U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Granulomatous hepatitis

MedGen UID:
115987
•Concept ID:
C0235369
•
Disease or Syndrome
Synonyms: Granulomatous Hepatitis; granulomatous hepatitis
SNOMED CT: Granulomatous hepatitis (86514004)
 
Monarch Initiative: MONDO:0002252

Definition

Hepatitis that is characterized by the presence of granulomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGranulomatous hepatitis

Professional guidelines

PubMed

Management of Hepatic Sarcoidosis.
Sollors J, Schlevogt B, Schmidt HJ, Woerns MA, Galle PR, Qian Y, Antoni C, Weis CA, Hetjens S, Bergner R, Ebert MP, Teufel A
J Gastrointestin Liver Dis 2022 Sep 15;31(3):323-330. doi: 10.15403/jgld-4122. PMID: 36112714
Hepatic Sarcoidosis: Diagnostic approach and management.
Hon SA, Lee LT, Tan KK, Lee RA, Low QJ
Med J Malaysia 2021 Nov;76(6):914-917. PMID: 34806684
Antibacterial-induced hepatotoxicity. Incidence, prevention and management.
George DK, Crawford DH
Drug Saf 1996 Jul;15(1):79-85. doi: 10.2165/00002018-199615010-00007. PMID: 8862966

Recent clinical studies

Etiology

Complementary and alternative medicines and liver disease.
Philips CA, Theruvath AH, Ravindran R, Augustine P
Hepatol Commun 2024 Apr 1;8(4) Epub 2024 Apr 3 doi: 10.1097/HC9.0000000000000417. PMID: 38563584Free PMC Article
Vemurafenib-induced granulomatous hepatitis.
Spengler EK, Kleiner DE, Fontana RJ
Hepatology 2017 Feb;65(2):745-748. Epub 2016 Jul 26 doi: 10.1002/hep.28692. PMID: 27335285Free PMC Article
Childhood sarcoidosis: Louisiana experience.
Gedalia A, Khan TA, Shetty AK, Dimitriades VR, Espinoza LR
Clin Rheumatol 2016 Jul;35(7):1879-84. Epub 2015 Jan 24 doi: 10.1007/s10067-015-2870-9. PMID: 25616361
Tuberculosis and liver disease: management issues.
Sonika U, Kar P
Trop Gastroenterol 2012 Apr-Jun;33(2):102-6. doi: 10.7869/tg.2012.25. PMID: 23025055
Histological patterns in drug-induced liver disease.
Ramachandran R, Kakar S
J Clin Pathol 2009 Jun;62(6):481-92. doi: 10.1136/jcp.2008.058248. PMID: 19474352

Diagnosis

Granulomatous liver diseases.
Mironova M, Gopalakrishna H, Rodriguez Franco G, Holland SM, Koh C, Kleiner DE, Heller T
Hepatol Commun 2024 Apr 1;8(4) Epub 2024 Mar 18 doi: 10.1097/HC9.0000000000000392. PMID: 38497932Free PMC Article
Management of Hepatic Sarcoidosis.
Sollors J, Schlevogt B, Schmidt HJ, Woerns MA, Galle PR, Qian Y, Antoni C, Weis CA, Hetjens S, Bergner R, Ebert MP, Teufel A
J Gastrointestin Liver Dis 2022 Sep 15;31(3):323-330. doi: 10.15403/jgld-4122. PMID: 36112714
Gastrointestinal and Abdominal Tuberculosis.
Eraksoy H
Gastroenterol Clin North Am 2021 Jun;50(2):341-360. doi: 10.1016/j.gtc.2021.02.004. PMID: 34024445
Characterization of liver injury induced by cancer immunotherapy using immune checkpoint inhibitors.
De Martin E, Michot JM, Papouin B, Champiat S, Mateus C, Lambotte O, Roche B, Antonini TM, Coilly A, Laghouati S, Robert C, Marabelle A, Guettier C, Samuel D
J Hepatol 2018 Jun;68(6):1181-1190. Epub 2018 Feb 8 doi: 10.1016/j.jhep.2018.01.033. PMID: 29427729
Granulomatous hepatitis.
Fauci AS, Wolff SM
Prog Liver Dis 1976;5:609-21. PMID: 775558

