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Thyroid crisis

MedGen UID:
11813
•Concept ID:
C0040127
•
Disease or Syndrome
Synonyms: Crisis, Thyroid; Crisis, Thyrotoxic; Storm, Thyroid; Storm, Thyrotoxic; Thyroid Crisis; Thyroid Storm; Thyrotoxic Crisis; Thyrotoxic Storm
SNOMED CT: Thyrotoxic crisis (29028009); Thyroid storm (29028009); Thyroid crisis (29028009)
 
HPO: HP:0011782
Monarch Initiative: MONDO:0006996

Definition

Acute onset of severe, life-threatening hyperthyroidism caused by a sudden release of excessive thyroid hormone. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyroid crisis

Professional guidelines

PubMed

PICU treatment of 3 cases of pediatric thyroid storm: Case series and literature review.
Li X, Chen J, Li Z
Medicine (Baltimore) 2023 Apr 7;102(14):e33447. doi: 10.1097/MD.0000000000033447. PMID: 37026965Free PMC Article
Management of Endocrine Emergencies in the ICU.
Jacobi J
J Pharm Pract 2019 Jun;32(3):314-326. Epub 2019 Mar 10 doi: 10.1177/0897190019834771. PMID: 30852927
Thyroid crisis: diagnosis and treatment.
Nelson NC, Becker WF
Ann Surg 1969 Aug;170(2):263-73. doi: 10.1097/00000658-196908000-00016. PMID: 5796710Free PMC Article

Recent clinical studies

Etiology

High risk and low prevalence diseases: Thyroid storm.
Farooqi S, Raj S, Koyfman A, Long B
Am J Emerg Med 2023 Jul;69:127-135. Epub 2023 Mar 27 doi: 10.1016/j.ajem.2023.03.035. PMID: 37104908
Comparison of Propylthiouracil vs Methimazole for Thyroid Storm in Critically Ill Patients.
Lee SY, Modzelewski KL, Law AC, Walkey AJ, Pearce EN, Bosch NA
JAMA Netw Open 2023 Apr 3;6(4):e238655. doi: 10.1001/jamanetworkopen.2023.8655. PMID: 37067797Free PMC Article
Risk of perioperative thyroid storm in hyperthyroid patients: a systematic review.
de Mul N, Damstra J, Nieveen van Dijkum EJM, Fischli S, Kalkman CJ, Schellekens WM, Immink RV
Br J Anaesth 2021 Dec;127(6):879-889. Epub 2021 Aug 11 doi: 10.1016/j.bja.2021.06.043. PMID: 34389171
Thyroid Storm in the ICU: A Retrospective Multicenter Study.
Bourcier S, Coutrot M, Kimmoun A, Sonneville R, de Montmollin E, Persichini R, Schnell D, Charpentier J, Aubron C, Morawiec E, Bigé N, Nseir S, Terzi N, Razazi K, Azoulay E, Ferré A, Tandjaoui-Lambiotte Y, Ellrodt O, Hraiech S, Delmas C, Barbier F, Lautrette A, Aissaoui N, Repessé X, Pichereau C, Zerbib Y, Lascarrou JB, Carreira S, Reuter D, Frérou A, Peigne V, Fillatre P, Megarbane B, Voiriot G, Combes A, Schmidt M
Crit Care Med 2020 Jan;48(1):83-90. doi: 10.1097/CCM.0000000000004078. PMID: 31714398
Hyperthyroidism.
De Leo S, Lee SY, Braverman LE
Lancet 2016 Aug 27;388(10047):906-918. Epub 2016 Mar 30 doi: 10.1016/S0140-6736(16)00278-6. PMID: 27038492Free PMC Article

