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Nissl degeneration

MedGen UID:: 11217
•Concept ID:: C0035354
•: Cell or Molecular Dysfunction

Synonyms:	Axon Reaction; Axon Reactions; Axonal Reaction; Axonal Reactions; Degeneration, Nissl; Degeneration, Retrograde; Degenerations, Retrograde; Nissl Degeneration; Reaction, Axon; Reaction, Axonal; Reactions, Axon; Reactions, Axonal; Retrograde Degeneration; Retrograde Degenerations
SNOMED CT:	Nissl degeneration (46551009)

Definition

Pathologic changes that occur in the axon and cell body of a neuron proximal to an axonal lesion. The process is characterized by central chromatolysis which features flattening and displacement of the nucleus, loss of Nissl bodies, and cellular edema. Central chromatolysis primarily occurs in lower motor neurons. [from MeSH]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVNissl degeneration

Congenital Systemic Disorder
- Abnormality of the nervous system
  - Abnormal nervous system morphology
    - Morphological central nervous system abnormality
      - Atrophy/Degeneration affecting the central nervous system
        Neurodegeneration
        Nissl degeneration

Professional guidelines

PubMed

Three "Red Lines" for Pattern Recognition-Based Differential Diagnosis Using Optical Coherence Tomography in Clinical Practice.

Petzold A
J Neuroophthalmol 2021 Sep 1;41(3):385-398. doi: 10.1097/WNO.0000000000001173. PMID: 34415273

Progressive damage after brain and spinal cord injury: pathomechanisms and treatment strategies.

Bramlett HM, Dietrich WD
Prog Brain Res 2007;161:125-41. doi: 10.1016/S0079-6123(06)61009-1. PMID: 17618974

Ampullary adenoma: clinical manifestations, diagnosis, and treatment.

Martin JA, Haber GB
Gastrointest Endosc Clin N Am 2003 Oct;13(4):649-69. doi: 10.1016/s1052-5157(03)00101-6. PMID: 14986792

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Recent clinical studies

Etiology

Changing Management of Type B Aortic Dissections.

Eidt JF, Vasquez J
Methodist Debakey Cardiovasc J 2023;19(2):59-69. Epub 2023 Mar 7 doi: 10.14797/mdcvj.1171. PMID: 36910545 Free PMC Article

Balance rehabilitation with a virtual reality protocol for patients with hereditary spastic paraplegia: Protocol for a clinical trial.

Zeigelboim BS, José MR, Santos GJBD, Severiano MIR, Teive HAG, Stechman-Neto J, Santos RS, de Araújo CM, Cavalcante-Leão BL
PLoS One 2021;16(4):e0249095. Epub 2021 Apr 1 doi: 10.1371/journal.pone.0249095. PMID: 33793609 Free PMC Article

Is Axonal Degeneration a Key Early Event in Parkinson's Disease?

Kurowska Z, Kordower JH, Stoessl AJ, Burke RE, Brundin P, Yue Z, Brady ST, Milbrandt J, Trapp BD, Sherer TB, Medicetty S
J Parkinsons Dis 2016 Oct 19;6(4):703-707. doi: 10.3233/JPD-160881. PMID: 27497486

Hereditary spastic paraplegia.

Fink JK
Neurol Clin 2002 Aug;20(3):711-26. doi: 10.1016/s0733-8619(02)00007-5. PMID: 12432827

Choledochocele-containing stones.

Tajiri H
Am J Gastroenterol 1996 May;91(5):1046-8. PMID: 8633554

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Diagnosis

Non-vasogenic cystoid maculopathies.

Gaudric A, Audo I, Vignal C, Couturier A, Boulanger-Scemama É, Tadayoni R, Cohen SY
Prog Retin Eye Res 2022 Nov;91:101092. Epub 2022 Aug 1 doi: 10.1016/j.preteyeres.2022.101092. PMID: 35927124

Imaging secondary neuronal degeneration.

Montoya-Filardi A, García-Junco Albacete M, Ortolá Fortes P, Carreres Polo J
Radiologia (Engl Ed) 2022 Mar-Apr;64(2):145-155. doi: 10.1016/j.rxeng.2022.01.001. PMID: 35504680

Chemical genetic activation of the cholinergic basal forebrain hippocampal circuit rescues memory loss in Alzheimer's disease.

Liu W, Li J, Yang M, Ke X, Dai Y, Lin H, Wang S, Chen L, Tao J
Alzheimers Res Ther 2022 Apr 13;14(1):53. doi: 10.1186/s13195-022-00994-w. PMID: 35418161 Free PMC Article

Alzheimer's Disease Seen through the Eye: Ocular Alterations and Neurodegeneration.

Romaus-Sanjurjo D, Regueiro U, López-López M, Vázquez-Vázquez L, Ouro A, Lema I, Sobrino T
Int J Mol Sci 2022 Feb 24;23(5) doi: 10.3390/ijms23052486. PMID: 35269629 Free PMC Article

Inherited neuropathies.

Kleopa KA, Scherer SS
Neurol Clin 2002 Aug;20(3):679-709. doi: 10.1016/s0733-8619(01)00016-0. PMID: 12432826

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Therapy

Changing Management of Type B Aortic Dissections.

