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Metastatic Malignant Neoplasm in the Brain

MedGen UID:
113095
Concept ID:
C0220650
Neoplastic Process
Synonyms: Brain Metastase; Brain Metastases
SNOMED CT: Secondary cancer of brain (94225005); Metastasis to brain (94225005); Secondary malignant neoplasm of brain (94225005); Metastatic malignant neoplasm to brain (94225005); Cancer metastatic to brain (94225005); Metastatic malignant neoplasm of brain (94225005)

Definition

A malignant neoplasm that has spread to the brain from another anatomic site or system. The majority are carcinomas (usually lung or breast carcinomas). [from NCI]

Professional guidelines

PubMed

McKinnon C, Nandhabalan M, Murray SA, Plaha P
BMJ 2021 Jul 14;374:n1560. doi: 10.1136/bmj.n1560. PMID: 34261630
Key NS, Khorana AA, Kuderer NM, Bohlke K, Lee AYY, Arcelus JI, Wong SL, Balaban EP, Flowers CR, Francis CW, Gates LE, Kakkar AK, Levine MN, Liebman HA, Tempero MA, Lyman GH, Falanga A
J Clin Oncol 2020 Feb 10;38(5):496-520. Epub 2019 Aug 5 doi: 10.1200/JCO.19.01461. PMID: 31381464
Melmed S, Casanueva FF, Hoffman AR, Kleinberg DL, Montori VM, Schlechte JA, Wass JA; Endocrine Society
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Recent clinical studies

Etiology

Rybarczyk-Kasiuchnicz A, Ramlau R, Stencel K
Int J Mol Sci 2021 Jan 8;22(2) doi: 10.3390/ijms22020593. PMID: 33435596Free PMC Article
Lapointe S, Perry A, Butowski NA
Lancet 2018 Aug 4;392(10145):432-446. Epub 2018 Jul 27 doi: 10.1016/S0140-6736(18)30990-5. PMID: 30060998
Cahill D, Turcan S
Semin Neurol 2018 Feb;38(1):5-10. Epub 2018 Mar 16 doi: 10.1055/s-0037-1620238. PMID: 29548046
McNeill KA
Neurol Clin 2016 Nov;34(4):981-998. doi: 10.1016/j.ncl.2016.06.014. PMID: 27720005
Wells EM, Packer RJ
Continuum (Minneap Minn) 2015 Apr;21(2 Neuro-oncology):373-96. doi: 10.1212/01.CON.0000464176.96311.d1. PMID: 25837902

Diagnosis

Partap S, Monje M
Continuum (Minneap Minn) 2020 Dec;26(6):1553-1583. doi: 10.1212/CON.0000000000000955. PMID: 33273172
Lah TT, Novak M, Breznik B
Semin Cancer Biol 2020 Feb;60:262-273. Epub 2019 Oct 22 doi: 10.1016/j.semcancer.2019.10.010. PMID: 31654711
Chen DY, Chen CC, Crawford JR, Wang SG
J Neurooncol 2018 Aug;139(1):13-21. Epub 2018 May 24 doi: 10.1007/s11060-018-2862-0. PMID: 29797181
Ostrom QT, Wright CH, Barnholtz-Sloan JS
Handb Clin Neurol 2018;149:27-42. doi: 10.1016/B978-0-12-811161-1.00002-5. PMID: 29307358
Dang M, Phillips PC
Continuum (Minneap Minn) 2017 Dec;23(6, Neuro-oncology):1727-1757. doi: 10.1212/CON.0000000000000545. PMID: 29200119

Therapy

Omuro A
Arq Neuropsiquiatr 2022 May;80(5 Suppl 1):266-269. doi: 10.1590/0004-282X-ANP-2022-S129. PMID: 35976319Free PMC Article
Rominiyi O, Vanderlinden A, Clenton SJ, Bridgewater C, Al-Tamimi Y, Collis SJ
Br J Cancer 2021 Feb;124(4):697-709. Epub 2020 Nov 4 doi: 10.1038/s41416-020-01136-5. PMID: 33144698Free PMC Article
Hollon TC, Pandian B, Adapa AR, Urias E, Save AV, Khalsa SSS, Eichberg DG, D'Amico RS, Farooq ZU, Lewis S, Petridis PD, Marie T, Shah AH, Garton HJL, Maher CO, Heth JA, McKean EL, Sullivan SE, Hervey-Jumper SL, Patil PG, Thompson BG, Sagher O, McKhann GM 2nd, Komotar RJ, Ivan ME, Snuderl M, Otten ML, Johnson TD, Sisti MB, Bruce JN, Muraszko KM, Trautman J, Freudiger CW, Canoll P, Lee H, Camelo-Piragua S, Orringer DA
Nat Med 2020 Jan;26(1):52-58. Epub 2020 Jan 6 doi: 10.1038/s41591-019-0715-9. PMID: 31907460Free PMC Article
Lin NU, Lee EQ, Aoyama H, Barani IJ, Barboriak DP, Baumert BG, Bendszus M, Brown PD, Camidge DR, Chang SM, Dancey J, de Vries EG, Gaspar LE, Harris GJ, Hodi FS, Kalkanis SN, Linskey ME, Macdonald DR, Margolin K, Mehta MP, Schiff D, Soffietti R, Suh JH, van den Bent MJ, Vogelbaum MA, Wen PY; Response Assessment in Neuro-Oncology (RANO) group
Lancet Oncol 2015 Jun;16(6):e270-8. Epub 2015 May 27 doi: 10.1016/S1470-2045(15)70057-4. PMID: 26065612
Gaspar L, Scott C, Rotman M, Asbell S, Phillips T, Wasserman T, McKenna WG, Byhardt R
Int J Radiat Oncol Biol Phys 1997 Mar 1;37(4):745-51. doi: 10.1016/s0360-3016(96)00619-0. PMID: 9128946

