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Rosacea

MedGen UID:
11269
•Concept ID:
C0035854
•
Disease or Syndrome
Synonym: Acne Rosacea
SNOMED CT: Rosacea (398909004); Acne rosacea (398909004); Acne erythematosa (398909004)
 
Monarch Initiative: MONDO:0006604

Definition

A chronic erythematous skin disorder that affects the face. It is characterized by the development of redness in the cheeks, nose, and/or forehead and telangiectasia. Sometimes, the erythematous changes may involve the eyelids. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRosacea

Professional guidelines

PubMed

Rosacea management: A comprehensive review.
Sharma A, Kroumpouzos G, Kassir M, Galadari H, Goren A, Grabbe S, Goldust M
J Cosmet Dermatol 2022 May;21(5):1895-1904. Epub 2022 Feb 14 doi: 10.1111/jocd.14816. PMID: 35104917
Rosacea: An Update in Diagnosis, Classification and Management.
Kang CN, Shah M, Tan J
Skin Therapy Lett 2021 Jul;26(4):1-8. PMID: 34347259
Rosacea: New Concepts in Classification and Treatment.
van Zuuren EJ, Arents BWM, van der Linden MMD, Vermeulen S, Fedorowicz Z, Tan J
Am J Clin Dermatol 2021 Jul;22(4):457-465. Epub 2021 Mar 23 doi: 10.1007/s40257-021-00595-7. PMID: 33759078Free PMC Article

Recent clinical studies

Etiology

Acne and rosacea in skin of colour.
Maruthappu T, Taylor M
Clin Exp Dermatol 2022 Feb;47(2):259-263. Epub 2021 Nov 28 doi: 10.1111/ced.14994. PMID: 34709676
Recommendations for rosacea diagnosis, classification and management: update from the global ROSacea COnsensus 2019 panel.
Schaller M, Almeida LMC, Bewley A, Cribier B, Del Rosso J, Dlova NC, Gallo RL, Granstein RD, Kautz G, Mannis MJ, Micali G, Oon HH, Rajagopalan M, Steinhoff M, Tanghetti E, Thiboutot D, Troielli P, Webster G, Zierhut M, van Zuuren EJ, Tan J
Br J Dermatol 2020 May;182(5):1269-1276. Epub 2019 Oct 16 doi: 10.1111/bjd.18420. PMID: 31392722Free PMC Article
Is rosacea a systemic disease?
Wollina U
Clin Dermatol 2019 Nov-Dec;37(6):629-635. Epub 2019 Jul 31 doi: 10.1016/j.clindermatol.2019.07.032. PMID: 31864441
Global epidemiology and clinical spectrum of rosacea, highlighting skin of color: Review and clinical practice experience.
Alexis AF, Callender VD, Baldwin HE, Desai SR, Rendon MI, Taylor SC
J Am Acad Dermatol 2019 Jun;80(6):1722-1729.e7. Epub 2018 Sep 19 doi: 10.1016/j.jaad.2018.08.049. PMID: 30240779
Interventions for rosacea.
van Zuuren EJ, Fedorowicz Z, Carter B, van der Linden MM, Charland L
Cochrane Database Syst Rev 2015 Apr 28;2015(4):CD003262. doi: 10.1002/14651858.CD003262.pub5. PMID: 25919144Free PMC Article

Diagnosis

Rosacea: An Update in Diagnosis, Classification and Management.
Kang CN, Shah M, Tan J
Skin Therapy Lett 2021 Jul;26(4):1-8. PMID: 34347259
Rosacea: New Concepts in Classification and Treatment.
van Zuuren EJ, Arents BWM, van der Linden MMD, Vermeulen S, Fedorowicz Z, Tan J
Am J Clin Dermatol 2021 Jul;22(4):457-465. Epub 2021 Mar 23 doi: 10.1007/s40257-021-00595-7. PMID: 33759078Free PMC Article
Rosacea.
Searle T, Al-Niaimi F, Ali FR
Br J Hosp Med (Lond) 2021 Feb 2;82(2):1-8. Epub 2021 Feb 27 doi: 10.12968/hmed.2020.0417. PMID: 33646026
Ocular rosacea.
Redd TK, Seitzman GD
Curr Opin Ophthalmol 2020 Nov;31(6):503-507. doi: 10.1097/ICU.0000000000000706. PMID: 33009083
Recent advances in understanding and managing rosacea.
Buddenkotte J, Steinhoff M
F1000Res 2018;7 Epub 2018 Dec 3 doi: 10.12688/f1000research.16537.1. PMID: 30631431Free PMC Article

Therapy

S2k guideline: Rosacea.
Clanner-Engelshofen BM, Bernhard D, Dargatz S, Flaig MJ, Gieler U, Kinberger M, Klövekorn W, Kuna AC, Läuchli S, Lehmann P, Nast A, Pleyer U, Schaller M, Schöfer H, Steinhoff M, Schwennesen T, Werner RN, Zierhut M, Reinholz M
J Dtsch Dermatol Ges 2022 Aug;20(8):1147-1165. Epub 2022 Aug 5 doi: 10.1111/ddg.14849. PMID: 35929658
Treatment of rosacea during pregnancy.
Gomolin T, Cline A, Pereira F
Dermatol Online J 2021 Jul 15;27(7) doi: 10.5070/D327754360. PMID: 34391325
Rosacea: An Update in Diagnosis, Classification and Management.
Kang CN, Shah M, Tan J
Skin Therapy Lett 2021 Jul;26(4):1-8. PMID: 34347259
Rosacea.
Searle T, Al-Niaimi F, Ali FR
Br J Hosp Med (Lond) 2021 Feb 2;82(2):1-8. Epub 2021 Feb 27 doi: 10.12968/hmed.2020.0417. PMID: 33646026
Ocular rosacea.
Redd TK, Seitzman GD
Curr Opin Ophthalmol 2020 Nov;31(6):503-507. doi: 10.1097/ICU.0000000000000706. PMID: 33009083

