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Chlamydial conjunctivitis

MedGen UID:
1095
•Concept ID:
C0009770
•
Disease or Syndrome
Synonyms: Blennorrhea, Inclusion; Blennorrheas, Inclusion; Conjunctivitides, Inclusion; Conjunctivitis, Inclusion; Inclusion Blennorrhea; Inclusion Blennorrheas; Inclusion Conjunctivitides; Inclusion Conjunctivitis
SNOMED CT: Chlamydial conjunctivitis (231861005); Inclusion blennorrhea (56009001); Inclusion conjunctivitis due to Chlamydia trachomatis (56009001); Chronic conjunctivitis due to Chlamydia trachomatis (56009001)

Definition

An infection of the eyes characterized by the presence in conjunctival epithelial cells of inclusion bodies indistinguishable from those of trachoma. It is acquired by infants during birth and by adults from swimming pools. The etiological agent is CHLAMYDIA TRACHOMATIS whose natural habitat appears to be the genito-urinary tract. Inclusion conjunctivitis is a less severe disease than trachoma and usually clears up spontaneously. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChlamydial conjunctivitis

Professional guidelines

PubMed

Treatment of Neonatal Chlamydial Conjunctivitis: A Systematic Review and Meta-analysis.
Zikic A, Schünemann H, Wi T, Lincetto O, Broutet N, Santesso N
J Pediatric Infect Dis Soc 2018 Aug 17;7(3):e107-e115. doi: 10.1093/jpids/piy060. PMID: 30007329Free PMC Article
Treatment of chlamydial conjunctivitis.
Nakagawa H
Ophthalmologica 1997;211 Suppl 1:25-8. doi: 10.1159/000310882. PMID: 9065934
Chlamydial cervicitis: complications and new treatment options.
Majeroni BA
Am Fam Physician 1994 Jun;49(8):1825-9, 1832. PMID: 8203320

Recent clinical studies

Etiology

Treatment of Neonatal Chlamydial Conjunctivitis: A Systematic Review and Meta-analysis.
Zikic A, Schünemann H, Wi T, Lincetto O, Broutet N, Santesso N
J Pediatric Infect Dis Soc 2018 Aug 17;7(3):e107-e115. doi: 10.1093/jpids/piy060. PMID: 30007329Free PMC Article
Interventions for treating genital Chlamydia trachomatis infection in pregnancy.
Cluver C, Novikova N, Eriksson DO, Bengtsson K, Lingman GK
Cochrane Database Syst Rev 2017 Sep 22;9(9):CD010485. doi: 10.1002/14651858.CD010485.pub2. PMID: 28937705Free PMC Article
Neonatal Bacterial Conjunctivitis in Korea in the 21st Century.
Pak KY, Kim SI, Lee JS
Cornea 2017 Apr;36(4):415-418. doi: 10.1097/ICO.0000000000001122. PMID: 28002109
Chlamydial conjunctivitis: prevalence and serovar distribution of Chlamydia trachomatis in adults.
Petrovay F, Németh I, Balázs A, Balla E
J Med Microbiol 2015 Sep;64(9):967-970. Epub 2015 Jun 30 doi: 10.1099/jmm.0.000115. PMID: 26297635
Chlamydial infections in infancy.
Gilbert GL
Aust Paediatr J 1986 Feb;22(1):13-7. doi: 10.1111/j.1440-1754.1986.tb00176.x. PMID: 3521572

Diagnosis

Neonatal Bacterial Conjunctivitis in Korea in the 21st Century.
Pak KY, Kim SI, Lee JS
Cornea 2017 Apr;36(4):415-418. doi: 10.1097/ICO.0000000000001122. PMID: 28002109
Bacterial conjunctivitis: a review for internists.
Tarabishy AB, Jeng BH
Cleve Clin J Med 2008 Jul;75(7):507-12. doi: 10.3949/ccjm.75.7.507. PMID: 18646586
Conjunctivitis of the newborn.
de Toledo AR, Chandler JW
Infect Dis Clin North Am 1992 Dec;6(4):807-13. PMID: 1460264
Neonatal chlamydial conjunctivitis.
Persson K, Rönnerstam R, Svanberg L, Polberger S
Arch Dis Child 1986 Jun;61(6):565-8. doi: 10.1136/adc.61.6.565. PMID: 3729525Free PMC Article
Chlamydial infections in infancy.
Gilbert GL
Aust Paediatr J 1986 Feb;22(1):13-7. doi: 10.1111/j.1440-1754.1986.tb00176.x. PMID: 3521572

