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Thyroglossal cyst

MedGen UID:
11810
•Concept ID:
C0040124
•
Congenital Abnormality
Synonym: Thyroglossal duct cyst
SNOMED CT: Thyroglossal duct cyst (39462005); Thyroglossal cyst (39462005)
 
HPO: HP:0010518
Monarch Initiative: MONDO:0006460
Orphanet: ORPHA489

Definition

An abnormality of the thyroid gland owing to the presence of a fibrous cyst resulting from the persistence of the thyroglossal duct. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyroglossal cyst

Professional guidelines

PubMed

Ethanol ablation for the treatment of thyroglossal duct cysts: follow-up results for longer than 2 years.
Park SI, Baek JH, Chung SR, Choi YJ, Lee JH, Kim TY, Lee YM, Baek SM
Eur Radiol 2022 May;32(5):3525-3531. Epub 2022 Jan 7 doi: 10.1007/s00330-021-08402-x. PMID: 34993573
Simple bone cyst of the hyoid: A radiological diagnosis and follow-up.
Koç N, Parlak Ş
Dent Med Probl 2020 Jul-Sep;57(3):333-337. doi: 10.17219/dmp/120079. PMID: 33113293
Management of well-differentiated thyroid carcinoma presenting within a thyroglossal duct cyst.
Patel SG, Escrig M, Shaha AR, Singh B, Shah JP
J Surg Oncol 2002 Mar;79(3):134-9; discussion 140-1. doi: 10.1002/jso.10059. PMID: 11870661

Recent clinical studies

Etiology

¿Who was Sistrunk?
Girón Vallejo O
Cir Pediatr 2022 Apr 1;35(2):55-56. doi: 10.54847/cp.2022.02.11. PMID: 35485751
Evidence and controversies in management of thyroglossal duct cyst carcinoma.
Lancini D, Lombardi D, Piazza C
Curr Opin Otolaryngol Head Neck Surg 2021 Apr 1;29(2):113-119. doi: 10.1097/MOO.0000000000000699. PMID: 33664197Free PMC Article
Congenital Neck Masses.
Pupić-Bakrač J, Pupić-Bakrač A, Novaković J, Skitarelić N
J Craniofac Surg 2021 Jun 1;32(4):1417-1420. doi: 10.1097/SCS.0000000000007122. PMID: 33170821
Congenital Neck Masses.
Quintanilla-Dieck L, Penn EB Jr
Clin Perinatol 2018 Dec;45(4):769-785. Epub 2018 Sep 18 doi: 10.1016/j.clp.2018.07.012. PMID: 30396417
Thyroglossal duct cyst and ectopic thyroid: surgical management.
Oomen KP, Modi VK, Maddalozzo J
Otolaryngol Clin North Am 2015 Feb;48(1):15-27. doi: 10.1016/j.otc.2014.09.003. PMID: 25439547

Diagnosis

Congenital Neck Masses.
Quintanilla-Dieck L, Penn EB Jr
Clin Perinatol 2018 Dec;45(4):769-785. Epub 2018 Sep 18 doi: 10.1016/j.clp.2018.07.012. PMID: 30396417
Thyroglossal duct cyst.
Thompson LD
Ear Nose Throat J 2017 Feb;96(2):54-55. doi: 10.1177/014556131709600204. PMID: 28231361
Pediatric neck masses.
Curtis WJ, Edwards SP
Atlas Oral Maxillofac Surg Clin North Am 2015 Mar;23(1):15-20. Epub 2014 Nov 26 doi: 10.1016/j.cxom.2014.10.002. PMID: 25707561
Pediatric neck masses.
Goins MR, Beasley MS
Oral Maxillofac Surg Clin North Am 2012 Aug;24(3):457-68. doi: 10.1016/j.coms.2012.05.006. PMID: 22857718
Thyroglossal-tract cyst.
Wampler HW, Krolls SO, Johnson RP
Oral Surg Oral Med Oral Pathol 1978 Jan;45(1):32-8. doi: 10.1016/0030-4220(78)90219-0. PMID: 271286

Therapy

Prevalence and Features of Thyroglossal Duct Cyst on Ultrasonography, According to Radioactive Iodine Therapy: A Single-Center Study.
Park JS, Kim DW, Shin GW, Park JY, Lee YJ, Choo HJ, Park HK, Ha TK, Kim DH, Jung SJ, Moon SH, Ahn KJ, Baek HJ
Front Endocrinol (Lausanne) 2020;11:188. Epub 2020 Apr 3 doi: 10.3389/fendo.2020.00188. PMID: 32328033Free PMC Article
The efficacy of OK-432 sclerotherapy on thyroglossal duct cyst and the influence on a subsequent surgical procedure.
Tachibana T, Kariya S, Orita Y, Makino T, Haruna T, Matsuyama Y, Komatsubara Y, Naoi Y, Nakada M, Wani Y, Fushimi S, Hotta M, Haruna K, Nagatani T, Sato Y, Nishizaki K
Acta Otolaryngol 2019 Sep;139(9):788-792. Epub 2019 Jul 4 doi: 10.1080/00016489.2019.1633019. PMID: 31271329
Curiositas.
Ulster Med J 2015 Oct;84(3):215-6. PMID: 26668426Free PMC Article
Surgical management outcomes of recurrent thyroglossal duct cyst in children--A systematic review.
Ibrahim FF, Alnoury MK, Varma N, Daniel SJ
Int J Pediatr Otorhinolaryngol 2015 Jun;79(6):863-867. Epub 2015 Mar 28 doi: 10.1016/j.ijporl.2015.03.019. PMID: 25890397
Cut-throat surgery.
Wade JS
Proc R Soc Med 1975 Jun;68(6):357-64. PMID: 1208528Free PMC Article

