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Seminoma

MedGen UID:
11371
Concept ID:
C0036631
Neoplastic Process
Synonym: Seminomas
SNOMED CT: Seminoma (443675005); Malignant seminoma (1162765005)
 
Monarch Initiative: MONDO:0003001
OMIM®: 273300

Definition

A radiosensitive malignant germ cell tumor found in the testis (especially undescended), and extragonadal sites (anterior mediastinum and pineal gland). It is characterized by the presence of uniform cells with clear or dense cytoplasm which contains glycogen, and by a large nucleus which contains one or more nucleoli. The neoplastic germ cells form aggregates separated by fibrous septa. The fibrous septa contain chronic inflammatory cells, mainly lymphocytes. [from NCI]

Professional guidelines

PubMed

Alsyouf M, Daneshmand S
World J Urol 2022 Feb;40(2):343-348. Epub 2021 Oct 16 doi: 10.1007/s00345-021-03854-8. PMID: 34655305
Gilligan T, Lin DW, Aggarwal R, Chism D, Cost N, Derweesh IH, Emamekhoo H, Feldman DR, Geynisman DM, Hancock SL, LaGrange C, Levine EG, Longo T, Lowrance W, McGregor B, Monk P, Picus J, Pierorazio P, Rais-Bahrami S, Saylor P, Sircar K, Smith DC, Tzou K, Vaena D, Vaughn D, Yamoah K, Yamzon J, Johnson-Chilla A, Keller J, Pluchino LA
J Natl Compr Canc Netw 2019 Dec;17(12):1529-1554. doi: 10.6004/jnccn.2019.0058. PMID: 31805523
Smith ZL, Werntz RP, Eggener SE
Med Clin North Am 2018 Mar;102(2):251-264. Epub 2017 Dec 21 doi: 10.1016/j.mcna.2017.10.003. PMID: 29406056

Recent clinical studies

Etiology

Koši Kunac A, Gnjidić M, Antunac Golubić Z, Gamulin M
Acta Clin Croat 2020 Sep;59(3):496-504. doi: 10.20471/acc.2020.59.03.14. PMID: 34177060Free PMC Article
Marko J, Wolfman DJ, Aubin AL, Sesterhenn IA
Radiographics 2017 Jul-Aug;37(4):1085-1098. Epub 2017 Jun 2 doi: 10.1148/rg.2017160164. PMID: 28574809Free PMC Article
Motzer RJ, Jonasch E, Agarwal N, Beard C, Bhayani S, Bolger GB, Chang SS, Choueiri TK, Costello BA, Derweesh IH, Gupta S, Hancock SL, Kim JJ, Kuzel TM, Lam ET, Lau C, Levine EG, Lin DW, Michaelson MD, Olencki T, Pili R, Plimack ER, Rampersaud EN, Redman BG, Ryan CJ, Sheinfeld J, Shuch B, Sircar K, Somer B, Wilder RB, Dwyer M, Kumar R
J Natl Compr Canc Netw 2015 Jun;13(6):772-99. doi: 10.6004/jnccn.2015.0092. PMID: 26085393
Hindley RG, Chandra A, Saunders A, O'Brien TS
BJU Int 2003 Oct;92(6):572-4. doi: 10.1046/j.1464-410x.2003.04432.x. PMID: 14511036
Aygun C, Slawson RG, Bajaj K, Salazar OM
Urology 1984 Feb;23(2):109-17. PMID: 6364524

Diagnosis

Marko J, Wolfman DJ, Aubin AL, Sesterhenn IA
Radiographics 2017 Jul-Aug;37(4):1085-1098. Epub 2017 Jun 2 doi: 10.1148/rg.2017160164. PMID: 28574809Free PMC Article
Aggarwal N, Parwani AV
Arch Pathol Lab Med 2009 Dec;133(12):1985-8. doi: 10.5858/133.12.1985. PMID: 19961257
Hindley RG, Chandra A, Saunders A, O'Brien TS
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Eble JN
Hum Pathol 1994 Oct;25(10):1035-42. doi: 10.1016/0046-8177(94)90062-0. PMID: 7927308
Shulman Y, Ware S, Al-Askari S, Morales P
Urology 1983 Apr;21(4):379-81. doi: 10.1016/0090-4295(83)90156-5. PMID: 6836826

