U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Neonatal leukemia

MedGen UID:
116003
•Concept ID:
C0235813
•
Neoplastic Process
Synonyms: Neonatal Leukemia; neonatal leukemia
 
Monarch Initiative: MONDO:0004354

Definition

Leukemia that occurs during the neonatal period. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeonatal leukemia

Professional guidelines

PubMed

Update on transcobalamin deficiency: clinical presentation, treatment and outcome.
Trakadis YJ, Alfares A, Bodamer OA, Buyukavci M, Christodoulou J, Connor P, Glamuzina E, Gonzalez-Fernandez F, Bibi H, Echenne B, Manoli I, Mitchell J, Nordwall M, Prasad C, Scaglia F, Schiff M, Schrewe B, Touati G, Tchan MC, Varet B, Venditti CP, Zafeiriou D, Rupar CA, Rosenblatt DS, Watkins D, Braverman N
J Inherit Metab Dis 2014 May;37(3):461-73. Epub 2013 Dec 5 doi: 10.1007/s10545-013-9664-5. PMID: 24305960

Recent clinical studies

Etiology

Neonatal Leukemia.
Brown PA
Clin Perinatol 2021 Mar;48(1):15-33. doi: 10.1016/j.clp.2020.11.002. PMID: 33583502
Congenital acute myeloid leukemia: challenges and lessons. A 15-year experience from the UK.
Green K, Tandon S, Ahmed M, Toscano W, O'Connor D, Ancliff P, Vora A, Bartram J, Samarasinghe S, Ghorashian S, Pavasovic V, Rao A
Leuk Lymphoma 2021 Mar;62(3):688-695. Epub 2020 Nov 23 doi: 10.1080/10428194.2020.1845335. PMID: 33225799
Evolution of myeloid leukemia in children with Down syndrome.
Saida S
Int J Hematol 2016 Apr;103(4):365-72. Epub 2016 Feb 24 doi: 10.1007/s12185-016-1959-5. PMID: 26910243
Clinical and molecular epidemiology of neonatal leukemia in Brazil.
Moura SV, Andrade F, Magalhães IQ, Costa I, Silva DB, D'Andrea ML, Pinheiro VP, Lee ML, Werneck F, Emerenciano M, Pombo-de-Oliveira MS
Leuk Lymphoma 2015 Apr;56(4):903-9. Epub 2015 Jan 30 doi: 10.3109/10428194.2014.938327. PMID: 24991719
Features and outcome of neonatal leukemia in Japan: experience of the Japan infant leukemia study group.
Ishii E, Oda M, Kinugawa N, Oda T, Takimoto T, Suzuki N, Kosaka Y, Ohara A, Ogawa A, Ishii M, Sakata N, Okamura T, Koike K, Kojima S, Horibe K, Mizutani S
Pediatr Blood Cancer 2006 Sep;47(3):268-72. doi: 10.1002/pbc.20599. PMID: 16333820

Diagnosis

"TAM"ing of the shrew-challenges in the diagnosis of Neonatal leukemia with Down's syndrome -A case report with literature review.
Manohar S, Jayakumar N
Indian J Pathol Microbiol 2022 Jul-Sep;65(3):699-701. doi: 10.4103/ijpm.ijpm_731_21. PMID: 35900507
Congenital acute myeloid leukemia: challenges and lessons. A 15-year experience from the UK.
Green K, Tandon S, Ahmed M, Toscano W, O'Connor D, Ancliff P, Vora A, Bartram J, Samarasinghe S, Ghorashian S, Pavasovic V, Rao A
Leuk Lymphoma 2021 Mar;62(3):688-695. Epub 2020 Nov 23 doi: 10.1080/10428194.2020.1845335. PMID: 33225799
Transient leukemia in a newborn without Down syndrome: case report and review of the literature.
Rozen L, Huybrechts S, Dedeken L, Heijmans C, Dessars B, Heimann P, Lambert F, Noubouossie DF, Ferster A, Demulder A
Eur J Pediatr 2014 Dec;173(12):1643-7. Epub 2013 Nov 20 doi: 10.1007/s00431-013-2163-8. PMID: 24253371
Fetal and neonatal leukemia.
Isaacs H Jr
J Pediatr Hematol Oncol 2003 May;25(5):348-61. doi: 10.1097/00043426-200305000-00002. PMID: 12759620
Congenital and neonatal leukemia.
Sande JE, Arceci RJ, Lampkin BC
Semin Perinatol 1999 Aug;23(4):274-85. doi: 10.1016/s0146-0005(99)80036-6. PMID: 10475541

