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Yellow nail syndrome(YNS)

MedGen UID:
113164
•Concept ID:
C0221348
•
Disease or Syndrome
Synonyms: LYMPHEDEMA AND YELLOW NAILS; Lymphedema with yellow nails; YNS
SNOMED CT: Hereditary lymphedema and yellow nails (400211001); Yellow nail syndrome (400211001)
 
Monarch Initiative: MONDO:0007921
OMIM®: 153300
Orphanet: ORPHA662

Definition

Yellow nail syndrome (YNS) is classically considered to comprise a clinical triad of yellow nails, lymphedema, and respiratory tract involvement. Two of these symptoms are required for the diagnosis, since the complete triad is only observed in about one-third of patients. Onset is usually after puberty (Hoque et al., 2007). [from OMIM]

Clinical features

From HPO
Hypoplasia of lymphatic vessels
MedGen UID:
871105
•Concept ID:
C4025570
•
Congenital Abnormality
Congenital underdevelopment of lymph vessels.
See: Feature record | Search on this feature
Lymphedema
MedGen UID:
6155
•Concept ID:
C0024236
•
Disease or Syndrome
Localized fluid retention and tissue swelling caused by a compromised lymphatic system.
See: Feature record | Search on this feature
Predominantly lower limb lymphedema
MedGen UID:
320552
•Concept ID:
C1835228
•
Finding
Localized fluid retention and tissue swelling caused by a compromised lymphatic system, affecting mainly the legs.
See: Feature record | Search on this feature
Yellow nails
MedGen UID:
369197
•Concept ID:
C1768507
•
Sign or Symptom
Yellowish discoloration of the nails.
See: Feature record | Search on this feature
Slow-growing nails
MedGen UID:
331935
•Concept ID:
C1835238
•
Finding
Nails whose growth is slower than normal.
See: Feature record | Search on this feature
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Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVYellow nail syndrome
Follow this link to review classifications for Yellow nail syndrome in Orphanet.

Professional guidelines

PubMed

Yellow Nail Syndrome: Analysis of 23 Consecutive Patients and Effect of Combined Fluconazole-Vitamin-E Treatment.
Benassaia E, Abba S, Fourgeaud C, Mihoubi A, Vignes S
Dermatology 2024;240(2):343-351. Epub 2023 Dec 9 doi: 10.1159/000535577. PMID: 38071959
Classification of vascular disorders in the skin and selected data on new evaluation and treatment.
Wollina U, Unger L, Haroske G, Heinig B
Dermatol Ther 2012 Jul-Aug;25(4):287-96. doi: 10.1111/j.1529-8019.2012.01514.x. PMID: 22950555
Diagnosis and treatment of cutaneous paraneoplastic disorders.
Abreu Velez AM, Howard MS
Dermatol Ther 2010 Nov-Dec;23(6):662-75. doi: 10.1111/j.1529-8019.2010.01371.x. PMID: 21054710

Recent clinical studies

Etiology

Sinonasal mucosal vasculature in yellow nail syndrome and chronic rhinosinusitis with or without polyps.
Chatzopoulos K, Gutierrez CN, Garcia JJ, Stokken JK, Choby G, O'Brien EK
Int Forum Allergy Rhinol 2020 Jan;10(1):128-132. Epub 2019 Oct 7 doi: 10.1002/alr.22446. PMID: 31589812
The color of skin: yellow diseases of the skin, nails, and mucosa.
Logan IT, Logan RA
Clin Dermatol 2019 Sep-Oct;37(5):580-590. Epub 2019 Jul 20 doi: 10.1016/j.clindermatol.2019.07.019. PMID: 31896411
Nonmalignant Adult Thoracic Lymphatic Disorders.
Itkin M, McCormack FX
Clin Chest Med 2016 Sep;37(3):409-20. doi: 10.1016/j.ccm.2016.04.004. PMID: 27514588
Yellow nail syndrome.
Dhillon SS
Am J Respir Crit Care Med 2012 Sep 15;186(6):e10. doi: 10.1164/rccm.201109-1750IM. PMID: 22984032
Yellow nail syndrome: not a genetic disorder? Eleven new cases and a review of the literature.
Hoque SR, Mansour S, Mortimer PS
Br J Dermatol 2007 Jun;156(6):1230-4. Epub 2007 Apr 25 doi: 10.1111/j.1365-2133.2007.07894.x. PMID: 17459037

