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Sertoli cell tumor

MedGen UID:
11387
Concept ID:
C0036769
Neoplastic Process
Synonyms: Sertoli Cell Tumor; Tumor, Sertoli Cell
SNOMED CT: Sertoli cell adenoma (89089007); Testicular adenoma (89089007); Sertoli cell tumor (89089007); Tubular androblastoma (89089007); Pick tubular adenoma (89089007)
 
Monarch Initiative: MONDO:0002696

Definition

A sex cord-stromal tumor of the testis or the ovary. It is characterized by the presence of Sertoli cells forming tubules. Leydig cells are rare or absent. It may be associated with Peutz-Jeghers syndrome. In males, the presenting symptom is a slow growing testicular mass. Most cases follow a benign clinical course. In females it may present with estrogenic or androgenic manifestations. The vast majority of cases have a benign clinical course. [from NCI]

Professional guidelines

PubMed

Han LM, Weiel JJ, Longacre TA, Folkins AK
Adv Anat Pathol 2022 Sep 1;29(5):297-308. Epub 2022 Jul 1 doi: 10.1097/PAP.0000000000000351. PMID: 35778792
Meserve EE, Nucci MR
Surg Pathol Clin 2016 Jun;9(2):243-68. doi: 10.1016/j.path.2016.01.006. PMID: 27241107
Stratakis CA, Kirschner LS, Carney JA
J Clin Endocrinol Metab 2001 Sep;86(9):4041-6. doi: 10.1210/jcem.86.9.7903. PMID: 11549623

Recent clinical studies

Etiology

Han LM, Weiel JJ, Longacre TA, Folkins AK
Adv Anat Pathol 2022 Sep 1;29(5):297-308. Epub 2022 Jul 1 doi: 10.1097/PAP.0000000000000351. PMID: 35778792
Dupeux M, Maxwell F, Rocher L, Izard V, Guettier C, Ferlicot S
Am J Clin Pathol 2022 Jun 7;157(6):936-941. doi: 10.1093/ajcp/aqab214. PMID: 34935941
Al-Obaidy KI, Idrees MT, Abdulfatah E, Kunju LP, Wu A, Ulbright TM
Am J Surg Pathol 2022 May 1;46(5):688-700. doi: 10.1097/PAS.0000000000001849. PMID: 34913878
Javadi S, Ganeshan DM, Jensen CT, Iyer RB, Bhosale PR
Abdom Radiol (NY) 2021 Apr;46(4):1519-1529. Epub 2021 Mar 16 doi: 10.1007/s00261-021-02998-w. PMID: 33725145
Lakis NS, Lombardo KA, Mangray S, Netto GJ, Salles D, Matoso A
Appl Immunohistochem Mol Morphol 2019 Mar;27(3):203-209. doi: 10.1097/PAI.0000000000000567. PMID: 29084059

Diagnosis

Han LM, Weiel JJ, Longacre TA, Folkins AK
Adv Anat Pathol 2022 Sep 1;29(5):297-308. Epub 2022 Jul 1 doi: 10.1097/PAP.0000000000000351. PMID: 35778792
Dupeux M, Maxwell F, Rocher L, Izard V, Guettier C, Ferlicot S
Am J Clin Pathol 2022 Jun 7;157(6):936-941. doi: 10.1093/ajcp/aqab214. PMID: 34935941
Gheorghisan-Galateanu AA, Carsote M, Terzea D, Valea A, Ghemigian A
J Pak Med Assoc 2020 Jan;70(1):129-133. doi: 10.5455/JPMA.1381. PMID: 31954037
Schuldt M, Retamero JA, Tourné M, Nogales FF
Int J Surg Pathol 2015 Apr;23(2):130-3. Epub 2014 Mar 13 doi: 10.1177/1066896914526779. PMID: 24626167
Peckham MJ, McElwain TJ
Clin Endocrinol Metab 1975 Nov;4(3):665-92. doi: 10.1016/s0300-595x(75)80052-1. PMID: 58746

