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Endemic typhus

MedGen UID:
11977
Concept ID:
C0041472
Disease or Syndrome
Synonyms: Endemic Flea-Borne Typhus; Endemic Typhus; Flea-Borne Typhus, Endemic; Infection, Murine Typhus; Infection, Rickettsia typhi; Infections, Murine Typhus; Infections, Rickettsia typhi; Murine Typhus; Murine Typhus Infection; Murine Typhus Infections; Rickettsia typhi Infection; Rickettsia typhi Infections; Typhus Infection, Murine; Typhus Infections, Murine; Typhus, Endemic; Typhus, Endemic Flea Borne; Typhus, Endemic Flea-Borne; Typhus, Murine
SNOMED CT: Murine typhus (25668000); Endemic typhus (25668000); Typhus due to Rickettsia typhi (25668000); Flea-born typhus (25668000); Murine endemic flea typhus (25668000); Shop typhus (25668000); Urban typhus (25668000)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0000330
Orphanet: ORPHA83315

Definition

A Rickettsial disease characterized by headache, fever and macular or maculopapular rash, with only one-third of patients manifesting all three symptoms. Other common symptoms are chills, malaise, stomach pain, myalgia, loss of appetite, and in some cases confusion and altered level of consciousness. Classical laboratory abnormalities include elevated liver enzymes, lactate dehydrogenase, erythrocyte sedimentation rate and hypoalbuminemia. In children, typical symptoms occur in only half of patients, and abdominal pain, diarrhea, sore throat and anemia are more common. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEndemic typhus

Professional guidelines

PubMed

Takhampunya R, Korkusol A, Promsathaporn S, Tippayachai B, Leepitakrat S, Richards AL, Davidson SA
PLoS Negl Trop Dis 2018 Jul;12(7):e0006632. Epub 2018 Jul 16 doi: 10.1371/journal.pntd.0006632. PMID: 30011267Free PMC Article
Deepak N A, Patel ND
Ann Hepatol 2006 Jul-Sep;5(3):150-6. PMID: 17060870
LEVY MD, ARNOLD WT
Tex State J Med 1946 Sep;42:314-6. PMID: 20997522

Recent clinical studies

Etiology

Rodríguez-Alonso B, Almeida H, Alonso-Sardón M, Velasco-Tirado V, Robaina Bordón JM, Carranza Rodríguez C, Pérez Arellano JL, Belhassen-García M
Int J Infect Dis 2020 Jul;96:165-171. Epub 2020 Apr 27 doi: 10.1016/j.ijid.2020.04.054. PMID: 32353550
Grouteau G, Lancelot O, Bertolotti A, Poubeau P, Manaquin R, Foucher A, Jaubert J, Parola P, Pagès F, Camuset G
Med Mal Infect 2020 Feb;50(1):22-27. Epub 2019 Aug 3 doi: 10.1016/j.medmal.2019.06.003. PMID: 31387814
Portillo A, Santibáñez S, García-Álvarez L, Palomar AM, Oteo JA
Microbes Infect 2015 Nov-Dec;17(11-12):834-8. Epub 2015 Sep 16 doi: 10.1016/j.micinf.2015.09.009. PMID: 26384814
Tsioutis C, Chaliotis G, Kokkini S, Doukakis S, Tselentis Y, Psaroulaki A, Gikas A
Scand J Infect Dis 2014 Nov;46(11):779-82. Epub 2014 Aug 14 doi: 10.3109/00365548.2014.943283. PMID: 25119441
Rydkina E, Silverman DJ, Sahni SK
Ann N Y Acad Sci 2005 Dec;1063:203-6. doi: 10.1196/annals.1355.030. PMID: 16481515

