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Spirochetal infection

MedGen UID:
11556
•Concept ID:
C0037974
•
Disease or Syndrome
Synonyms: Spirochaetales Infections; Spirochetes disease
SNOMED CT: Spirochetal infection (41116009); Spirochetosis (41116009)
 
Monarch Initiative: MONDO:0021839

Definition

Infections with bacteria of the order SPIROCHAETALES. [from MONDO]

Professional guidelines

PubMed

Lyme disease: a review of its epidemiology, evaluation, and treatment.
Gerstenblith TA, Stern TA
Psychosomatics 2014 Sep-Oct;55(5):421-9. Epub 2014 Apr 19 doi: 10.1016/j.psym.2014.02.006. PMID: 25016354
Alzheimer's disease - a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria.
Miklossy J
J Neuroinflammation 2011 Aug 4;8:90. doi: 10.1186/1742-2094-8-90. PMID: 21816039Free PMC Article
Treatment of Lyme disease.
Schoen RT
Conn Med 1989 Jun;53(6):335-7. PMID: 2667887

Recent clinical studies

Etiology

Leptospirosis: A Potential Culprit for Chronic Kidney Disease of Uncertain Etiology.
Premarathne SS, Gamage C, Chandrajith R, Ratnatunge NV, Wijetunge S, Wazil A, Chou LF, Ko YC, Huang CT, Yang HY, Fonseka A, Sonnadara T, Herath D, Hewavitharane P, Yang CW, Nanayakkara N
Nephron 2023;147(8):510-520. Epub 2023 Feb 21 doi: 10.1159/000528703. PMID: 36809758Free PMC Article
BACE1 and Other Alzheimer's-Related Biomarkers in Cerebrospinal Fluid and Plasma Distinguish Alzheimer's Disease Patients from Cognitively-Impaired Neurosyphilis Patients.
Zhang M, Zhong X, Shi H, Vanmechelen E, De Vos A, Liu S, Chen B, Mai N, Peng Q, Chen X, Wu Z, Hou L, Zhou H, Ouyang C, Zhang W, Liang W, Dai C, Ning Y
J Alzheimers Dis 2020;77(1):313-322. doi: 10.3233/JAD-200362. PMID: 32804135
Bacterial infection and Alzheimer's disease: a meta-analysis.
Maheshwari P, Eslick GD
J Alzheimers Dis 2015;43(3):957-66. doi: 10.3233/JAD-140621. PMID: 25182736
Lipoprotein-dependent and -independent immune responses to spirochetal infection.
Salazar JC, Pope CD, Moore MW, Pope J, Kiely TG, Radolf JD
Clin Diagn Lab Immunol 2005 Aug;12(8):949-58. doi: 10.1128/CDLI.12.8.949-958.2005. PMID: 16085913Free PMC Article
Lyme disease: an orthopedic perspective.
Lawrence SJ
Orthopedics 1992 Nov;15(11):1331-5. doi: 10.3928/0147-7447-19921101-12. PMID: 1461815

Diagnosis

Trauma-related Lyme arthritis.
Roberts J 4th, Merchant E
BMJ Case Rep 2023 Jul 5;16(7) doi: 10.1136/bcr-2023-255532. PMID: 37407232Free PMC Article
Lyme disease: a review of its epidemiology, evaluation, and treatment.
Gerstenblith TA, Stern TA
Psychosomatics 2014 Sep-Oct;55(5):421-9. Epub 2014 Apr 19 doi: 10.1016/j.psym.2014.02.006. PMID: 25016354
Spirochetal infection of the nervous system.
Estanislao LB, Pachner AR
Neurol Clin 1999 Nov;17(4):783-800. doi: 10.1016/s0733-8619(05)70166-3. PMID: 10517928
Neuropsychiatric manifestations of Lyme disease.
Paparone PW
J Am Osteopath Assoc 1998 Jul;98(7):373-8. PMID: 9695456
Leptospiral pneumonia.
Hill MK, Sanders CV
Semin Respir Infect 1997 Mar;12(1):44-9. PMID: 9097376