Therapy

Kağızmanlı GA, Besci Ö, Acinikli KY, Şeker G, Yaşar E, Öztürk Y, Demir K, Böber E, Abacı A
J Pediatr Endocrinol Metab 2022 Dec 16;35(12):1565-1570. Epub 2022 Oct 3 doi: 10.1515/jpem-2022-0368. PMID: 36181314
Lakis NS, Lombardo KA, Mangray S, Netto GJ, Salles D, Matoso A
Appl Immunohistochem Mol Morphol 2019 Mar;27(3):203-209. doi: 10.1097/PAI.0000000000000567. PMID: 29084059
Hofmann M, Schlegel PG, Hippert F, Schmidt P, von-Schweinitz D, Leuschner I, Göbel U, Calaminus G, Schneider DT; MAKEI study group
Pediatr Blood Cancer 2013 Oct;60(10):1651-5. Epub 2013 Jun 3 doi: 10.1002/pbc.24607. PMID: 23733594
Gourgari E, Saloustros E, Stratakis CA
Curr Opin Pediatr 2012 Aug;24(4):518-22. doi: 10.1097/MOP.0b013e328355a279. PMID: 22732638Free PMC Article
Peckham MJ, McElwain TJ
Clin Endocrinol Metab 1975 Nov;4(3):665-92. doi: 10.1016/s0300-595x(75)80052-1. PMID: 58746

Prognosis

Bužinskienė D, Šidlovska E, Vilutytė G
Medicina (Kaunas) 2022 Nov 13;58(11) doi: 10.3390/medicina58111638. PMID: 36422177Free PMC Article
Al-Obaidy KI, Idrees MT, Abdulfatah E, Kunju LP, Wu A, Ulbright TM
Am J Surg Pathol 2022 May 1;46(5):688-700. doi: 10.1097/PAS.0000000000001849. PMID: 34913878
Javadi S, Ganeshan DM, Jensen CT, Iyer RB, Bhosale PR
Abdom Radiol (NY) 2021 Apr;46(4):1519-1529. Epub 2021 Mar 16 doi: 10.1007/s00261-021-02998-w. PMID: 33725145
Hanley KZ, Mosunjac MB
Surg Pathol Clin 2019 Jun;12(2):587-620. doi: 10.1016/j.path.2019.02.005. PMID: 31097116
Brunocilla E, Pultrone CV, Schiavina R, Rocca C, Passaretti G, Corti B, Martorana G
Anticancer Res 2012 Nov;32(11):5127-30. PMID: 23155292

Clinical prediction guides

Anderson WJ, Gordetsky JB, Idrees MT, Al-Obaidy KI, Kao CS, Cornejo KM, Wobker SE, Cheville JC, Vargas SO, Fletcher CDM, Hirsch MS, Acosta AM
Histopathology 2022 Mar;80(4):677-685. Epub 2022 Jan 5 doi: 10.1111/his.14599. PMID: 34780072
Grogg J, Schneider K, Bode PK, Kranzbühler B, Eberli D, Sulser T, Lorch A, Beyer J, Hermanns T, Fankhauser CD
Oncologist 2020 Jul;25(7):585-590. Epub 2020 Feb 11 doi: 10.1634/theoncologist.2019-0692. PMID: 32043680Free PMC Article
Ulbright TM
Arch Pathol Lab Med 2019 Jun;143(6):711-721. Epub 2018 Jun 27 doi: 10.5858/arpa.2017-0478-RA. PMID: 29949388
Mesa H, Gilles S, Datta MW, Murugan P, Larson W, Dachel S, Manivel JC
Hum Pathol 2017 Mar;61:181-189. Epub 2016 Dec 8 doi: 10.1016/j.humpath.2016.11.004. PMID: 27939779
Yan W, Burns KH, Matzuk MM
APMIS 2003 Jan;111(1):174-81; discussion 182-3. doi: 10.1034/j.1600-0463.2003.1110121.x. PMID: 12760377

Recent systematic reviews

Grogg J, Schneider K, Bode PK, Kranzbühler B, Eberli D, Sulser T, Lorch A, Beyer J, Hermanns T, Fankhauser CD
Oncologist 2020 Jul;25(7):585-590. Epub 2020 Feb 11 doi: 10.1634/theoncologist.2019-0692. PMID: 32043680Free PMC Article

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