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Prostate sarcoma

MedGen UID:
116060
•Concept ID:
C0238393
•
Neoplastic Process
Synonyms: prostate gland sarcoma; Prostate Sarcoma; prostate sarcoma; Sarcoma of Prostate; sarcoma of prostate; sarcoma of prostate gland; Sarcoma of the Prostate; sarcoma of the prostate
 
Monarch Initiative: MONDO:0002854

Definition

A rare malignant mesenchymal neoplasm that arises from the prostate gland. Representative examples include leiomyosarcoma, rhabdomyosarcoma, and stromal sarcoma. [from NCI]

Professional guidelines

PubMed

Multimodal Therapy in the Treatment of Prostate Sarcoma: The Johns Hopkins Experience.
Ball MW, Sundi D, Reese AC, Meyer CF, Terezakis SA, Efron JE, Schoenberg MP, Epstein JI, Ahuja N, Bivalacqua TJ
Clin Genitourin Cancer 2015 Oct;13(5):435-40. Epub 2015 May 2 doi: 10.1016/j.clgc.2015.04.011. PMID: 26003268
Best practices recommendations in the application of immunohistochemistry in the prostate: report from the International Society of Urologic Pathology consensus conference.
Epstein JI, Egevad L, Humphrey PA, Montironi R; Members of the ISUP Immunohistochemistry in Diagnostic Urologic Pathology Group
Am J Surg Pathol 2014 Aug;38(8):e6-e19. doi: 10.1097/PAS.0000000000000238. PMID: 25029122
Insulin-like growth factor 1 receptor targeted therapeutics: novel compounds and novel treatment strategies for cancer medicine.
Hewish M, Chau I, Cunningham D
Recent Pat Anticancer Drug Discov 2009 Jan;4(1):54-72. doi: 10.2174/157489209787002515. PMID: 19149688

Recent clinical studies

Etiology

Adult primary prostate sarcoma: A multi-center cohort study and comparison between Chinese and American cases.
Ding B, Zhang Y, Hu W, Hu D, Liu J, Zhao S, Wang F, Xue L, Xu Z, Chen L
Asian J Surg 2021 Jan;44(1):247-253. Epub 2020 Jul 4 doi: 10.1016/j.asjsur.2020.06.004. PMID: 32636119
Histologic variability and diverse oncologic outcomes of prostate sarcomas.
Sohn M, Kwon T, Jeong IG, Hong S, You D, Hong JH, Ahn H, Kim CS
Korean J Urol 2014 Dec;55(12):797-801. Epub 2014 Nov 28 doi: 10.4111/kju.2014.55.12.797. PMID: 25512813Free PMC Article
Survey of clinical and pathological characteristics and outcomes of patients with prostate cancer.
Alizadeh M, Alizadeh S
Glob J Health Sci 2014 Sep 18;6(7 Spec No):49-57. doi: 10.5539/gjhs.v6n7p49. PMID: 25363179Free PMC Article
Sarcoma of the prostate: a single institutional review.
Janet NL, May AW, Akins RS
Am J Clin Oncol 2009 Feb;32(1):27-9. doi: 10.1097/COC.0b013e31817b6061. PMID: 19194120
Adult prostate sarcoma: radiological-clinical correlation.
Ren FY, Lu JP, Wang J, Ye JJ, Shao CW, Wang MJ
Clin Radiol 2009 Feb;64(2):171-7. Epub 2008 Sep 26 doi: 10.1016/j.crad.2008.07.013. PMID: 19103347

Diagnosis

Adult primary prostate sarcoma: A multi-center cohort study and comparison between Chinese and American cases.
Ding B, Zhang Y, Hu W, Hu D, Liu J, Zhao S, Wang F, Xue L, Xu Z, Chen L
Asian J Surg 2021 Jan;44(1):247-253. Epub 2020 Jul 4 doi: 10.1016/j.asjsur.2020.06.004. PMID: 32636119
Histologic variability and diverse oncologic outcomes of prostate sarcomas.
Sohn M, Kwon T, Jeong IG, Hong S, You D, Hong JH, Ahn H, Kim CS
Korean J Urol 2014 Dec;55(12):797-801. Epub 2014 Nov 28 doi: 10.4111/kju.2014.55.12.797. PMID: 25512813Free PMC Article
Survey of clinical and pathological characteristics and outcomes of patients with prostate cancer.
Alizadeh M, Alizadeh S
Glob J Health Sci 2014 Sep 18;6(7 Spec No):49-57. doi: 10.5539/gjhs.v6n7p49. PMID: 25363179Free PMC Article
Prostate sarcoma: report of 2 cases and bibliographic review.
Busto Martín L, Carral Freire M, Hermida T, Aller M, Busto Castañón L
Arch Esp Urol 2014 Oct;67(8):699-704. PMID: 25306988
Adult prostate sarcoma: the Memorial Sloan Kettering experience.
Musser JE, Assel M, Mashni JW, Sjoberg DD, Russo P
Urology 2014 Sep;84(3):624-8. doi: 10.1016/j.urology.2014.05.036. PMID: 25168544Free PMC Article

