U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Subcorneal pustular dermatosis

MedGen UID:
108687
•Concept ID:
C0600336
•
Disease or Syndrome
Synonyms: Dermatoses, Subcorneal Pustular; Dermatosis, Subcorneal Pustular; Pustular Dermatoses, Subcorneal; Pustular Dermatosis, Subcorneal; Sneddon Wilkinson Disease; Sneddon-Wilkinson Disease; Subcorneal Pustular Dermatoses; Subcorneal Pustular Dermatosis
SNOMED CT: Subcorneal pustular dermatosis (25147002); Sneddon-Wilkinson disease (25147002); Sneddon-Wilkinson syndrome (25147002)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0006614
Orphanet: ORPHA48377

Definition

Subcorneal pustular dermatosis is a rare, benign, chronic disease characterized by sterile pustular eruption, typically involving the flexural sites of the trunk and proximal extremities. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSubcorneal pustular dermatosis
Follow this link to review classifications for Subcorneal pustular dermatosis in Orphanet.

Professional guidelines

PubMed

Successful treatment of severe subcorneal pustular dermatosis with the 308-nm ultraviolet B excimer laser.
Miura H, Fujiwara S
Br J Dermatol 2022 Oct;187(4):e157. Epub 2022 May 28 doi: 10.1111/bjd.21633. PMID: 35633096
Treatment of recalcitrant subcorneal pustular dermatosis with guselkumab.
Teraki Y, Sugai S
Int J Dermatol 2021 Apr;60(4):e153-e154. Epub 2020 Nov 23 doi: 10.1111/ijd.15311. PMID: 33226124
Pustular skin disorders: diagnosis and treatment.
Mengesha YM, Bennett ML
Am J Clin Dermatol 2002;3(6):389-400. doi: 10.2165/00128071-200203060-00003. PMID: 12113648

Recent clinical studies

Etiology

Subcorneal Pustular Dermatosis Following SARS-CoV-2 Infection.
Iurillo A, Yumeen S, Imbriano D, Moad J, Kawaoka J, Grenier N, Wisco O
R I Med J (2013) 2023 Nov 1;106(10):51-53. PMID: 37890065
Neutrophilic dermatoses.
Delaleu J, Lepelletier C, Calugareanu A, De Masson A, Charvet E, Petit A, Giurgea I, Amselem S, Karabina S, Jachiet M, Mahevas T, Ram-Wolff C, Vignon-Pennamen MD, Bagot M, Battistella M, Bouaziz JD
Rev Med Interne 2022 Dec;43(12):727-738. Epub 2022 Jul 20 doi: 10.1016/j.revmed.2022.06.007. PMID: 35870984
Papulosquamous annular diseases.
Aslan Kayıran M, Wang JV, Karadag AS
Clin Dermatol 2022 Sep-Oct;40(5):441-449. Epub 2022 Jan 1 doi: 10.1016/j.clindermatol.2021.12.007. PMID: 34979266
Annular bullous diseases.
Sussman M, Zhai L, Morquette A, Huang S, Hsu S
Clin Dermatol 2022 Sep-Oct;40(5):516-528. Epub 2022 Jan 1 doi: 10.1016/j.clindermatol.2021.12.012. PMID: 34979265
Intraepidermal IgA pustulosis.
Wallach D
J Am Acad Dermatol 1992 Dec;27(6 Pt 1):993-1000. doi: 10.1016/0190-9622(92)70301-u. PMID: 1479108

Diagnosis

Neutrophilic dermatoses.
Delaleu J, Lepelletier C, Calugareanu A, De Masson A, Charvet E, Petit A, Giurgea I, Amselem S, Karabina S, Jachiet M, Mahevas T, Ram-Wolff C, Vignon-Pennamen MD, Bagot M, Battistella M, Bouaziz JD
Rev Med Interne 2022 Dec;43(12):727-738. Epub 2022 Jul 20 doi: 10.1016/j.revmed.2022.06.007. PMID: 35870984
Papulosquamous annular diseases.
Aslan Kayıran M, Wang JV, Karadag AS
Clin Dermatol 2022 Sep-Oct;40(5):441-449. Epub 2022 Jan 1 doi: 10.1016/j.clindermatol.2021.12.007. PMID: 34979266
Annular bullous diseases.
Sussman M, Zhai L, Morquette A, Huang S, Hsu S
Clin Dermatol 2022 Sep-Oct;40(5):516-528. Epub 2022 Jan 1 doi: 10.1016/j.clindermatol.2021.12.012. PMID: 34979265
Subcorneal Pustular Dermatosis: A Review of 30 Years of Progress.
Watts PJ, Khachemoune A
Am J Clin Dermatol 2016 Dec;17(6):653-671. doi: 10.1007/s40257-016-0202-8. PMID: 27349653
Subcorneal pustular dermatosis.
Reed J, Wilkinson J
Clin Dermatol 2000 May-Jun;18(3):301-13. doi: 10.1016/s0738-081x(99)00121-2. PMID: 10856662