Therapy

Congenital acute myeloid leukemia: challenges and lessons. A 15-year experience from the UK.
Green K, Tandon S, Ahmed M, Toscano W, O'Connor D, Ancliff P, Vora A, Bartram J, Samarasinghe S, Ghorashian S, Pavasovic V, Rao A
Leuk Lymphoma 2021 Mar;62(3):688-695. Epub 2020 Nov 23 doi: 10.1080/10428194.2020.1845335. PMID: 33225799
Update on transcobalamin deficiency: clinical presentation, treatment and outcome.
Trakadis YJ, Alfares A, Bodamer OA, Buyukavci M, Christodoulou J, Connor P, Glamuzina E, Gonzalez-Fernandez F, Bibi H, Echenne B, Manoli I, Mitchell J, Nordwall M, Prasad C, Scaglia F, Schiff M, Schrewe B, Touati G, Tchan MC, Varet B, Venditti CP, Zafeiriou D, Rupar CA, Rosenblatt DS, Watkins D, Braverman N
J Inherit Metab Dis 2014 May;37(3):461-73. Epub 2013 Dec 5 doi: 10.1007/s10545-013-9664-5. PMID: 24305960
Features and outcome of neonatal leukemia in Japan: experience of the Japan infant leukemia study group.
Ishii E, Oda M, Kinugawa N, Oda T, Takimoto T, Suzuki N, Kosaka Y, Ohara A, Ogawa A, Ishii M, Sakata N, Okamura T, Koike K, Kojima S, Horibe K, Mizutani S
Pediatr Blood Cancer 2006 Sep;47(3):268-72. doi: 10.1002/pbc.20599. PMID: 16333820
Congenital and neonatal leukemia.
Sande JE, Arceci RJ, Lampkin BC
Semin Perinatol 1999 Aug;23(4):274-85. doi: 10.1016/s0146-0005(99)80036-6. PMID: 10475541
Congenital and neonatal leukemia-- lymphocytic or myelocytic?
Wolk JA, Stuart MJ, Davey FR, Nelson DA
Am J Dis Child 1974 Dec;128(6):864-6. PMID: 4531222

Prognosis

Clinical and molecular epidemiology of neonatal leukemia in Brazil.
Moura SV, Andrade F, Magalhães IQ, Costa I, Silva DB, D'Andrea ML, Pinheiro VP, Lee ML, Werneck F, Emerenciano M, Pombo-de-Oliveira MS
Leuk Lymphoma 2015 Apr;56(4):903-9. Epub 2015 Jan 30 doi: 10.3109/10428194.2014.938327. PMID: 24991719
Features and outcome of neonatal leukemia in Japan: experience of the Japan infant leukemia study group.
Ishii E, Oda M, Kinugawa N, Oda T, Takimoto T, Suzuki N, Kosaka Y, Ohara A, Ogawa A, Ishii M, Sakata N, Okamura T, Koike K, Kojima S, Horibe K, Mizutani S
Pediatr Blood Cancer 2006 Sep;47(3):268-72. doi: 10.1002/pbc.20599. PMID: 16333820
Fetal and neonatal leukemia.
Isaacs H Jr
J Pediatr Hematol Oncol 2003 May;25(5):348-61. doi: 10.1097/00043426-200305000-00002. PMID: 12759620
Congenital and neonatal leukemia.
Sande JE, Arceci RJ, Lampkin BC
Semin Perinatol 1999 Aug;23(4):274-85. doi: 10.1016/s0146-0005(99)80036-6. PMID: 10475541
Neonatal oncology.
Bertolone S
Pediatr Clin North Am 1977 Aug;24(3):585-98. doi: 10.1016/s0031-3955(16)33467-8. PMID: 197475

Clinical prediction guides

Congenital acute myeloid leukemia: challenges and lessons. A 15-year experience from the UK.
Green K, Tandon S, Ahmed M, Toscano W, O'Connor D, Ancliff P, Vora A, Bartram J, Samarasinghe S, Ghorashian S, Pavasovic V, Rao A
Leuk Lymphoma 2021 Mar;62(3):688-695. Epub 2020 Nov 23 doi: 10.1080/10428194.2020.1845335. PMID: 33225799
t(8;16)(p11;p13) predisposes to a transient but potentially recurring neonatal leukemia.
Wong KF, Yuen HL, Siu LL, Pang A, Kwong YL
Hum Pathol 2008 Nov;39(11):1702-7. Epub 2008 Jul 26 doi: 10.1016/j.humpath.2008.02.018. PMID: 18657848
Features and outcome of neonatal leukemia in Japan: experience of the Japan infant leukemia study group.
Ishii E, Oda M, Kinugawa N, Oda T, Takimoto T, Suzuki N, Kosaka Y, Ohara A, Ogawa A, Ishii M, Sakata N, Okamura T, Koike K, Kojima S, Horibe K, Mizutani S
Pediatr Blood Cancer 2006 Sep;47(3):268-72. doi: 10.1002/pbc.20599. PMID: 16333820
Cytogenetic, cytomorphologic, and immunologic analysis in 55 children with acute lymphoblastic leukemia.
Petković I, Josip K, Nakić M, Kastelan M
Cancer Genet Cytogenet 1996 May;88(1):57-65. doi: 10.1016/0165-4608(95)00293-6. PMID: 8630981

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...