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Critical Illness

MedGen UID:
1173
•Concept ID:
C0010340
•
Disease or Syndrome
Synonyms: Critical Illnesses; Critically Ill; Illness, Critical; Illnesses, Critical

Definition

A disease or state in which death is possible or imminent. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCritical Illness

Professional guidelines

PubMed

Delirium in critical illness: clinical manifestations, outcomes, and management.
Stollings JL, Kotfis K, Chanques G, Pun BT, Pandharipande PP, Ely EW
Intensive Care Med 2021 Oct;47(10):1089-1103. Epub 2021 Aug 16 doi: 10.1007/s00134-021-06503-1. PMID: 34401939Free PMC Article
Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU.
Devlin JW, Skrobik Y, Gélinas C, Needham DM, Slooter AJC, Pandharipande PP, Watson PL, Weinhouse GL, Nunnally ME, Rochwerg B, Balas MC, van den Boogaard M, Bosma KJ, Brummel NE, Chanques G, Denehy L, Drouot X, Fraser GL, Harris JE, Joffe AM, Kho ME, Kress JP, Lanphere JA, McKinley S, Neufeld KJ, Pisani MA, Payen JF, Pun BT, Puntillo KA, Riker RR, Robinson BRH, Shehabi Y, Szumita PM, Winkelman C, Centofanti JE, Price C, Nikayin S, Misak CJ, Flood PD, Kiedrowski K, Alhazzani W
Crit Care Med 2018 Sep;46(9):e825-e873. doi: 10.1097/CCM.0000000000003299. PMID: 30113379
Sepsis: pathophysiology and clinical management.
Gotts JE, Matthay MA
BMJ 2016 May 23;353:i1585. doi: 10.1136/bmj.i1585. PMID: 27217054

Recent clinical studies

Etiology

Survivorship After Critical Illness and Post-Intensive Care Syndrome.
Cagino LM, Seagly KS, McSparron JI
Clin Chest Med 2022 Sep;43(3):551-561. doi: 10.1016/j.ccm.2022.05.009. PMID: 36116822
Pathophysiology and management of critical illness polyneuropathy and myopathy.
Cheung K, Rathbone A, Melanson M, Trier J, Ritsma BR, Allen MD
J Appl Physiol (1985) 2021 May 1;130(5):1479-1489. Epub 2021 Mar 18 doi: 10.1152/japplphysiol.00019.2021. PMID: 33734888Free PMC Article
Atrial Fibrillation in the ICU.
Bosch NA, Cimini J, Walkey AJ
Chest 2018 Dec;154(6):1424-1434. Epub 2018 Apr 6 doi: 10.1016/j.chest.2018.03.040. PMID: 29627355Free PMC Article
ICU-Acquired Weakness.
Jolley SE, Bunnell AE, Hough CL
Chest 2016 Nov;150(5):1129-1140. Epub 2016 Apr 7 doi: 10.1016/j.chest.2016.03.045. PMID: 27063347Free PMC Article
Sleep in the intensive care unit.
Pisani MA, Friese RS, Gehlbach BK, Schwab RJ, Weinhouse GL, Jones SF
Am J Respir Crit Care Med 2015 Apr 1;191(7):731-8. doi: 10.1164/rccm.201411-2099CI. PMID: 25594808Free PMC Article

