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Gastric leiomyoma

MedGen UID:
116062
•Concept ID:
C0238440
•
Neoplastic Process
Synonyms: Gastric Leiomyoma; gastric leiomyoma; Leiomyoma of stomach; Leiomyoma of Stomach; leiomyoma of stomach; Leiomyoma of the Stomach; leiomyoma of the stomach; stomach leiomyoma
SNOMED CT: Gastric leiomyoma (276812001); Leiomyoma of stomach (276812001)
 
Monarch Initiative: MONDO:0000938

Definition

A rare benign smooth muscle neoplasm arising from the wall of the stomach. It is characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern. Unlike gastrointestinal stromal tumors, gastric leiomyomas are by definition negative for CD34 and CD117 (C-KIT). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGastric leiomyoma

Professional guidelines

PubMed

The accumulating appreciation of endoscopic submucosal dissection in the treatment of gastrointestinal neoplasms: preliminary experience in local eastern China.
Zhang J, Yang JM, Xu QS, Shigetomo M, Fei BY, Lou GC, Li CH, Si P
Hepatogastroenterology 2013 Sep;60(126):1257-62. doi: 10.5754/hge121255. PMID: 23425807

Recent clinical studies

Etiology

Clinical and CT Imaging Differences Between Gastric Schwannoma and Gastric Leiomyoma.
Zhao L, Xue H, Sun Z, Chen Y, Yu H, Mao S
J Coll Physicians Surg Pak 2023 Apr;33(4):369-373. doi: 10.29271/jcpsp.2023.04.369. PMID: 37190705
Computed tomography features of gastric leiomyoma versus gastric stromal tumor: a case-control study with propensity score matching.
Wang Q, Wang L, Qi X, Liu X, Xie Q, Wang Y, Shi G
J Int Med Res 2023 May;51(5):3000605231171025. doi: 10.1177/03000605231171025. PMID: 37170626Free PMC Article
Differentiation of Small Gastrointestinal Stromal Tumor and Gastric Leiomyoma with Contrast-Enhanced CT.
Yan M, Liu Y, You H, Zhao Y, Jin J, Wang J
J Healthc Eng 2023;2023:6423617. Epub 2023 Feb 8 doi: 10.1155/2023/6423617. PMID: 36818387Free PMC Article
Value of CT Imaging in the Differentiation of Gastric Leiomyoma From Gastric Stromal Tumor.
Wang J, Zhou X, Xu F, Ao W, Hu H
Can Assoc Radiol J 2021 Aug;72(3):444-451. Epub 2020 Feb 28 doi: 10.1177/0846537119885671. PMID: 32106696
Histopathology Findings in Patients Undergoing Laparoscopic Sleeve Gastrectomy.
Canil AM, Iossa A, Termine P, Caporilli D, Petrozza V, Silecchia G
Obes Surg 2018 Jun;28(6):1760-1765. doi: 10.1007/s11695-017-3092-9. PMID: 29305814

Diagnosis

Cutaneous lesions and other non-endocrine manifestations of Multiple Endocrine Neoplasia type 1 syndrome.
Pierotti L, Pardi E, Dinoi E, Piaggi P, Borsari S, Della Valentina S, Sardella C, Michelucci A, Caligo MA, Bogazzi F, Marcocci C, Cetani F
Front Endocrinol (Lausanne) 2023;14:1191040. Epub 2023 Jul 7 doi: 10.3389/fendo.2023.1191040. PMID: 37484956Free PMC Article
Clinical and CT Imaging Differences Between Gastric Schwannoma and Gastric Leiomyoma.
Zhao L, Xue H, Sun Z, Chen Y, Yu H, Mao S
J Coll Physicians Surg Pak 2023 Apr;33(4):369-373. doi: 10.29271/jcpsp.2023.04.369. PMID: 37190705
Computed tomography features of gastric leiomyoma versus gastric stromal tumor: a case-control study with propensity score matching.
Wang Q, Wang L, Qi X, Liu X, Xie Q, Wang Y, Shi G
J Int Med Res 2023 May;51(5):3000605231171025. doi: 10.1177/03000605231171025. PMID: 37170626Free PMC Article
Differentiation of Small Gastrointestinal Stromal Tumor and Gastric Leiomyoma with Contrast-Enhanced CT.
Yan M, Liu Y, You H, Zhao Y, Jin J, Wang J
J Healthc Eng 2023;2023:6423617. Epub 2023 Feb 8 doi: 10.1155/2023/6423617. PMID: 36818387Free PMC Article
Value of CT Imaging in the Differentiation of Gastric Leiomyoma From Gastric Stromal Tumor.
Wang J, Zhou X, Xu F, Ao W, Hu H
Can Assoc Radiol J 2021 Aug;72(3):444-451. Epub 2020 Feb 28 doi: 10.1177/0846537119885671. PMID: 32106696

