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Reactive arthritis triad

MedGen UID:
11170
•Concept ID:
C0035012
•
Disease or Syndrome
Synonyms: Reiter Disease; Reiter Syndrome; Reiter's Disease; Reiter's Syndrome; Reiters Disease; Reiters Syndrome
SNOMED CT: Reiter's disease (67224007); Urethrooculoarticular syndrome (67224007); Reiter's syndrome (67224007); Reiter disease (67224007); Reactive arthritis triad (67224007)

Definition

A rare, reactive inflammatory disorder seen following bacterial infection. It predominantly affects males aged 20-40. Individuals with HLA-B27 antigen are estimated to have a 50 % increased risk. The disorder is characterized by arthritis, conjunctivitis, uveitis, iritis and ulceration of the oral cavity, genitals and volar surfaces of the hands and feet. The clinical course is self-limited with resolution of clinical disease usually within six months of onset. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReactive arthritis triad

Professional guidelines

PubMed

ASAS-EULAR recommendations for the management of axial spondyloarthritis: 2022 update.
Ramiro S, Nikiphorou E, Sepriano A, Ortolan A, Webers C, Baraliakos X, Landewé RBM, Van den Bosch FE, Boteva B, Bremander A, Carron P, Ciurea A, van Gaalen FA, Géher P, Gensler L, Hermann J, de Hooge M, Husakova M, Kiltz U, López-Medina C, Machado PM, Marzo-Ortega H, Molto A, Navarro-Compán V, Nissen MJ, Pimentel-Santos FM, Poddubnyy D, Proft F, Rudwaleit M, Telkman M, Zhao SS, Ziade N, van der Heijde D
Ann Rheum Dis 2023 Jan;82(1):19-34. Epub 2022 Oct 21 doi: 10.1136/ard-2022-223296. PMID: 36270658
2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, Faiella-Tommasino J, Forman DE, Goldberg R, Heidenreich PA, Hlatky MA, Jones DW, Lloyd-Jones D, Lopez-Pajares N, Ndumele CE, Orringer CE, Peralta CA, Saseen JJ, Smith SC Jr, Sperling L, Virani SS, Yeboah J
Circulation 2019 Jun 18;139(25):e1082-e1143. Epub 2018 Nov 10 doi: 10.1161/CIR.0000000000000625. PMID: 30586774Free PMC Article
Diagnosis and management of rheumatoid arthritis.
Wasserman AM
Am Fam Physician 2011 Dec 1;84(11):1245-52. PMID: 22150658

Recent clinical studies

Etiology

Reactive arthritis: a clinical review.
Jubber A, Moorthy A
J R Coll Physicians Edinb 2021 Sep;51(3):288-297. doi: 10.4997/JRCPE.2021.319. PMID: 34528623
Reactive Arthritis Update: Spotlight on New and Rare Infectious Agents Implicated as Pathogens.
Zeidler H, Hudson AP
Curr Rheumatol Rep 2021 Jul 1;23(7):53. doi: 10.1007/s11926-021-01018-6. PMID: 34196842Free PMC Article
Understanding the Pathogenesis of Spondyloarthritis.
Sharip A, Kunz J
Biomolecules 2020 Oct 20;10(10) doi: 10.3390/biom10101461. PMID: 33092023Free PMC Article
Post-Streptococcal Reactive Arthritis.
Bawazir Y, Towheed T, Anastassiades T
Curr Rheumatol Rev 2020;16(1):2-8. doi: 10.2174/1573397115666190808110337. PMID: 31393253
The Seronegative Spondyloarthropathies.
Duba AS, Mathew SD
Prim Care 2018 Jun;45(2):271-287. doi: 10.1016/j.pop.2018.02.005. PMID: 29759124