Eidt JF, Vasquez J
Methodist Debakey Cardiovasc J 2023;19(2):59-69. Epub 2023 Mar 7 doi: 10.14797/mdcvj.1171. PMID: 36910545 Free PMC Article

Sarm1 activation produces cADPR to increase intra-axonal Ca++ and promote axon degeneration in PIPN.

Li Y, Pazyra-Murphy MF, Avizonis D, de Sá Tavares Russo M, Tang S, Chen CY, Hsueh YP, Bergholz JS, Jiang T, Zhao JJ, Zhu J, Ko KW, Milbrandt J, DiAntonio A, Segal RA
J Cell Biol 2022 Feb 7;221(2) Epub 2021 Dec 22 doi: 10.1083/jcb.202106080. PMID: 34935867 Free PMC Article

Balance rehabilitation with a virtual reality protocol for patients with hereditary spastic paraplegia: Protocol for a clinical trial.

Glaucoma and the brain: Trans-synaptic degeneration, structural change, and implications for neuroprotection.

Lawlor M, Danesh-Meyer H, Levin LA, Davagnanam I, De Vita E, Plant GT
Surv Ophthalmol 2018 May-Jun;63(3):296-306. Epub 2017 Oct 3 doi: 10.1016/j.survophthal.2017.09.010. PMID: 28986311

Neuroprotection for optic nerve disorders.

Bessero AC, Clarke PG
Curr Opin Neurol 2010 Feb;23(1):10-5. doi: 10.1097/WCO.0b013e3283344461. PMID: 19915465

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Prognosis

Alzheimer's Disease Seen through the Eye: Ocular Alterations and Neurodegeneration.

Romaus-Sanjurjo D, Regueiro U, López-López M, Vázquez-Vázquez L, Ouro A, Lema I, Sobrino T
Int J Mol Sci 2022 Feb 24;23(5) doi: 10.3390/ijms23052486. PMID: 35269629 Free PMC Article

Visual loss and recovery in chiasmal compression.

Danesh-Meyer HV, Yoon JJ, Lawlor M, Savino PJ
Prog Retin Eye Res 2019 Nov;73:100765. Epub 2019 Jun 14 doi: 10.1016/j.preteyeres.2019.06.001. PMID: 31202890

Trans-synaptic Retrograde Degeneration in the Human Visual System: Slow, Silent, and Real.

Dinkin M
Curr Neurol Neurosci Rep 2017 Feb;17(2):16. doi: 10.1007/s11910-017-0725-2. PMID: 28229400

Aetiology, classification and pathogenesis of pulp and periapical disease.

López-Marcos JF
Med Oral Patol Oral Cir Bucal 2004;9 Suppl:58-62; 52-7. PMID: 15580137

Hereditary spastic paraplegia.

Fink JK
Neurol Clin 2002 Aug;20(3):711-26. doi: 10.1016/s0733-8619(02)00007-5. PMID: 12432827

See all (109)

Clinical prediction guides

Clinical review of retinotopy.

Nij Bijvank J, Maillette de Buy Wenniger L, de Graaf P, Petzold A
Br J Ophthalmol 2023 Mar;107(3):304-312. Epub 2021 Dec 9 doi: 10.1136/bjophthalmol-2021-320563. PMID: 34887243

Chemical genetic activation of the cholinergic basal forebrain hippocampal circuit rescues memory loss in Alzheimer's disease.

Liu W, Li J, Yang M, Ke X, Dai Y, Lin H, Wang S, Chen L, Tao J
Alzheimers Res Ther 2022 Apr 13;14(1):53. doi: 10.1186/s13195-022-00994-w. PMID: 35418161 Free PMC Article

Alzheimer's Disease Seen through the Eye: Ocular Alterations and Neurodegeneration.

Romaus-Sanjurjo D, Regueiro U, López-López M, Vázquez-Vázquez L, Ouro A, Lema I, Sobrino T
Int J Mol Sci 2022 Feb 24;23(5) doi: 10.3390/ijms23052486. PMID: 35269629 Free PMC Article

Visual loss and recovery in chiasmal compression.

Danesh-Meyer HV, Yoon JJ, Lawlor M, Savino PJ
Prog Retin Eye Res 2019 Nov;73:100765. Epub 2019 Jun 14 doi: 10.1016/j.preteyeres.2019.06.001. PMID: 31202890

Hereditary spastic paraplegia.

Fink JK
Neurol Clin 2002 Aug;20(3):711-26. doi: 10.1016/s0733-8619(02)00007-5. PMID: 12432827

See all (194)

Recent systematic reviews

Effectiveness and harms of recombinant human bone morphogenetic protein-2 in spine fusion: a systematic review and meta-analysis.

Fu R, Selph S, McDonagh M, Peterson K, Tiwari A, Chou R, Helfand M
Ann Intern Med 2013 Jun 18;158(12):890-902. doi: 10.7326/0003-4819-158-12-201306180-00006. PMID: 23778906

Optical coherence tomography in multiple sclerosis: a systematic review and meta-analysis.

Petzold A, de Boer JF, Schippling S, Vermersch P, Kardon R, Green A, Calabresi PA, Polman C
Lancet Neurol 2010 Sep;9(9):921-32. doi: 10.1016/S1474-4422(10)70168-X. PMID: 20723847

See all (2)

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Nissl degeneration

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

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