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Tenesmus

MedGen UID:
115914
Concept ID:
C0232726
Sign or Symptom
Synonyms: Anal tenesmus; Anorectal tenesmus; Rectal tenesmus; Tenesmus of anus and/or rectum
SNOMED CT: Tenesmus of anus and/or rectum (302770003); Anorectal tenesmus (302770003); Anal tenesmus (302770003); Rectal tenesmus (302770003)
 
HPO: HP:0012702

Definition

A repeated, painful urge to defecate without excreting stool. [from HPO]

Term Hierarchy

Conditions with this feature

Fabry disease
MedGen UID:
8083
Concept ID:
C0002986
Disease or Syndrome
Fabry disease is the most common of the lysosomal storage disorders and results from deficient activity of the enzyme alpha-galactosidase A (a-Gal A), leading to progressive lysosomal deposition of globotriaosylceramide and its derivatives in cells throughout the body. The classic form, occurring in males with less than 1% a-Gal A enzyme activity, usually has its onset in childhood or adolescence with periodic crises of severe pain in the extremities (acroparesthesia), the appearance of vascular cutaneous lesions (angiokeratomas), sweating abnormalities (anhidrosis, hypohidrosis, and rarely hyperhidrosis), characteristic corneal and lenticular opacities, and proteinuria. Gradual deterioration of renal function to end-stage renal disease (ESRD) usually occurs in men in the third to fifth decade. In middle age, most males successfully treated for ESRD develop cardiac and/or cerebrovascular disease, a major cause of morbidity and mortality. Heterozygous females typically have milder symptoms at a later age of onset than males. Rarely, females may be relatively asymptomatic throughout a normal life span or may have symptoms as severe as those observed in males with the classic phenotype. In contrast, late-onset forms occur in males with greater than 1% a-Gal A activity. Clinical manifestations include cardiac disease, which usually presents in the sixth to eighth decade with left ventricular hypertrophy, cardiomyopathy, arrhythmia, and proteinuria; renal failure, associated with ESRD but without the skin lesions or pain; or cerebrovascular disease presenting as stroke or transient ischemic attack.

Professional guidelines

PubMed

da Cruz Gouveia MA, Lins MTC, da Silva GAP
J Pediatr (Rio J) 2020 Mar-Apr;96 Suppl 1(Suppl 1):20-28. Epub 2019 Oct 8 doi: 10.1016/j.jped.2019.08.006. PMID: 31604059Free PMC Article
Feuerstein JD, Cheifetz AS
Mayo Clin Proc 2014 Nov;89(11):1553-63. Epub 2014 Sep 8 doi: 10.1016/j.mayocp.2014.07.002. PMID: 25199861
Goddard AF, James MW, McIntyre AS, Scott BB; British Society of Gastroenterology
Gut 2011 Oct;60(10):1309-16. Epub 2011 May 11 doi: 10.1136/gut.2010.228874. PMID: 21561874

Recent clinical studies

Etiology

Adams SM, Close ED, Shreenath AP
Am Fam Physician 2022 Apr 1;105(4):406-411. PMID: 35426646
Sheikh P, Lohsiriwat V, Shelygin Y
Adv Ther 2020 Jun;37(6):2792-2812. Epub 2020 May 12 doi: 10.1007/s12325-020-01353-7. PMID: 32399811Free PMC Article
Gajendran M, Loganathan P, Jimenez G, Catinella AP, Ng N, Umapathy C, Ziade N, Hashash JG
Dis Mon 2019 Dec;65(12):100851. Epub 2019 Mar 2 doi: 10.1016/j.disamonth.2019.02.004. PMID: 30837080
Feuerstein JD, Cheifetz AS
Mayo Clin Proc 2014 Nov;89(11):1553-63. Epub 2014 Sep 8 doi: 10.1016/j.mayocp.2014.07.002. PMID: 25199861
Goddard AF, James MW, McIntyre AS, Scott BB; British Society of Gastroenterology
Gut 2011 Oct;60(10):1309-16. Epub 2011 May 11 doi: 10.1136/gut.2010.228874. PMID: 21561874

Diagnosis

Adams SM, Close ED, Shreenath AP
Am Fam Physician 2022 Apr 1;105(4):406-411. PMID: 35426646
da Cruz Gouveia MA, Lins MTC, da Silva GAP
J Pediatr (Rio J) 2020 Mar-Apr;96 Suppl 1(Suppl 1):20-28. Epub 2019 Oct 8 doi: 10.1016/j.jped.2019.08.006. PMID: 31604059Free PMC Article
Feuerstein JD, Moss AC, Farraye FA
Mayo Clin Proc 2019 Jul;94(7):1357-1373. doi: 10.1016/j.mayocp.2019.01.018. PMID: 31272578
Gajendran M, Loganathan P, Jimenez G, Catinella AP, Ng N, Umapathy C, Ziade N, Hashash JG
Dis Mon 2019 Dec;65(12):100851. Epub 2019 Mar 2 doi: 10.1016/j.disamonth.2019.02.004. PMID: 30837080
Feuerstein JD, Cheifetz AS
Mayo Clin Proc 2014 Nov;89(11):1553-63. Epub 2014 Sep 8 doi: 10.1016/j.mayocp.2014.07.002. PMID: 25199861

