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Pulmonary tuberculosis

MedGen UID:
11947
•Concept ID:
C0041327
•
Disease or Syndrome
Synonyms: Consumption, Pulmonary; Consumptions, Pulmonary; Phthises, Pulmonary; Phthisis, Pulmonary; Pulmonary Consumption; Pulmonary Consumptions; Pulmonary Phthises; Pulmonary Phthisis; Pulmonary Tuberculoses; Pulmonary Tuberculosis; Tuberculoses, Pulmonary; Tuberculosis, Pulmonary
SNOMED CT: PTB - Pulmonary tuberculosis (154283005); TB - Pulmonary tuberculosis (154283005); Pulmonary tuberculosis (154283005); Tuberculosis of respiratory system (700272008); Respiratory tuberculosis (700272008)
 
HPO: HP:0032262
Monarch Initiative: MONDO:0006052

Definition

A lung infection by Mycobacterium tuberculosis a slightly curved non-motile, aerobic, non-capsulated and non-spore forming strains of mycobacteria. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPulmonary tuberculosis

Conditions with this feature

X-linked Mendelian susceptibility to mycobacterial diseases due to CYBB deficiency
MedGen UID:
370369
•Concept ID:
C1970859
•
Disease or Syndrome
IMD34 results in predisposition to infections by poorly virulent mycobacteria, such as bacillus Calmette-Guerin (BCG) vaccines and nontuberculous environmental bacteria. Affected individuals are also susceptible to the more virulent species Mycobacterium tuberculosis (Bustamante et al., 2007).
See: Condition Record
X-linked Mendelian susceptibility to mycobacterial diseases due to CYBB deficiency

Professional guidelines

PubMed

Review of advances in diagnosis and treatment of pulmonary tuberculosis.
Tendolkar MS, Tyagi R, Handa A
Indian J Tuberc 2021 Oct;68(4):510-515. Epub 2021 Jul 7 doi: 10.1016/j.ijtb.2021.07.002. PMID: 34752322
Current Medical Management of Pulmonary Tuberculosis.
Belknap RW
Thorac Surg Clin 2019 Feb;29(1):27-35. doi: 10.1016/j.thorsurg.2018.09.004. PMID: 30454919
Pulmonary Tuberculosis: Role of Radiology in Diagnosis and Management.
Nachiappan AC, Rahbar K, Shi X, Guy ES, Mortani Barbosa EJ Jr, Shroff GS, Ocazionez D, Schlesinger AE, Katz SI, Hammer MM
Radiographics 2017 Jan-Feb;37(1):52-72. doi: 10.1148/rg.2017160032. PMID: 28076011

Recent clinical studies

Etiology

Pulmonary tuberculosis and diabetes mellitus: Clinical profile and outcomes.
George JT, Miraclin AT, Sathyendra S, Michael JS, Prasad J, Rebekah G
Int J Mycobacteriol 2022 Oct-Dec;11(4):400-406. doi: 10.4103/ijmy.ijmy_154_22. PMID: 36510925
Obstetrics outcome in pulmonary tuberculosis.
Yadav V, Sharma JB, Kriplani A, Bhatla N, Kachhawa G, Mahey R, Kumari R
Indian J Tuberc 2022 Jul;69(3):305-310. Epub 2021 Jan 7 doi: 10.1016/j.ijtb.2020.12.006. PMID: 35760479
Clinical features and risk factors of pulmonary tuberculosis complicated with pulmonary aspergillosis.
Teng GL, Huang Q, Xu L, Chi JY, Wang C, Hu H
Eur Rev Med Pharmacol Sci 2022 Apr;26(8):2692-2701. doi: 10.26355/eurrev_202204_28599. PMID: 35503614
Clinical metagenomic sequencing for diagnosis of pulmonary tuberculosis.
Shi CL, Han P, Tang PJ, Chen MM, Ye ZJ, Wu MY, Shen J, Wu HY, Tan ZQ, Yu X, Rao GH, Zhang JP
J Infect 2020 Oct;81(4):567-574. Epub 2020 Aug 5 doi: 10.1016/j.jinf.2020.08.004. PMID: 32768450
Gastrointestinal tuberculosis.
Sheer TA, Coyle WJ
Curr Gastroenterol Rep 2003 Aug;5(4):273-8. doi: 10.1007/s11894-003-0063-1. PMID: 12864956

