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Nissl degeneration

MedGen UID:
11217
Concept ID:
C0035354
Cell or Molecular Dysfunction
Synonyms: Axon Reaction; Axon Reactions; Axonal Reaction; Axonal Reactions; Degeneration, Nissl; Degeneration, Retrograde; Degenerations, Retrograde; Nissl Degeneration; Reaction, Axon; Reaction, Axonal; Reactions, Axon; Reactions, Axonal; Retrograde Degeneration; Retrograde Degenerations
SNOMED CT: Nissl degeneration (46551009)

Definition

Pathologic changes that occur in the axon and cell body of a neuron proximal to an axonal lesion. The process is characterized by central chromatolysis which features flattening and displacement of the nucleus, loss of Nissl bodies, and cellular edema. Central chromatolysis primarily occurs in lower motor neurons. [from MeSH]

Professional guidelines

PubMed

Petzold A
J Neuroophthalmol 2021 Sep 1;41(3):385-398. doi: 10.1097/WNO.0000000000001173. PMID: 34415273
Borroto-Escuela DO, Fuxe K
J Neural Transm (Vienna) 2019 Apr;126(4):455-471. Epub 2019 Jan 14 doi: 10.1007/s00702-019-01969-2. PMID: 30637481Free PMC Article
Martin JA, Haber GB
Gastrointest Endosc Clin N Am 2003 Oct;13(4):649-69. doi: 10.1016/s1052-5157(03)00101-6. PMID: 14986792

Recent clinical studies

Etiology

Fan C, Wang JX, Xiong ZE, Hu SS, Zhou AJ, Yuan D, Zhang CC, Zhou ZY, Wang T
Pharm Biol 2023 Dec;61(1):1401-1412. doi: 10.1080/13880209.2023.2244532. PMID: 37667488Free PMC Article
Hakim A, Guido B, Narsineni L, Chen DW, Foldvari M
Adv Drug Deliv Rev 2023 May;196:114781. Epub 2023 Mar 20 doi: 10.1016/j.addr.2023.114781. PMID: 36940751
Zakani M, Nigritinou M, Ponleitner M, Takai Y, Hofmann D, Hillebrand S, Höftberger R, Bauer J, Lasztoczi B, Misu T, Kasprian G, Rommer P, Bradl M
Neuropathol Appl Neurobiol 2023 Apr;49(2):e12893. doi: 10.1111/nan.12893. PMID: 36811295Free PMC Article
Kurowska Z, Kordower JH, Stoessl AJ, Burke RE, Brundin P, Yue Z, Brady ST, Milbrandt J, Trapp BD, Sherer TB, Medicetty S
J Parkinsons Dis 2016 Oct 19;6(4):703-707. doi: 10.3233/JPD-160881. PMID: 27497486
Fink JK
Neurol Clin 2002 Aug;20(3):711-26. doi: 10.1016/s0733-8619(02)00007-5. PMID: 12432827

Diagnosis

Gaudric A, Audo I, Vignal C, Couturier A, Boulanger-Scemama É, Tadayoni R, Cohen SY
Prog Retin Eye Res 2022 Nov;91:101092. Epub 2022 Aug 1 doi: 10.1016/j.preteyeres.2022.101092. PMID: 35927124
Montoya-Filardi A, García-Junco Albacete M, Ortolá Fortes P, Carreres Polo J
Radiologia (Engl Ed) 2022 Mar-Apr;64(2):145-155. doi: 10.1016/j.rxeng.2022.01.001. PMID: 35504680
Maiya RP, Messing RO
Handb Clin Neurol 2014;125:513-25. doi: 10.1016/B978-0-444-62619-6.00029-X. PMID: 25307593
Fink JK
Neurol Clin 2002 Aug;20(3):711-26. doi: 10.1016/s0733-8619(02)00007-5. PMID: 12432827
Orendácová J, Cízková D, Kafka J, Lukácová N, Marsala M, Sulla I, Marsala J, Katsube N
Prog Neurobiol 2001 Aug;64(6):613-37. doi: 10.1016/s0301-0082(00)00065-4. PMID: 11311464