Diagnosis

Chylothorax and Pseudochylothorax.
Braun CM, Ryu JH
Clin Chest Med 2021 Dec;42(4):667-675. doi: 10.1016/j.ccm.2021.08.003. PMID: 34774173
Yellow nail syndrome.
Sil A, Chandra A, Banik B, Biswas SK, Chakraborty U
J R Coll Physicians Edinb 2021 Jun;51(2):166-167. doi: 10.4997/JRCPE.2021.217. PMID: 34131678
Orphan Lung Diseases.
Ali MS, Ghori UK, Musani AI
Med Clin North Am 2019 May;103(3):503-515. doi: 10.1016/j.mcna.2018.12.009. PMID: 30955517
Yellow Nail Syndrome.
Lübbert C, Kunz M
Dtsch Arztebl Int 2017 Dec 15;114(50):874. doi: 10.3238/arztebl.2017.0874b. PMID: 29271348Free PMC Article
Yellow nail syndrome: a review.
Vignes S, Baran R
Orphanet J Rare Dis 2017 Feb 27;12(1):42. doi: 10.1186/s13023-017-0594-4. PMID: 28241848Free PMC Article

Therapy

Yellow Nail Syndrome: Analysis of 23 Consecutive Patients and Effect of Combined Fluconazole-Vitamin-E Treatment.
Benassaia E, Abba S, Fourgeaud C, Mihoubi A, Vignes S
Dermatology 2024;240(2):343-351. Epub 2023 Dec 9 doi: 10.1159/000535577. PMID: 38071959
Bronchiectasis in yellow nail syndrome.
Woodfield G, Nisbet M, Jacob J, Mok W, Loebinger MR, Hansell DM, Wells AU, Wilson R
Respirology 2017 Jan;22(1):101-107. Epub 2016 Aug 23 doi: 10.1111/resp.12866. PMID: 27551950
Yellow nail syndrome: a case report and review of treatment options.
Kurin M, Wiesen J, Mehta AC
Clin Respir J 2017 Jul;11(4):405-410. Epub 2015 Sep 24 doi: 10.1111/crj.12354. PMID: 26257383
Yellow nail syndrome.
Dhillon SS
Am J Respir Crit Care Med 2012 Sep 15;186(6):e10. doi: 10.1164/rccm.201109-1750IM. PMID: 22984032
Yellow nail syndrome.
Maldonado F, Ryu JH
Curr Opin Pulm Med 2009 Jul;15(4):371-5. doi: 10.1097/MCP.0b013e32832ad45a. PMID: 19373089

Prognosis

Yellow Nail Syndrome: A Case Presentation and a Review of Management Options.
Abdalla A, Jamous F
S D Med 2021 Aug;74(8):368-371. PMID: 34461002
Orphan Lung Diseases.
Ali MS, Ghori UK, Musani AI
Med Clin North Am 2019 May;103(3):503-515. doi: 10.1016/j.mcna.2018.12.009. PMID: 30955517
Yellow nail syndrome: a case report and review of treatment options.
Kurin M, Wiesen J, Mehta AC
Clin Respir J 2017 Jul;11(4):405-410. Epub 2015 Sep 24 doi: 10.1111/crj.12354. PMID: 26257383
Yellow nail syndrome.
Dhillon SS
Am J Respir Crit Care Med 2012 Sep 15;186(6):e10. doi: 10.1164/rccm.201109-1750IM. PMID: 22984032
Yellow nail syndrome.
Maldonado F, Ryu JH
Curr Opin Pulm Med 2009 Jul;15(4):371-5. doi: 10.1097/MCP.0b013e32832ad45a. PMID: 19373089

Clinical prediction guides

Yellow nail syndrome: a genetic Disorder?
Abid N, Loukil M, Mahmoud N, Badri I, Bouzaidi K, Ghrairi H
Tunis Med 2021 Avril;99(4):475-477. PMID: 35244933Free PMC Article
Effectiveness of clarithromycin in patients with yellow nail syndrome.
Matsubayashi S, Suzuki M, Suzuki T, Shiozawa A, Kobayashi K, Ishii S, Iikura M, Izumi S, Kudo K, Sugiyama H
BMC Pulm Med 2018 Aug 15;18(1):138. doi: 10.1186/s12890-018-0707-4. PMID: 30111321Free PMC Article
Yellow nail syndrome: a review.
Vignes S, Baran R
Orphanet J Rare Dis 2017 Feb 27;12(1):42. doi: 10.1186/s13023-017-0594-4. PMID: 28241848Free PMC Article
Bronchiectasis in yellow nail syndrome.
Woodfield G, Nisbet M, Jacob J, Mok W, Loebinger MR, Hansell DM, Wells AU, Wilson R
Respirology 2017 Jan;22(1):101-107. Epub 2016 Aug 23 doi: 10.1111/resp.12866. PMID: 27551950
Yellow nail syndrome.
DeCoste SD, Imber MJ, Baden HP
J Am Acad Dermatol 1990 Apr;22(4):608-11. doi: 10.1016/0190-9622(90)70081-r. PMID: 2319021

Recent systematic reviews

Characteristics of patients with yellow nail syndrome and pleural effusion.
Valdés L, Huggins JT, Gude F, Ferreiro L, Alvarez-Dobaño JM, Golpe A, Toubes ME, González-Barcala FJ, José ES, Sahn SA
Respirology 2014 Oct;19(7):985-92. Epub 2014 Aug 14 doi: 10.1111/resp.12357. PMID: 25123563

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