Prognosis

Ostrom QT, Cioffi G, Gittleman H, Patil N, Waite K, Kruchko C, Barnholtz-Sloan JS
Neuro Oncol 2019 Nov 1;21(Suppl 5):v1-v100. doi: 10.1093/neuonc/noz150. PMID: 31675094Free PMC Article
Witthayanuwat S, Pesee M, Supaadirek C, Supakalin N, Thamronganantasakul K, Krusun S
Asian Pac J Cancer Prev 2018 Sep 26;19(9):2613-2617. doi: 10.22034/APJCP.2018.19.9.2613. PMID: 30256068Free PMC Article
Mahajan A, Ahmed S, McAleer MF, Weinberg JS, Li J, Brown P, Settle S, Prabhu SS, Lang FF, Levine N, McGovern S, Sulman E, McCutcheon IE, Azeem S, Cahill D, Tatsui C, Heimberger AB, Ferguson S, Ghia A, Demonte F, Raza S, Guha-Thakurta N, Yang J, Sawaya R, Hess KR, Rao G
Lancet Oncol 2017 Aug;18(8):1040-1048. Epub 2017 Jul 4 doi: 10.1016/S1470-2045(17)30414-X. PMID: 28687375Free PMC Article
Cagney DN, Martin AM, Catalano PJ, Redig AJ, Lin NU, Lee EQ, Wen PY, Dunn IF, Bi WL, Weiss SE, Haas-Kogan DA, Alexander BM, Aizer AA
Neuro Oncol 2017 Oct 19;19(11):1511-1521. doi: 10.1093/neuonc/nox077. PMID: 28444227Free PMC Article
Lu-Emerson C, Eichler AF
Continuum (Minneap Minn) 2012 Apr;18(2):295-311. doi: 10.1212/01.CON.0000413659.12304.a6. PMID: 22810128

Clinical prediction guides

Tyagi A, Wu SY, Watabe K
Cancer Lett 2022 Jul 28;539:215713. Epub 2022 May 2 doi: 10.1016/j.canlet.2022.215713. PMID: 35513201Free PMC Article
Wan RJ, Peng W, Xia QX, Zhou HH, Mao XY
CNS Neurosci Ther 2021 Aug;27(8):973-986. Epub 2021 May 10 doi: 10.1111/cns.13654. PMID: 33969928Free PMC Article
Li G, Wu F, Zeng F, Zhai Y, Feng Y, Chang Y, Wang D, Jiang T, Zhang W
CNS Neurosci Ther 2021 Feb;27(2):186-195. Epub 2020 Oct 16 doi: 10.1111/cns.13464. PMID: 33063446Free PMC Article
Suh JH, Kotecha R, Chao ST, Ahluwalia MS, Sahgal A, Chang EL
Nat Rev Clin Oncol 2020 May;17(5):279-299. Epub 2020 Feb 20 doi: 10.1038/s41571-019-0320-3. PMID: 32080373
Davis ME
Semin Oncol Nurs 2018 Dec;34(5):420-429. Epub 2018 Nov 2 doi: 10.1016/j.soncn.2018.10.001. PMID: 30392758

Recent systematic reviews

Grishchuk D, Dimitriadis A, Sahgal A, De Salles A, Fariselli L, Kotecha R, Levivier M, Ma L, Pollock BE, Regis J, Sheehan J, Suh J, Yomo S, Paddick I
Pract Radiat Oncol 2023 May-Jun;13(3):183-194. Epub 2022 Nov 24 doi: 10.1016/j.prro.2022.10.013. PMID: 36435388
Li Y, Liu Y, Liang Y, Wei R, Zhang W, Yao W, Luo S, Pang X, Wang Y, Jiang X, Lai S, Yang R
Eur Radiol 2022 Nov;32(11):8039-8051. Epub 2022 May 19 doi: 10.1007/s00330-022-08828-x. PMID: 35587827
Gondi V, Bauman G, Bradfield L, Burri SH, Cabrera AR, Cunningham DA, Eaton BR, Hattangadi-Gluth JA, Kim MM, Kotecha R, Kraemer L, Li J, Nagpal S, Rusthoven CG, Suh JH, Tomé WA, Wang TJC, Zimmer AS, Ziu M, Brown PD
Pract Radiat Oncol 2022 Jul-Aug;12(4):265-282. Epub 2022 May 6 doi: 10.1016/j.prro.2022.02.003. PMID: 35534352
Vogelbaum MA, Brown PD, Messersmith H, Brastianos PK, Burri S, Cahill D, Dunn IF, Gaspar LE, Gatson NTN, Gondi V, Jordan JT, Lassman AB, Maues J, Mohile N, Redjal N, Stevens G, Sulman E, van den Bent M, Wallace HJ, Weinberg JS, Zadeh G, Schiff D
J Clin Oncol 2022 Feb 10;40(5):492-516. Epub 2021 Dec 21 doi: 10.1200/JCO.21.02314. PMID: 34932393
Mohile NA, Messersmith H, Gatson NT, Hottinger AF, Lassman A, Morton J, Ney D, Nghiemphu PL, Olar A, Olson J, Perry J, Portnow J, Schiff D, Shannon A, Shih HA, Strowd R, van den Bent M, Ziu M, Blakeley J
J Clin Oncol 2022 Feb 1;40(4):403-426. Epub 2021 Dec 13 doi: 10.1200/JCO.21.02036. PMID: 34898238

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