Therapy

Management of Hepatic Sarcoidosis.
Sollors J, Schlevogt B, Schmidt HJ, Woerns MA, Galle PR, Qian Y, Antoni C, Weis CA, Hetjens S, Bergner R, Ebert MP, Teufel A
J Gastrointestin Liver Dis 2022 Sep 15;31(3):323-330. doi: 10.15403/jgld-4122. PMID: 36112714
Characterization of liver injury induced by cancer immunotherapy using immune checkpoint inhibitors.
De Martin E, Michot JM, Papouin B, Champiat S, Mateus C, Lambotte O, Roche B, Antonini TM, Coilly A, Laghouati S, Robert C, Marabelle A, Guettier C, Samuel D
J Hepatol 2018 Jun;68(6):1181-1190. Epub 2018 Feb 8 doi: 10.1016/j.jhep.2018.01.033. PMID: 29427729
Vemurafenib-induced granulomatous hepatitis.
Spengler EK, Kleiner DE, Fontana RJ
Hepatology 2017 Feb;65(2):745-748. Epub 2016 Jul 26 doi: 10.1002/hep.28692. PMID: 27335285Free PMC Article
Tuberculosis and liver disease: management issues.
Sonika U, Kar P
Trop Gastroenterol 2012 Apr-Jun;33(2):102-6. doi: 10.7869/tg.2012.25. PMID: 23025055
Granulomatous hepatitis and necrotizing splenitis due to Bartonella henselae in a patient with cancer: case report and review of hepatosplenic manifestations of bartonella infection.
Liston TE, Koehler JE
Clin Infect Dis 1996 Jun;22(6):951-7. doi: 10.1093/clinids/22.6.951. PMID: 8783692

Prognosis

Complementary and alternative medicines and liver disease.
Philips CA, Theruvath AH, Ravindran R, Augustine P
Hepatol Commun 2024 Apr 1;8(4) Epub 2024 Apr 3 doi: 10.1097/HC9.0000000000000417. PMID: 38563584Free PMC Article
Management of Hepatic Sarcoidosis.
Sollors J, Schlevogt B, Schmidt HJ, Woerns MA, Galle PR, Qian Y, Antoni C, Weis CA, Hetjens S, Bergner R, Ebert MP, Teufel A
J Gastrointestin Liver Dis 2022 Sep 15;31(3):323-330. doi: 10.15403/jgld-4122. PMID: 36112714
Hepatic manifestations of inflammatory bowel diseases.
Restellini S, Chazouillères O, Frossard JL
Liver Int 2017 Apr;37(4):475-489. Epub 2016 Nov 6 doi: 10.1111/liv.13265. PMID: 27712010
Vemurafenib-induced granulomatous hepatitis.
Spengler EK, Kleiner DE, Fontana RJ
Hepatology 2017 Feb;65(2):745-748. Epub 2016 Jul 26 doi: 10.1002/hep.28692. PMID: 27335285Free PMC Article
Childhood sarcoidosis: Louisiana experience.
Gedalia A, Khan TA, Shetty AK, Dimitriades VR, Espinoza LR
Clin Rheumatol 2016 Jul;35(7):1879-84. Epub 2015 Jan 24 doi: 10.1007/s10067-015-2870-9. PMID: 25616361

Clinical prediction guides

Complementary and alternative medicines and liver disease.
Philips CA, Theruvath AH, Ravindran R, Augustine P
Hepatol Commun 2024 Apr 1;8(4) Epub 2024 Apr 3 doi: 10.1097/HC9.0000000000000417. PMID: 38563584Free PMC Article
Characterization of clinical presentation, histological features, ultrasonographic findings, and survival in 29 dogs with granulomatous hepatitis.
Prentice KD, Callahan-Clark JE, Parry NM, Schwarz LA, Webster CRL
J Vet Intern Med 2024 Jan-Feb;38(1):167-175. Epub 2023 Nov 23 doi: 10.1111/jvim.16937. PMID: 37994296Free PMC Article
Checkpoint inhibitor-induced liver injury: A novel form of liver disease emerging in the era of cancer immunotherapy.
Zen Y, Yeh MM
Semin Diagn Pathol 2019 Nov;36(6):434-440. Epub 2019 Jul 24 doi: 10.1053/j.semdp.2019.07.009. PMID: 31358424
Granulomatous liver disease.
Flamm SL
Clin Liver Dis 2012 May;16(2):387-96. doi: 10.1016/j.cld.2012.03.013. PMID: 22541705
Histological patterns in drug-induced liver disease.
Ramachandran R, Kakar S
J Clin Pathol 2009 Jun;62(6):481-92. doi: 10.1136/jcp.2008.058248. PMID: 19474352

Recent systematic reviews

Digestive Toxicities Secondary to Immune Checkpoint Inhibition Therapy - Reports of Rare Events. A Systematic Review.
Radulescu L, Crisan D, Grapa C, Radulescu D
J Gastrointestin Liver Dis 2021 Dec 21;30(4):506-516. doi: 10.15403/jgld-3671. PMID: 34752584
BCG infection (BCGitis) following intravesical instillation for bladder cancer and time interval between treatment and presentation: A systematic review.
Cabas P, Rizzo M, Giuffrè M, Antonello RM, Trombetta C, Luzzati R, Liguori G, Di Bella S
Urol Oncol 2021 Feb;39(2):85-92. Epub 2020 Dec 8 doi: 10.1016/j.urolonc.2020.11.037. PMID: 33308969

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...