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Spondylitis

MedGen UID:
11560
Concept ID:
C0038012
Disease or Syndrome
Synonym: Spondylitides
SNOMED CT: Spondylitis (84172003); Undifferentiated spondylitis (399096009)
 
HPO: HP:0033631
Monarch Initiative: MONDO:0003937

Definition

Inflammation of the vertebrae (vertebral bodies) or spine. [from HPO]

Conditions with this feature

Autoinflammatory syndrome with immunodeficiency
MedGen UID:
1784363
Concept ID:
C5543547
Disease or Syndrome
Familial autoinflammatory syndrome with or without immunodeficiency (AISIMD) is characterized by onset of various autoimmune features usually in the first decades of life, although later onset has been reported. Typical features include autoimmune cytopenia, hemolytic anemia, thrombocytopenia, and lymphadenopathy. More variable features may include autoimmune thyroiditis, psoriasis or eczema, nephritis, hepatitis, and symptoms of systemic lupus erythematosus (SLE; see 152700). Some patients may have recurrent infections or exacerbation of the disease with acute infection. Laboratory studies show variable findings, often decreased numbers of naive B cells, lymphopenia with skewed subsets, hypogammaglobulinemia, presence of autoantibodies, and a hyperinflammatory state. The disorder shows autosomal dominant inheritance with incomplete penetrance (summary by Hadjadj et al., 2020).

Professional guidelines

PubMed

Ramiro S, Nikiphorou E, Sepriano A, Ortolan A, Webers C, Baraliakos X, Landewé RBM, Van den Bosch FE, Boteva B, Bremander A, Carron P, Ciurea A, van Gaalen FA, Géher P, Gensler L, Hermann J, de Hooge M, Husakova M, Kiltz U, López-Medina C, Machado PM, Marzo-Ortega H, Molto A, Navarro-Compán V, Nissen MJ, Pimentel-Santos FM, Poddubnyy D, Proft F, Rudwaleit M, Telkman M, Zhao SS, Ziade N, van der Heijde D
Ann Rheum Dis 2023 Jan;82(1):19-34. Epub 2022 Oct 21 doi: 10.1136/ard-2022-223296. PMID: 36270658
Danve A, Deodhar A
Nat Rev Rheumatol 2022 Apr;18(4):205-216. Epub 2022 Mar 10 doi: 10.1038/s41584-022-00761-z. PMID: 35273385
Rogler G, Singh A, Kavanaugh A, Rubin DT
Gastroenterology 2021 Oct;161(4):1118-1132. Epub 2021 Aug 3 doi: 10.1053/j.gastro.2021.07.042. PMID: 34358489Free PMC Article

Recent clinical studies

Etiology

Sato K, Yamada K, Yokosuka K, Yoshida T, Goto M, Matsubara T, Iwahashi S, Shimazaki T, Nagata K, Shiba N; RESEARCH GROUP FOR SPINE AND SPINAL CORD DISORDERS (HONNEKAI)
Kurume Med J 2019 Sep 25;65(3):83-89. Epub 2019 Aug 9 doi: 10.2739/kurumemedj.MS653001. PMID: 31406038
Garcia-Montoya L, Gul H, Emery P
F1000Res 2018;7 Epub 2018 Sep 21 doi: 10.12688/f1000research.14956.1. PMID: 30345001Free PMC Article
Wang R, Ward MM
Curr Opin Rheumatol 2018 Mar;30(2):137-143. doi: 10.1097/BOR.0000000000000475. PMID: 29227352Free PMC Article
Hanson A, Brown MA
Rheum Dis Clin North Am 2017 Aug;43(3):401-414. doi: 10.1016/j.rdc.2017.04.006. PMID: 28711142Free PMC Article
Sharan D, Rajkumar JS
Curr Rheumatol Rev 2017;13(2):121-125. doi: 10.2174/1573397112666161025112750. PMID: 27784233

Diagnosis

Sato K, Yamada K, Yokosuka K, Yoshida T, Goto M, Matsubara T, Iwahashi S, Shimazaki T, Nagata K, Shiba N; RESEARCH GROUP FOR SPINE AND SPINAL CORD DISORDERS (HONNEKAI)
Kurume Med J 2019 Sep 25;65(3):83-89. Epub 2019 Aug 9 doi: 10.2739/kurumemedj.MS653001. PMID: 31406038
Fiorillo MT, Haroon N, Ciccia F, Breban M
Front Immunol 2019;10:1232. Epub 2019 Jun 4 doi: 10.3389/fimmu.2019.01232. PMID: 31214188Free PMC Article
Wang R, Ward MM
Curr Opin Rheumatol 2018 Mar;30(2):137-143. doi: 10.1097/BOR.0000000000000475. PMID: 29227352Free PMC Article
Sieper J, Poddubnyy D
Lancet 2017 Jul 1;390(10089):73-84. Epub 2017 Jan 20 doi: 10.1016/S0140-6736(16)31591-4. PMID: 28110981
Zochling J
Arthritis Care Res (Hoboken) 2011 Nov;63 Suppl 11:S47-58. doi: 10.1002/acr.20575. PMID: 22588768

