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Rosacea

MedGen UID:
11269
•Concept ID:
C0035854
•
Disease or Syndrome
Synonym: Acne Rosacea
SNOMED CT: Rosacea (398909004); Acne rosacea (398909004); Acne erythematosa (398909004)
 
Monarch Initiative: MONDO:0006604

Definition

A chronic erythematous skin disorder that affects the face. It is characterized by the development of redness in the cheeks, nose, and/or forehead and telangiectasia. Sometimes, the erythematous changes may involve the eyelids. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRosacea

Professional guidelines

PubMed

Rosacea management: A comprehensive review.
Sharma A, Kroumpouzos G, Kassir M, Galadari H, Goren A, Grabbe S, Goldust M
J Cosmet Dermatol 2022 May;21(5):1895-1904. Epub 2022 Feb 14 doi: 10.1111/jocd.14816. PMID: 35104917
Rosacea: Treatment targets based on new physiopathology data.
Cribier B
Ann Dermatol Venereol 2022 Jun;149(2):99-107. Epub 2021 Dec 8 doi: 10.1016/j.annder.2021.11.001. PMID: 34893359
Rosacea: New Concepts in Classification and Treatment.
van Zuuren EJ, Arents BWM, van der Linden MMD, Vermeulen S, Fedorowicz Z, Tan J
Am J Clin Dermatol 2021 Jul;22(4):457-465. Epub 2021 Mar 23 doi: 10.1007/s40257-021-00595-7. PMID: 33759078Free PMC Article

Recent clinical studies

Etiology

Microbotox: A prospective evaluation of dermatological improvement in patients with mild-to-moderate acne and erythematotelangiectatic rosacea.
Calvisi L, Diaspro A, Sito G
J Cosmet Dermatol 2022 Sep;21(9):3747-3753. Epub 2022 Mar 21 doi: 10.1111/jocd.14692. PMID: 35312149
Rosacea and the cardiovascular system.
Searle T, Al-Niaimi F, Ali FR
J Cosmet Dermatol 2020 Sep;19(9):2182-2187. Epub 2020 Aug 1 doi: 10.1111/jocd.13587. PMID: 32621366
Demodex folliculorum infestations in common facial dermatoses: acne vulgaris, rosacea, seborrheic dermatitis.
Aktaş Karabay E, Aksu Çerman A
An Bras Dermatol 2020 Mar-Apr;95(2):187-193. Epub 2020 Feb 12 doi: 10.1016/j.abd.2019.08.023. PMID: 32113677Free PMC Article
Recommendations for rosacea diagnosis, classification and management: update from the global ROSacea COnsensus 2019 panel.
Schaller M, Almeida LMC, Bewley A, Cribier B, Del Rosso J, Dlova NC, Gallo RL, Granstein RD, Kautz G, Mannis MJ, Micali G, Oon HH, Rajagopalan M, Steinhoff M, Tanghetti E, Thiboutot D, Troielli P, Webster G, Zierhut M, van Zuuren EJ, Tan J
Br J Dermatol 2020 May;182(5):1269-1276. Epub 2019 Oct 16 doi: 10.1111/bjd.18420. PMID: 31392722Free PMC Article
Global epidemiology and clinical spectrum of rosacea, highlighting skin of color: Review and clinical practice experience.
Alexis AF, Callender VD, Baldwin HE, Desai SR, Rendon MI, Taylor SC
J Am Acad Dermatol 2019 Jun;80(6):1722-1729.e7. Epub 2018 Sep 19 doi: 10.1016/j.jaad.2018.08.049. PMID: 30240779

Diagnosis

Rosacea: An Update in Diagnosis, Classification and Management.
Kang CN, Shah M, Tan J
Skin Therapy Lett 2021 Jul;26(4):1-8. PMID: 34347259
Rosacea: New Concepts in Classification and Treatment.
van Zuuren EJ, Arents BWM, van der Linden MMD, Vermeulen S, Fedorowicz Z, Tan J
Am J Clin Dermatol 2021 Jul;22(4):457-465. Epub 2021 Mar 23 doi: 10.1007/s40257-021-00595-7. PMID: 33759078Free PMC Article
Rosacea.
Searle T, Al-Niaimi F, Ali FR
Br J Hosp Med (Lond) 2021 Feb 2;82(2):1-8. Epub 2021 Feb 27 doi: 10.12968/hmed.2020.0417. PMID: 33646026
Recent advances in understanding and managing rosacea.
Buddenkotte J, Steinhoff M
F1000Res 2018;7 Epub 2018 Dec 3 doi: 10.12688/f1000research.16537.1. PMID: 30631431Free PMC Article
Rosacea: Diagnosis and Treatment.
Oge' LK, Muncie HL, Phillips-Savoy AR
Am Fam Physician 2015 Aug 1;92(3):187-96. PMID: 26280139

Therapy

Neurogenic Rosacea Treatment: A Literature Review.
Ivanic MG, Oulee A, Norden A, Javadi SS, Gold MH, Wu JJ
J Drugs Dermatol 2023 Jun 1;22(6):566-575. doi: 10.36849/JDD.7181. PMID: 37276164
Treatment of rosacea during pregnancy.
Gomolin T, Cline A, Pereira F
Dermatol Online J 2021 Jul 15;27(7) doi: 10.5070/D327754360. PMID: 34391325
Rosacea: An Update in Diagnosis, Classification and Management.
Kang CN, Shah M, Tan J
Skin Therapy Lett 2021 Jul;26(4):1-8. PMID: 34347259
Rosacea.
Searle T, Al-Niaimi F, Ali FR
Br J Hosp Med (Lond) 2021 Feb 2;82(2):1-8. Epub 2021 Feb 27 doi: 10.12968/hmed.2020.0417. PMID: 33646026
Rosacea.
van Zuuren EJ
N Engl J Med 2017 Nov 2;377(18):1754-1764. doi: 10.1056/NEJMcp1506630. PMID: 29091565

