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Nontoxic goiter

MedGen UID:
113172
•Concept ID:
C0221777
•
Disease or Syndrome
Synonyms: euthyroid goiter; euthyroid goitre; goiter, non-toxic; Nodule-thyroid, non tox; Non-toxic goiter; non-toxic goiter; non-toxic goitre; Non-toxic simple goiter; non-toxic simple goiter; non-toxic simple goitre; Nontoxic Goiter; nontoxic goiter
SNOMED CT: Non-toxic goiter (267369002); Non-toxic simple goiter (267369002)
 
Monarch Initiative: MONDO:0001658

Definition

Sporadic enlargement of the thyroid gland that is not associated with changes in thyroid function or malignancy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNontoxic goiter

Professional guidelines

PubMed

Evaluation and treatment of sporadic nontoxic goiter--some answers and more questions.
Samuels MH
J Clin Endocrinol Metab 2001 Mar;86(3):994-7. doi: 10.1210/jcem.86.3.7384. PMID: 11238475
Treatment of Graves' disease: the advantages of surgery.
Alsanea O, Clark OH
Endocrinol Metab Clin North Am 2000 Jun;29(2):321-37. doi: 10.1016/s0889-8529(05)70134-1. PMID: 10874532
Management of goiter and thyroid nodules in an area of endemic goiter.
Röher HD, Goretzki PE
Surg Clin North Am 1987 Apr;67(2):233-49. doi: 10.1016/s0039-6109(16)44181-2. PMID: 3551146

Recent clinical studies

Etiology

Tension-free thyroidectomy (TFT): initial report.
Sleptsov I, Chernikov R, Pushkaruk A, Sablin I, Tilloev T, Timofeeva N, Knyazeva P
Updates Surg 2022 Dec;74(6):1953-1960. Epub 2022 Aug 1 doi: 10.1007/s13304-022-01338-x. PMID: 35913529
Increased Cardiovascular Mortality and Morbidity in Patients Treated for Toxic Nodular Goiter Compared to Graves' Disease and Nontoxic Goiter.
Giesecke P, Rosenqvist M, Frykman V, Friberg L, Wallin G, Höijer J, Lönn S, Törring O
Thyroid 2017 Jul;27(7):878-885. Epub 2017 Jun 5 doi: 10.1089/thy.2017.0029. PMID: 28471268
A clinical and therapeutic approach to thyrotoxicosis with thyroid-stimulating hormone suppression only.
Papi G, Pearce EN, Braverman LE, Betterle C, Roti E
Am J Med 2005 Apr;118(4):349-61. doi: 10.1016/j.amjmed.2005.01.004. PMID: 15808130
Treatment of Graves' disease: the advantages of surgery.
Alsanea O, Clark OH
Endocrinol Metab Clin North Am 2000 Jun;29(2):321-37. doi: 10.1016/s0889-8529(05)70134-1. PMID: 10874532
Radioiodine for nontoxic multinodular goiter.
Huysmans D, Hermus A, Edelbroek M, Barentsz J, Corstens F, Kloppenborg P
Thyroid 1997 Apr;7(2):235-9. doi: 10.1089/thy.1997.7.235. PMID: 9133693

Diagnosis

A clinical and therapeutic approach to thyrotoxicosis with thyroid-stimulating hormone suppression only.
Papi G, Pearce EN, Braverman LE, Betterle C, Roti E
Am J Med 2005 Apr;118(4):349-61. doi: 10.1016/j.amjmed.2005.01.004. PMID: 15808130
Treatment of Graves' disease: the advantages of surgery.
Alsanea O, Clark OH
Endocrinol Metab Clin North Am 2000 Jun;29(2):321-37. doi: 10.1016/s0889-8529(05)70134-1. PMID: 10874532
Thyroidopathies.
Koutras DA
Ann N Y Acad Sci 2000;900:77-88. doi: 10.1111/j.1749-6632.2000.tb06218.x. PMID: 10818394
Management of goiter and thyroid nodules in an area of endemic goiter.
Röher HD, Goretzki PE
Surg Clin North Am 1987 Apr;67(2):233-49. doi: 10.1016/s0039-6109(16)44181-2. PMID: 3551146
Nontoxic goiter-diffuse or nodular.
Maloof F, Wang CA, Vickery AL Jr
Med Clin North Am 1975 Sep;59(5):1221-32. doi: 10.1016/s0025-7125(16)31970-8. PMID: 1174255

