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Malignant phyllodes tumor

MedGen UID:
109372
•Concept ID:
C0600066
•
Neoplastic Process
Synonyms: Cystosarcoma Phyllodes, Malignant; Malignant Cystosarcoma Phyllodes
SNOMED CT: Phyllodes tumor, malignant (87913009); Cystosarcoma phyllodes, malignant (87913009); Malignant phyllodes tumor (87913009); Malignant cystosarcoma phyllodes (87913009)
 
Monarch Initiative: MONDO:0037003

Definition

A phyllodes tumor with sarcomatous stroma. The sarcomatous component is usually of the fibrosarcomatous type. Liposarcomatous, chondrosarcomatous, osteosarcomatous, or rhabdomyosarcomatous differentiation may also occur in the stroma. It may recur and metastasize following surgical resection. The lung and skeleton are the anatomic sites most frequently involved by metastases. [from NCI]

Professional guidelines

PubMed

Metastatic and Malignant Phyllodes Tumors of the Breast: An Update for Current Management.
Goodwin B, Oyinlola AF, Palhang M, Lehman D, Platoff R, Atabek U, Spitz F, Hong Y
Am Surg 2023 Dec;89(12):6190-6196. Epub 2023 Aug 23 doi: 10.1177/00031348231198114. PMID: 37611540
Re-Classification with Outcome Correlation of Previously Diagnosed Malignant Phyllodes Tumors Applying the 2016 Consensus Guidelines.
Duckworth LA, Hoda R, Komforti MK, Rowe JJ, Downs-Kelly E, McIntire PJ
Int J Surg Pathol 2023 Aug;31(5):557-563. Epub 2022 Jul 3 doi: 10.1177/10668969221106105. PMID: 35786083
Malignant phyllodes tumor of the breast: treatment and prognosis.
Mituś J, Reinfuss M, Mituś JW, Jakubowicz J, Blecharz P, Wysocki WM, Skotnicki P
Breast J 2014 Nov-Dec;20(6):639-44. Epub 2014 Sep 17 doi: 10.1111/tbj.12333. PMID: 25227987

Recent clinical studies

Etiology

Metastatic and Malignant Phyllodes Tumors of the Breast: An Update for Current Management.
Goodwin B, Oyinlola AF, Palhang M, Lehman D, Platoff R, Atabek U, Spitz F, Hong Y
Am Surg 2023 Dec;89(12):6190-6196. Epub 2023 Aug 23 doi: 10.1177/00031348231198114. PMID: 37611540
Organoid models derived from patients with malignant phyllodes tumor of the breast.
Chu X, Wu M, Yang J, Fu Y, Wang X, Wang H, Xiao Y, Chen D, He J
Breast Cancer Res Treat 2023 Jul;200(2):193-201. Epub 2023 May 19 doi: 10.1007/s10549-023-06973-5. PMID: 37204665
Malignant phyllodes tumor of the breast: a systematic review.
Lissidini G, Mulè A, Santoro A, Papa G, Nicosia L, Cassano E, Ashoor AA, Veronesi P, Pantanowitz L, Hornick JL, Rossi ED
Pathologica 2022 Apr;114(2):111-120. Epub 2022 Apr 13 doi: 10.32074/1591-951X-754. PMID: 35414723Free PMC Article
Malignant Phyllodes of Breast.
Yom CK
Adv Exp Med Biol 2021;1187:601-612. doi: 10.1007/978-981-32-9620-6_32. PMID: 33983602
Malignant phyllodes tumor of the breast: treatment and prognosis.
Mituś J, Reinfuss M, Mituś JW, Jakubowicz J, Blecharz P, Wysocki WM, Skotnicki P
Breast J 2014 Nov-Dec;20(6):639-44. Epub 2014 Sep 17 doi: 10.1111/tbj.12333. PMID: 25227987

