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Carotid sinus syncope

MedGen UID:
113141
•Concept ID:
C0221046
•
Disease or Syndrome
Synonyms: Carotid Sinus Syncope; Carotid Sinus Syncopes; Syncope, Carotid Sinus; Syncopes, Carotid Sinus
SNOMED CT: Carotid sinus syncope (51723007); Carotid sinus syndrome (51723007)
 
HPO: HP:0012669

Definition

An exaggerated response to carotid sinus baroreceptor stimulation resulting in syncope from transient diminished cerebral perfusion. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCarotid sinus syncope

Professional guidelines

PubMed

An approach to the clinical assessment and management of syncope in adults.
Ntusi NA, Coccia CB, Cupido BJ, Chin A
S Afr Med J 2015 Aug;105(8):690-3. doi: 10.7196/samjnew.8065. PMID: 26543940
Fludrocortisone in the treatment of hypotensive disorders in the elderly.
Hussain RM, McIntosh SJ, Lawson J, Kenny RA
Heart 1996 Dec;76(6):507-9. doi: 10.1136/hrt.76.6.507. PMID: 9014799Free PMC Article
The role of pacing for the management of neurally mediated syncope: carotid sinus syndrome and vasovagal syncope.
Maloney JD, Jaeger FJ, Rizo-Patron C, Zhu DW
Am Heart J 1994 Apr;127(4 Pt 2):1030-7. doi: 10.1016/0002-8703(94)90083-3. PMID: 8160577

Recent clinical studies

Etiology

Does A Therapy for Reflex Vasovagal Syncope Really Exist?
Romano S, Branz L, Fondrieschi L, Minuz P
High Blood Press Cardiovasc Prev 2019 Aug;26(4):273-281. Epub 2019 Jul 11 doi: 10.1007/s40292-019-00327-3. PMID: 31297720
Safety and tolerability of Tilt Testing and Carotid Sinus Massage in the octogenarians.
Ungar A, Rivasi G, Rafanelli M, Toffanello G, Mussi C, Ceccofiglio A, McDonagh R, Drumm B, Marchionni N, Alboni P, Kenny RA
Age Ageing 2016 Mar;45(2):242-8. Epub 2016 Jan 31 doi: 10.1093/ageing/afw004. PMID: 26833302
The different clinical presentations of vasovagal syncope.
Alboni P
Heart 2015 May;101(9):674-8. Epub 2015 Mar 19 doi: 10.1136/heartjnl-2014-307096. PMID: 25792719
Drugs and pacemakers for vasovagal, carotid sinus and situational syncope.
Romme JJ, Reitsma JB, Black CN, Colman N, Scholten RJ, Wieling W, Van Dijk N
Cochrane Database Syst Rev 2011 Oct 5;(10):CD004194. doi: 10.1002/14651858.CD004194.pub3. PMID: 21975744
Clinical and electroencephalographic features of carotid sinus syncope induced by internal carotid artery angioplasty.
Martinez-Fernandez E, García FB, Gonzalez-Marcos JR, Peralta AG, Garcia AG, Deya AM
AJNR Am J Neuroradiol 2008 Feb;29(2):269-72. Epub 2007 Nov 1 doi: 10.3174/ajnr.A0823. PMID: 17974603Free PMC Article

Diagnosis

Does A Therapy for Reflex Vasovagal Syncope Really Exist?
Romano S, Branz L, Fondrieschi L, Minuz P
High Blood Press Cardiovasc Prev 2019 Aug;26(4):273-281. Epub 2019 Jul 11 doi: 10.1007/s40292-019-00327-3. PMID: 31297720
Safety and tolerability of Tilt Testing and Carotid Sinus Massage in the octogenarians.
Ungar A, Rivasi G, Rafanelli M, Toffanello G, Mussi C, Ceccofiglio A, McDonagh R, Drumm B, Marchionni N, Alboni P, Kenny RA
Age Ageing 2016 Mar;45(2):242-8. Epub 2016 Jan 31 doi: 10.1093/ageing/afw004. PMID: 26833302
The different clinical presentations of vasovagal syncope.
Alboni P
Heart 2015 May;101(9):674-8. Epub 2015 Mar 19 doi: 10.1136/heartjnl-2014-307096. PMID: 25792719
Carotid sinus syncope.
Morley CA, Sutton R
Int J Cardiol 1984 Sep;6(3):287-93. doi: 10.1016/0167-5273(84)90188-8. PMID: 6480160
Carotid sinus hypersensitivity and syncope.
Walter PF, Crawley IS, Dorney ER
Am J Cardiol 1978 Sep;42(3):396-403. doi: 10.1016/0002-9149(78)90934-7. PMID: 356576

