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Salt craving

MedGen UID:
116112
Concept ID:
C0240928
Finding; Sign or Symptom
HPO: HP:0030083

Definition

Hypersalivation, also known as salt craving, refers to an excessive desire to consume salt (sodium chloride) or salty foods. [from HPO]

Term Hierarchy

Conditions with this feature

Familial hypokalemia-hypomagnesemia
MedGen UID:
75681
Concept ID:
C0268450
Disease or Syndrome
Gitelman syndrome (GTLMNS) is an autosomal recessive renal tubular salt-wasting disorder characterized by hypokalemic metabolic alkalosis with hypomagnesemia and hypocalciuria. It is the most common renal tubular disorder among Caucasians (prevalence of 1 in 40,000). Most patients have onset of symptoms as adults, but some present in childhood. Clinical features include transient periods of muscle weakness and tetany, abdominal pains, and chondrocalcinosis (summary by Glaudemans et al., 2012). Gitelman syndrome is sometimes referred to as a mild variant of classic Bartter syndrome (607364). For a discussion of genetic heterogeneity of Bartter syndrome, see 607364.
EAST syndrome
MedGen UID:
411243
Concept ID:
C2748572
Disease or Syndrome
Syndrome with characteristics of seizures, sensorineural deafness, ataxia, intellectual deficit, and electrolyte imbalance. It has been described in five patients from four families. The disease is caused by homozygous or compound heterozygous mutations in the KCNJ10 gene, encoding a potassium channel expressed in the brain, spinal cord, inner ear and kidneys. Transmission is autosomal recessive.

Professional guidelines

PubMed

Charoensri S, Auchus RJ
Endocrinol Metab (Seoul) 2024 Feb;39(1):73-82. Epub 2024 Jan 22 doi: 10.3803/EnM.2024.1894. PMID: 38253474Free PMC Article
Michels A, Michels N
Am Fam Physician 2014 Apr 1;89(7):563-8. PMID: 24695602

Recent clinical studies

Etiology

Flokas ME, Bustamante VH, Kanakatti Shankar R
Horm Res Paediatr 2022;95(4):397-401. Epub 2022 May 24 doi: 10.1159/000525227. PMID: 35609533Free PMC Article
Margulies SL, Corrigan K, Bathgate S, Macri C
J Neonatal Perinatal Med 2020;13(2):275-278. doi: 10.3233/NPM-190231. PMID: 31744021
Smits MM, Ten Kulve JS, van Bloemendaal L, Tonneijck L, Muskiet MHA, Kramer MHH, Ijzerman RG, van Raalte DH
Nutrition 2019 Nov-Dec;67-68:110524. Epub 2019 Jun 14 doi: 10.1016/j.nut.2019.06.005. PMID: 31415908
Bhardwaj S, Thergaonkar R, Sinha A, Hari P, Hi C, Bagga A
Indian Pediatr 2016 Nov 15;53(11):977-982. doi: 10.1007/s13312-016-0971-4. PMID: 27889724
Morris MJ, Na ES, Johnson AK
Physiol Behav 2008 Aug 6;94(5):709-21. Epub 2008 Apr 13 doi: 10.1016/j.physbeh.2008.04.008. PMID: 18514747Free PMC Article

Diagnosis

Zhou J, Reddy SSK
Cleve Clin J Med 2022 Apr 1;89(4):180-181. doi: 10.3949/ccjm.89a.21036. PMID: 35365554
Younes N, Bourdeau I, Lacroix A
Front Endocrinol (Lausanne) 2021;12:720769. Epub 2021 Aug 27 doi: 10.3389/fendo.2021.720769. PMID: 34512551Free PMC Article
Mustafa QU, Haroon ZH, Ijaz A, Sajid MT, Ayyub M
J Coll Physicians Surg Pak 2017 Mar;27(3):S30-S32. PMID: 28302238
Fares AB, Santos RA
Rev Assoc Med Bras (1992) 2016 Nov;62(8):728-734. doi: 10.1590/1806-9282.62.08.728. PMID: 27992012
Michels A, Michels N
Am Fam Physician 2014 Apr 1;89(7):563-8. PMID: 24695602

