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Host-Tumor Interaction

MedGen UID:
109300
•Concept ID:
C0596722
•
Pathologic Function

Definition

The efforts by the host to reject a tumor, and the mechanisms by a tumor to evade recognition by the immune system. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHost-Tumor Interaction

Professional guidelines

PubMed

Emerging patient-specific treatment modalities in head and neck cancer - a systematic review.
Elicin O, Cihoric N, Vlaskou Badra E, Ozsahin M
Expert Opin Investig Drugs 2019 Apr;28(4):365-376. Epub 2019 Feb 26 doi: 10.1080/13543784.2019.1582642. PMID: 30760055
Integration of host-related signatures with cancer cell-derived predictors for the optimal management of anticancer chemotherapy.
Zitvogel L, Kepp O, Aymeric L, Ma Y, Locher C, Delahaye NF, André F, Kroemer G
Cancer Res 2010 Dec 1;70(23):9538-43. Epub 2010 Nov 23 doi: 10.1158/0008-5472.CAN-10-1003. PMID: 21098713
The biology of interleukin-2 efficacy in the treatment of patients with renal cell carcinoma.
Romo de Vivar Chavez A, de Vera ME, Liang X, Lotze MT
Med Oncol 2009;26 Suppl 1:3-12. Epub 2009 Jan 16 doi: 10.1007/s12032-008-9162-z. PMID: 19148593

Recent clinical studies

Etiology

Inflammatory burden as a prognostic biomarker for cancer.
Xie H, Ruan G, Ge Y, Zhang Q, Zhang H, Lin S, Song M, Zhang X, Liu X, Li X, Zhang K, Yang M, Tang M, Song CH, Shi H
Clin Nutr 2022 Jun;41(6):1236-1243. Epub 2022 Apr 22 doi: 10.1016/j.clnu.2022.04.019. PMID: 35504166
Desmoplastic Reaction, Immune Cell Response, and Prognosis in Colorectal Cancer.
Akimoto N, Väyrynen JP, Zhao M, Ugai T, Fujiyoshi K, Borowsky J, Zhong R, Haruki K, Arima K, Lau MC, Kishikawa J, Twombly TS, Takashima Y, Song M, Zhang X, Wu K, Chan AT, Meyerhardt JA, Giannakis M, Nowak JA, Ogino S
Front Immunol 2022;13:840198. Epub 2022 Mar 22 doi: 10.3389/fimmu.2022.840198. PMID: 35392092Free PMC Article
Racial disparities in breast cancer outcome: insights into host-tumor interactions.
Demicheli R, Retsky MW, Hrushesky WJ, Baum M, Gukas ID, Jatoi I
Cancer 2007 Nov 1;110(9):1880-8. doi: 10.1002/cncr.22998. PMID: 17876835
Leveraging the activity of tumor vaccines with cytotoxic chemotherapy.
Emens LA, Jaffee EM
Cancer Res 2005 Sep 15;65(18):8059-64. doi: 10.1158/0008-5472.CAN-05-1797. PMID: 16166275
Advances in specific immunotherapy of malignant melanoma.
Curiel-Lewandrowski C, Demierre MF
J Am Acad Dermatol 2000 Aug;43(2 Pt 1):167-85; quiz 186-8. doi: 10.1067/mjd.2000.104513. PMID: 10906637

Diagnosis

Treg and Oligoclonal Expansion of Terminal Effector CD8(+) T Cell as Key Players in Multiple Myeloma.
Joshua DE, Vuckovic S, Favaloro J, Lau KHA, Yang S, Bryant CE, Gibson J, Ho PJ
Front Immunol 2021;12:620596. Epub 2021 Feb 23 doi: 10.3389/fimmu.2021.620596. PMID: 33708212Free PMC Article
The Latest Findings of PD-1/PD-L1 Inhibitor Application in Gynecologic Cancers.
Kooshkaki O, Derakhshani A, Safarpour H, Najafi S, Vahedi P, Brunetti O, Torabi M, Lotfinejad P, Paradiso AV, Racanelli V, Silvestris N, Baradaran B
Int J Mol Sci 2020 Jul 16;21(14) doi: 10.3390/ijms21145034. PMID: 32708748Free PMC Article
Proteomic analysis of neuroblastoma microenvironment: effect of the host-tumor interaction on disease progression.
Turner KE, Kumar HR, Hoelz DJ, Zhong X, Rescorla FJ, Hickey RJ, Malkas LH, Sandoval JA
J Surg Res 2009 Sep;156(1):116-22. Epub 2009 Mar 25 doi: 10.1016/j.jss.2009.02.019. PMID: 19592021
Leveraging the activity of tumor vaccines with cytotoxic chemotherapy.
Emens LA, Jaffee EM
Cancer Res 2005 Sep 15;65(18):8059-64. doi: 10.1158/0008-5472.CAN-05-1797. PMID: 16166275
Hormonal and metabolic abnormalities in the malnourished cancer patient: effects on host-tumor interaction.
Heber D, Byerley LO, Tchekmedyian NS
JPEN J Parenter Enteral Nutr 1992 Nov-Dec;16(6 Suppl):60S-64S. doi: 10.1177/014860719201600605. PMID: 1287226

