U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Prostate carcinoma

MedGen UID:
108657
Concept ID:
C0600139
Neoplastic Process
Synonyms: CA - Carcinoma of prostate; Cancer of Prostate; Cancer of the Prostate; Carcinoma of prostate; Carcinoma of Prostate; carcinoma of prostate; carcinoma of prostate gland; Carcinoma of the Prostate; carcinoma of the prostate; Prostate Cancer; Prostate Carcinoma; prostate carcinoma; prostate gland carcinoma
SNOMED CT: Carcinoma of prostate (254900004); CA - Carcinoma of prostate (254900004); Prostate carcinoma (254900004)
 
Monarch Initiative: MONDO:0005159

Definition

One of the most common malignant tumors afflicting men. The majority of carcinomas arise in the peripheral zone and a minority occur in the central or the transitional zone of the prostate gland. Grossly, prostatic carcinomas appear as ill-defined yellow areas of discoloration in the prostate gland lobes. Adenocarcinomas represent the overwhelming majority of prostatic carcinomas. Prostatic-specific antigen (PSA) serum test is widely used as a screening test for the early detection of prostatic carcinoma. Treatment options include radical prostatectomy, radiation therapy, androgen ablation and cryotherapy. Watchful waiting or surveillance alone is an option for older patients with low-grade or low-stage disease. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProstate carcinoma

Professional guidelines

PubMed

Ranasinghe W, Shapiro DD, Zhang M, Bathala T, Navone N, Thompson TC, Broom B, Aparicio A, Tu SM, Tang C, Davis JW, Pisters L, Chapin BF
Nat Rev Urol 2021 Jun;18(6):337-358. Epub 2021 Apr 6 doi: 10.1038/s41585-021-00447-3. PMID: 33824525
Groeben C, Wirth MP
Med Monatsschr Pharm 2017 May;40(5):192-201. PMID: 29950285
Arista-Nasr J, Martínez-Benítez B, Aguilar-Ayala EL, Aleman-Sanchez CN, Bornstein-Quevedo L, Albores-Saavedra J
Ann Diagn Pathol 2015 Aug;19(4):253-60. Epub 2015 May 22 doi: 10.1016/j.anndiagpath.2015.04.009. PMID: 26101154

Recent clinical studies

Etiology

Paner GP, Gandhi J, Choy B, Amin MB
Arch Pathol Lab Med 2019 May;143(5):550-564. Epub 2019 Mar 13 doi: 10.5858/arpa.2018-0334-RA. PMID: 30865487
Fervaha G, Izard JP, Tripp DA, Rajan S, Leong DP, Siemens DR
Urol Oncol 2019 Apr;37(4):282-288. Epub 2019 Jan 7 doi: 10.1016/j.urolonc.2018.12.020. PMID: 30630735
Montironi R, Zhou M, Magi-Galluzzi C, Epstein JI
Eur Urol Oncol 2018 May;1(1):21-28. Epub 2018 May 15 doi: 10.1016/j.euo.2018.03.013. PMID: 31100224
Yu J, Fulcher AS, Turner MA, Cockrell CH, Cote EP, Wallace TJ
Br J Radiol 2014 May;87(1037):20130659. Epub 2014 Mar 20 doi: 10.1259/bjr.20130659. PMID: 24646125Free PMC Article
Rhoden EL, Averbeck MA
Curr Urol Rep 2009 Nov;10(6):453-9. doi: 10.1007/s11934-009-0072-1. PMID: 19863857

Diagnosis

Pokhrel A, Heravi O, Enayati L, Nelson R, Mooppan U, Wu R, Wang JC
Discov Med 2023 Oct;35(178):664-672. doi: 10.24976/Discov.Med.202335178.65. PMID: 37811608
Szentirmai E, Giannico GA
Pathologica 2020 Mar;112(1):17-24. doi: 10.32074/1591-951X-5-20. PMID: 32202536Free PMC Article
Sanguedolce F, Russo D, Mancini V, Selvaggio O, Calò B, Carrieri G, Cormio L
Int J Surg Pathol 2019 Apr;27(2):120-133. Epub 2018 Dec 3 doi: 10.1177/1066896918814198. PMID: 30509113
Montironi R, Zhou M, Magi-Galluzzi C, Epstein JI
Eur Urol Oncol 2018 May;1(1):21-28. Epub 2018 May 15 doi: 10.1016/j.euo.2018.03.013. PMID: 31100224
Ellis WJ, Lange PH
Endocrinol Metab Clin North Am 1994 Dec;23(4):809-24. PMID: 7705321