Prognosis

Frontal Fibrosing Alopecia - a review and a practical guide for clinicians.
Kępińska K, Jałowska M, Bowszyc-Dmochowska M
Ann Agric Environ Med 2022 Jun 24;29(2):169-184. Epub 2021 Aug 31 doi: 10.26444/aaem/141324. PMID: 35767748
Rosacea pathogenesis, common triggers, and dietary role: The cause, the trigger, and the positive effects of different foods.
Alia E, Feng H
Clin Dermatol 2022 Mar-Apr;40(2):122-127. Epub 2021 Oct 27 doi: 10.1016/j.clindermatol.2021.10.004. PMID: 34819228
Bioinformatics and Network Pharmacology Identify the Therapeutic Role and Potential Mechanism of Melatonin in AD and Rosacea.
Zhang H, Zhang Y, Li Y, Wang Y, Yan S, Xu S, Deng Z, Yang X, Xie H, Li J
Front Immunol 2021;12:756550. Epub 2021 Nov 23 doi: 10.3389/fimmu.2021.756550. PMID: 34899707Free PMC Article
Treatment of Demodex-associated inflammatory skin conditions: A systematic review.
Jacob S, VanDaele MA, Brown JN
Dermatol Ther 2019 Nov;32(6):e13103. Epub 2019 Oct 28 doi: 10.1111/dth.13103. PMID: 31583801
Standard classification and pathophysiology of rosacea: The 2017 update by the National Rosacea Society Expert Committee.
Gallo RL, Granstein RD, Kang S, Mannis M, Steinhoff M, Tan J, Thiboutot D
J Am Acad Dermatol 2018 Jan;78(1):148-155. Epub 2017 Oct 28 doi: 10.1016/j.jaad.2017.08.037. PMID: 29089180

Clinical prediction guides

The causal relationship between gut microbiota and inflammatory dermatoses: a Mendelian randomization study.
Mao R, Yu Q, Li J
Front Immunol 2023;14:1231848. Epub 2023 Sep 27 doi: 10.3389/fimmu.2023.1231848. PMID: 37828993Free PMC Article
Paroxetine is an effective treatment for refractory erythema of rosacea: Primary results from the Prospective Rosacea Refractory Erythema Randomized Clinical Trial.
Wang B, Huang Y, Tang Y, Zhao Z, Shi W, Jian D, Liu F, Gao Q, Wang P, Yang J, Li L, Xie H, Li J
J Am Acad Dermatol 2023 Jun;88(6):1300-1307. Epub 2023 Feb 15 doi: 10.1016/j.jaad.2023.01.044. PMID: 36806645
Bioinformatics and Network Pharmacology Identify the Therapeutic Role and Potential Mechanism of Melatonin in AD and Rosacea.
Zhang H, Zhang Y, Li Y, Wang Y, Yan S, Xu S, Deng Z, Yang X, Xie H, Li J
Front Immunol 2021;12:756550. Epub 2021 Nov 23 doi: 10.3389/fimmu.2021.756550. PMID: 34899707Free PMC Article
Exploring metformin as a candidate drug for rosacea through network pharmacology and experimental validation.
Li Y, Yang L, Wang Y, Deng Z, Xu S, Xie H, Zhang Y, Li J
Pharmacol Res 2021 Dec;174:105971. Epub 2021 Nov 8 doi: 10.1016/j.phrs.2021.105971. PMID: 34763093
Therapeutic uses of metronidazole and its side effects: an update.
Hernández Ceruelos A, Romero-Quezada LC, Ruvalcaba Ledezma JC, López Contreras L
Eur Rev Med Pharmacol Sci 2019 Jan;23(1):397-401. doi: 10.26355/eurrev_201901_16788. PMID: 30657582

Recent systematic reviews

Guidelines of care for the management of acne vulgaris.
Reynolds RV, Yeung H, Cheng CE, Cook-Bolden F, Desai SR, Druby KM, Freeman EE, Keri JE, Stein Gold LF, Tan JKL, Tollefson MM, Weiss JS, Wu PA, Zaenglein AL, Han JM, Barbieri JS
J Am Acad Dermatol 2024 May;90(5):1006.e1-1006.e30. Epub 2024 Jan 30 doi: 10.1016/j.jaad.2023.12.017. PMID: 38300170
Topical corticosteroid withdrawal ('steroid addiction'): an update of a systematic review.
Hwang J, Lio PA
J Dermatolog Treat 2022 May;33(3):1293-1298. Epub 2021 Feb 4 doi: 10.1080/09546634.2021.1882659. PMID: 33499686
Serum zinc levels and efficacy of zinc treatment in acne vulgaris: A systematic review and meta-analysis.
Yee BE, Richards P, Sui JY, Marsch AF
Dermatol Ther 2020 Nov;33(6):e14252. Epub 2020 Sep 15 doi: 10.1111/dth.14252. PMID: 32860489
Treatment of Demodex-associated inflammatory skin conditions: A systematic review.
Jacob S, VanDaele MA, Brown JN
Dermatol Ther 2019 Nov;32(6):e13103. Epub 2019 Oct 28 doi: 10.1111/dth.13103. PMID: 31583801
Interventions for rosacea.
van Zuuren EJ, Fedorowicz Z, Carter B, van der Linden MM, Charland L
Cochrane Database Syst Rev 2015 Apr 28;2015(4):CD003262. doi: 10.1002/14651858.CD003262.pub5. PMID: 25919144Free PMC Article

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