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Septic shock

MedGen UID:
11410
Concept ID:
C0036983
Pathologic Function
Synonyms: Septic Shock; Shock, Septic
SNOMED CT: Septicemic shock (76571007); Sepsis-associated hypotension (76571007); Septic shock (76571007)

Definition

A state of acute circulatory failure characterized by persistent arterial hypotension despite adequate fluid resuscitation or by tissue hypoperfusion unexplained by other causes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSeptic shock

Professional guidelines

PubMed

Schlapbach LJ, Watson RS, Sorce LR, Argent AC, Menon K, Hall MW, Akech S, Albers DJ, Alpern ER, Balamuth F, Bembea M, Biban P, Carrol ED, Chiotos K, Chisti MJ, DeWitt PE, Evans I, Flauzino de Oliveira C, Horvat CM, Inwald D, Ishimine P, Jaramillo-Bustamante JC, Levin M, Lodha R, Martin B, Nadel S, Nakagawa S, Peters MJ, Randolph AG, Ranjit S, Rebull MN, Russell S, Scott HF, de Souza DC, Tissieres P, Weiss SL, Wiens MO, Wynn JL, Kissoon N, Zimmerman JJ, Sanchez-Pinto LN, Bennett TD; Society of Critical Care Medicine Pediatric Sepsis Definition Task Force
JAMA 2024 Feb 27;331(8):665-674. doi: 10.1001/jama.2024.0179. PMID: 38245889Free PMC Article
Liu D, Huang SY, Sun JH, Zhang HC, Cai QL, Gao C, Li L, Cao J, Xu F, Zhou Y, Guan CX, Jin SW, Deng J, Fang XM, Jiang JX, Zeng L
Mil Med Res 2022 Oct 9;9(1):56. doi: 10.1186/s40779-022-00422-y. PMID: 36209190Free PMC Article
Gotts JE, Matthay MA
BMJ 2016 May 23;353:i1585. doi: 10.1136/bmj.i1585. PMID: 27217054

Recent clinical studies

Etiology

Ibarra-Estrada M, Kattan E, Aguilera-González P, Sandoval-Plascencia L, Rico-Jauregui U, Gómez-Partida CA, Ortiz-Macías IX, López-Pulgarín JA, Chávez-Peña Q, Mijangos-Méndez JC, Aguirre-Avalos G, Hernández G
Crit Care 2023 Mar 13;27(1):110. doi: 10.1186/s13054-023-04397-7. PMID: 36915146Free PMC Article
Spaggiari V, Passini E, Crestani S, Roversi MF, Bedetti L, Rossi K, Lucaccioni L, Baraldi C, Della Casa Muttini E, Lugli L, Iughetti L, Berardi A
Acta Biomed 2022 Jul 1;93(3):e2022141. doi: 10.23750/abm.v93i3.12577. PMID: 35775767Free PMC Article
Lee EP, Wu HP, Chan OW, Lin JJ, Hsia SH
Biomed J 2022 Feb;45(1):63-73. Epub 2021 Oct 12 doi: 10.1016/j.bj.2021.10.004. PMID: 34653683Free PMC Article
Cinel I, Kasapoglu US, Gul F, Dellinger RP
J Crit Care 2020 Jun;57:108-117. Epub 2020 Feb 11 doi: 10.1016/j.jcrc.2020.02.004. PMID: 32135409
Angus DC, van der Poll T
N Engl J Med 2013 Aug 29;369(9):840-51. doi: 10.1056/NEJMra1208623. PMID: 23984731

Diagnosis

Srzić I, Nesek Adam V, Tunjić Pejak D
Acta Clin Croat 2022 Jun;61(Suppl 1):67-72. doi: 10.20471/acc.2022.61.s1.11. PMID: 36304809Free PMC Article
Lee EP, Wu HP, Chan OW, Lin JJ, Hsia SH
Biomed J 2022 Feb;45(1):63-73. Epub 2021 Oct 12 doi: 10.1016/j.bj.2021.10.004. PMID: 34653683Free PMC Article
Bleakley G, Cole M
Br J Nurs 2020 Nov 26;29(21):1248-1251. doi: 10.12968/bjon.2020.29.21.1248. PMID: 33242267
Font MD, Thyagarajan B, Khanna AK
Med Clin North Am 2020 Jul;104(4):573-585. Epub 2020 May 12 doi: 10.1016/j.mcna.2020.02.011. PMID: 32505253
Angus DC, van der Poll T
N Engl J Med 2013 Aug 29;369(9):840-51. doi: 10.1056/NEJMra1208623. PMID: 23984731

