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Critical Illness

MedGen UID:
1173
•Concept ID:
C0010340
•
Disease or Syndrome
Synonyms: Critical Illnesses; Critically Ill; Illness, Critical; Illnesses, Critical

Definition

A disease or state in which death is possible or imminent. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCritical Illness

Professional guidelines

PubMed

Delirium in critical illness: clinical manifestations, outcomes, and management.
Stollings JL, Kotfis K, Chanques G, Pun BT, Pandharipande PP, Ely EW
Intensive Care Med 2021 Oct;47(10):1089-1103. Epub 2021 Aug 16 doi: 10.1007/s00134-021-06503-1. PMID: 34401939Free PMC Article
Epidemiology, pathogenesis, clinical presentations, diagnosis and treatment of COVID-19: a review of current evidence.
Rahman S, Montero MTV, Rowe K, Kirton R, Kunik F Jr
Expert Rev Clin Pharmacol 2021 May;14(5):601-621. Epub 2021 May 3 doi: 10.1080/17512433.2021.1902303. PMID: 33705239Free PMC Article
Sepsis: pathophysiology and clinical management.
Gotts JE, Matthay MA
BMJ 2016 May 23;353:i1585. doi: 10.1136/bmj.i1585. PMID: 27217054

Recent clinical studies

Etiology

Pathophysiology and management of critical illness polyneuropathy and myopathy.
Cheung K, Rathbone A, Melanson M, Trier J, Ritsma BR, Allen MD
J Appl Physiol (1985) 2021 May 1;130(5):1479-1489. Epub 2021 Mar 18 doi: 10.1152/japplphysiol.00019.2021. PMID: 33734888Free PMC Article
Critical Illness Myopathy.
Z'Graggen WJ, Tankisi H
J Clin Neurophysiol 2020 May;37(3):200-204. doi: 10.1097/WNP.0000000000000652. PMID: 32358245
Atrial Fibrillation in the ICU.
Bosch NA, Cimini J, Walkey AJ
Chest 2018 Dec;154(6):1424-1434. Epub 2018 Apr 6 doi: 10.1016/j.chest.2018.03.040. PMID: 29627355Free PMC Article
ICU-Acquired Weakness.
Jolley SE, Bunnell AE, Hough CL
Chest 2016 Nov;150(5):1129-1140. Epub 2016 Apr 7 doi: 10.1016/j.chest.2016.03.045. PMID: 27063347Free PMC Article
Sleep in the intensive care unit.
Pisani MA, Friese RS, Gehlbach BK, Schwab RJ, Weinhouse GL, Jones SF
Am J Respir Crit Care Med 2015 Apr 1;191(7):731-8. doi: 10.1164/rccm.201411-2099CI. PMID: 25594808Free PMC Article

Diagnosis

Critical Illness Neuropathy.
Tankisi H, de Carvalho M, Z'Graggen WJ
J Clin Neurophysiol 2020 May;37(3):205-207. doi: 10.1097/WNP.0000000000000658. PMID: 32358246
Critical Illness Myopathy.
Z'Graggen WJ, Tankisi H
J Clin Neurophysiol 2020 May;37(3):200-204. doi: 10.1097/WNP.0000000000000652. PMID: 32358245
Atrial Fibrillation in the ICU.
Bosch NA, Cimini J, Walkey AJ
Chest 2018 Dec;154(6):1424-1434. Epub 2018 Apr 6 doi: 10.1016/j.chest.2018.03.040. PMID: 29627355Free PMC Article
ICU-Acquired Weakness.
Jolley SE, Bunnell AE, Hough CL
Chest 2016 Nov;150(5):1129-1140. Epub 2016 Apr 7 doi: 10.1016/j.chest.2016.03.045. PMID: 27063347Free PMC Article
Clinical review: intensive care unit acquired weakness.
Hermans G, Van den Berghe G
Crit Care 2015 Aug 5;19(1):274. doi: 10.1186/s13054-015-0993-7. PMID: 26242743Free PMC Article

Therapy

Fluid Therapy for Critically Ill Adults With Sepsis: A Review.
Zampieri FG, Bagshaw SM, Semler MW
JAMA 2023 Jun 13;329(22):1967-1980. doi: 10.1001/jama.2023.7560. PMID: 37314271
Daily sedation interruption and mechanical ventilation weaning: a literature review.
Vagionas D, Vasileiadis I, Rovina N, Alevrakis E, Koutsoukou A, Koulouris N
Anaesthesiol Intensive Ther 2019;51(5):380-389. doi: 10.5114/ait.2019.90921. PMID: 31893604
The SOFA score-development, utility and challenges of accurate assessment in clinical trials.
Lambden S, Laterre PF, Levy MM, Francois B
Crit Care 2019 Nov 27;23(1):374. doi: 10.1186/s13054-019-2663-7. PMID: 31775846Free PMC Article
Music therapy reduces stress and anxiety in critically ill patients: a systematic review of randomized clinical trials.
Umbrello M, Sorrenti T, Mistraletti G, Formenti P, Chiumello D, Terzoni S
Minerva Anestesiol 2019 Aug;85(8):886-898. Epub 2019 Apr 3 doi: 10.23736/S0375-9393.19.13526-2. PMID: 30947484
Treatment of electrolyte disorders in adult patients in the intensive care unit.
Kraft MD, Btaiche IF, Sacks GS, Kudsk KA
Am J Health Syst Pharm 2005 Aug 15;62(16):1663-82. doi: 10.2146/ajhp040300. PMID: 16085929