Therapy

Zeng L, Yang T, Yang K, Yu G, Li J, Xiang W, Chen H
Front Immunol 2022;13:891822. Epub 2022 Jul 22 doi: 10.3389/fimmu.2022.891822. PMID: 35935936Free PMC Article
Gottlieb AB, Deodhar A, Mcinnes IB, Baraliakos X, Reich K, Schreiber S, Bao W, Marfo K, Richards HB, Pricop L, Shete A, Trivedi V, Keefe D, Papavassilis CC, Jagiello P, Papanastasiou P, Mease PJ, Lebwohl M
Acta Derm Venereol 2022 Apr 27;102:adv00698. doi: 10.2340/actadv.v102.563. PMID: 35146532Free PMC Article
Fauny M, Moulin D, D'Amico F, Netter P, Petitpain N, Arnone D, Jouzeau JY, Loeuille D, Peyrin-Biroulet L
Ann Rheum Dis 2020 Sep;79(9):1132-1138. Epub 2020 Jul 21 doi: 10.1136/annrheumdis-2020-217927. PMID: 32719044
Ward MM, Deodhar A, Gensler LS, Dubreuil M, Yu D, Khan MA, Haroon N, Borenstein D, Wang R, Biehl A, Fang MA, Louie G, Majithia V, Ng B, Bigham R, Pianin M, Shah AA, Sullivan N, Turgunbaev M, Oristaglio J, Turner A, Maksymowych WP, Caplan L
Arthritis Care Res (Hoboken) 2019 Oct;71(10):1285-1299. Epub 2019 Aug 21 doi: 10.1002/acr.24025. PMID: 31436026Free PMC Article
Blair HA
Drugs 2019 Mar;79(4):433-443. doi: 10.1007/s40265-019-01075-3. PMID: 30793255Free PMC Article

Prognosis

Li Z, Khan MK, van der Linden SM, Winkens B, Villiger PM, Baumberger H, van Zandwijk H, Khan MA, Brown MA
Ann Rheum Dis 2023 Dec;82(12):1558-1567. Epub 2023 Sep 7 doi: 10.1136/ard-2023-224434. PMID: 37679034
Raychaudhuri SP, Deodhar A
J Autoimmun 2014 Feb-Mar;48-49:128-33. Epub 2014 Feb 16 doi: 10.1016/j.jaut.2014.01.015. PMID: 24534717
Cheung WY, Luk KD
Int Orthop 2012 Feb;36(2):397-404. Epub 2011 Oct 28 doi: 10.1007/s00264-011-1384-6. PMID: 22033610Free PMC Article
Zochling J, Smith EU
Best Pract Res Clin Rheumatol 2010 Dec;24(6):747-56. doi: 10.1016/j.berh.2011.02.002. PMID: 21665123
Winter WG Jr, Larson RK, Zettas JP, Libke R
J Bone Joint Surg Am 1978 Mar;60(2):240-4. PMID: 641091

Clinical prediction guides

Park YG, Goh TS, Kim DS, Jung SJ, Lee JS
Clin Orthop Surg 2023 Apr;15(2):249-256. Epub 2023 Jan 30 doi: 10.4055/cios22112. PMID: 37008970Free PMC Article
Rogler G, Singh A, Kavanaugh A, Rubin DT
Gastroenterology 2021 Oct;161(4):1118-1132. Epub 2021 Aug 3 doi: 10.1053/j.gastro.2021.07.042. PMID: 34358489Free PMC Article
van der Heijde D, Braun J, Deodhar A, Baraliakos X, Landewé R, Richards HB, Porter B, Readie A
Rheumatology (Oxford) 2019 Mar 1;58(3):388-400. doi: 10.1093/rheumatology/key128. PMID: 29860356Free PMC Article
Braun J, Baraliakos X, Buehring B, Kiltz U, Fruth M
Clin Exp Rheumatol 2018 Sep-Oct;36 Suppl 114(5):35-42. Epub 2018 Oct 1 PMID: 30296971
Salaffi F, Stancati A, Silvestri CA, Ciapetti A, Grassi W
Eur J Pain 2004 Aug;8(4):283-91. doi: 10.1016/j.ejpain.2003.09.004. PMID: 15207508

Recent systematic reviews

Webers C, Ortolan A, Sepriano A, Falzon L, Baraliakos X, Landewé RBM, Ramiro S, van der Heijde D, Nikiphorou E
Ann Rheum Dis 2023 Jan;82(1):130-141. Epub 2022 Oct 21 doi: 10.1136/ard-2022-223298. PMID: 36270657
Ortolan A, Webers C, Sepriano A, Falzon L, Baraliakos X, Landewé RB, Ramiro S, van der Heijde D, Nikiphorou E
Ann Rheum Dis 2023 Jan;82(1):142-152. Epub 2022 Oct 19 doi: 10.1136/ard-2022-223297. PMID: 36261247
Zeng L, Yang T, Yang K, Yu G, Li J, Xiang W, Chen H
Front Immunol 2022;13:891822. Epub 2022 Jul 22 doi: 10.3389/fimmu.2022.891822. PMID: 35935936Free PMC Article
Hwang MC, Ridley L, Reveille JD
Clin Rheumatol 2021 Aug;40(8):3079-3093. Epub 2021 Mar 22 doi: 10.1007/s10067-021-05679-7. PMID: 33754220Free PMC Article
Millner JR, Barron JS, Beinke KM, Butterworth RH, Chasle BE, Dutton LJ, Lewington MA, Lim EG, Morley TB, O'Reilly JE, Pickering KA, Winzenberg T, Zochling J
Semin Arthritis Rheum 2016 Feb;45(4):411-27. Epub 2015 Aug 18 doi: 10.1016/j.semarthrit.2015.08.003. PMID: 26493464

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