Diagnosis

Predicting mortality in pulmonary tuberculosis: A systematic review of prognostic models.
Bert-Dulanto A, Alarcón-Braga EA, Castillo-Soto A, Escalante-Kanashiro R
Indian J Tuberc 2022 Oct;69(4):432-440. Epub 2021 Oct 19 doi: 10.1016/j.ijtb.2021.10.007. PMID: 36460372
Role of chest radiography in the diagnosis of pulmonary tuberculosis during nCovid19 pandemic.
Vishnu Sharma M, Arora VK, Anupama N
Indian J Tuberc 2022 Oct;69(4):385-388. Epub 2022 Mar 11 doi: 10.1016/j.ijtb.2022.03.008. PMID: 36460367
Clinical features and risk factors of pulmonary tuberculosis complicated with pulmonary aspergillosis.
Teng GL, Huang Q, Xu L, Chi JY, Wang C, Hu H
Eur Rev Med Pharmacol Sci 2022 Apr;26(8):2692-2701. doi: 10.26355/eurrev_202204_28599. PMID: 35503614
Review of advances in diagnosis and treatment of pulmonary tuberculosis.
Tendolkar MS, Tyagi R, Handa A
Indian J Tuberc 2021 Oct;68(4):510-515. Epub 2021 Jul 7 doi: 10.1016/j.ijtb.2021.07.002. PMID: 34752322
Making a timely diagnosis of pulmonary tuberculosis.
Long R
Can Respir J 2015 Nov-Dec;22(6):317-21. Epub 2015 Oct 15 doi: 10.1155/2015/826035. PMID: 26469154Free PMC Article

Therapy

Efficacy of vitamin D(3) supplementation for the prevention of pulmonary tuberculosis and mortality in HIV: a randomised, double-blind, placebo-controlled trial.
Sudfeld CR, Mugusi F, Muhihi A, Aboud S, Nagu TJ, Ulenga N, Hong B, Wang M, Fawzi WW
Lancet HIV 2020 Jul;7(7):e463-e471. doi: 10.1016/S2352-3018(20)30108-9. PMID: 32621874Free PMC Article
ADVANCES IN PHARMACOTHERAPY OF TUBERCULOSIS.
Pstragowski M, Zbrzezna M, Bujalska-Zadrozny M
Acta Pol Pharm 2017 Jan;74(1):3-11. PMID: 29474756
Adjunctive steroid therapy for managing pulmonary tuberculosis.
Critchley JA, Orton LC, Pearson F
Cochrane Database Syst Rev 2014 Nov 12;2014(11):CD011370. doi: 10.1002/14651858.CD011370. PMID: 25387839Free PMC Article
Endobronchial tuberculosis.
Rikimaru T
Expert Rev Anti Infect Ther 2004 Apr;2(2):245-51. doi: 10.1586/14787210.2.2.245. PMID: 15482190
Rifapentine.
Jarvis B, Lamb HM
Drugs 1998 Oct;56(4):607-16; discussion 617. doi: 10.2165/00003495-199856040-00008. PMID: 9806107

Prognosis

Age-period-cohort analysis of pulmonary tuberculosis reported incidence, China, 2006-2020.
Dong Z, Wang QQ, Yu SC, Huang F, Liu JJ, Yao HY, Zhao YL
Infect Dis Poverty 2022 Jul 28;11(1):85. doi: 10.1186/s40249-022-01009-4. PMID: 35902982Free PMC Article
Population aging and trends of pulmonary tuberculosis incidence in the elderly.
Li SJ, Li YF, Song WM, Zhang QY, Liu SQ, Xu TT, An QQ, Liu JY, Li HC
BMC Infect Dis 2021 Mar 25;21(1):302. doi: 10.1186/s12879-021-05994-z. PMID: 33765943Free PMC Article
Comparing the performance of time series models with or without meteorological factors in predicting incident pulmonary tuberculosis in eastern China.
Li ZQ, Pan HQ, Liu Q, Song H, Wang JM
Infect Dis Poverty 2020 Nov 5;9(1):151. doi: 10.1186/s40249-020-00771-7. PMID: 33148337Free PMC Article
Tuberculous meningitis.
Garg RK
Acta Neurol Scand 2010 Aug;122(2):75-90. Epub 2010 Jan 6 doi: 10.1111/j.1600-0404.2009.01316.x. PMID: 20055767
Pulmonary tuberculosis.
Hirsch CS, Johnson JL, Ellner JJ
Curr Opin Pulm Med 1999 May;5(3):143-50. doi: 10.1097/00063198-199905000-00004. PMID: 10228738