Diagnosis

Clinical Review and Update on the Management of Thyroid Storm.
De Almeida R, McCalmon S, Cabandugama PK
Mo Med 2022 Jul-Aug;119(4):366-371. PMID: 36118802Free PMC Article
Thyroid emergencies.
Ylli D, Klubo-Gwiezdzinska J, Wartofsky L
Pol Arch Intern Med 2019 Aug 29;129(7-8):526-534. Epub 2019 Jun 25 doi: 10.20452/pamw.14876. PMID: 31237256Free PMC Article
Hyperthyroidism.
De Leo S, Lee SY, Braverman LE
Lancet 2016 Aug 27;388(10047):906-918. Epub 2016 Mar 30 doi: 10.1016/S0140-6736(16)00278-6. PMID: 27038492Free PMC Article
Thyroid storm: an updated review.
Chiha M, Samarasinghe S, Kabaker AS
J Intensive Care Med 2015 Mar;30(3):131-40. Epub 2013 Aug 5 doi: 10.1177/0885066613498053. PMID: 23920160
Thyrotoxicosis and thyroid storm.
Nayak B, Burman K
Endocrinol Metab Clin North Am 2006 Dec;35(4):663-86, vii. doi: 10.1016/j.ecl.2006.09.008. PMID: 17127140

Therapy

Clinical Review and Update on the Management of Thyroid Storm.
De Almeida R, McCalmon S, Cabandugama PK
Mo Med 2022 Jul-Aug;119(4):366-371. PMID: 36118802Free PMC Article
Risk of perioperative thyroid storm in hyperthyroid patients: a systematic review.
de Mul N, Damstra J, Nieveen van Dijkum EJM, Fischli S, Kalkman CJ, Schellekens WM, Immink RV
Br J Anaesth 2021 Dec;127(6):879-889. Epub 2021 Aug 11 doi: 10.1016/j.bja.2021.06.043. PMID: 34389171
2016 Guidelines for the management of thyroid storm from The Japan Thyroid Association and Japan Endocrine Society (First edition).
Satoh T, Isozaki O, Suzuki A, Wakino S, Iburi T, Tsuboi K, Kanamoto N, Otani H, Furukawa Y, Teramukai S, Akamizu T
Endocr J 2016 Dec 30;63(12):1025-1064. Epub 2016 Oct 15 doi: 10.1507/endocrj.EJ16-0336. PMID: 27746415
Hyperthyroidism.
De Leo S, Lee SY, Braverman LE
Lancet 2016 Aug 27;388(10047):906-918. Epub 2016 Mar 30 doi: 10.1016/S0140-6736(16)00278-6. PMID: 27038492Free PMC Article
Thyrotoxicosis and thyroid storm.
Nayak B, Burman K
Endocrinol Metab Clin North Am 2006 Dec;35(4):663-86, vii. doi: 10.1016/j.ecl.2006.09.008. PMID: 17127140

Prognosis

Comparison of Propylthiouracil vs Methimazole for Thyroid Storm in Critically Ill Patients.
Lee SY, Modzelewski KL, Law AC, Walkey AJ, Pearce EN, Bosch NA
JAMA Netw Open 2023 Apr 3;6(4):e238655. doi: 10.1001/jamanetworkopen.2023.8655. PMID: 37067797Free PMC Article
Thyroid storm in pediatrics: a systematic review.
Abisad DA, Glenn Lecea EM, Ballesteros AM, Alarcon G, Diaz A, Pagan-Banchs P
J Pediatr Endocrinol Metab 2023 Mar 28;36(3):225-233. Epub 2022 Nov 2 doi: 10.1515/jpem-2022-0309. PMID: 36318760
Thyroid Storm in the ICU: A Retrospective Multicenter Study.
Bourcier S, Coutrot M, Kimmoun A, Sonneville R, de Montmollin E, Persichini R, Schnell D, Charpentier J, Aubron C, Morawiec E, Bigé N, Nseir S, Terzi N, Razazi K, Azoulay E, Ferré A, Tandjaoui-Lambiotte Y, Ellrodt O, Hraiech S, Delmas C, Barbier F, Lautrette A, Aissaoui N, Repessé X, Pichereau C, Zerbib Y, Lascarrou JB, Carreira S, Reuter D, Frérou A, Peigne V, Fillatre P, Megarbane B, Voiriot G, Combes A, Schmidt M
Crit Care Med 2020 Jan;48(1):83-90. doi: 10.1097/CCM.0000000000004078. PMID: 31714398
Thyroid Storm: A Japanese Perspective.
Akamizu T
Thyroid 2018 Jan;28(1):32-40. Epub 2017 Oct 5 doi: 10.1089/thy.2017.0243. PMID: 28899229Free PMC Article
2016 Guidelines for the management of thyroid storm from The Japan Thyroid Association and Japan Endocrine Society (First edition).
Satoh T, Isozaki O, Suzuki A, Wakino S, Iburi T, Tsuboi K, Kanamoto N, Otani H, Furukawa Y, Teramukai S, Akamizu T
Endocr J 2016 Dec 30;63(12):1025-1064. Epub 2016 Oct 15 doi: 10.1507/endocrj.EJ16-0336. PMID: 27746415