Therapy

Zampieri FG, Bagshaw SM, Semler MW
JAMA 2023 Jun 13;329(22):1967-1980. doi: 10.1001/jama.2023.7560. PMID: 37314271
Kattan E, Bakker J, Estenssoro E, Ospina-Tascón GA, Cavalcanti AB, Backer D, Vieillard-Baron A, Teboul JL, Castro R, Hernández G
Rev Bras Ter Intensiva 2022 Jan-Mar;34(1):96-106. doi: 10.5935/0103-507X.20220004-pt. PMID: 35766659Free PMC Article
Osborn TM
Crit Care Clin 2017 Apr;33(2):323-344. doi: 10.1016/j.ccc.2016.12.004. PMID: 28284298
Seymour CW, Rosengart MR
JAMA 2015 Aug 18;314(7):708-17. doi: 10.1001/jama.2015.7885. PMID: 26284722Free PMC Article
Goldstein B, Giroir B, Randolph A; International Consensus Conference on Pediatric Sepsis
Pediatr Crit Care Med 2005 Jan;6(1):2-8. doi: 10.1097/01.PCC.0000149131.72248.E6. PMID: 15636651

Prognosis

Kalimouttou A, Lerner I, Cheurfa C, Jannot AS, Pirracchio R
Intensive Care Med 2023 Jan;49(1):26-36. Epub 2022 Nov 29 doi: 10.1007/s00134-022-06928-2. PMID: 36446854
Chiu C, Legrand M
Curr Opin Anaesthesiol 2021 Apr 1;34(2):71-76. doi: 10.1097/ACO.0000000000000958. PMID: 33492864
Escobar MF, Echavarría MP, Zambrano MA, Ramos I, Kusanovic JP
Am J Obstet Gynecol MFM 2020 Aug;2(3):100149. Epub 2020 Jun 29 doi: 10.1016/j.ajogmf.2020.100149. PMID: 33345880
Jaramillo-Bustamante JC, Piñeres-Olave BE, González-Dambrauskas S
Bol Med Hosp Infant Mex 2020;77(6):293-302. doi: 10.24875/BMHIM.20000202. PMID: 33186343
Angus DC, van der Poll T
N Engl J Med 2013 Aug 29;369(9):840-51. doi: 10.1056/NEJMra1208623. PMID: 23984731

Clinical prediction guides

Oduncu AF, Kıyan GS, Yalçınlı S
Am J Emerg Med 2021 Oct;48:54-59. Epub 2021 Apr 6 doi: 10.1016/j.ajem.2021.04.006. PMID: 33839632
Gotur DB
Methodist Debakey Cardiovasc J 2018 Apr-Jun;14(2):89-100. doi: 10.14797/mdcj-14-2-89. PMID: 29977465Free PMC Article
Godinjak A, Iglica A, Rama A, Tančica I, Jusufović S, Ajanović A, Kukuljac A
Acta Med Acad 2016 Nov;45(2):97-103. doi: 10.5644/ama2006-124.165. PMID: 28000485
Ait-Oufella H, Lemoinne S, Boelle PY, Galbois A, Baudel JL, Lemant J, Joffre J, Margetis D, Guidet B, Maury E, Offenstadt G
Intensive Care Med 2011 May;37(5):801-7. Epub 2011 Mar 4 doi: 10.1007/s00134-011-2163-y. PMID: 21373821
Boyd JH, Forbes J, Nakada TA, Walley KR, Russell JA
Crit Care Med 2011 Feb;39(2):259-65. doi: 10.1097/CCM.0b013e3181feeb15. PMID: 20975548

Recent systematic reviews

Menon K, Schlapbach LJ, Akech S, Argent A, Biban P, Carrol ED, Chiotos K, Jobayer Chisti M, Evans IVR, Inwald DP, Ishimine P, Kissoon N, Lodha R, Nadel S, Oliveira CF, Peters M, Sadeghirad B, Scott HF, de Souza DC, Tissieres P, Watson RS, Wiens MO, Wynn JL, Zimmerman JJ, Sorce LR; Pediatric Sepsis Definition Taskforce of the Society of Critical Care Medicine
Crit Care Med 2022 Jan 1;50(1):21-36. doi: 10.1097/CCM.0000000000005294. PMID: 34612847Free PMC Article
Ruslan MA, Baharuddin KA, Noor NM, Yazid MB, Noh AYM, Rahman A
West J Emerg Med 2021 Feb 16;22(2):196-203. doi: 10.5811/westjem.2020.10.47825. PMID: 33856300Free PMC Article
Gibbison B, López-López JA, Higgins JP, Miller T, Angelini GD, Lightman SL, Annane D
Crit Care 2017 Mar 28;21(1):78. doi: 10.1186/s13054-017-1659-4. PMID: 28351429Free PMC Article
Shankar-Hari M, Phillips GS, Levy ML, Seymour CW, Liu VX, Deutschman CS, Angus DC, Rubenfeld GD, Singer M; Sepsis Definitions Task Force
JAMA 2016 Feb 23;315(8):775-87. doi: 10.1001/jama.2016.0289. PMID: 26903336Free PMC Article
Avni T, Lador A, Lev S, Leibovici L, Paul M, Grossman A
PLoS One 2015;10(8):e0129305. Epub 2015 Aug 3 doi: 10.1371/journal.pone.0129305. PMID: 26237037Free PMC Article

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