Therapy

Trauma-related Lyme arthritis.
Roberts J 4th, Merchant E
BMJ Case Rep 2023 Jul 5;16(7) doi: 10.1136/bcr-2023-255532. PMID: 37407232Free PMC Article
Lyme disease: a review of its epidemiology, evaluation, and treatment.
Gerstenblith TA, Stern TA
Psychosomatics 2014 Sep-Oct;55(5):421-9. Epub 2014 Apr 19 doi: 10.1016/j.psym.2014.02.006. PMID: 25016354
Spirochetal infection of the nervous system.
Estanislao LB, Pachner AR
Neurol Clin 1999 Nov;17(4):783-800. doi: 10.1016/s0733-8619(05)70166-3. PMID: 10517928
Leptospiral pneumonia.
Hill MK, Sanders CV
Semin Respir Infect 1997 Mar;12(1):44-9. PMID: 9097376
Lyme disease: an orthopedic perspective.
Lawrence SJ
Orthopedics 1992 Nov;15(11):1331-5. doi: 10.3928/0147-7447-19921101-12. PMID: 1461815

Prognosis

Trauma-related Lyme arthritis.
Roberts J 4th, Merchant E
BMJ Case Rep 2023 Jul 5;16(7) doi: 10.1136/bcr-2023-255532. PMID: 37407232Free PMC Article
Lyme disease: a review of its epidemiology, evaluation, and treatment.
Gerstenblith TA, Stern TA
Psychosomatics 2014 Sep-Oct;55(5):421-9. Epub 2014 Apr 19 doi: 10.1016/j.psym.2014.02.006. PMID: 25016354
Pediatric facial paralysis--a spirochetal infection with good prognosis?
Peltomaa M, Saxen H, Pyykkö I
Acta Otolaryngol Suppl 1997;529:116-8. doi: 10.3109/00016489709124099. PMID: 9288287
Leptospiral pneumonia.
Hill MK, Sanders CV
Semin Respir Infect 1997 Mar;12(1):44-9. PMID: 9097376
Cardiac manifestations of Lyme disease: a review.
Nagi KS, Joshi R, Thakur RK
Can J Cardiol 1996 May;12(5):503-6. PMID: 8640597

Clinical prediction guides

Leptospirosis: A Potential Culprit for Chronic Kidney Disease of Uncertain Etiology.
Premarathne SS, Gamage C, Chandrajith R, Ratnatunge NV, Wijetunge S, Wazil A, Chou LF, Ko YC, Huang CT, Yang HY, Fonseka A, Sonnadara T, Herath D, Hewavitharane P, Yang CW, Nanayakkara N
Nephron 2023;147(8):510-520. Epub 2023 Feb 21 doi: 10.1159/000528703. PMID: 36809758Free PMC Article
Mucosal eosinophilic infiltration may be a characteristic of human intestinal spirochetosis.
Ogata S, Shimizu K, Tominaga S, Matsukuma S
BMC Infect Dis 2021 Jul 31;21(1):721. doi: 10.1186/s12879-021-06418-8. PMID: 34332545Free PMC Article
Emerging roles of pathogens in Alzheimer disease.
Miklossy J
Expert Rev Mol Med 2011 Sep 20;13:e30. doi: 10.1017/S1462399411002006. PMID: 21933454
Alzheimer's disease - a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria.
Miklossy J
J Neuroinflammation 2011 Aug 4;8:90. doi: 10.1186/1742-2094-8-90. PMID: 21816039Free PMC Article
The pathogenesis of lyme neuroborreliosis: from infection to inflammation.
Rupprecht TA, Koedel U, Fingerle V, Pfister HW
Mol Med 2008 Mar-Apr;14(3-4):205-12. doi: 10.2119/2007-00091.Rupprecht. PMID: 18097481Free PMC Article

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