Prognosis

Bioinformatics and Network Pharmacology Identify the Therapeutic Role and Potential Mechanism of Melatonin in AD and Rosacea.
Zhang H, Zhang Y, Li Y, Wang Y, Yan S, Xu S, Deng Z, Yang X, Xie H, Li J
Front Immunol 2021;12:756550. Epub 2021 Nov 23 doi: 10.3389/fimmu.2021.756550. PMID: 34899707Free PMC Article
Exploring metformin as a candidate drug for rosacea through network pharmacology and experimental validation.
Li Y, Yang L, Wang Y, Deng Z, Xu S, Xie H, Zhang Y, Li J
Pharmacol Res 2021 Dec;174:105971. Epub 2021 Nov 8 doi: 10.1016/j.phrs.2021.105971. PMID: 34763093
Is rosacea a systemic disease?
Wollina U
Clin Dermatol 2019 Nov-Dec;37(6):629-635. Epub 2019 Jul 31 doi: 10.1016/j.clindermatol.2019.07.032. PMID: 31864441
Treatment of Demodex-associated inflammatory skin conditions: A systematic review.
Jacob S, VanDaele MA, Brown JN
Dermatol Ther 2019 Nov;32(6):e13103. Epub 2019 Oct 28 doi: 10.1111/dth.13103. PMID: 31583801
Standard classification and pathophysiology of rosacea: The 2017 update by the National Rosacea Society Expert Committee.
Gallo RL, Granstein RD, Kang S, Mannis M, Steinhoff M, Tan J, Thiboutot D
J Am Acad Dermatol 2018 Jan;78(1):148-155. Epub 2017 Oct 28 doi: 10.1016/j.jaad.2017.08.037. PMID: 29089180

Clinical prediction guides

Association of rosacea with depression and anxiety: A systematic review and meta-analysis.
Chang HC, Huang YC, Lien YJ, Chang YS
J Affect Disord 2022 Feb 15;299:239-245. Epub 2021 Dec 5 doi: 10.1016/j.jad.2021.12.008. PMID: 34879261
Bioinformatics and Network Pharmacology Identify the Therapeutic Role and Potential Mechanism of Melatonin in AD and Rosacea.
Zhang H, Zhang Y, Li Y, Wang Y, Yan S, Xu S, Deng Z, Yang X, Xie H, Li J
Front Immunol 2021;12:756550. Epub 2021 Nov 23 doi: 10.3389/fimmu.2021.756550. PMID: 34899707Free PMC Article
Exploring metformin as a candidate drug for rosacea through network pharmacology and experimental validation.
Li Y, Yang L, Wang Y, Deng Z, Xu S, Xie H, Zhang Y, Li J
Pharmacol Res 2021 Dec;174:105971. Epub 2021 Nov 8 doi: 10.1016/j.phrs.2021.105971. PMID: 34763093
Is rosacea a systemic disease?
Wollina U
Clin Dermatol 2019 Nov-Dec;37(6):629-635. Epub 2019 Jul 31 doi: 10.1016/j.clindermatol.2019.07.032. PMID: 31864441
Therapeutic uses of metronidazole and its side effects: an update.
Hernández Ceruelos A, Romero-Quezada LC, Ruvalcaba Ledezma JC, López Contreras L
Eur Rev Med Pharmacol Sci 2019 Jan;23(1):397-401. doi: 10.26355/eurrev_201901_16788. PMID: 30657582

Recent systematic reviews

Photodynamic therapy in the treatment of rosacea: A systematic review.
Li A, Fang R, Mao X, Sun Q
Photodiagnosis Photodyn Ther 2022 Jun;38:102875. Epub 2022 Apr 22 doi: 10.1016/j.pdpdt.2022.102875. PMID: 35470124
Association of rosacea with depression and anxiety: A systematic review and meta-analysis.
Chang HC, Huang YC, Lien YJ, Chang YS
J Affect Disord 2022 Feb 15;299:239-245. Epub 2021 Dec 5 doi: 10.1016/j.jad.2021.12.008. PMID: 34879261
Serum zinc levels and efficacy of zinc treatment in acne vulgaris: A systematic review and meta-analysis.
Yee BE, Richards P, Sui JY, Marsch AF
Dermatol Ther 2020 Nov;33(6):e14252. Epub 2020 Sep 15 doi: 10.1111/dth.14252. PMID: 32860489
Treatment of Demodex-associated inflammatory skin conditions: A systematic review.
Jacob S, VanDaele MA, Brown JN
Dermatol Ther 2019 Nov;32(6):e13103. Epub 2019 Oct 28 doi: 10.1111/dth.13103. PMID: 31583801
Interventions for rosacea.
van Zuuren EJ, Fedorowicz Z, Carter B, van der Linden MM, Charland L
Cochrane Database Syst Rev 2015 Apr 28;2015(4):CD003262. doi: 10.1002/14651858.CD003262.pub5. PMID: 25919144Free PMC Article

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