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Space motion sickness

MedGen UID:
116642
•Concept ID:
C0242700
•
Disease or Syndrome
Synonyms: Adaptation Syndrome, Space; Motion Sickness, Space; Space Adaptation Syndrome; Space Motion Sickness; Syndrome, Space Adaptation
SNOMED CT: Outer space sickness (21162009)
 
Monarch Initiative: MONDO:0003147

Definition

Disorder characterized by nausea, vomiting, and dizziness, possibly in response to vestibular disorientation or fluid shifts associated with space flight. (From Webster's New World Dictionary) [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSpace motion sickness

Professional guidelines

PubMed

Comparison of treatment strategies for Space Motion Sickness.
Davis JR, Jennings RT, Beck BG
Acta Astronaut 1993 Aug;29(8):587-91. doi: 10.1016/0094-5765(93)90074-7. PMID: 11541638
Treatment efficacy of intramuscular promethazine for space motion sickness.
Davis JR, Jennings RT, Beck BG, Bagian JP
Aviat Space Environ Med 1993 Mar;64(3 Pt 1):230-3. PMID: 8447805
Comparison of treatment strategies for Space Motion Sickness.
Davis JR, Jennings RT, Beck BG
Microgravity Q 1992 Jul;2(3):173-7. PMID: 11541442

Recent clinical studies

Etiology

Orientation Preferences and Motion Sickness Induced in a Virtual Reality Environment.
Chen W, Chao JG, Zhang Y, Wang JK, Chen XW, Tan C
Aerosp Med Hum Perform 2017 Oct 1;88(10):903-910. doi: 10.3357/AMHP.4817.2017. PMID: 28923138
Quantitative orientation preference and susceptibility to space motion sickness simulated in a virtual reality environment.
Chen W, Chao JG, Chen XW, Wang JK, Tan C
Brain Res Bull 2015 Apr;113:17-26. Epub 2015 Jan 31 doi: 10.1016/j.brainresbull.2015.01.007. PMID: 25647233
Exercise equipment used in microgravity: challenges and opportunities.
Davis SA, Davis BL
Curr Sports Med Rep 2012 May-Jun;11(3):142-7. doi: 10.1249/JSR.0b013e3182578fc3. PMID: 22580492
Managing space motion sickness.
Jennings RT
J Vestib Res 1998 Jan-Feb;8(1):67-70. PMID: 9416592
Nutrition and human physiological adaptations to space flight.
Lane HW, LeBlanc AD, Putcha L, Whitson PA
Am J Clin Nutr 1993 Nov;58(5):583-8. doi: 10.1093/ajcn/58.5.583. PMID: 8237860

Diagnosis

A Case Study of Severe Space Motion Sickness.
Reschke MF, Wood SJ, Clément GR
Aerosp Med Hum Perform 2018 Aug 1;89(8):749-753. doi: 10.3357/AMHP.5071.2018. PMID: 30020061
Effects of sex and gender on adaptation to space: neurosensory systems.
Reschke MF, Cohen HS, Cerisano JM, Clayton JA, Cromwell R, Danielson RW, Hwang EY, Tingen C, Allen JR, Tomko DL
J Womens Health (Larchmt) 2014 Nov;23(11):959-62. doi: 10.1089/jwh.2014.4908. PMID: 25401941Free PMC Article
Space motion sickness.
Lackner JR, Dizio P
Exp Brain Res 2006 Nov;175(3):377-99. Epub 2006 Oct 5 doi: 10.1007/s00221-006-0697-y. PMID: 17021896
Pharmacotherapeutics in space.
Putcha L
J Gravit Physiol 1999 Jul;6(1):P165-8. PMID: 11543005
Clinical characterization and etiology of space motion sickness.
Thornton WE, Moore TP, Pool SL, Vanderploeg J
Aviat Space Environ Med 1987 Sep;58(9 Pt 2):A1-8. PMID: 3499891

