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Hemorrhagic shock

MedGen UID:
11409
•Concept ID:
C0036982
•
Pathologic Function
Synonyms: Hemorrhagic Shock; Shock, Hemorrhagic
SNOMED CT: Hemorrhagic shock (355001)

Definition

Hypoperfusion of body tissues due to acute blood loss, resulting in cellular injury and vital organ dysfunction. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHemorrhagic shock

Professional guidelines

PubMed

Evaluation and Treatment of Massive Hemoptysis.
Prey B, Francis A, Williams J, Krishnadasan B
Surg Clin North Am 2022 Jun;102(3):465-481. doi: 10.1016/j.suc.2021.11.002. PMID: 35671767
Consensus Recommendations for RBC Transfusion Practice in Critically Ill Children From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative.
Valentine SL, Bembea MM, Muszynski JA, Cholette JM, Doctor A, Spinella PC, Steiner ME, Tucci M, Hassan NE, Parker RI, Lacroix J, Argent A, Carson JL, Remy KE, Demaret P, Emeriaud G, Kneyber MCJ, Guzzetta N, Hall MW, Macrae D, Karam O, Russell RT, Stricker PA, Vogel AM, Tasker RC, Turgeon AF, Schwartz SM, Willems A, Josephson CD, Luban NLC, Lehmann LE, Stanworth SJ, Zantek ND, Bunchman TE, Cheifetz IM, Fortenberry JD, Delaney M, van de Watering L, Robinson KA, Malone S, Steffen KM, Bateman ST; Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI); Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network
Pediatr Crit Care Med 2018 Sep;19(9):884-898. doi: 10.1097/PCC.0000000000001613. PMID: 30180125Free PMC Article
The Diagnosis and Treatment of Ectopic Pregnancy.
Taran FA, Kagan KO, Hübner M, Hoopmann M, Wallwiener D, Brucker S
Dtsch Arztebl Int 2015 Oct 9;112(41):693-703; quiz 704-5. doi: 10.3238/arztebl.2015.0693. PMID: 26554319Free PMC Article

Recent clinical studies

Etiology

Trauma-induced hypocalcemia.
DeBot M, Sauaia A, Schaid T, Moore EE
Transfusion 2022 Aug;62 Suppl 1:S274-S280. Epub 2022 Jun 24 doi: 10.1111/trf.16959. PMID: 35748689
Association of Prehospital Plasma Transfusion With Survival in Trauma Patients With Hemorrhagic Shock When Transport Times Are Longer Than 20 Minutes: A Post Hoc Analysis of the PAMPer and COMBAT Clinical Trials.
Pusateri AE, Moore EE, Moore HB, Le TD, Guyette FX, Chapman MP, Sauaia A, Ghasabyan A, Chandler J, McVaney K, Brown JB, Daley BJ, Miller RS, Harbrecht BG, Claridge JA, Phelan HA, Witham WR, Putnam AT, Sperry JL
JAMA Surg 2020 Feb 1;155(2):e195085. Epub 2020 Feb 19 doi: 10.1001/jamasurg.2019.5085. PMID: 31851290Free PMC Article
Risks and benefits of hypotensive resuscitation in patients with traumatic hemorrhagic shock: a meta-analysis.
Owattanapanich N, Chittawatanarat K, Benyakorn T, Sirikun J
Scand J Trauma Resusc Emerg Med 2018 Dec 17;26(1):107. doi: 10.1186/s13049-018-0572-4. PMID: 30558650Free PMC Article
Complications of massive transfusion.
Sihler KC, Napolitano LM
Chest 2010 Jan;137(1):209-20. doi: 10.1378/chest.09-0252. PMID: 20051407
Clinical review: hemorrhagic shock.
Gutierrez G, Reines HD, Wulf-Gutierrez ME
Crit Care 2004 Oct;8(5):373-81. Epub 2004 Apr 2 doi: 10.1186/cc2851. PMID: 15469601Free PMC Article