Diagnosis

Post-Streptococcal Reactive Arthritis.
Bawazir Y, Towheed T, Anastassiades T
Curr Rheumatol Rev 2020;16(1):2-8. doi: 10.2174/1573397115666190808110337. PMID: 31393253
The Seronegative Spondyloarthropathies.
Duba AS, Mathew SD
Prim Care 2018 Jun;45(2):271-287. doi: 10.1016/j.pop.2018.02.005. PMID: 29759124
Reactive arthritis: update 2018.
García-Kutzbach A, Chacón-Súchite J, García-Ferrer H, Iraheta I
Clin Rheumatol 2018 Apr;37(4):869-874. Epub 2018 Feb 17 doi: 10.1007/s10067-018-4022-5. PMID: 29455267
Reactive Arthritis.
Schmitt SK
Infect Dis Clin North Am 2017 Jun;31(2):265-277. Epub 2017 Mar 11 doi: 10.1016/j.idc.2017.01.002. PMID: 28292540
Diagnosis and classification of reactive arthritis.
Selmi C, Gershwin ME
Autoimmun Rev 2014 Apr-May;13(4-5):546-9. Epub 2014 Jan 10 doi: 10.1016/j.autrev.2014.01.005. PMID: 24418301

Therapy

Infectious mimics of rheumatoid arthritis.
Sharma V, Sharma A
Best Pract Res Clin Rheumatol 2022 Mar;36(1):101736. Epub 2021 Dec 31 doi: 10.1016/j.berh.2021.101736. PMID: 34974970
Reactive arthritis after COVID-19 vaccination.
An QJ, Qin DA, Pei JX
Hum Vaccin Immunother 2021 Sep 2;17(9):2954-2956. Epub 2021 May 25 doi: 10.1080/21645515.2021.1920274. PMID: 34033732Free PMC Article
Reactive Arthritis: Treatment Challenges and Future Perspectives.
Wendling D, Prati C, Chouk M, Verhoeven F
Curr Rheumatol Rep 2020 May 26;22(7):29. doi: 10.1007/s11926-020-00904-9. PMID: 32458153
Post-Streptococcal Reactive Arthritis.
Bawazir Y, Towheed T, Anastassiades T
Curr Rheumatol Rev 2020;16(1):2-8. doi: 10.2174/1573397115666190808110337. PMID: 31393253
Reactive Arthritis.
Schmitt SK
Infect Dis Clin North Am 2017 Jun;31(2):265-277. Epub 2017 Mar 11 doi: 10.1016/j.idc.2017.01.002. PMID: 28292540

Prognosis

Reactive arthritis before and after the onset of the COVID-19 pandemic.
Bekaryssova D, Yessirkepov M, Zimba O, Gasparyan AY, Ahmed S
Clin Rheumatol 2022 Jun;41(6):1641-1652. Epub 2022 Mar 5 doi: 10.1007/s10067-022-06120-3. PMID: 35247132Free PMC Article
Reactive arthritis: a clinical review.
Jubber A, Moorthy A
J R Coll Physicians Edinb 2021 Sep;51(3):288-297. doi: 10.4997/JRCPE.2021.319. PMID: 34528623
Reactive arthritis after COVID-19 infection.
Ono K, Kishimoto M, Shimasaki T, Uchida H, Kurai D, Deshpande GA, Komagata Y, Kaname S
RMD Open 2020 Aug;6(2) doi: 10.1136/rmdopen-2020-001350. PMID: 32763956Free PMC Article
Reactive Arthritis.
Schmitt SK
Infect Dis Clin North Am 2017 Jun;31(2):265-277. Epub 2017 Mar 11 doi: 10.1016/j.idc.2017.01.002. PMID: 28292540
Reactive arthritis.
Hannu T
Best Pract Res Clin Rheumatol 2011 Jun;25(3):347-57. doi: 10.1016/j.berh.2011.01.018. PMID: 22100285