Therapy

Wood GE, Chamberlain F, Tran B, Conduit C, Liow E, Nicol DL, Shamash J, Alifrangis C, Rajan P
Nat Rev Urol 2023 Aug;20(8):502-512. Epub 2023 Mar 7 doi: 10.1038/s41585-023-00727-0. PMID: 36882564
Alsyouf M, Daneshmand S
World J Urol 2022 Feb;40(2):343-348. Epub 2021 Oct 16 doi: 10.1007/s00345-021-03854-8. PMID: 34655305
Chung P, Warde P
BMJ Clin Evid 2011 Jan 25;2011 PMID: 21477387Free PMC Article
Oliver RT
Curr Opin Oncol 1999 May;11(3):236-41. doi: 10.1097/00001622-199905000-00017. PMID: 10328600
Sommer K, Brockmann WP, Hübener KH
Cancer 1990 Jul 15;66(2):259-63. doi: 10.1002/1097-0142(19900715)66:2<259::aid-cncr2820660211>3.0.co;2-o. PMID: 2114939

Prognosis

Sokoloff MH, Joyce GF, Wise M; Urologic Diseases in America Project
J Urol 2007 Jun;177(6):2030-41. doi: 10.1016/j.juro.2007.01.127. PMID: 17509283
Hindley RG, Chandra A, Saunders A, O'Brien TS
BJU Int 2003 Oct;92(6):572-4. doi: 10.1046/j.1464-410x.2003.04432.x. PMID: 14511036
Schulz TF, Boshoff CH, Weiss RA
Lancet 1996 Aug 31;348(9027):587-91. doi: 10.1016/S0140-6736(95)11033-X. PMID: 8774574
Cefaro GA, Luzi S, Turriziani A, Salvi G, Marmiroli L
Br J Urol 1988 Nov;62(5):461-4. doi: 10.1111/j.1464-410x.1988.tb04397.x. PMID: 3061558
Aygun C, Slawson RG, Bajaj K, Salazar OM
Urology 1984 Feb;23(2):109-17. PMID: 6364524

Clinical prediction guides

Lesko P, Chovanec M, Mego M
Nat Rev Urol 2022 Nov;19(11):637-658. Epub 2022 Aug 26 doi: 10.1038/s41585-022-00624-y. PMID: 36028719
von Amsberg G, Hamilton R, Papachristofilou A
Oncol Res Treat 2018;41(6):360-363. Epub 2018 May 16 doi: 10.1159/000489408. PMID: 29763926
Chung P, Warde P
BMJ Clin Evid 2011 Jan 25;2011 PMID: 21477387Free PMC Article
Neal RD, Stuart N, Wilkinson C
BMJ Clin Evid 2007 Feb 1;2007 PMID: 19454048Free PMC Article
MacVicar GR, Pienta KJ
Curr Opin Oncol 2004 May;16(3):253-6. doi: 10.1097/00001622-200405000-00011. PMID: 15069322

Recent systematic reviews

Heinzelbecker J, Schmidt S, Lackner J, Busch J, Bokemeyer C, Classen J, Dieing A, Hakenberg O, Krege S, Papachristofilou A, Pfister D, Ruf C, Schmelz H, Schmidberger H, Souchon R, Winter C, Zengerling F, Kliesch S, Albers P, Oing C
World J Urol 2022 Dec;40(12):2829-2841. Epub 2021 Nov 15 doi: 10.1007/s00345-021-03873-5. PMID: 34779882Free PMC Article
Gurney J, Shaw C, Stanley J, Signal V, Sarfati D
BMC Cancer 2015 Nov 11;15:897. doi: 10.1186/s12885-015-1905-6. PMID: 26560314Free PMC Article
Stang A, Kuss O
Hematol Oncol Clin North Am 2011 Jun;25(3):473-86, vii. Epub 2011 Apr 15 doi: 10.1016/j.hoc.2011.03.003. PMID: 21570603
Chung P, Warde P
BMJ Clin Evid 2011 Jan 25;2011 PMID: 21477387Free PMC Article
Neal RD, Stuart N, Wilkinson C
BMJ Clin Evid 2007 Feb 1;2007 PMID: 19454048Free PMC Article

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