Diagnosis

Bleeding, Hemorrhagic Shock, and the Global Blood Supply.
Faria I, Thivalapill N, Makin J, Puyana JC, Raykar N
Crit Care Clin 2022 Oct;38(4):775-793. doi: 10.1016/j.ccc.2022.06.013. PMID: 36162910
Evaluation and Treatment of Massive Hemoptysis.
Prey B, Francis A, Williams J, Krishnadasan B
Surg Clin North Am 2022 Jun;102(3):465-481. doi: 10.1016/j.suc.2021.11.002. PMID: 35671767
Hemorrhagic Shock.
Cannon JW
N Engl J Med 2018 Jan 25;378(4):370-379. doi: 10.1056/NEJMra1705649. PMID: 29365303
Prediction of Massive Transfusion in Trauma.
Cantle PM, Cotton BA
Crit Care Clin 2017 Jan;33(1):71-84. doi: 10.1016/j.ccc.2016.08.002. PMID: 27894500
Optimal Fluid Therapy for Traumatic Hemorrhagic Shock.
Chang R, Holcomb JB
Crit Care Clin 2017 Jan;33(1):15-36. doi: 10.1016/j.ccc.2016.08.007. PMID: 27894494Free PMC Article

Therapy

Risks and benefits of hypotensive resuscitation in patients with traumatic hemorrhagic shock: a meta-analysis.
Owattanapanich N, Chittawatanarat K, Benyakorn T, Sirikun J
Scand J Trauma Resusc Emerg Med 2018 Dec 17;26(1):107. doi: 10.1186/s13049-018-0572-4. PMID: 30558650Free PMC Article
Resuscitation for Hypovolemic Shock.
Kalkwarf KJ, Cotton BA
Surg Clin North Am 2017 Dec;97(6):1307-1321. doi: 10.1016/j.suc.2017.07.011. PMID: 29132511
Balanced Resuscitation in Trauma Management.
Cantle PM, Cotton BA
Surg Clin North Am 2017 Oct;97(5):999-1014. Epub 2017 Aug 17 doi: 10.1016/j.suc.2017.06.002. PMID: 28958369
Optimal Fluid Therapy for Traumatic Hemorrhagic Shock.
Chang R, Holcomb JB
Crit Care Clin 2017 Jan;33(1):15-36. doi: 10.1016/j.ccc.2016.08.007. PMID: 27894494Free PMC Article
Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial.
Holcomb JB, Tilley BC, Baraniuk S, Fox EE, Wade CE, Podbielski JM, del Junco DJ, Brasel KJ, Bulger EM, Callcut RA, Cohen MJ, Cotton BA, Fabian TC, Inaba K, Kerby JD, Muskat P, O'Keeffe T, Rizoli S, Robinson BR, Scalea TM, Schreiber MA, Stein DM, Weinberg JA, Callum JL, Hess JR, Matijevic N, Miller CN, Pittet JF, Hoyt DB, Pearson GD, Leroux B, van Belle G; PROPPR Study Group
JAMA 2015 Feb 3;313(5):471-82. doi: 10.1001/jama.2015.12. PMID: 25647203Free PMC Article

Prognosis

Risk Factors for Neonatal/Maternal Morbidity and Mortality in African American Women with Placental Abruption.
Elkafrawi D, Sisti G, Araji S, Khoury A, Miller J, Rodriguez Echevarria B
Medicina (Kaunas) 2020 Apr 13;56(4) doi: 10.3390/medicina56040174. PMID: 32295061Free PMC Article
Association of Prehospital Plasma Transfusion With Survival in Trauma Patients With Hemorrhagic Shock When Transport Times Are Longer Than 20 Minutes: A Post Hoc Analysis of the PAMPer and COMBAT Clinical Trials.
Pusateri AE, Moore EE, Moore HB, Le TD, Guyette FX, Chapman MP, Sauaia A, Ghasabyan A, Chandler J, McVaney K, Brown JB, Daley BJ, Miller RS, Harbrecht BG, Claridge JA, Phelan HA, Witham WR, Putnam AT, Sperry JL
JAMA Surg 2020 Feb 1;155(2):e195085. Epub 2020 Feb 19 doi: 10.1001/jamasurg.2019.5085. PMID: 31851290Free PMC Article
Military Application of Tranexamic Acid in Trauma Emergency Resuscitation (MATTERs) Study.
Morrison JJ, Dubose JJ, Rasmussen TE, Midwinter MJ
Arch Surg 2012 Feb;147(2):113-9. Epub 2011 Oct 17 doi: 10.1001/archsurg.2011.287. PMID: 22006852
Complications of massive transfusion.
Sihler KC, Napolitano LM
Chest 2010 Jan;137(1):209-20. doi: 10.1378/chest.09-0252. PMID: 20051407
Massive obstetric haemorrhage.
Bonnar J
Baillieres Best Pract Res Clin Obstet Gynaecol 2000 Feb;14(1):1-18. doi: 10.1053/beog.1999.0060. PMID: 10789257