Diagnosis

Current insights in ICU nutrition: tailored nutrition.
Hermans AJH, Laarhuis BI, Kouw IWK, van Zanten ARH
Curr Opin Crit Care 2023 Apr 1;29(2):101-107. Epub 2023 Jan 27 doi: 10.1097/MCC.0000000000001016. PMID: 36762671Free PMC Article
Obstetric Disorders and Critical Illness.
Griffin KM, Oxford-Horrey C, Bourjeily G
Clin Chest Med 2022 Sep;43(3):471-488. doi: 10.1016/j.ccm.2022.04.008. PMID: 36116815Free PMC Article
Atrial Fibrillation in the ICU.
Bosch NA, Cimini J, Walkey AJ
Chest 2018 Dec;154(6):1424-1434. Epub 2018 Apr 6 doi: 10.1016/j.chest.2018.03.040. PMID: 29627355Free PMC Article
ICU-Acquired Weakness.
Jolley SE, Bunnell AE, Hough CL
Chest 2016 Nov;150(5):1129-1140. Epub 2016 Apr 7 doi: 10.1016/j.chest.2016.03.045. PMID: 27063347Free PMC Article
Sleep in the intensive care unit.
Pisani MA, Friese RS, Gehlbach BK, Schwab RJ, Weinhouse GL, Jones SF
Am J Respir Crit Care Med 2015 Apr 1;191(7):731-8. doi: 10.1164/rccm.201411-2099CI. PMID: 25594808Free PMC Article

Therapy

Fluid Therapy for Critically Ill Adults With Sepsis: A Review.
Zampieri FG, Bagshaw SM, Semler MW
JAMA 2023 Jun 13;329(22):1967-1980. doi: 10.1001/jama.2023.7560. PMID: 37314271
Effect of Neuromuscular Electrical Stimulation in Patients With Critical Illness: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Nakanishi N, Yoshihiro S, Kawamura Y, Aikawa G, Shida H, Shimizu M, Fujinami Y, Matsuoka A, Watanabe S, Taito S, Inoue S
Crit Care Med 2023 Oct 1;51(10):1386-1396. Epub 2023 May 26 doi: 10.1097/CCM.0000000000005941. PMID: 37232695
Etomidate as an induction agent for endotracheal intubation in critically ill patients: A meta-analysis of randomized trials.
Kotani Y, Piersanti G, Maiucci G, Fresilli S, Turi S, Montanaro G, Zangrillo A, Lee TC, Landoni G
J Crit Care 2023 Oct;77:154317. Epub 2023 Apr 29 doi: 10.1016/j.jcrc.2023.154317. PMID: 37127020
The SOFA score-development, utility and challenges of accurate assessment in clinical trials.
Lambden S, Laterre PF, Levy MM, Francois B
Crit Care 2019 Nov 27;23(1):374. doi: 10.1186/s13054-019-2663-7. PMID: 31775846Free PMC Article
Music therapy reduces stress and anxiety in critically ill patients: a systematic review of randomized clinical trials.
Umbrello M, Sorrenti T, Mistraletti G, Formenti P, Chiumello D, Terzoni S
Minerva Anestesiol 2019 Aug;85(8):886-898. Epub 2019 Apr 3 doi: 10.23736/S0375-9393.19.13526-2. PMID: 30947484

Prognosis

Defining critical illness using immunological endotypes in patients with and without sepsis: a cohort study.
Balch JA, Chen UI, Liesenfeld O, Starostik P, Loftus TJ, Efron PA, Brakenridge SC, Sweeney TE, Moldawer LL
Crit Care 2023 Jul 20;27(1):292. doi: 10.1186/s13054-023-04571-x. PMID: 37474944Free PMC Article
Cirrhosis Management in the Intensive Care Unit.
Smith TN, Gallo de Moraes A, Simonetto DA
Semin Liver Dis 2023 Feb;43(1):117-132. Epub 2023 Jan 18 doi: 10.1055/a-2015-1290. PMID: 36652959
Risk Factors for Dysphagia in ICU Patients After Invasive Mechanical Ventilation.
Zuercher P, Schenk NV, Moret C, Berger D, Abegglen R, Schefold JC
Chest 2020 Nov;158(5):1983-1991. Epub 2020 Jun 7 doi: 10.1016/j.chest.2020.05.576. PMID: 32525018
Clinical review: intensive care unit acquired weakness.
Hermans G, Van den Berghe G
Crit Care 2015 Aug 5;19(1):274. doi: 10.1186/s13054-015-0993-7. PMID: 26242743Free PMC Article
Incidence and outcomes of acute lung injury.
Rubenfeld GD, Caldwell E, Peabody E, Weaver J, Martin DP, Neff M, Stern EJ, Hudson LD
N Engl J Med 2005 Oct 20;353(16):1685-93. doi: 10.1056/NEJMoa050333. PMID: 16236739