Therapy

Fan C, Wang JX, Xiong ZE, Hu SS, Zhou AJ, Yuan D, Zhang CC, Zhou ZY, Wang T
Pharm Biol 2023 Dec;61(1):1401-1412. doi: 10.1080/13880209.2023.2244532. PMID: 37667488Free PMC Article
Eidt JF, Vasquez J
Methodist Debakey Cardiovasc J 2023;19(2):59-69. Epub 2023 Mar 7 doi: 10.14797/mdcvj.1171. PMID: 36910545Free PMC Article
Khoynezhad A, Worthington T
Ann Vasc Surg 2023 Aug;94:56-60. Epub 2022 Oct 27 doi: 10.1016/j.avsg.2022.10.002. PMID: 36377067
Li Y, Pazyra-Murphy MF, Avizonis D, de Sá Tavares Russo M, Tang S, Chen CY, Hsueh YP, Bergholz JS, Jiang T, Zhao JJ, Zhu J, Ko KW, Milbrandt J, DiAntonio A, Segal RA
J Cell Biol 2022 Feb 7;221(2) Epub 2021 Dec 22 doi: 10.1083/jcb.202106080. PMID: 34935867Free PMC Article
Lawlor M, Danesh-Meyer H, Levin LA, Davagnanam I, De Vita E, Plant GT
Surv Ophthalmol 2018 May-Jun;63(3):296-306. Epub 2017 Oct 3 doi: 10.1016/j.survophthal.2017.09.010. PMID: 28986311

Prognosis

Khoynezhad A, Worthington T
Ann Vasc Surg 2023 Aug;94:56-60. Epub 2022 Oct 27 doi: 10.1016/j.avsg.2022.10.002. PMID: 36377067
Danesh-Meyer HV, Yoon JJ, Lawlor M, Savino PJ
Prog Retin Eye Res 2019 Nov;73:100765. Epub 2019 Jun 14 doi: 10.1016/j.preteyeres.2019.06.001. PMID: 31202890
Dinkin M
Curr Neurol Neurosci Rep 2017 Feb;17(2):16. doi: 10.1007/s11910-017-0725-2. PMID: 28229400
López-Marcos JF
Med Oral Patol Oral Cir Bucal 2004;9 Suppl:58-62; 52-7. PMID: 15580137
Fink JK
Neurol Clin 2002 Aug;20(3):711-26. doi: 10.1016/s0733-8619(02)00007-5. PMID: 12432827

Clinical prediction guides

Zakani M, Nigritinou M, Ponleitner M, Takai Y, Hofmann D, Hillebrand S, Höftberger R, Bauer J, Lasztoczi B, Misu T, Kasprian G, Rommer P, Bradl M
Neuropathol Appl Neurobiol 2023 Apr;49(2):e12893. doi: 10.1111/nan.12893. PMID: 36811295Free PMC Article
Nij Bijvank J, Maillette de Buy Wenniger L, de Graaf P, Petzold A
Br J Ophthalmol 2023 Mar;107(3):304-312. Epub 2021 Dec 9 doi: 10.1136/bjophthalmol-2021-320563. PMID: 34887243
Danesh-Meyer HV, Yoon JJ, Lawlor M, Savino PJ
Prog Retin Eye Res 2019 Nov;73:100765. Epub 2019 Jun 14 doi: 10.1016/j.preteyeres.2019.06.001. PMID: 31202890
Fink JK
Neurol Clin 2002 Aug;20(3):711-26. doi: 10.1016/s0733-8619(02)00007-5. PMID: 12432827
Camasta CA
Clin Podiatr Med Surg 1996 Jul;13(3):423-48. PMID: 8829034

Recent systematic reviews

Fu R, Selph S, McDonagh M, Peterson K, Tiwari A, Chou R, Helfand M
Ann Intern Med 2013 Jun 18;158(12):890-902. doi: 10.7326/0003-4819-158-12-201306180-00006. PMID: 23778906
Petzold A, de Boer JF, Schippling S, Vermersch P, Kardon R, Green A, Calabresi PA, Polman C
Lancet Neurol 2010 Sep;9(9):921-32. doi: 10.1016/S1474-4422(10)70168-X. PMID: 20723847

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