Therapy

Treatment of Neonatal Chlamydial Conjunctivitis: A Systematic Review and Meta-analysis.
Zikic A, Schünemann H, Wi T, Lincetto O, Broutet N, Santesso N
J Pediatric Infect Dis Soc 2018 Aug 17;7(3):e107-e115. doi: 10.1093/jpids/piy060. PMID: 30007329Free PMC Article
Neonatal Bacterial Conjunctivitis in Korea in the 21st Century.
Pak KY, Kim SI, Lee JS
Cornea 2017 Apr;36(4):415-418. doi: 10.1097/ICO.0000000000001122. PMID: 28002109
Treatment of chlamydial conjunctivitis.
Nakagawa H
Ophthalmologica 1997;211 Suppl 1:25-8. doi: 10.1159/000310882. PMID: 9065934
Conjunctivitis of the newborn.
de Toledo AR, Chandler JW
Infect Dis Clin North Am 1992 Dec;6(4):807-13. PMID: 1460264
Chlamydial infections in infancy.
Gilbert GL
Aust Paediatr J 1986 Feb;22(1):13-7. doi: 10.1111/j.1440-1754.1986.tb00176.x. PMID: 3521572

Prognosis

Neonatal prophylaxis with antibiotic containing ointments does not reduce incidence of chlamydial conjunctivitis in newborns.
Smith-Norowitz TA, Ukaegbu C, Kohlhoff S, Hammerschlag MR
BMC Infect Dis 2021 Mar 17;21(1):270. doi: 10.1186/s12879-021-05974-3. PMID: 33731049Free PMC Article
Treatment of Neonatal Chlamydial Conjunctivitis: A Systematic Review and Meta-analysis.
Zikic A, Schünemann H, Wi T, Lincetto O, Broutet N, Santesso N
J Pediatric Infect Dis Soc 2018 Aug 17;7(3):e107-e115. doi: 10.1093/jpids/piy060. PMID: 30007329Free PMC Article
Recent trends in chlamydial and gonococcal conjunctivitis among neonates and adults in an Irish hospital.
Quirke M, Cullinane A
Int J Infect Dis 2008 Jul;12(4):371-3. Epub 2008 Feb 21 doi: 10.1016/j.ijid.2007.09.013. PMID: 18093859
Chlamydial conjunctivitis in neonates and adults. History, clinical findings and follow-up.
Stenberg K, Mårdh PA
Acta Ophthalmol (Copenh) 1990 Dec;68(6):651-7. doi: 10.1111/j.1755-3768.1990.tb01688.x. PMID: 2080692
Chlamydial infections in infancy.
Gilbert GL
Aust Paediatr J 1986 Feb;22(1):13-7. doi: 10.1111/j.1440-1754.1986.tb00176.x. PMID: 3521572

Clinical prediction guides

Physical distancing and non-respiratory notifiable diseases in the Northern Territory, March-May 2020.
Xie O, Markey PG, Draper ADK, Krause VL
Commun Dis Intell (2018) 2020 Oct 25;44 doi: 10.33321/cdi.2020.44.90. PMID: 33278872
Interventions for treating genital Chlamydia trachomatis infection in pregnancy.
Cluver C, Novikova N, Eriksson DO, Bengtsson K, Lingman GK
Cochrane Database Syst Rev 2017 Sep 22;9(9):CD010485. doi: 10.1002/14651858.CD010485.pub2. PMID: 28937705Free PMC Article
Neonatal Bacterial Conjunctivitis in Korea in the 21st Century.
Pak KY, Kim SI, Lee JS
Cornea 2017 Apr;36(4):415-418. doi: 10.1097/ICO.0000000000001122. PMID: 28002109
Treatment of neonatal conjunctivitis.
Sandström I
Arch Ophthalmol 1987 Jul;105(7):925-8. doi: 10.1001/archopht.1987.01060070061029. PMID: 3496872
Epidemiology of neonatal conjunctivitis.
Rapoza PA, Quinn TC, Kiessling LA, Taylor HR
Ophthalmology 1986 Apr;93(4):456-61. doi: 10.1016/s0161-6420(86)33716-3. PMID: 3703518

Recent systematic reviews

Neonatal prophylaxis with antibiotic containing ointments does not reduce incidence of chlamydial conjunctivitis in newborns.
Smith-Norowitz TA, Ukaegbu C, Kohlhoff S, Hammerschlag MR
BMC Infect Dis 2021 Mar 17;21(1):270. doi: 10.1186/s12879-021-05974-3. PMID: 33731049Free PMC Article
Treatment of Neonatal Chlamydial Conjunctivitis: A Systematic Review and Meta-analysis.
Zikic A, Schünemann H, Wi T, Lincetto O, Broutet N, Santesso N
J Pediatric Infect Dis Soc 2018 Aug 17;7(3):e107-e115. doi: 10.1093/jpids/piy060. PMID: 30007329Free PMC Article
Interventions for treating genital Chlamydia trachomatis infection in pregnancy.
Cluver C, Novikova N, Eriksson DO, Bengtsson K, Lingman GK
Cochrane Database Syst Rev 2017 Sep 22;9(9):CD010485. doi: 10.1002/14651858.CD010485.pub2. PMID: 28937705Free PMC Article

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