Clinical prediction guides

Thyroid storm in pediatrics: a systematic review.
Abisad DA, Glenn Lecea EM, Ballesteros AM, Alarcon G, Diaz A, Pagan-Banchs P
J Pediatr Endocrinol Metab 2023 Mar 28;36(3):225-233. Epub 2022 Nov 2 doi: 10.1515/jpem-2022-0309. PMID: 36318760
Thyroid Storm in the ICU: A Retrospective Multicenter Study.
Bourcier S, Coutrot M, Kimmoun A, Sonneville R, de Montmollin E, Persichini R, Schnell D, Charpentier J, Aubron C, Morawiec E, Bigé N, Nseir S, Terzi N, Razazi K, Azoulay E, Ferré A, Tandjaoui-Lambiotte Y, Ellrodt O, Hraiech S, Delmas C, Barbier F, Lautrette A, Aissaoui N, Repessé X, Pichereau C, Zerbib Y, Lascarrou JB, Carreira S, Reuter D, Frérou A, Peigne V, Fillatre P, Megarbane B, Voiriot G, Combes A, Schmidt M
Crit Care Med 2020 Jan;48(1):83-90. doi: 10.1097/CCM.0000000000004078. PMID: 31714398
Thyroid emergencies.
Ylli D, Klubo-Gwiezdzinska J, Wartofsky L
Pol Arch Intern Med 2019 Aug 29;129(7-8):526-534. Epub 2019 Jun 25 doi: 10.20452/pamw.14876. PMID: 31237256Free PMC Article
Thyroid storm: an updated review.
Chiha M, Samarasinghe S, Kabaker AS
J Intensive Care Med 2015 Mar;30(3):131-40. Epub 2013 Aug 5 doi: 10.1177/0885066613498053. PMID: 23920160
Hyperthyroidism in pregnancy.
Mestman JH
Clin Obstet Gynecol 1997 Mar;40(1):45-64. doi: 10.1097/00003081-199703000-00007. PMID: 9103949

Recent systematic reviews

Thyroid storm in pediatrics: a systematic review.
Abisad DA, Glenn Lecea EM, Ballesteros AM, Alarcon G, Diaz A, Pagan-Banchs P
J Pediatr Endocrinol Metab 2023 Mar 28;36(3):225-233. Epub 2022 Nov 2 doi: 10.1515/jpem-2022-0309. PMID: 36318760
Clinical Pharmacokinetics of Metoprolol: A Systematic Review.
Zamir A, Hussain I, Ur Rehman A, Ashraf W, Imran I, Saeed H, Majeed A, Alqahtani F, Rasool MF
Clin Pharmacokinet 2022 Aug;61(8):1095-1114. Epub 2022 Jun 28 doi: 10.1007/s40262-022-01145-y. PMID: 35764772
SARS-CoV-2 infection induced thyroid storm and heart failure in an adolescent girl.
Das BB, Shakti D, Akam-Venkata J, Obi O, Weiland MD, Moskowitz W
Cardiol Young 2022 Jun;32(6):988-992. Epub 2021 Oct 18 doi: 10.1017/S1047951121004352. PMID: 34657643Free PMC Article
Risk of perioperative thyroid storm in hyperthyroid patients: a systematic review.
de Mul N, Damstra J, Nieveen van Dijkum EJM, Fischli S, Kalkman CJ, Schellekens WM, Immink RV
Br J Anaesth 2021 Dec;127(6):879-889. Epub 2021 Aug 11 doi: 10.1016/j.bja.2021.06.043. PMID: 34389171
Concurrent presentation of thyroid storm and diabetic ketoacidosis: a systematic review of previously reported cases.
Rathish D, Karalliyadda S
BMC Endocr Disord 2019 May 17;19(1):49. doi: 10.1186/s12902-019-0374-3. PMID: 31101104Free PMC Article

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