Clinical prediction guides

Reactive arthritis before and after the onset of the COVID-19 pandemic.
Bekaryssova D, Yessirkepov M, Zimba O, Gasparyan AY, Ahmed S
Clin Rheumatol 2022 Jun;41(6):1641-1652. Epub 2022 Mar 5 doi: 10.1007/s10067-022-06120-3. PMID: 35247132Free PMC Article
EULAR points to consider for the diagnosis and management of rheumatic immune-related adverse events due to cancer immunotherapy with checkpoint inhibitors.
Kostine M, Finckh A, Bingham CO, Visser K, Leipe J, Schulze-Koops H, Choy EH, Benesova K, Radstake TRDJ, Cope AP, Lambotte O, Gottenberg JE, Allenbach Y, Visser M, Rusthoven C, Thomasen L, Jamal S, Marabelle A, Larkin J, Haanen JBAG, Calabrese LH, Mariette X, Schaeverbeke T
Ann Rheum Dis 2021 Jan;80(1):36-48. Epub 2020 Apr 23 doi: 10.1136/annrheumdis-2020-217139. PMID: 32327425Free PMC Article
Diagnosis and classification of reactive arthritis.
Selmi C, Gershwin ME
Autoimmun Rev 2014 Apr-May;13(4-5):546-9. Epub 2014 Jan 10 doi: 10.1016/j.autrev.2014.01.005. PMID: 24418301
Reactive arthritis.
Schumacher HR Jr
Rheum Dis Clin North Am 1998 May;24(2):261-73. doi: 10.1016/s0889-857x(05)70008-9. PMID: 9606758
Reactive arthritis.
Toivanen A, Toivanen P
Curr Opin Rheumatol 1997 Jul;9(4):321-7. doi: 10.1097/00002281-199707000-00009. PMID: 9229179

Recent systematic reviews

Effect of Anti-Inflammatory Diets on Pain in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis.
Schönenberger KA, Schüpfer AC, Gloy VL, Hasler P, Stanga Z, Kaegi-Braun N, Reber E
Nutrients 2021 Nov 24;13(12) doi: 10.3390/nu13124221. PMID: 34959772Free PMC Article
Rheumatoid meningitis: A systematic review and meta-analysis.
Villa E, Sarquis T, de Grazia J, Núñez R, Alarcón P, Villegas R, Guevara C
Eur J Neurol 2021 Sep;28(9):3201-3210. Epub 2021 Jun 29 doi: 10.1111/ene.14904. PMID: 33966315
Prediction models for diagnosis and prognosis of covid-19: systematic review and critical appraisal.
Wynants L, Van Calster B, Collins GS, Riley RD, Heinze G, Schuit E, Bonten MMJ, Dahly DL, Damen JAA, Debray TPA, de Jong VMT, De Vos M, Dhiman P, Haller MC, Harhay MO, Henckaerts L, Heus P, Kammer M, Kreuzberger N, Lohmann A, Luijken K, Ma J, Martin GP, McLernon DJ, Andaur Navarro CL, Reitsma JB, Sergeant JC, Shi C, Skoetz N, Smits LJM, Snell KIE, Sperrin M, Spijker R, Steyerberg EW, Takada T, Tzoulaki I, van Kuijk SMJ, van Bussel B, van der Horst ICC, van Royen FS, Verbakel JY, Wallisch C, Wilkinson J, Wolff R, Hooft L, Moons KGM, van Smeden M
BMJ 2020 Apr 7;369:m1328. doi: 10.1136/bmj.m1328. PMID: 32265220Free PMC Article
2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, Faiella-Tommasino J, Forman DE, Goldberg R, Heidenreich PA, Hlatky MA, Jones DW, Lloyd-Jones D, Lopez-Pajares N, Ndumele CE, Orringer CE, Peralta CA, Saseen JJ, Smith SC Jr, Sperling L, Virani SS, Yeboah J
Circulation 2019 Jun 18;139(25):e1082-e1143. Epub 2018 Nov 10 doi: 10.1161/CIR.0000000000000625. PMID: 30586774Free PMC Article
Evidence-based diagnostics: adult septic arthritis.
Carpenter CR, Schuur JD, Everett WW, Pines JM
Acad Emerg Med 2011 Aug;18(8):781-96. doi: 10.1111/j.1553-2712.2011.01121.x. PMID: 21843213Free PMC Article

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