Therapy

Safety and tolerability of Tilt Testing and Carotid Sinus Massage in the octogenarians.
Ungar A, Rivasi G, Rafanelli M, Toffanello G, Mussi C, Ceccofiglio A, McDonagh R, Drumm B, Marchionni N, Alboni P, Kenny RA
Age Ageing 2016 Mar;45(2):242-8. Epub 2016 Jan 31 doi: 10.1093/ageing/afw004. PMID: 26833302
Drugs and pacemakers for vasovagal, carotid sinus and situational syncope.
Romme JJ, Reitsma JB, Black CN, Colman N, Scholten RJ, Wieling W, Van Dijk N
Cochrane Database Syst Rev 2011 Oct 5;(10):CD004194. doi: 10.1002/14651858.CD004194.pub3. PMID: 21975744
Risk factors and neurological consequences of syncopes induced by internal carotid artery angioplasty.
Martinez-Fernandez E, Boza Garcia F, Gonzalez-Marcos JR, Gil-Peralta A, Gonzalez Garcia A, Mayol Deya A
Stroke 2008 Apr;39(4):1336-9. Epub 2008 Feb 28 doi: 10.1161/STROKEAHA.107.501627. PMID: 18309152
Fludrocortisone in the treatment of hypotensive disorders in the elderly.
Hussain RM, McIntosh SJ, Lawson J, Kenny RA
Heart 1996 Dec;76(6):507-9. doi: 10.1136/hrt.76.6.507. PMID: 9014799Free PMC Article
Vasodepressor carotid sinus syncope.
Rentmeester T, Van Zile J, Van Hal M, Levene D
Br Med J (Clin Res Ed) 1984 Sep 22;289(6447):720. doi: 10.1136/bmj.289.6447.720. PMID: 6434054Free PMC Article

Prognosis

Safety and tolerability of Tilt Testing and Carotid Sinus Massage in the octogenarians.
Ungar A, Rivasi G, Rafanelli M, Toffanello G, Mussi C, Ceccofiglio A, McDonagh R, Drumm B, Marchionni N, Alboni P, Kenny RA
Age Ageing 2016 Mar;45(2):242-8. Epub 2016 Jan 31 doi: 10.1093/ageing/afw004. PMID: 26833302
An approach to the clinical assessment and management of syncope in adults.
Ntusi NA, Coccia CB, Cupido BJ, Chin A
S Afr Med J 2015 Aug;105(8):690-3. doi: 10.7196/samjnew.8065. PMID: 26543940
Clinical and electroencephalographic features of carotid sinus syncope induced by internal carotid artery angioplasty.
Martinez-Fernandez E, García FB, Gonzalez-Marcos JR, Peralta AG, Garcia AG, Deya AM
AJNR Am J Neuroradiol 2008 Feb;29(2):269-72. Epub 2007 Nov 1 doi: 10.3174/ajnr.A0823. PMID: 17974603Free PMC Article
Value and limitations of noninvasive assessment of syncope.
Hammill SC
Cardiol Clin 1997 May;15(2):195-218. doi: 10.1016/s0733-8651(05)70330-1. PMID: 9164710
Carotid sinus syndrome: treatment by carotid sinus denervation.
Trout HH 3rd, Brown LL, Thompson JE
Ann Surg 1979 May;189(5):575-80. doi: 10.1097/00000658-197905000-00006. PMID: 443910Free PMC Article

Clinical prediction guides

Safety and tolerability of Tilt Testing and Carotid Sinus Massage in the octogenarians.
Ungar A, Rivasi G, Rafanelli M, Toffanello G, Mussi C, Ceccofiglio A, McDonagh R, Drumm B, Marchionni N, Alboni P, Kenny RA
Age Ageing 2016 Mar;45(2):242-8. Epub 2016 Jan 31 doi: 10.1093/ageing/afw004. PMID: 26833302
Lack of correlation between the responses to tilt testing and adenosine triphosphate test and the mechanism of spontaneous neurally mediated syncope.
Brignole M, Sutton R, Menozzi C, Garcia-Civera R, Moya A, Wieling W, Andresen D, Benditt DG, Grovale N, De Santo T, Vardas P; International Study on Syncope of Uncertain Etiology 2 (ISSUE 2) Group
Eur Heart J 2006 Sep;27(18):2232-9. Epub 2006 Jul 24 doi: 10.1093/eurheartj/ehl164. PMID: 16864606
Early application of an implantable loop recorder allows effective specific therapy in patients with recurrent suspected neurally mediated syncope.
Brignole M, Sutton R, Menozzi C, Garcia-Civera R, Moya A, Wieling W, Andresen D, Benditt DG, Vardas P; International Study on Syncope of Uncertain Etiology 2 (ISSUE 2) Group
Eur Heart J 2006 May;27(9):1085-92. Epub 2006 Mar 28 doi: 10.1093/eurheartj/ehi842. PMID: 16569653
Value and limitations of noninvasive assessment of syncope.
Hammill SC
Cardiol Clin 1997 May;15(2):195-218. doi: 10.1016/s0733-8651(05)70330-1. PMID: 9164710
Adams-Stokes attacks associated with carotid sinus syncope. Pathogenesis and therapy of the carotid sinus syncopes.
Solti F, Szabó Z, Czakó E, Bodor E, Rényi-Vámos F Jr
Z Kardiol 1980 Sep;69(9):656-9. PMID: 7210771

Recent systematic reviews

Drugs and pacemakers for vasovagal, carotid sinus and situational syncope.
Romme JJ, Reitsma JB, Black CN, Colman N, Scholten RJ, Wieling W, Van Dijk N
Cochrane Database Syst Rev 2011 Oct 5;(10):CD004194. doi: 10.1002/14651858.CD004194.pub3. PMID: 21975744

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