013. PMID: 31100224
Tsuzuki T
Int J Urol 2015 Feb;22(2):140-5. Epub 2014 Oct 31 doi: 10.1111/iju.12657. PMID: 25358604
Ellis WJ, Lange PH
Endocrinol Metab Clin North Am 1994 Dec;23(4):809-24. PMID: 7705321

Therapy

Tamura RE, Lana MG, Costanzi-Strauss E, Strauss BE
Gene Ther 2020 Feb;27(1-2):15-26. Epub 2019 Mar 29 doi: 10.1038/s41434-019-0071-x. PMID: 30926960
Wale DJ, Viglianti BL, Gross MD, Ferretti A, Rubello D, Wong KK
Am J Clin Oncol 2019 Jan;42(1):99-106. doi: 10.1097/COC.0000000000000479. PMID: 30204613
Aparicio AM, Harzstark AL, Corn PG, Wen S, Araujo JC, Tu SM, Pagliaro LC, Kim J, Millikan RE, Ryan C, Tannir NM, Zurita AJ, Mathew P, Arap W, Troncoso P, Thall PF, Logothetis CJ
Clin Cancer Res 2013 Jul 1;19(13):3621-30. Epub 2013 May 6 doi: 10.1158/1078-0432.CCR-12-3791. PMID: 23649003Free PMC Article
Arranz S, Chiva-Blanch G, Valderas-Martínez P, Medina-Remón A, Lamuela-Raventós RM, Estruch R
Nutrients 2012 Jul;4(7):759-781. Epub 2012 Jul 10 doi: 10.3390/nu4070759. PMID: 22852062Free PMC Article
Rhoden EL, Averbeck MA
Curr Urol Rep 2009 Nov;10(6):453-9. doi: 10.1007/s11934-009-0072-1. PMID: 19863857

Prognosis

Guo G, Zhu L
Ann Clin Lab Sci 2022 Sep;52(5):731-740. PMID: 36261186
Guo Z, Lu X, Yang F, Qin L, Yang N, Cai P, Han C, Wu J, Wang H
Comput Math Methods Med 2022;2022:1784791. Epub 2022 Aug 30 doi: 10.1155/2022/1784791. PMID: 36081431Free PMC Article
Szentirmai E, Giannico GA
Pathologica 2020 Mar;112(1):17-24. doi: 10.32074/1591-951X-5-20. PMID: 32202536Free PMC Article
Lateef N, Abdul Basit K, Abbasi N, Kazmi SM, Ansari AB, Shah M
Exp Clin Transplant 2016 Feb;14(1):12-6. Epub 2015 Dec 1 doi: 10.6002/ect.2015.0214. PMID: 26643469
Günalp I, Gündüz K
Jpn J Ophthalmol 1995;39(1):65-70. PMID: 7643486

Clinical prediction guides

Guo Z, Lu X, Yang F, Qin L, Yang N, Cai P, Han C, Wu J, Wang H
Comput Math Methods Med 2022;2022:1784791. Epub 2022 Aug 30 doi: 10.1155/2022/1784791. PMID: 36081431Free PMC Article
Montironi R, Zhou M, Magi-Galluzzi C, Epstein JI
Eur Urol Oncol 2018 May;1(1):21-28. Epub 2018 May 15 doi: 10.1016/j.euo.2018.03.013. PMID: 31100224
Galoczová M, Nenutil R, Coates P, Vojtěšek B
Klin Onkol 2018 Winter;31(Suppl 2):27-31. doi: 10.14735/amko20182S27. PMID: 31023021
Tsuzuki T
Int J Urol 2015 Feb;22(2):140-5. Epub 2014 Oct 31 doi: 10.1111/iju.12657. PMID: 25358604
Rhoden EL, Averbeck MA
Curr Urol Rep 2009 Nov;10(6):453-9. doi: 10.1007/s11934-009-0072-1. PMID: 19863857

Recent systematic reviews

Miura N, Pradere B, Mori K, Mostafaei H, Quhal F, Misrai V, D'Andrea D, Albisinni S, Papalia R, Saika T, Scarpa RM, Shariat SF, Esperto F
Minerva Urol Nefrol 2020 Oct;72(5):531-542. Epub 2020 Jun 16 doi: 10.23736/S0393-2249.20.03779-0. PMID: 32550632
Siepe G, Buwenge M, Nguyen NP, Macchia G, Deodato F, Cilla S, Mattiucci GC, Capocaccia I, Cammelli S, Guido A, Arcelli A, Ntreta M, Guerri S, Morganti AG
Anticancer Res 2018 Mar;38(3):1221-1230. doi: 10.21873/anticanres.12343. PMID: 29491044
Aucoin M, Cooley K, Knee C, Fritz H, Balneaves LG, Breau R, Fergusson D, Skidmore B, Wong R, Seely D
Integr Cancer Ther 2017 Mar;16(1):32-62. Epub 2016 Jun 29 doi: 10.1177/1534735416656052. PMID: 27365385Free PMC Article
Luo Y, Gou X, Huang P, Mou C
Chin Med J (Engl) 2014;127(9):1768-74. PMID: 24791889
Serpa Neto A, Tobias-Machado M, Esteves MA, Senra MD, Wroclawski ML, Fonseca FL, dos Reis RB, Pompeo AC, Del Giglio A
BMC Urol 2010 May 19;10:9. doi: 10.1186/1471-2490-10-9. PMID: 20482867Free PMC Article

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