Clinical prediction guides

Tuberculosis in children: screening, diagnosis and management.
Howard-Jones AR, Marais BJ
Curr Opin Pediatr 2020 Jun;32(3):395-404. doi: 10.1097/MOP.0000000000000897. PMID: 32374579
Value of procalcitonin in differentiating pulmonary tuberculosis from other pulmonary infections: a meta-analysis.
Huang SL, Lee HC, Yu CW, Chen HC, Wang CC, Wu JY, Lee CC
Int J Tuberc Lung Dis 2014 Apr;18(4):470-7. doi: 10.5588/ijtld.13.0449. PMID: 24670705
Delays in diagnosis and treatment of pulmonary tuberculosis in India: a systematic review.
Sreeramareddy CT, Qin ZZ, Satyanarayana S, Subbaraman R, Pai M
Int J Tuberc Lung Dis 2014 Mar;18(3):255-266. doi: 10.5588/ijtld.13.0585. PMID: 24670558Free PMC Article
Chronic inactive pulmonary tuberculosis and treatment sequelae: chest radiographic features.
Hicks A, Muthukumarasamy S, Maxwell D, Howlett D
Int J Tuberc Lung Dis 2014 Feb;18(2):128-33. doi: 10.5588/ijtld.13.0360. PMID: 24429302
Advances in the diagnosis of pulmonary tuberculosis in HIV-infected and HIV-uninfected children.
Connell TG, Zar HJ, Nicol MP
J Infect Dis 2011 Nov 15;204 Suppl 4(Suppl 4):S1151-8. doi: 10.1093/infdis/jir413. PMID: 21996697Free PMC Article

Recent systematic reviews

The natural history of untreated pulmonary tuberculosis in adults: a systematic review and meta-analysis.
Sossen B, Richards AS, Heinsohn T, Frascella B, Balzarini F, Oradini-Alacreu A, Odone A, Rogozinska E, Häcker B, Cobelens F, Kranzer K, Houben RMGJ, Esmail H
Lancet Respir Med 2023 Apr;11(4):367-379. Epub 2023 Mar 23 doi: 10.1016/S2213-2600(23)00097-8. PMID: 36966795
Post-tuberculosis sequelae in children and adolescents: a systematic review.
Igbokwe V, Ruby LC, Sultanli A, Bélard S
Lancet Infect Dis 2023 Apr;23(4):e138-e150. doi: 10.1016/S1473-3099(23)00004-X. PMID: 36963920
Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and amikacin.
Pillay S, Steingart KR, Davies GR, Chaplin M, De Vos M, Schumacher SG, Warren R, Theron G
Cochrane Database Syst Rev 2022 May 18;5(5):CD014841. doi: 10.1002/14651858.CD014841.pub2. PMID: 35583175Free PMC Article
A systemic review on tuberculosis.
Natarajan A, Beena PM, Devnikar AV, Mali S
Indian J Tuberc 2020 Jul;67(3):295-311. Epub 2020 Feb 28 doi: 10.1016/j.ijtb.2020.02.005. PMID: 32825856
Xpert® MTB/RIF assay for pulmonary tuberculosis and rifampicin resistance in adults.
Steingart KR, Schiller I, Horne DJ, Pai M, Boehme CC, Dendukuri N
Cochrane Database Syst Rev 2014 Jan 21;2014(1):CD009593. doi: 10.1002/14651858.CD009593.pub3. PMID: 24448973Free PMC Article

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