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Necrolytic migratory erythema

MedGen UID:
113156
•Concept ID:
C0221243
•
Disease or Syndrome
Synonyms: Erythema, Necrolytic Migratory; Erythemas, Necrolytic Migratory; Migratory Erythema, Necrolytic; Migratory Erythemas, Necrolytic; Necrolytic Migratory Erythema; Necrolytic Migratory Erythemas
SNOMED CT: Necrolytic migratory erythema (15576007)
 
HPO: HP:0031181

Definition

Acral or periorificial lesions that evolve in recurrent crops, with an annular and migratory distribution. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNecrolytic migratory erythema

Professional guidelines

PubMed

Necrolytic migratory erythema-like eruption and paradoxical psoriasis associated with adalimumab treatment.
Lin S, Qiu X, Hong Y, Wang X, Ren J
J Dermatol 2021 Nov;48(11):e572-e573. Epub 2021 Sep 6 doi: 10.1111/1346-8138.16140. PMID: 34487569
Glucagonoma syndrome: a review and update on treatment.
John AM, Schwartz RA
J Eur Acad Dermatol Venereol 2016 Dec;30(12):2016-2022. Epub 2016 Jul 16 doi: 10.1111/jdv.13752. PMID: 27422767
Pellagra and pellagralike dermatoses: etiology, differential diagnosis, dermatopathology, and treatment.
Hendricks WM
Semin Dermatol 1991 Dec;10(4):282-92. PMID: 1764355

Recent clinical studies

Etiology

Third reported case of rare necrolytic migratory erythema associated with bacteraemia due to severe zinc deficiency after revisional Roux-En-Y gastric bypass: case report and literature review.
Salaheldin Y, El Ansari W, Aljaloudi E, Elhag W
Eat Weight Disord 2022 Apr;27(3):1235-1241. Epub 2021 Jun 1 doi: 10.1007/s40519-021-01154-z. PMID: 34061321Free PMC Article
Cutaneous paraneoplastic syndromes.
Wick MR, Patterson JW
Semin Diagn Pathol 2019 Jul;36(4):211-228. Epub 2019 Jan 31 doi: 10.1053/j.semdp.2019.01.001. PMID: 30736994
A review of cutaneous manifestations within glucagonoma syndrome: necrolytic migratory erythema.
Tolliver S, Graham J, Kaffenberger BH
Int J Dermatol 2018 Jun;57(6):642-645. Epub 2018 Feb 16 doi: 10.1111/ijd.13947. PMID: 29450880
Necrolytic acral erythema.
Patel U, Loyd A, Patel R, Meehan S, Kundu R
Dermatol Online J 2010 Nov 15;16(11):15. PMID: 21163166
Necrolytic acral erythema: a variant of necrolytic migratory erythema or a distinct entity?
Nofal AA, Nofal E, Attwa E, El-Assar O, Assaf M
Int J Dermatol 2005 Nov;44(11):916-21. doi: 10.1111/j.1365-4632.2004.02232.x. PMID: 16336523

Diagnosis

Skin manifestations of pancreatic diseases.
Kunovsky L, Dite P, Brezinova E, Sedlakova L, Trna J, Jabandziev P
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2022 Dec;166(4):353-358. Epub 2022 Jul 22 doi: 10.5507/bp.2022.035. PMID: 35938387
Necrolytic migratory erythema and pancreatic glucagonoma.
Rodríguez G, Vargas E, Abaúnza C, Cáceres S
Biomedica 2016 Jun 3;36(2):176-81. doi: 10.7705/biomedica.v36i3.2723. PMID: 27622478
Intertriginous eruption.
Wolf R, Oumeish OY, Parish LC
Clin Dermatol 2011 Mar-Apr;29(2):173-9. doi: 10.1016/j.clindermatol.2010.09.009. PMID: 21396557
Rare syndromes.
Jabbour SA, Davidovici BB, Wolf R
Clin Dermatol 2006 Jul-Aug;24(4):299-316. doi: 10.1016/j.clindermatol.2006.04.005. PMID: 16828412
Necrolytic migratory erythema.
Kovács RK, Korom I, Dobozy A, Farkas G, Ormos J, Kemény L
J Cutan Pathol 2006 Mar;33(3):242-5. doi: 10.1111/j.0303-6987.2006.00408.x. PMID: 16466513