Therapy

Tamura RE, Lana MG, Costanzi-Strauss E, Strauss BE
Gene Ther 2020 Feb;27(1-2):15-26. Epub 2019 Mar 29 doi: 10.1038/s41434-019-0071-x. PMID: 30926960
Wale DJ, Viglianti BL, Gross MD, Ferretti A, Rubello D, Wong KK
Am J Clin Oncol 2019 Jan;42(1):99-106. doi: 10.1097/COC.0000000000000479. PMID: 30204613
Aparicio AM, Harzstark AL, Corn PG, Wen S, Araujo JC, Tu SM, Pagliaro LC, Kim J, Millikan RE, Ryan C, Tannir NM, Zurita AJ, Mathew P, Arap W, Troncoso P, Thall PF, Logothetis CJ
Clin Cancer Res 2013 Jul 1;19(13):3621-30. Epub 2013 May 6 doi: 10.1158/1078-0432.CCR-12-3791. PMID: 23649003Free PMC Article
Arranz S, Chiva-Blanch G, Valderas-Martínez P, Medina-Remón A, Lamuela-Raventós RM, Estruch R
Nutrients 2012 Jul;4(7):759-781. Epub 2012 Jul 10 doi: 10.3390/nu4070759. PMID: 22852062Free PMC Article
Rhoden EL, Averbeck MA
Curr Urol Rep 2009 Nov;10(6):453-9. doi: 10.1007/s11934-009-0072-1. PMID: 19863857

Prognosis

Szentirmai E, Giannico GA
Pathologica 2020 Mar;112(1):17-24. doi: 10.32074/1591-951X-5-20. PMID: 32202536Free PMC Article
Wagenlehner FM, Pilatz A, Waliszewski P, Weidner W, Johansen TE
Nat Rev Urol 2014 Feb;11(2):80-6. Epub 2014 Jan 14 doi: 10.1038/nrurol.2013.322. PMID: 24418806
Binkley N
Best Pract Res Clin Rheumatol 2009 Dec;23(6):755-68. doi: 10.1016/j.berh.2009.10.001. PMID: 19945687
Scher HI
Cancer 2003 Feb 1;97(3 Suppl):758-71. doi: 10.1002/cncr.11151. PMID: 12548573
Günalp I, Gündüz K
Jpn J Ophthalmol 1995;39(1):65-70. PMID: 7643486

Clinical prediction guides

Montironi R, Zhou M, Magi-Galluzzi C, Epstein JI
Eur Urol Oncol 2018 May;1(1):21-28. Epub 2018 May 15 doi: 10.1016/j.euo.2018.03.013. PMID: 31100224
Galoczová M, Nenutil R, Coates P, Vojtěšek B
Klin Onkol 2018 Winter;31(Suppl 2):27-31. doi: 10.14735/amko20182S27. PMID: 31023021
Remo A, Pancione M, Zanella C, Manfrin E
Appl Immunohistochem Mol Morphol 2016 Mar;24(3):201-6. doi: 10.1097/PAI.0000000000000171. PMID: 25906117
Tsuzuki T
Int J Urol 2015 Feb;22(2):140-5. Epub 2014 Oct 31 doi: 10.1111/iju.12657. PMID: 25358604
Rhoden EL, Averbeck MA
Curr Urol Rep 2009 Nov;10(6):453-9. doi: 10.1007/s11934-009-0072-1. PMID: 19863857

Recent systematic reviews

Van de Wiele C, Sathekge M, de Spiegeleer B, de Jonghe PJ, Beels L, Maes A
Int J Mol Sci 2019 Oct 2;20(19) doi: 10.3390/ijms20194886. PMID: 31581638Free PMC Article
Siepe G, Buwenge M, Nguyen NP, Macchia G, Deodato F, Cilla S, Mattiucci GC, Capocaccia I, Cammelli S, Guido A, Arcelli A, Ntreta M, Guerri S, Morganti AG
Anticancer Res 2018 Mar;38(3):1221-1230. doi: 10.21873/anticanres.12343. PMID: 29491044
Aucoin M, Cooley K, Knee C, Fritz H, Balneaves LG, Breau R, Fergusson D, Skidmore B, Wong R, Seely D
Integr Cancer Ther 2017 Mar;16(1):32-62. Epub 2016 Jun 29 doi: 10.1177/1534735416656052. PMID: 27365385Free PMC Article
Luo Y, Gou X, Huang P, Mou C
Chin Med J (Engl) 2014;127(9):1768-74. PMID: 24791889
Serpa Neto A, Tobias-Machado M, Esteves MA, Senra MD, Wroclawski ML, Fonseca FL, dos Reis RB, Pompeo AC, Del Giglio A
BMC Urol 2010 May 19;10:9. doi: 10.1186/1471-2490-10-9. PMID: 20482867Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...