Prognosis

Congenital Neck Masses.
Quintanilla-Dieck L, Penn EB Jr
Clin Perinatol 2018 Dec;45(4):769-785. Epub 2018 Sep 18 doi: 10.1016/j.clp.2018.07.012. PMID: 30396417
Thyroglossal Duct Cyst Carcinoma: A Systematic Review of Clinical Features and Outcomes.
Rayess HM, Monk I, Svider PF, Gupta A, Raza SN, Lin HS
Otolaryngol Head Neck Surg 2017 May;156(5):794-802. Epub 2017 Mar 21 doi: 10.1177/0194599817696504. PMID: 28322121
Thyroglossal duct cyst and ectopic thyroid: surgical management.
Oomen KP, Modi VK, Maddalozzo J
Otolaryngol Clin North Am 2015 Feb;48(1):15-27. doi: 10.1016/j.otc.2014.09.003. PMID: 25439547
Thyroglossal duct carcinoma.
Motamed M, McGlashan JA
Curr Opin Otolaryngol Head Neck Surg 2004 Apr;12(2):106-9. doi: 10.1097/00020840-200404000-00009. PMID: 15167046
Thyroglossal duct carcinoma.
Joseph TJ, Komorowski RA
Hum Pathol 1975 Nov;6(6):717-29. doi: 10.1016/s0046-8177(75)80080-3. PMID: 1102426

Clinical prediction guides

Removal of Thyroglossal Duct Cyst by a Submental Approach.
Roh JL
World J Surg 2022 Jun;46(6):1431-1437. Epub 2022 Feb 23 doi: 10.1007/s00268-022-06493-1. PMID: 35195754
Cancer in thyroglossal duct cysts.
Wong J, Lee JC, Grodski S, Yeung M, Serpell J
ANZ J Surg 2022 Mar;92(3):443-447. Epub 2021 Nov 18 doi: 10.1111/ans.17369. PMID: 34791748
Thyroglossal duct cyst: Factors affecting cosmetic outcome and recurrence.
Batazzi A, Leng S, Ghionzoli M, Lo Piccolo R, Martin A, Facchini F, Messineo A
Pediatr Int 2019 Oct;61(10):1020-1024. doi: 10.1111/ped.13955. PMID: 31282046
Intra-thyroid thyroglossal duct cyst: a case report and review of literature.
Huang LD, Gao SQ, Dai RJ, Chen DD, He B, Shi HQ, Yang K, Shan YF
Int J Clin Exp Pathol 2015;8(6):7229-33. Epub 2015 Jun 1 PMID: 26261619Free PMC Article
Recurrences after thyroglossal duct cyst surgery: Results in 207 consecutive cases and review of the literature.
Rohof D, Honings J, Theunisse HJ, Schutte HW, van den Hoogen FJ, van den Broek GB, Takes RP, Wijnen MH, Marres HA
Head Neck 2015 Dec;37(12):1699-704. Epub 2014 Sep 25 doi: 10.1002/hed.23817. PMID: 24985922

Recent systematic reviews

Endoscopic management of intralingual thyroglossal duct cysts: Case series and systematic review.
Pereira NM, Drusin MA, Modi VK
Auris Nasus Larynx 2023 Feb;50(1):119-125. Epub 2022 Jun 2 doi: 10.1016/j.anl.2022.05.014. PMID: 35659788
Chemical ablation using ethanol or OK-432 for the treatment of thyroglossal duct cysts: a systematic review and meta-analysis.
Park SI, Baek JH, Suh CH, Chung SR, Choi YJ, Kim TY, Lee YM, Lee JH
Eur Radiol 2021 Dec;31(12):9048-9056. Epub 2021 May 18 doi: 10.1007/s00330-021-08033-2. PMID: 34003346
Thyroglossal Duct Cyst Carcinoma: A Systematic Review of Clinical Features and Outcomes.
Rayess HM, Monk I, Svider PF, Gupta A, Raza SN, Lin HS
Otolaryngol Head Neck Surg 2017 May;156(5):794-802. Epub 2017 Mar 21 doi: 10.1177/0194599817696504. PMID: 28322121
Surgical management outcomes of recurrent thyroglossal duct cyst in children--A systematic review.
Ibrahim FF, Alnoury MK, Varma N, Daniel SJ
Int J Pediatr Otorhinolaryngol 2015 Jun;79(6):863-867. Epub 2015 Mar 28 doi: 10.1016/j.ijporl.2015.03.019. PMID: 25890397
Clinical presentation and treatment outcomes of thyroglossal duct cysts: a systematic review.
Gioacchini FM, Alicandri-Ciufelli M, Kaleci S, Magliulo G, Presutti L, Re M
Int J Oral Maxillofac Surg 2015 Jan;44(1):119-26. Epub 2014 Aug 15 doi: 10.1016/j.ijom.2014.07.007. PMID: 25132570

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