Therapy

Charoensri S, Auchus RJ
Endocrinol Metab (Seoul) 2024 Feb;39(1):73-82. Epub 2024 Jan 22 doi: 10.3803/EnM.2024.1894. PMID: 38253474Free PMC Article
Flokas ME, Bustamante VH, Kanakatti Shankar R
Horm Res Paediatr 2022;95(4):397-401. Epub 2022 May 24 doi: 10.1159/000525227. PMID: 35609533Free PMC Article
Smits MM, Ten Kulve JS, van Bloemendaal L, Tonneijck L, Muskiet MHA, Kramer MHH, Ijzerman RG, van Raalte DH
Nutrition 2019 Nov-Dec;67-68:110524. Epub 2019 Jun 14 doi: 10.1016/j.nut.2019.06.005. PMID: 31415908
Esposito D, Pasquali D, Johannsson G
J Clin Endocrinol Metab 2018 Feb 1;103(2):376-387. doi: 10.1210/jc.2017-01928. PMID: 29156052
Quinkler M, Oelkers W, Remde H, Allolio B
Best Pract Res Clin Endocrinol Metab 2015 Jan;29(1):17-24. Epub 2014 Aug 27 doi: 10.1016/j.beem.2014.08.008. PMID: 25617169

Prognosis

Charoensri S, Auchus RJ
Endocrinol Metab (Seoul) 2024 Feb;39(1):73-82. Epub 2024 Jan 22 doi: 10.3803/EnM.2024.1894. PMID: 38253474Free PMC Article
Flokas ME, Bustamante VH, Kanakatti Shankar R
Horm Res Paediatr 2022;95(4):397-401. Epub 2022 May 24 doi: 10.1159/000525227. PMID: 35609533Free PMC Article
Azeez TA, Irojah OA, Lakoh S, Lawal AO, Ajiboso OA
Int J Mycobacteriol 2021 Jan-Mar;10(1):1-7. doi: 10.4103/ijmy.ijmy_4_21. PMID: 33707364
Mustafa QU, Haroon ZH, Ijaz A, Sajid MT, Ayyub M
J Coll Physicians Surg Pak 2017 Mar;27(3):S30-S32. PMID: 28302238
De Luca LA Jr, Vendramini RC, Pereira DT, Colombari DA, David RB, de Paula PM, Menani JV
Braz J Med Biol Res 2007 May;40(5):707-12. doi: 10.1590/s0100-879x2007000500015. PMID: 17464434

Clinical prediction guides

Chantzichristos D, Svensson PA, Garner T, Glad CA, Walker BR, Bergthorsdottir R, Ragnarsson O, Trimpou P, Stimson RH, Borresen SW, Feldt-Rasmussen U, Jansson PA, Skrtic S, Stevens A, Johannsson G
Elife 2021 Apr 6;10 doi: 10.7554/eLife.62236. PMID: 33821793Free PMC Article
Azeez TA, Irojah OA, Lakoh S, Lawal AO, Ajiboso OA
Int J Mycobacteriol 2021 Jan-Mar;10(1):1-7. doi: 10.4103/ijmy.ijmy_4_21. PMID: 33707364
Patel FB, Newman SA, Norton SA
Skinmed 2016;14(1):53-4. Epub 2016 Feb 1 PMID: 27072733
De Luca LA Jr, Vendramini RC, Pereira DT, Colombari DA, David RB, de Paula PM, Menani JV
Braz J Med Biol Res 2007 May;40(5):707-12. doi: 10.1590/s0100-879x2007000500015. PMID: 17464434
Kabra SK, Kabra M, Lodha R, Shastri S, Ghosh M, Pandey RM, Kapil A, Aggarwal G, Kapoor V
Indian Pediatr 2003 Jul;40(7):612-9. PMID: 12881616

Recent systematic reviews

Azeez TA, Irojah OA, Lakoh S, Lawal AO, Ajiboso OA
Int J Mycobacteriol 2021 Jan-Mar;10(1):1-7. doi: 10.4103/ijmy.ijmy_4_21. PMID: 33707364
Esposito D, Pasquali D, Johannsson G
J Clin Endocrinol Metab 2018 Feb 1;103(2):376-387. doi: 10.1210/jc.2017-01928. PMID: 29156052

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