Therapy

Incidental gastric mesenchymal tumors identified during laparoscopic sleeve gastrectomy.
Crouthamel MR, Kaufman JA, Billing JP, Billing PS, Landerholm RW
Surg Obes Relat Dis 2015 Sep-Oct;11(5):1025-8. Epub 2015 Jun 10 doi: 10.1016/j.soard.2015.06.004. PMID: 26645488
Endoscopic alcohol injection therapy of giant gastric leiomyomas: an alternative method to surgery.
Ozdil B, Akkiz H, Kece C, Sandikci M
Can J Gastroenterol 2010 Sep;24(9):533-5. doi: 10.1155/2010/936936. PMID: 21152456Free PMC Article
The role of serum chromogranin A in diarrhoea predominant irritable bowel syndrome.
Sidhu R, McAlindon ME, Leeds JS, Skilling J, Sanders DS
J Gastrointestin Liver Dis 2009 Mar;18(1):23-6. PMID: 19337629
Laparoscopic management of a gastric perforation after snare removal of a gastric leiomyoma.
Yu BL, Yuan RH, Wong JM, Yu SC
Endoscopy 1998 May;30(4):425-7. doi: 10.1055/s-2007-1001295. PMID: 9689521
Drug-induced bleeding of gastric leiomyoma.
Stalnikowicz R, Eliakim R, Ligumsky M, Rachmilewitz D
Am J Gastroenterol 1987 May;82(5):419-20. PMID: 3495170

Prognosis

Clinical and CT Imaging Differences Between Gastric Schwannoma and Gastric Leiomyoma.
Zhao L, Xue H, Sun Z, Chen Y, Yu H, Mao S
J Coll Physicians Surg Pak 2023 Apr;33(4):369-373. doi: 10.29271/jcpsp.2023.04.369. PMID: 37190705
Value of CT Imaging in the Differentiation of Gastric Leiomyoma From Gastric Stromal Tumor.
Wang J, Zhou X, Xu F, Ao W, Hu H
Can Assoc Radiol J 2021 Aug;72(3):444-451. Epub 2020 Feb 28 doi: 10.1177/0846537119885671. PMID: 32106696
Gastric leiomyoma casusing gastrointestinal bleeding.
Cervantes-Pérez E, Cervantes-Guevara G, Cervantes-Pérez LA, Cervantes-Cardona GA, González-Ojeda A, Fuentes-Orozco C
Cir Cir 2020;88(Suppl 1):116-119. doi: 10.24875/CIRU.20001766. PMID: 32963385
Histopathology Findings in Patients Undergoing Laparoscopic Sleeve Gastrectomy.
Canil AM, Iossa A, Termine P, Caporilli D, Petrozza V, Silecchia G
Obes Surg 2018 Jun;28(6):1760-1765. doi: 10.1007/s11695-017-3092-9. PMID: 29305814
Incidental gastric mesenchymal tumors identified during laparoscopic sleeve gastrectomy.
Crouthamel MR, Kaufman JA, Billing JP, Billing PS, Landerholm RW
Surg Obes Relat Dis 2015 Sep-Oct;11(5):1025-8. Epub 2015 Jun 10 doi: 10.1016/j.soard.2015.06.004. PMID: 26645488

Clinical prediction guides

Cutaneous lesions and other non-endocrine manifestations of Multiple Endocrine Neoplasia type 1 syndrome.
Pierotti L, Pardi E, Dinoi E, Piaggi P, Borsari S, Della Valentina S, Sardella C, Michelucci A, Caligo MA, Bogazzi F, Marcocci C, Cetani F
Front Endocrinol (Lausanne) 2023;14:1191040. Epub 2023 Jul 7 doi: 10.3389/fendo.2023.1191040. PMID: 37484956Free PMC Article
Clinical and CT Imaging Differences Between Gastric Schwannoma and Gastric Leiomyoma.
Zhao L, Xue H, Sun Z, Chen Y, Yu H, Mao S
J Coll Physicians Surg Pak 2023 Apr;33(4):369-373. doi: 10.29271/jcpsp.2023.04.369. PMID: 37190705
Computed tomography features of gastric leiomyoma versus gastric stromal tumor: a case-control study with propensity score matching.
Wang Q, Wang L, Qi X, Liu X, Xie Q, Wang Y, Shi G
J Int Med Res 2023 May;51(5):3000605231171025. doi: 10.1177/03000605231171025. PMID: 37170626Free PMC Article
Value of CT Imaging in the Differentiation of Gastric Leiomyoma From Gastric Stromal Tumor.
Wang J, Zhou X, Xu F, Ao W, Hu H
Can Assoc Radiol J 2021 Aug;72(3):444-451. Epub 2020 Feb 28 doi: 10.1177/0846537119885671. PMID: 32106696
Histopathology Findings in Patients Undergoing Laparoscopic Sleeve Gastrectomy.
Canil AM, Iossa A, Termine P, Caporilli D, Petrozza V, Silecchia G
Obes Surg 2018 Jun;28(6):1760-1765. doi: 10.1007/s11695-017-3092-9. PMID: 29305814

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