Therapy

Primary malignant peripheral nerve sheath tumor of prostate in a young adult: A case report.
Kim H, Kim DY, Seol YM, Ku JY, Choi KU, Choi YJ
Medicine (Baltimore) 2018 Sep;97(39):e12040. doi: 10.1097/MD.0000000000012040. PMID: 30278486Free PMC Article
Sarcoma of the prostate: a single institutional review.
Janet NL, May AW, Akins RS
Am J Clin Oncol 2009 Feb;32(1):27-9. doi: 10.1097/COC.0b013e31817b6061. PMID: 19194120
Postradiation prostatic sarcoma: de novo carcinogenesis or dedifferentiation of prostatic adenocarcinoma?
Canfield SE, Gans TH, Unger P, Hall SJ
Tech Urol 2001 Dec;7(4):294-5. PMID: 11763492

Prognosis

Adult primary prostate sarcoma: A multi-center cohort study and comparison between Chinese and American cases.
Ding B, Zhang Y, Hu W, Hu D, Liu J, Zhao S, Wang F, Xue L, Xu Z, Chen L
Asian J Surg 2021 Jan;44(1):247-253. Epub 2020 Jul 4 doi: 10.1016/j.asjsur.2020.06.004. PMID: 32636119
Demographics, stage distribution, and relative roles of surgery and radiotherapy on survival of persons with primary prostate sarcomas.
Tward JD, Poppe MM, Hitchcock YJ, O'Neil B, Albertson DJ, Shrieve DC
Cancer Med 2018 Dec;7(12):6030-6039. Epub 2018 Nov 19 doi: 10.1002/cam4.1872. PMID: 30453392Free PMC Article
Histologic variability and diverse oncologic outcomes of prostate sarcomas.
Sohn M, Kwon T, Jeong IG, Hong S, You D, Hong JH, Ahn H, Kim CS
Korean J Urol 2014 Dec;55(12):797-801. Epub 2014 Nov 28 doi: 10.4111/kju.2014.55.12.797. PMID: 25512813Free PMC Article
Adult prostate sarcoma: the Memorial Sloan Kettering experience.
Musser JE, Assel M, Mashni JW, Sjoberg DD, Russo P
Urology 2014 Sep;84(3):624-8. doi: 10.1016/j.urology.2014.05.036. PMID: 25168544Free PMC Article
Sarcoma of the prostate: a single institutional review.
Janet NL, May AW, Akins RS
Am J Clin Oncol 2009 Feb;32(1):27-9. doi: 10.1097/COC.0b013e31817b6061. PMID: 19194120

Clinical prediction guides

Survey of clinical and pathological characteristics and outcomes of patients with prostate cancer.
Alizadeh M, Alizadeh S
Glob J Health Sci 2014 Sep 18;6(7 Spec No):49-57. doi: 10.5539/gjhs.v6n7p49. PMID: 25363179Free PMC Article
Adult prostate sarcoma: the Memorial Sloan Kettering experience.
Musser JE, Assel M, Mashni JW, Sjoberg DD, Russo P
Urology 2014 Sep;84(3):624-8. doi: 10.1016/j.urology.2014.05.036. PMID: 25168544Free PMC Article
Twenty-five cases of adult prostate sarcoma treated at a high-volume institution from 1989 to 2009.
Wang X, Liu L, Tang H, Rao Z, Zhan W, Li X, Zeng H, Zhang P, Wei B, Lin T, Wei Q, Lu Y, Li X
Urology 2013 Jul;82(1):160-5. Epub 2013 Apr 16 doi: 10.1016/j.urology.2013.01.034. PMID: 23601444
Sarcoma of the prostate: a single institutional review.
Janet NL, May AW, Akins RS
Am J Clin Oncol 2009 Feb;32(1):27-9. doi: 10.1097/COC.0b013e31817b6061. PMID: 19194120
Adult prostate sarcoma: the M. D. Anderson Cancer Center Experience.
Sexton WJ, Lance RE, Reyes AO, Pisters PW, Tu SM, Pisters LL
J Urol 2001 Aug;166(2):521-5. doi: 10.1016/s0022-5347(05)65974-5. PMID: 11458058

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