Diagnosis

Metastatic and Malignant Phyllodes Tumors of the Breast: An Update for Current Management.
Goodwin B, Oyinlola AF, Palhang M, Lehman D, Platoff R, Atabek U, Spitz F, Hong Y
Am Surg 2023 Dec;89(12):6190-6196. Epub 2023 Aug 23 doi: 10.1177/00031348231198114. PMID: 37611540
Malignant phyllodes tumor of the breast: a systematic review.
Lissidini G, Mulè A, Santoro A, Papa G, Nicosia L, Cassano E, Ashoor AA, Veronesi P, Pantanowitz L, Hornick JL, Rossi ED
Pathologica 2022 Apr;114(2):111-120. Epub 2022 Apr 13 doi: 10.32074/1591-951X-754. PMID: 35414723Free PMC Article
Expression of TRPS1 in phyllodes tumor and sarcoma of the breast.
Wang J, Wang WL, Sun H, Huo L, Wu Y, Chen H, Gan Q, Meis JM, Maloney N, Lazar AJ, Yoon EC, Albarracin CT, Krishnamurthy S, Middleton LP, Resetkova E, Yu W, Tan D, Lu W, Solis Soto LM, Wang S, Wistuba II, Parwani AV, Prieto VG, Sahin AA, Li Z, Ding Q
Hum Pathol 2022 Mar;121:73-80. Epub 2022 Jan 19 doi: 10.1016/j.humpath.2022.01.002. PMID: 35063444
Malignant Phyllodes of Breast.
Yom CK
Adv Exp Med Biol 2021;1187:601-612. doi: 10.1007/978-981-32-9620-6_32. PMID: 33983602
Primary Breast Atypical Lipomatous Tumor/ Well-Differentiated Liposarcoma and Dedifferentiated Liposarcoma.
Briski LM, Jorns JM
Arch Pathol Lab Med 2018 Feb;142(2):268-274. doi: 10.5858/arpa.2016-0380-RSR2. PMID: 29372852

Therapy

Organoid models derived from patients with malignant phyllodes tumor of the breast.
Chu X, Wu M, Yang J, Fu Y, Wang X, Wang H, Xiao Y, Chen D, He J
Breast Cancer Res Treat 2023 Jul;200(2):193-201. Epub 2023 May 19 doi: 10.1007/s10549-023-06973-5. PMID: 37204665
Radiotherapy with apatinib for recurrence of malignant phyllodes tumor of the breast: A case report.
Wu H, Li L, Yang J, Guo C, Zhang W, Wang H
Medicine (Baltimore) 2020 Jan;99(3):e18808. doi: 10.1097/MD.0000000000018808. PMID: 32011486Free PMC Article
Breast Phyllodes Tumors Recruit and Repolarize Tumor-Associated Macrophages via Secreting CCL5 to Promote Malignant Progression, Which Can Be Inhibited by CCR5 Inhibition Therapy.
Nie Y, Huang H, Guo M, Chen J, Wu W, Li W, Xu X, Lin X, Fu W, Yao Y, Zheng F, Luo ML, Saw PE, Yao H, Song E, Hu H
Clin Cancer Res 2019 Jul 1;25(13):3873-3886. Epub 2019 Mar 19 doi: 10.1158/1078-0432.CCR-18-3421. PMID: 30890553
Risk Factors for Recurrence of Malignant Phyllodes Tumors of the Breast.
Park HJ, Ryu HS, Kim K, Shin KH, Han W, Noh DY
In Vivo 2019 Jan-Feb;33(1):263-269. doi: 10.21873/invivo.11470. PMID: 30587634Free PMC Article
Unusual aggressive breast cancer: metastatic malignant phyllodes tumor.
Singer A, Tresley J, Velazquez-Vega J, Yepes M
J Radiol Case Rep 2013 Feb;7(2):24-37. Epub 2013 Feb 1 doi: 10.3941/jrcr.v7i2.1430. PMID: 23705037Free PMC Article