Therapy

Sheikh P, Lohsiriwat V, Shelygin Y
Adv Ther 2020 Jun;37(6):2792-2812. Epub 2020 May 12 doi: 10.1007/s12325-020-01353-7. PMID: 32399811Free PMC Article
Gajendran M, Loganathan P, Jimenez G, Catinella AP, Ng N, Umapathy C, Ziade N, Hashash JG
Dis Mon 2019 Dec;65(12):100851. Epub 2019 Mar 2 doi: 10.1016/j.disamonth.2019.02.004. PMID: 30837080
Roman LI, Efel CF, França VT, Merten CM, Dummer CD
J Bras Nefrol 2017 Oct-Dec;39(4):458-461. doi: 10.5935/0101-2800.20170080. PMID: 29319774
Feuerstein JD, Cheifetz AS
Mayo Clin Proc 2014 Nov;89(11):1553-63. Epub 2014 Sep 8 doi: 10.1016/j.mayocp.2014.07.002. PMID: 25199861
Goddard AF, James MW, McIntyre AS, Scott BB; British Society of Gastroenterology
Gut 2011 Oct;60(10):1309-16. Epub 2011 May 11 doi: 10.1136/gut.2010.228874. PMID: 21561874

Prognosis

Kelly ME, Heriot AG
Dis Colon Rectum 2023 Mar 1;66(3):355-357. Epub 2023 Jan 4 doi: 10.1097/DCR.0000000000002706. PMID: 36728599
Gajendran M, Loganathan P, Jimenez G, Catinella AP, Ng N, Umapathy C, Ziade N, Hashash JG
Dis Mon 2019 Dec;65(12):100851. Epub 2019 Mar 2 doi: 10.1016/j.disamonth.2019.02.004. PMID: 30837080
Gallo G, Kotze PG, Spinelli A
Best Pract Res Clin Gastroenterol 2018 Feb-Apr;32-33:71-78. Epub 2018 Jun 14 doi: 10.1016/j.bpg.2018.05.017. PMID: 30060941
Roman LI, Efel CF, França VT, Merten CM, Dummer CD
J Bras Nefrol 2017 Oct-Dec;39(4):458-461. doi: 10.5935/0101-2800.20170080. PMID: 29319774
Mastoraki A, Psarras D, Mastoraki S, Vassiliu P, Danias N, Smyrniotis V, Arkadopoulos N
J Gastrointest Cancer 2013 Sep;44(3):260-3. doi: 10.1007/s12029-013-9506-6. PMID: 23712252

Clinical prediction guides

Kelly ME, Heriot AG
Dis Colon Rectum 2023 Mar 1;66(3):355-357. Epub 2023 Jan 4 doi: 10.1097/DCR.0000000000002706. PMID: 36728599
Gajendran M, Loganathan P, Jimenez G, Catinella AP, Ng N, Umapathy C, Ziade N, Hashash JG
Dis Mon 2019 Dec;65(12):100851. Epub 2019 Mar 2 doi: 10.1016/j.disamonth.2019.02.004. PMID: 30837080
Gallo G, Kotze PG, Spinelli A
Best Pract Res Clin Gastroenterol 2018 Feb-Apr;32-33:71-78. Epub 2018 Jun 14 doi: 10.1016/j.bpg.2018.05.017. PMID: 30060941
Zezos P, Saibil F
World J Gastroenterol 2015 Aug 7;21(29):8739-52. doi: 10.3748/wjg.v21.i29.8739. PMID: 26269664Free PMC Article
Cheney CP, Wong RK
Med Clin North Am 1993 Sep;77(5):1169-96. doi: 10.1016/s0025-7125(16)30216-4. PMID: 8371621

Recent systematic reviews

Ramakrishnan R, Shenoy A, Madhavan R, Meyer D
BMJ Open Gastroenterol 2024 Jan 6;11(1) doi: 10.1136/bmjgast-2023-001266. PMID: 38184298Free PMC Article
Huang Z, Wei C, Yang K, Yu Z, Wang Z, Hu H
J Ethnopharmacol 2021 Nov 15;280:114372. Epub 2021 Jun 26 doi: 10.1016/j.jep.2021.114372. PMID: 34186101
Sheikh P, Lohsiriwat V, Shelygin Y
Adv Ther 2020 Jun;37(6):2792-2812. Epub 2020 May 12 doi: 10.1007/s12325-020-01353-7. PMID: 32399811Free PMC Article
Mueller K, Karimuddin AA, Metcalf C, Woo A, Lefresne S
J Palliat Med 2020 Jul;23(7):964-971. Epub 2019 Nov 4 doi: 10.1089/jpm.2019.0139. PMID: 31682188
Ní Laoire Á, Fettes L, Murtagh FE
Palliat Med 2017 Dec;31(10):975-981. Epub 2017 Mar 1 doi: 10.1177/0269216317697897. PMID: 28590211

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