Therapy

Subcorneal pustular dermatosis associated with IgG monoclonal gammopathy of undetermined significance.
Young PA, Bae GH, Konia TH
Dermatol Online J 2021 Apr 15;27(4) PMID: 33999577
Subcorneal Pustular Dermatosis: A Review of 30 Years of Progress.
Watts PJ, Khachemoune A
Am J Clin Dermatol 2016 Dec;17(6):653-671. doi: 10.1007/s40257-016-0202-8. PMID: 27349653
Subcorneal pustular dermatosis: 50 years on.
Cheng S, Edmonds E, Ben-Gashir M, Yu RC
Clin Exp Dermatol 2008 May;33(3):229-33. Epub 2008 Mar 18 doi: 10.1111/j.1365-2230.2008.02706.x. PMID: 18355359
Intraepidermal IgA pustulosis.
Wallach D
J Am Acad Dermatol 1992 Dec;27(6 Pt 1):993-1000. doi: 10.1016/0190-9622(92)70301-u. PMID: 1479108
Subcorneal pustular dermatosis.
Sneddon IB
Int J Dermatol 1977 Oct;16(8):640-4. doi: 10.1111/j.1365-4362.1977.tb01874.x. PMID: 334683

Prognosis

Subcorneal pustular dermatosis-type IgA pemphigus associated with multiple myeloma: A case report and literature review.
Koga H, Tsutsumi M, Teye K, Ishii N, Yamaguchi M, Nagafuji K, Nakama T
J Dermatol 2023 Feb;50(2):234-238. Epub 2022 Jul 15 doi: 10.1111/1346-8138.16516. PMID: 35838241
IgA pemphigus.
Tsuruta D, Ishii N, Hamada T, Ohyama B, Fukuda S, Koga H, Imamura K, Kobayashi H, Karashima T, Nakama T, Dainichi T, Hashimoto T
Clin Dermatol 2011 Jul-Aug;29(4):437-42. doi: 10.1016/j.clindermatol.2011.01.014. PMID: 21679872
Subcorneal pustular dermatosis and Sjögren's syndrome.
Tsuruta D, Matsumura-Oura A, Ishii M
Int J Dermatol 2005 Nov;44(11):955-7. doi: 10.1111/j.1365-4632.2004.02290.x. PMID: 16336533
Subcorneal pustular dermatosis in a patient with aplastic anemia.
Park BS, Cho KH, Eun HC, Youn JI
J Am Acad Dermatol 1998 Aug;39(2 Pt 1):287-9. doi: 10.1016/s0190-9622(98)70093-3. PMID: 9704851
Subcorneal pustular dermatosis and pustular psoriasis. A clinicopathologic correlation.
Sanchez NP, Perry HO, Muller SA, Winkelmann RK
Arch Dermatol 1983 Sep;119(9):715-21. PMID: 6351757

Clinical prediction guides

Three cases of subcorneal pustular dermatosis with immunohistochemical examinations.
Kishimoto M, Komine M, Okada H, Sato A, Kamiya K, Maekawa T, Murata S, Ohtsuki M
J Dermatol 2023 Sep;50(9):1150-1155. Epub 2023 Jun 8 doi: 10.1111/1346-8138.16850. PMID: 37288510
IgA pemphigus.
Tsuruta D, Ishii N, Hamada T, Ohyama B, Fukuda S, Koga H, Imamura K, Kobayashi H, Karashima T, Nakama T, Dainichi T, Hashimoto T
Clin Dermatol 2011 Jul-Aug;29(4):437-42. doi: 10.1016/j.clindermatol.2011.01.014. PMID: 21679872
Successful treatment of subcorneal pustular dermatosis (Sneddon-wilkinson disease) by acitretin: report of a case.
Marlière V, Beylot-Barry M, Beylot C, Doutre M
Dermatology 1999;199(2):153-5. doi: 10.1159/000018224. PMID: 10559583
Skin reactions to diltiazem.
Wittal RA, Fischer GO, Georgouras KE, Baird PJ
Australas J Dermatol 1992;33(1):11-8. doi: 10.1111/j.1440-0960.1992.tb00047.x. PMID: 1445088
Subcorneal pustular dermatosis and pustular psoriasis. A clinicopathologic correlation.
Sanchez NP, Perry HO, Muller SA, Winkelmann RK
Arch Dermatol 1983 Sep;119(9):715-21. PMID: 6351757

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...