Prognosis

Organoid models derived from patients with malignant phyllodes tumor of the breast.
Chu X, Wu M, Yang J, Fu Y, Wang X, Wang H, Xiao Y, Chen D, He J
Breast Cancer Res Treat 2023 Jul;200(2):193-201. Epub 2023 May 19 doi: 10.1007/s10549-023-06973-5. PMID: 37204665
Rethinking on the management strategy of malignant phyllodes tumor of the breast: An analysis based on the SEER database.
Chen C, Huang X, Xu Y, Sun Q
Medicine (Baltimore) 2023 Mar 24;102(12):e33326. doi: 10.1097/MD.0000000000033326. PMID: 36961178Free PMC Article
Malignant Phyllodes of Breast.
Yom CK
Adv Exp Med Biol 2021;1187:601-612. doi: 10.1007/978-981-32-9620-6_32. PMID: 33983602
Malignant phyllodes tumor of the breast: treatment and prognosis.
Mituś J, Reinfuss M, Mituś JW, Jakubowicz J, Blecharz P, Wysocki WM, Skotnicki P
Breast J 2014 Nov-Dec;20(6):639-44. Epub 2014 Sep 17 doi: 10.1111/tbj.12333. PMID: 25227987
Malignant phyllodes tumor.
Pandey M, Mathew A, Kattoor J, Abraham EK, Mathew BS, Rajan B, Nair KM
Breast J 2001 Nov-Dec;7(6):411-6. doi: 10.1046/j.1524-4741.2001.07606.x. PMID: 11843853

Clinical prediction guides

Organoid models derived from patients with malignant phyllodes tumor of the breast.
Chu X, Wu M, Yang J, Fu Y, Wang X, Wang H, Xiao Y, Chen D, He J
Breast Cancer Res Treat 2023 Jul;200(2):193-201. Epub 2023 May 19 doi: 10.1007/s10549-023-06973-5. PMID: 37204665
Rethinking on the management strategy of malignant phyllodes tumor of the breast: An analysis based on the SEER database.
Chen C, Huang X, Xu Y, Sun Q
Medicine (Baltimore) 2023 Mar 24;102(12):e33326. doi: 10.1097/MD.0000000000033326. PMID: 36961178Free PMC Article
Genomic characteristics of two breast malignant phyllodes tumors during pregnancy and lactation identified through whole-exome sequencing.
Lei T, Shen M, Deng X, Shi Y, Peng Y, Wang H, Chen T
Orphanet J Rare Dis 2022 Oct 21;17(1):382. doi: 10.1186/s13023-022-02537-w. PMID: 36271373Free PMC Article
Malignant Phyllodes of Breast.
Yom CK
Adv Exp Med Biol 2021;1187:601-612. doi: 10.1007/978-981-32-9620-6_32. PMID: 33983602
Malignant phyllodes tumors of the breast: a study in clinical practice.
Majeski J, Stroud J
Int Surg 2012 Apr-Jun;97(2):95-8. doi: 10.9738/CC79.1. PMID: 23102073Free PMC Article

Recent systematic reviews

Metastatic and Malignant Phyllodes Tumors of the Breast: An Update for Current Management.
Goodwin B, Oyinlola AF, Palhang M, Lehman D, Platoff R, Atabek U, Spitz F, Hong Y
Am Surg 2023 Dec;89(12):6190-6196. Epub 2023 Aug 23 doi: 10.1177/00031348231198114. PMID: 37611540
Malignant phyllodes tumor of the breast: a systematic review.
Lissidini G, Mulè A, Santoro A, Papa G, Nicosia L, Cassano E, Ashoor AA, Veronesi P, Pantanowitz L, Hornick JL, Rossi ED
Pathologica 2022 Apr;114(2):111-120. Epub 2022 Apr 13 doi: 10.32074/1591-951X-754. PMID: 35414723Free PMC Article

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