Therapy

Tension-free thyroidectomy (TFT): initial report.
Sleptsov I, Chernikov R, Pushkaruk A, Sablin I, Tilloev T, Timofeeva N, Knyazeva P
Updates Surg 2022 Dec;74(6):1953-1960. Epub 2022 Aug 1 doi: 10.1007/s13304-022-01338-x. PMID: 35913529
Treatment of Graves' disease: the advantages of surgery.
Alsanea O, Clark OH
Endocrinol Metab Clin North Am 2000 Jun;29(2):321-37. doi: 10.1016/s0889-8529(05)70134-1. PMID: 10874532
Radioiodine for nontoxic multinodular goiter.
Huysmans D, Hermus A, Edelbroek M, Barentsz J, Corstens F, Kloppenborg P
Thyroid 1997 Apr;7(2):235-9. doi: 10.1089/thy.1997.7.235. PMID: 9133693
Thyroid hormone suppressive therapy of sporadic nontoxic goiter.
Ross DS
Thyroid 1992 Fall;2(3):263-9. doi: 10.1089/thy.1992.2.263. PMID: 1422239
Suppressive therapy of nontoxic goiter.
Shimaoka K, Sokal JE
Am J Med 1974 Oct;57(4):576-83. doi: 10.1016/0002-9343(74)90009-6. PMID: 4432862

Prognosis

Association between various thyroid gland diseases, TSH values and thyroid cancer: a case-control study.
Schiffmann L, Kostev K, Kalder M
J Cancer Res Clin Oncol 2020 Nov;146(11):2989-2994. Epub 2020 Jun 9 doi: 10.1007/s00432-020-03283-x. PMID: 32518973
Elevated serum concentrations of IGF-1 and IGF-1R in patients with thyroid cancers.
Lawnicka H, Motylewska E, Borkowska M, Kuzdak K, Siejka A, Swietoslawski J, Stepien H, Stepien T
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2020 Mar;164(1):77-83. Epub 2019 May 23 doi: 10.5507/bp.2019.018. PMID: 31132076
Increased Cardiovascular Mortality and Morbidity in Patients Treated for Toxic Nodular Goiter Compared to Graves' Disease and Nontoxic Goiter.
Giesecke P, Rosenqvist M, Frykman V, Friberg L, Wallin G, Höijer J, Lönn S, Törring O
Thyroid 2017 Jul;27(7):878-885. Epub 2017 Jun 5 doi: 10.1089/thy.2017.0029. PMID: 28471268
Incidental thyroid cancer in toxic and nontoxic goiter: Is TSH associated with malignanCy rate? Results of a meta-analysis.
Negro R, Valcavi R, Toulis KA
Endocr Pract 2013 Mar-Apr;19(2):212-8. doi: 10.4158/EP12234.OR. PMID: 23186976
Does unilateral lobectomy suffice to manage unilateral nontoxic goiter?
Yetkin G, Uludag M, Onceken O, Citgez B, Isgor A, Akgun I
Endocr Pract 2010 Jan-Feb;16(1):36-41. doi: 10.4158/EP09140.OR. PMID: 19703811

Clinical prediction guides

Tension-free thyroidectomy (TFT): initial report.
Sleptsov I, Chernikov R, Pushkaruk A, Sablin I, Tilloev T, Timofeeva N, Knyazeva P
Updates Surg 2022 Dec;74(6):1953-1960. Epub 2022 Aug 1 doi: 10.1007/s13304-022-01338-x. PMID: 35913529
The Influence of Diffuse Nontoxic Goiter on the State of Protective Mechanisms of the Oral Cavity in Children.
Godovantes OI, Kitsak TS, Vitkovsky OO, Kuzniak LV, Godovantes OS, Chaikovska NM, Fedoniuk LY
J Med Life 2020 Jan-Mar;13(1):21-25. doi: 10.25122/jml-2020-0013. PMID: 32341696Free PMC Article
Increased Cardiovascular Mortality and Morbidity in Patients Treated for Toxic Nodular Goiter Compared to Graves' Disease and Nontoxic Goiter.
Giesecke P, Rosenqvist M, Frykman V, Friberg L, Wallin G, Höijer J, Lönn S, Törring O
Thyroid 2017 Jul;27(7):878-885. Epub 2017 Jun 5 doi: 10.1089/thy.2017.0029. PMID: 28471268
Thyroid autoimmunity and thyroid autonomy.
Vitti P, Mariotti S, Marcocci C, Chiovato L, Giachetti M, Fenzi G, Pinchera A
Acta Med Austriaca 1990;17 Suppl 1:90-2. PMID: 2202187
Clinical, laboratory and immunologic effects of the treatment of endemic goiter with T4, T3 and KI.
Koutras DA, Piperingos GD, Pallas D, Katsouyanni K, Karaiskos KS, Marafelia P, Makriyannis D, Kitsopanides J, Sfontouris J, Mantzos J
Thyroidology 1990 Aug;2(2):81-8. PMID: 1724914

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