Prognosis

Comparison between pressure support ventilation and T-piece in spontaneous breathing trials.
Na SJ, Ko RE, Nam J, Ko MG, Jeon K
Respir Res 2022 Feb 7;23(1):22. doi: 10.1186/s12931-022-01942-w. PMID: 35130914Free PMC Article
Etomidate, Adrenal Insufficiency and Mortality Associated With Severity of Illness: A Meta-Analysis.
Albert SG, Sitaula S
J Intensive Care Med 2021 Oct;36(10):1124-1129. Epub 2020 Sep 10 doi: 10.1177/0885066620957596. PMID: 32912050
Risk Factors for Dysphagia in ICU Patients After Invasive Mechanical Ventilation.
Zuercher P, Schenk NV, Moret C, Berger D, Abegglen R, Schefold JC
Chest 2020 Nov;158(5):1983-1991. Epub 2020 Jun 7 doi: 10.1016/j.chest.2020.05.576. PMID: 32525018
Epidemiology of Invasive Fungal Disease in Children.
Pana ZD, Roilides E, Warris A, Groll AH, Zaoutis T
J Pediatric Infect Dis Soc 2017 Sep 1;6(suppl_1):S3-S11. doi: 10.1093/jpids/pix046. PMID: 28927200Free PMC Article
Clinical review: intensive care unit acquired weakness.
Hermans G, Van den Berghe G
Crit Care 2015 Aug 5;19(1):274. doi: 10.1186/s13054-015-0993-7. PMID: 26242743Free PMC Article

Clinical prediction guides

Biomarker Evidence of the Persistent Inflammation, Immunosuppression and Catabolism Syndrome (PICS) in Chronic Critical Illness (CCI) After Surgical Sepsis.
Darden DB, Brakenridge SC, Efron PA, Ghita GL, Fenner BP, Kelly LS, Mohr AM, Moldawer LL, Moore FA
Ann Surg 2021 Oct 1;274(4):664-673. doi: 10.1097/SLA.0000000000005067. PMID: 34506322Free PMC Article
Development of the Gastrointestinal Dysfunction Score (GIDS) for critically ill patients - A prospective multicenter observational study (iSOFA study).
Reintam Blaser A, Padar M, Mändul M, Elke G, Engel C, Fischer K, Giabicani M, Gold T, Hess B, Hiesmayr M, Jakob SM, Loudet CI, Meesters DM, Mongkolpun W, Paugam-Burtz C, Poeze M, Preiser JC, Renberg M, Rooijackers O, Tamme K, Wernerman J, Starkopf J
Clin Nutr 2021 Aug;40(8):4932-4940. Epub 2021 Jul 18 doi: 10.1016/j.clnu.2021.07.015. PMID: 34358839
The Future of Biomarkers.
Vincent JL, Bogossian E, Menozzi M
Crit Care Clin 2020 Jan;36(1):177-187. doi: 10.1016/j.ccc.2019.08.014. PMID: 31733679
Predictive factors of weaning from mechanical ventilation and extubation outcome: A systematic review.
Baptistella AR, Sarmento FJ, da Silva KR, Baptistella SF, Taglietti M, Zuquello RÁ, Nunes Filho JR
J Crit Care 2018 Dec;48:56-62. Epub 2018 Aug 20 doi: 10.1016/j.jcrc.2018.08.023. PMID: 30172034
Assessment of limb muscle strength in critically ill patients: a systematic review.
Vanpee G, Hermans G, Segers J, Gosselink R
Crit Care Med 2014 Mar;42(3):701-11. doi: 10.1097/CCM.0000000000000030. PMID: 24201180

Recent systematic reviews

Early mobilization of critically ill patients in the intensive care unit: A systematic review and meta-analysis.
Zhang L, Hu W, Cai Z, Liu J, Wu J, Deng Y, Yu K, Chen X, Zhu L, Ma J, Qin Y
PLoS One 2019;14(10):e0223185. Epub 2019 Oct 3 doi: 10.1371/journal.pone.0223185. PMID: 31581205Free PMC Article
Music therapy reduces stress and anxiety in critically ill patients: a systematic review of randomized clinical trials.
Umbrello M, Sorrenti T, Mistraletti G, Formenti P, Chiumello D, Terzoni S
Minerva Anestesiol 2019 Aug;85(8):886-898. Epub 2019 Apr 3 doi: 10.23736/S0375-9393.19.13526-2. PMID: 30947484
Monitoring nutrition in the ICU.
Berger MM, Reintam-Blaser A, Calder PC, Casaer M, Hiesmayr MJ, Mayer K, Montejo JC, Pichard C, Preiser JC, van Zanten ARH, Bischoff SC, Singer P
Clin Nutr 2019 Apr;38(2):584-593. Epub 2018 Jul 20 doi: 10.1016/j.clnu.2018.07.009. PMID: 30077342
Early intervention (mobilization or active exercise) for critically ill adults in the intensive care unit.
Doiron KA, Hoffmann TC, Beller EM
Cochrane Database Syst Rev 2018 Mar 27;3(3):CD010754. doi: 10.1002/14651858.CD010754.pub2. PMID: 29582429Free PMC Article
The effects of active mobilisation and rehabilitation in ICU on mortality and function: a systematic review.
Tipping CJ, Harrold M, Holland A, Romero L, Nisbet T, Hodgson CL
Intensive Care Med 2017 Feb;43(2):171-183. Epub 2016 Nov 18 doi: 10.1007/s00134-016-4612-0. PMID: 27864615

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