Clinical prediction guides

Risks and benefits of hypotensive resuscitation in patients with traumatic hemorrhagic shock: a meta-analysis.
Owattanapanich N, Chittawatanarat K, Benyakorn T, Sirikun J
Scand J Trauma Resusc Emerg Med 2018 Dec 17;26(1):107. doi: 10.1186/s13049-018-0572-4. PMID: 30558650Free PMC Article
Prediction of Massive Transfusion in Trauma.
Cantle PM, Cotton BA
Crit Care Clin 2017 Jan;33(1):71-84. doi: 10.1016/j.ccc.2016.08.002. PMID: 27894500
Optimal Fluid Therapy for Traumatic Hemorrhagic Shock.
Chang R, Holcomb JB
Crit Care Clin 2017 Jan;33(1):15-36. doi: 10.1016/j.ccc.2016.08.007. PMID: 27894494Free PMC Article
Hypoalbuminemia.
Gatta A, Verardo A, Bolognesi M
Intern Emerg Med 2012 Oct;7 Suppl 3:S193-9. doi: 10.1007/s11739-012-0802-0. PMID: 23073857
Complications of massive transfusion.
Sihler KC, Napolitano LM
Chest 2010 Jan;137(1):209-20. doi: 10.1378/chest.09-0252. PMID: 20051407

Recent systematic reviews

Resuscitative endovascular balloon occlusion of the aorta (REBOA) in patients with major trauma and uncontrolled haemorrhagic shock: a systematic review with meta-analysis.
Castellini G, Gianola S, Biffi A, Porcu G, Fabbri A, Ruggieri MP, Coniglio C, Napoletano A, Coclite D, D'Angelo D, Fauci AJ, Iacorossi L, Latina R, Salomone K, Gupta S, Iannone P, Chiara O; Italian National Institute of Health guideline working group on Major Trauma
World J Emerg Surg 2021 Aug 12;16(1):41. doi: 10.1186/s13017-021-00386-9. PMID: 34384452Free PMC Article
Risks and benefits of hypotensive resuscitation in patients with traumatic hemorrhagic shock: a meta-analysis.
Owattanapanich N, Chittawatanarat K, Benyakorn T, Sirikun J
Scand J Trauma Resusc Emerg Med 2018 Dec 17;26(1):107. doi: 10.1186/s13049-018-0572-4. PMID: 30558650Free PMC Article
Fluid therapy and shock: an integrative literature review.
Silva J, Gonçalves L, Sousa PP
Br J Nurs 2018 Apr 26;27(8):449-454. doi: 10.12968/bjon.2018.27.8.449. PMID: 29683753
Permissive hypotension versus conventional resuscitation strategies in adult trauma patients with hemorrhagic shock: A systematic review and meta-analysis of randomized controlled trials.
Tran A, Yates J, Lau A, Lampron J, Matar M
J Trauma Acute Care Surg 2018 May;84(5):802-808. doi: 10.1097/TA.0000000000001816. PMID: 29370058
Permissive hypotensive resuscitation in adult patients with traumatic haemorrhagic shock: a systematic review.
Albreiki M, Voegeli D
Eur J Trauma Emerg Surg 2018 Apr;44(2):191-202. Epub 2017 Oct 27 doi: 10.1007/s00068-017-0862-y. PMID: 29079917Free PMC Article

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