Therapy

GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity.
Watson DC, Bayik D, Storevik S, Moreino SS, Sprowls SA, Han J, Augustsson MT, Lauko A, Sravya P, Røsland GV, Troike K, Tronstad KJ, Wang S, Sarnow K, Kay K, Lunavat TR, Silver DJ, Dayal S, Joseph JV, Mulkearns-Hubert E, Ystaas LAR, Deshpande G, Guyon J, Zhou Y, Magaut CR, Seder J, Neises L, Williford SE, Meiser J, Scott AJ, Sajjakulnukit P, Mears JA, Bjerkvig R, Chakraborty A, Daubon T, Cheng F, Lyssiotis CA, Wahl DR, Hjelmeland AB, Hossain JA, Miletic H, Lathia JD
Nat Cancer 2023 May;4(5):648-664. Epub 2023 May 11 doi: 10.1038/s43018-023-00556-5. PMID: 37169842Free PMC Article
The Latest Findings of PD-1/PD-L1 Inhibitor Application in Gynecologic Cancers.
Kooshkaki O, Derakhshani A, Safarpour H, Najafi S, Vahedi P, Brunetti O, Torabi M, Lotfinejad P, Paradiso AV, Racanelli V, Silvestris N, Baradaran B
Int J Mol Sci 2020 Jul 16;21(14) doi: 10.3390/ijms21145034. PMID: 32708748Free PMC Article
The T Cell in Myeloma.
Joshua D, Suen H, Brown R, Bryant C, Ho PJ, Hart D, Gibson J
Clin Lymphoma Myeloma Leuk 2016 Oct;16(10):537-542. Epub 2016 Aug 10 doi: 10.1016/j.clml.2016.08.003. PMID: 27601001
Antibody-based immunotherapy of solid cancers: progress and possibilities.
Nicodemus CF
Immunotherapy 2015;7(8):923-39. Epub 2015 Aug 28 doi: 10.2217/imt.15.57. PMID: 26314410Free PMC Article
PD-1/PD-L1 inhibitors.
Sunshine J, Taube JM
Curr Opin Pharmacol 2015 Aug;23:32-8. Epub 2015 Jun 2 doi: 10.1016/j.coph.2015.05.011. PMID: 26047524Free PMC Article

Prognosis

Inflammatory burden as a prognostic biomarker for cancer.
Xie H, Ruan G, Ge Y, Zhang Q, Zhang H, Lin S, Song M, Zhang X, Liu X, Li X, Zhang K, Yang M, Tang M, Song CH, Shi H
Clin Nutr 2022 Jun;41(6):1236-1243. Epub 2022 Apr 22 doi: 10.1016/j.clnu.2022.04.019. PMID: 35504166
Desmoplastic Reaction, Immune Cell Response, and Prognosis in Colorectal Cancer.
Akimoto N, Väyrynen JP, Zhao M, Ugai T, Fujiyoshi K, Borowsky J, Zhong R, Haruki K, Arima K, Lau MC, Kishikawa J, Twombly TS, Takashima Y, Song M, Zhang X, Wu K, Chan AT, Meyerhardt JA, Giannakis M, Nowak JA, Ogino S
Front Immunol 2022;13:840198. Epub 2022 Mar 22 doi: 10.3389/fimmu.2022.840198. PMID: 35392092Free PMC Article
Cancer models in preclinical research: A chronicle review of advancement in effective cancer research.
Sajjad H, Imtiaz S, Noor T, Siddiqui YH, Sajjad A, Zia M
Animal Model Exp Med 2021 Jun;4(2):87-103. Epub 2021 Mar 29 doi: 10.1002/ame2.12165. PMID: 34179717Free PMC Article
PD-1/PD-L1 inhibitors.
Sunshine J, Taube JM
Curr Opin Pharmacol 2015 Aug;23:32-8. Epub 2015 Jun 2 doi: 10.1016/j.coph.2015.05.011. PMID: 26047524Free PMC Article
Regulatory T cells and multiple myeloma.
Joshua DE, Brown RD, Ho PJ, Gibson J
Clin Lymphoma Myeloma 2008 Oct;8(5):283-6. doi: 10.3816/CLM.2008.n.039. PMID: 18854282

Clinical prediction guides

Inflammatory burden as a prognostic biomarker for cancer.
Xie H, Ruan G, Ge Y, Zhang Q, Zhang H, Lin S, Song M, Zhang X, Liu X, Li X, Zhang K, Yang M, Tang M, Song CH, Shi H
Clin Nutr 2022 Jun;41(6):1236-1243. Epub 2022 Apr 22 doi: 10.1016/j.clnu.2022.04.019. PMID: 35504166
Desmoplastic Reaction, Immune Cell Response, and Prognosis in Colorectal Cancer.
Akimoto N, Väyrynen JP, Zhao M, Ugai T, Fujiyoshi K, Borowsky J, Zhong R, Haruki K, Arima K, Lau MC, Kishikawa J, Twombly TS, Takashima Y, Song M, Zhang X, Wu K, Chan AT, Meyerhardt JA, Giannakis M, Nowak JA, Ogino S
Front Immunol 2022;13:840198. Epub 2022 Mar 22 doi: 10.3389/fimmu.2022.840198. PMID: 35392092Free PMC Article
Cancer models in preclinical research: A chronicle review of advancement in effective cancer research.
Sajjad H, Imtiaz S, Noor T, Siddiqui YH, Sajjad A, Zia M
Animal Model Exp Med 2021 Jun;4(2):87-103. Epub 2021 Mar 29 doi: 10.1002/ame2.12165. PMID: 34179717Free PMC Article
PD-1/PD-L1 inhibitors.
Sunshine J, Taube JM
Curr Opin Pharmacol 2015 Aug;23:32-8. Epub 2015 Jun 2 doi: 10.1016/j.coph.2015.05.011. PMID: 26047524Free PMC Article
Regulatory T cells and multiple myeloma.
Joshua DE, Brown RD, Ho PJ, Gibson J
Clin Lymphoma Myeloma 2008 Oct;8(5):283-6. doi: 10.3816/CLM.2008.n.039. PMID: 18854282

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