Therapy

A review of cutaneous manifestations within glucagonoma syndrome: necrolytic migratory erythema.
Tolliver S, Graham J, Kaffenberger BH
Int J Dermatol 2018 Jun;57(6):642-645. Epub 2018 Feb 16 doi: 10.1111/ijd.13947. PMID: 29450880
Necrolytic acral erythema.
Patel U, Loyd A, Patel R, Meehan S, Kundu R
Dermatol Online J 2010 Nov 15;16(11):15. PMID: 21163166
Necrolytic acral erythema: a review of the literature.
Geria AN, Holcomb KZ, Scheinfeld NS
Cutis 2009 Jun;83(6):309-14. PMID: 19681342
Necrolytic migratory erythema: case report and clinical review.
Adam DN, Cohen PD, Ghazarian D
J Cutan Med Surg 2003 Jul-Aug;7(4):333-8. doi: 10.1007/s10227-002-0127-0. PMID: 14738101
Iatrogenic necrolytic migratory erythema: a case report and review of nonglucagonoma-associated necrolytic migratory erythema.
Mullans EA, Cohen PR
J Am Acad Dermatol 1998 May;38(5 Pt 2):866-73. doi: 10.1016/s0190-9622(98)70478-5. PMID: 9591806

Prognosis

A review of cutaneous manifestations within glucagonoma syndrome: necrolytic migratory erythema.
Tolliver S, Graham J, Kaffenberger BH
Int J Dermatol 2018 Jun;57(6):642-645. Epub 2018 Feb 16 doi: 10.1111/ijd.13947. PMID: 29450880
Current knowledge in inflammatory dermatopathology.
Fung MA, Barr KL
Dermatol Clin 2012 Oct;30(4):667-84, vii. Epub 2012 Jul 28 doi: 10.1016/j.det.2012.06.004. PMID: 23021053
Is necrolytic migratory erythema due to glucagonoma a misnomer? A more apt name might be mucosal and intertriginous erosive dermatitis.
Grewal P, Salopek TG
J Cutan Med Surg 2012 Mar-Apr;16(2):76-82. doi: 10.2310/7750.2011.10134. PMID: 22513058
Necrolytic acral erythema: a variant of necrolytic migratory erythema or a distinct entity?
Nofal AA, Nofal E, Attwa E, El-Assar O, Assaf M
Int J Dermatol 2005 Nov;44(11):916-21. doi: 10.1111/j.1365-4632.2004.02232.x. PMID: 16336523
Necrolytic migratory erythema: case report and clinical review.
Adam DN, Cohen PD, Ghazarian D
J Cutan Med Surg 2003 Jul-Aug;7(4):333-8. doi: 10.1007/s10227-002-0127-0. PMID: 14738101

Clinical prediction guides

Autophagy in malnutrition-associated dermatoses.
Hirai Y, Miyake T, Hamada T, Yamasaki O, Morizane S, Mori T, Iwatsuki K
J Dermatol 2019 Jan;46(1):43-47. Epub 2018 Oct 31 doi: 10.1111/1346-8138.14694. PMID: 30379352
Intertriginous eruption.
Wolf R, Oumeish OY, Parish LC
Clin Dermatol 2011 Mar-Apr;29(2):173-9. doi: 10.1016/j.clindermatol.2010.09.009. PMID: 21396557
Necrolytic migratory erythema.
Kovács RK, Korom I, Dobozy A, Farkas G, Ormos J, Kemény L
J Cutan Pathol 2006 Mar;33(3):242-5. doi: 10.1111/j.0303-6987.2006.00408.x. PMID: 16466513
Etiology and pathogenesis of necrolytic migratory erythema: review of the literature.
Tierney EP, Badger J
MedGenMed 2004 Sep 10;6(3):4. PMID: 15520626Free PMC Article
Iatrogenic necrolytic migratory erythema: a case report and review of nonglucagonoma-associated necrolytic migratory erythema.
Mullans EA, Cohen PR
J Am Acad Dermatol 1998 May;38(5 Pt 2):866-73. doi: 10.1016/s0190-9622(98)70478-5. PMID: 9591806

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