Diagnosis

Rees R, Park C, Long B, Spencer S, Sutter D
J Pediatric Infect Dis Soc 2021 Apr 30;10(4):540-542. doi: 10.1093/jpids/piaa138. PMID: 33269795
Rodríguez-Alonso B, Almeida H, Alonso-Sardón M, Velasco-Tirado V, Robaina Bordón JM, Carranza Rodríguez C, Pérez Arellano JL, Belhassen-García M
Int J Infect Dis 2020 Jul;96:165-171. Epub 2020 Apr 27 doi: 10.1016/j.ijid.2020.04.054. PMID: 32353550
Grouteau G, Lancelot O, Bertolotti A, Poubeau P, Manaquin R, Foucher A, Jaubert J, Parola P, Pagès F, Camuset G
Med Mal Infect 2020 Feb;50(1):22-27. Epub 2019 Aug 3 doi: 10.1016/j.medmal.2019.06.003. PMID: 31387814
Tsioutis C, Zafeiri M, Avramopoulos A, Prousali E, Miligkos M, Karageorgos SA
Acta Trop 2017 Feb;166:16-24. Epub 2016 Oct 29 doi: 10.1016/j.actatropica.2016.10.018. PMID: 27983969
Portillo A, Santibáñez S, García-Álvarez L, Palomar AM, Oteo JA
Microbes Infect 2015 Nov-Dec;17(11-12):834-8. Epub 2015 Sep 16 doi: 10.1016/j.micinf.2015.09.009. PMID: 26384814

Therapy

Tsioutis C, Chaliotis G, Kokkini S, Doukakis S, Tselentis Y, Psaroulaki A, Gikas A
Scand J Infect Dis 2014 Nov;46(11):779-82. Epub 2014 Aug 14 doi: 10.3109/00365548.2014.943283. PMID: 25119441
Zhang J, Pau D, Lee AG
J Neuroophthalmol 2011 Dec;31(4):342-3. doi: 10.1097/WNO.0b013e31822db434. PMID: 21897295
Silva LJ, Papaiordanou PM
Rev Inst Med Trop Sao Paulo 2004 Sep-Oct;46(5):283-5. Epub 2004 Oct 22 doi: 10.1590/s0036-46652004000500010. PMID: 15517036
Wilde H, Pornsilapatip J, Sokly T, Thee S
Trop Geogr Med 1991 Oct;43(4):363-9. PMID: 1812601
Manor E, Politi F, Marmor A, Cohn DF
Am J Ophthalmol 1977 Oct;84(4):559-62. doi: 10.1016/0002-9394(77)90452-4. PMID: 910862

Prognosis

Rodríguez-Alonso B, Almeida H, Alonso-Sardón M, Velasco-Tirado V, Robaina Bordón JM, Carranza Rodríguez C, Pérez Arellano JL, Belhassen-García M
Int J Infect Dis 2020 Jul;96:165-171. Epub 2020 Apr 27 doi: 10.1016/j.ijid.2020.04.054. PMID: 32353550
Gao Y, Niu Y, Sun W, Liu K, Liu X, Zhao N, Yue Y, Wu H, Meng F, Wang J, Wang X, Liu Q
Environ Health 2020 Jan 8;19(1):3. doi: 10.1186/s12940-019-0558-3. PMID: 31915005Free PMC Article
Chen NY, Huang PY, Leu HS, Chiang PC, Huang CT
J Microbiol Immunol Infect 2008 Oct;41(5):362-8. PMID: 19122916

Clinical prediction guides

Grouteau G, Lancelot O, Bertolotti A, Poubeau P, Manaquin R, Foucher A, Jaubert J, Parola P, Pagès F, Camuset G
Med Mal Infect 2020 Feb;50(1):22-27. Epub 2019 Aug 3 doi: 10.1016/j.medmal.2019.06.003. PMID: 31387814
Tsioutis C, Zafeiri M, Avramopoulos A, Prousali E, Miligkos M, Karageorgos SA
Acta Trop 2017 Feb;166:16-24. Epub 2016 Oct 29 doi: 10.1016/j.actatropica.2016.10.018. PMID: 27983969
Chen NY, Huang PY, Leu HS, Chiang PC, Huang CT
J Microbiol Immunol Infect 2008 Oct;41(5):362-8. PMID: 19122916
Gikas A, Doukakis S, Pediaditis J, Kastanakis S, Manios A, Tselentis Y
Am J Trop Med Hyg 2004 May;70(5):576-9. PMID: 15155995
Woodward TE
J Infect Dis 1992 Feb;165(2):235-44. doi: 10.1093/infdis/165.2.235. PMID: 1730891

Recent systematic reviews

Tsioutis C, Zafeiri M, Avramopoulos A, Prousali E, Miligkos M, Karageorgos SA
Acta Trop 2017 Feb;166:16-24. Epub 2016 Oct 29 doi: 10.1016/j.actatropica.2016.10.018. PMID: 27983969

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