Clinical prediction guides

A score for predicting invasive pulmonary aspergillosis in immunocompetent critically ill patients.
Li W, Chen G, Lin F, Yang H, Cui Y, Lu R, Song C, Li H, Li Y, Pan P
Eur J Clin Invest 2023 Jul;53(7):e13985. Epub 2023 Mar 24 doi: 10.1111/eci.13985. PMID: 36920323
Development of the Gastrointestinal Dysfunction Score (GIDS) for critically ill patients - A prospective multicenter observational study (iSOFA study).
Reintam Blaser A, Padar M, Mändul M, Elke G, Engel C, Fischer K, Giabicani M, Gold T, Hess B, Hiesmayr M, Jakob SM, Loudet CI, Meesters DM, Mongkolpun W, Paugam-Burtz C, Poeze M, Preiser JC, Renberg M, Rooijackers O, Tamme K, Wernerman J, Starkopf J
Clin Nutr 2021 Aug;40(8):4932-4940. Epub 2021 Jul 18 doi: 10.1016/j.clnu.2021.07.015. PMID: 34358839
The Future of Biomarkers.
Vincent JL, Bogossian E, Menozzi M
Crit Care Clin 2020 Jan;36(1):177-187. doi: 10.1016/j.ccc.2019.08.014. PMID: 31733679
Predictive factors of weaning from mechanical ventilation and extubation outcome: A systematic review.
Baptistella AR, Sarmento FJ, da Silva KR, Baptistella SF, Taglietti M, Zuquello RÁ, Nunes Filho JR
J Crit Care 2018 Dec;48:56-62. Epub 2018 Aug 20 doi: 10.1016/j.jcrc.2018.08.023. PMID: 30172034
Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome.
Marshall JC, Cook DJ, Christou NV, Bernard GR, Sprung CL, Sibbald WJ
Crit Care Med 1995 Oct;23(10):1638-52. doi: 10.1097/00003246-199510000-00007. PMID: 7587228

Recent systematic reviews

The rate and assessment of muscle wasting during critical illness: a systematic review and meta-analysis.
Fazzini B, Märkl T, Costas C, Blobner M, Schaller SJ, Prowle J, Puthucheary Z, Wackerhage H
Crit Care 2023 Jan 3;27(1):2. doi: 10.1186/s13054-022-04253-0. PMID: 36597123Free PMC Article
Effects of nonpharmacological interventions on sleep improvement and delirium prevention in critically ill patients: A systematic review and meta-analysis.
Kang J, Cho YS, Lee M, Yun S, Jeong YJ, Won YH, Hong J, Kim S
Aust Crit Care 2023 Jul;36(4):640-649. Epub 2022 Jun 17 doi: 10.1016/j.aucc.2022.04.006. PMID: 35718628
Music therapy reduces stress and anxiety in critically ill patients: a systematic review of randomized clinical trials.
Umbrello M, Sorrenti T, Mistraletti G, Formenti P, Chiumello D, Terzoni S
Minerva Anestesiol 2019 Aug;85(8):886-898. Epub 2019 Apr 3 doi: 10.23736/S0375-9393.19.13526-2. PMID: 30947484
The effects of active mobilisation and rehabilitation in ICU on mortality and function: a systematic review.
Tipping CJ, Harrold M, Holland A, Romero L, Nisbet T, Hodgson CL
Intensive Care Med 2017 Feb;43(2):171-183. Epub 2016 Nov 18 doi: 10.1007/s00134-016-4612-0. PMID: 27864615
Physical rehabilitation for critical illness myopathy and neuropathy.
Mehrholz J, Pohl M, Kugler J, Burridge J, Mückel S, Elsner B
Cochrane Database Syst Rev 2015 Mar 4;2015(3):CD010942. doi: 10.1002/14651858.CD010942.pub2. PMID: 25737049Free PMC Article

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