Therapy

Pharmacological and non-pharmacological countermeasures to Space Motion Sickness: a systematic review.
Khalid A, Prusty PP, Arshad I, Gustafson HE, Jalaly I, Nockels K, Bentley BL, Goel R, Ferrè ER
Front Neural Circuits 2023;17:1150233. Epub 2023 Jun 16 doi: 10.3389/fncir.2023.1150233. PMID: 37396400Free PMC Article
Space motion sickness: A common neurovestibular dysfunction in microgravity.
Russomano T, da Rosa M, Dos Santos MA
Neurol India 2019 May-Jun;67(Supplement):S214-S218. doi: 10.4103/0028-3886.259127. PMID: 31134912
Space motion sickness.
Lackner JR, Dizio P
Exp Brain Res 2006 Nov;175(3):377-99. Epub 2006 Oct 5 doi: 10.1007/s00221-006-0697-y. PMID: 17021896
Pharmacological approaches.
Vernikos J
Acta Astronaut 1995 Feb-Mar;35(4-5):281-95. doi: 10.1016/0094-5765(95)98733-p. PMID: 11541472
Space motion sickness.
Homick JL
Acta Astronaut 1979 Oct;6(10):1259-72. doi: 10.1016/0094-5765(79)90119-x. PMID: 11902170

Prognosis

Subjective Vertical Conflict Theory and Space Motion Sickness.
Chen W, Chao JG, Wang JK, Chen XW, Tan C
Aerosp Med Hum Perform 2016 Feb;87(2):128-36. doi: 10.3357/AMHP.4327.2016. PMID: 26802378
Quantitative orientation preference and susceptibility to space motion sickness simulated in a virtual reality environment.
Chen W, Chao JG, Chen XW, Wang JK, Tan C
Brain Res Bull 2015 Apr;113:17-26. Epub 2015 Jan 31 doi: 10.1016/j.brainresbull.2015.01.007. PMID: 25647233
Space motion sickness.
Lackner JR, Dizio P
Exp Brain Res 2006 Nov;175(3):377-99. Epub 2006 Oct 5 doi: 10.1007/s00221-006-0697-y. PMID: 17021896
The influence of weightlessness on pharmacokinetics.
Gandia P, Saivin S, Houin G
Fundam Clin Pharmacol 2005 Dec;19(6):625-36. doi: 10.1111/j.1472-8206.2005.00374.x. PMID: 16313274
Space motion sickness.
Homick JL
Acta Astronaut 1979 Oct;6(10):1259-72. doi: 10.1016/0094-5765(79)90119-x. PMID: 11902170

Clinical prediction guides

Space motion sickness: A common neurovestibular dysfunction in microgravity.
Russomano T, da Rosa M, Dos Santos MA
Neurol India 2019 May-Jun;67(Supplement):S214-S218. doi: 10.4103/0028-3886.259127. PMID: 31134912
Drugs in space: Pharmacokinetics and pharmacodynamics in astronauts.
Kast J, Yu Y, Seubert CN, Wotring VE, Derendorf H
Eur J Pharm Sci 2017 Nov 15;109S:S2-S8. Epub 2017 May 19 doi: 10.1016/j.ejps.2017.05.025. PMID: 28533143
A rationale for space motion sickness.
Thornton WE
Aviat Space Environ Med 2011 Apr;82(4):467-8. doi: 10.3357/asem.2907.2011. PMID: 21485406
Space motion sickness.
Lackner JR, Dizio P
Exp Brain Res 2006 Nov;175(3):377-99. Epub 2006 Oct 5 doi: 10.1007/s00221-006-0697-y. PMID: 17021896
Space motion sickness.
Homick JL
Acta Astronaut 1979 Oct;6(10):1259-72. doi: 10.1016/0094-5765(79)90119-x. PMID: 11902170

Recent systematic reviews

Pharmacological and non-pharmacological countermeasures to Space Motion Sickness: a systematic review.
Khalid A, Prusty PP, Arshad I, Gustafson HE, Jalaly I, Nockels K, Bentley BL, Goel R, Ferrè ER
Front Neural Circuits 2023;17:1150233. Epub 2023 Jun 16 doi: 10.3389/fncir.2023.1150233. PMID: 37396400Free PMC Article

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