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Upper respiratory infection

MedGen UID:
12004
Concept ID:
C0041912
Disease or Syndrome
Synonyms: Infections, Upper Respiratory; Infections, Upper Respiratory Tract; Respiratory Infection, Upper; Upper Respiratory Infections; Upper Respiratory Tract Infection; Upper Respiratory Tract Infections
SNOMED CT: URTI - Infection of the upper respiratory tract (54150009); Upper respiratory tract infection (54150009); URI - Upper respiratory infection (54150009); Upper respiratory infection (54150009)

Definition

An infectious process affecting the upper respiratory tract (nose, paranasal sinuses, pharynx, larynx, or trachea). Symptoms include congestion, sneezing, coughing, fever, and sore throat. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUpper respiratory infection

Professional guidelines

PubMed

Devonshire AL, Kumar R
Allergy Asthma Proc 2019 Nov 1;40(6):389-392. doi: 10.2500/aap.2019.40.4254. PMID: 31690377
El Ramahi R, Freifeld A
J Oncol Pract 2019 Apr;15(4):177-184. doi: 10.1200/JOP.18.00567. PMID: 30970229
Piltcher OB, Kosugi EM, Sakano E, Mion O, Testa JRG, Romano FR, Santos MCJ, Di Francesco RC, Mitre EI, Bezerra TFP, Roithmann R, Padua FG, Valera FCP, Lubianca Neto JF, Sá LCB, Pignatari SSN, Avelino MAG, Caixeta JAS, Anselmo-Lima WT, Tamashiro E
Braz J Otorhinolaryngol 2018 May-Jun;84(3):265-279. Epub 2018 Feb 25 doi: 10.1016/j.bjorl.2018.02.001. PMID: 29588108Free PMC Article

Recent clinical studies

Etiology

Cosgrove P, Krauss BS, Cravero JP, Fleegler EW
Ann Emerg Med 2022 Dec;80(6):485-496. Epub 2022 Jun 23 doi: 10.1016/j.annemergmed.2022.05.002. PMID: 35752522
Devonshire AL, Kumar R
Allergy Asthma Proc 2019 Nov 1;40(6):389-392. doi: 10.2500/aap.2019.40.4254. PMID: 31690377
Wraith JE, Jones S
Pediatr Endocrinol Rev 2014 Sep;12 Suppl 1:102-6. PMID: 25345091
Grief SN
Prim Care 2013 Sep;40(3):757-70. Epub 2013 Jul 12 doi: 10.1016/j.pop.2013.06.004. PMID: 23958368Free PMC Article
Saper RB, Rash R
Am Fam Physician 2009 May 1;79(9):768-72. PMID: 20141096Free PMC Article

Diagnosis

Stenberg-Hammar K, Hedlin G, Söderhäll C
Pediatr Allergy Immunol 2017 Sep;28(6):513-520. Epub 2017 Jul 26 doi: 10.1111/pai.12740. PMID: 28599066
Florin TA, Plint AC, Zorc JJ
Lancet 2017 Jan 14;389(10065):211-224. Epub 2016 Aug 20 doi: 10.1016/S0140-6736(16)30951-5. PMID: 27549684Free PMC Article
Grief SN
Prim Care 2013 Sep;40(3):757-70. Epub 2013 Jul 12 doi: 10.1016/j.pop.2013.06.004. PMID: 23958368Free PMC Article
Tan R, Spector S
Curr Allergy Asthma Rep 2007 Nov;7(6):421-6. doi: 10.1007/s11882-007-0064-5. PMID: 17986371
Skolnik N
J Fam Pract 1993 Aug;37(2):165-70. PMID: 8336098

Therapy

Devonshire AL, Kumar R
Allergy Asthma Proc 2019 Nov 1;40(6):389-392. doi: 10.2500/aap.2019.40.4254. PMID: 31690377
Chen N, Hao C, Liu BC, Lin H, Wang C, Xing C, Liang X, Jiang G, Liu Z, Li X, Zuo L, Luo L, Wang J, Zhao MH, Liu Z, Cai GY, Hao L, Leong R, Wang C, Liu C, Neff T, Szczech L, Yu KP
N Engl J Med 2019 Sep 12;381(11):1011-1022. Epub 2019 Jul 24 doi: 10.1056/NEJMoa1901713. PMID: 31340116
Florin TA, Plint AC, Zorc JJ
Lancet 2017 Jan 14;389(10065):211-224. Epub 2016 Aug 20 doi: 10.1016/S0140-6736(16)30951-5. PMID: 27549684Free PMC Article
Grief SN
Prim Care 2013 Sep;40(3):757-70. Epub 2013 Jul 12 doi: 10.1016/j.pop.2013.06.004. PMID: 23958368Free PMC Article
Saper RB, Rash R
Am Fam Physician 2009 May 1;79(9):768-72. PMID: 20141096Free PMC Article

Prognosis

Cosgrove P, Krauss BS, Cravero JP, Fleegler EW
Ann Emerg Med 2022 Dec;80(6):485-496. Epub 2022 Jun 23 doi: 10.1016/j.annemergmed.2022.05.002. PMID: 35752522
Itkin M
Tech Vasc Interv Radiol 2016 Dec;19(4):299-304. Epub 2016 Oct 8 doi: 10.1053/j.tvir.2016.10.005. PMID: 27993326
Hwang VJ, Ulu A, van Hoorebeke J, Weiss RH
Biomark Med 2014;8(10):1263-77. doi: 10.2217/bmm.14.92. PMID: 25525986
Gates GA, Avery C, Prihoda TJ, Holt GR
Laryngoscope 1986 Jun;96(6):630-4. doi: 10.1288/00005537-198606000-00008. PMID: 3713407
McCoy RC, Abramowsky CR, Tisher CC
Am J Pathol 1974 Jul;76(1):123-44. PMID: 4601708Free PMC Article

Clinical prediction guides

Cosgrove P, Krauss BS, Cravero JP, Fleegler EW
Ann Emerg Med 2022 Dec;80(6):485-496. Epub 2022 Jun 23 doi: 10.1016/j.annemergmed.2022.05.002. PMID: 35752522
Leung AKC, Leong KF, Lam JM
Curr Pediatr Rev 2020;16(4):285-293. doi: 10.2174/1573396316666200727145039. PMID: 32718294
Genovese MC, Kalunian K, Gottenberg JE, Mozaffarian N, Bartok B, Matzkies F, Gao J, Guo Y, Tasset C, Sundy JS, de Vlam K, Walker D, Takeuchi T
JAMA 2019 Jul 23;322(4):315-325. doi: 10.1001/jama.2019.9055. PMID: 31334793Free PMC Article
Itkin M
Tech Vasc Interv Radiol 2016 Dec;19(4):299-304. Epub 2016 Oct 8 doi: 10.1053/j.tvir.2016.10.005. PMID: 27993326
Hwang VJ, Ulu A, van Hoorebeke J, Weiss RH
Biomark Med 2014;8(10):1263-77. doi: 10.2217/bmm.14.92. PMID: 25525986

Recent systematic reviews

Keyhani S, Falk R, Howell EA, Bishop T, Korenstein D
Med Care 2013 Jun;51(6):503-8. doi: 10.1097/MLR.0b013e31828dbafe. PMID: 23552430Free PMC Article
Kania DS, Gonzalvo JD, Weber ZA
Clin Ther 2011 Aug;33(8):1005-22. Epub 2011 Jul 28 doi: 10.1016/j.clinthera.2011.06.016. PMID: 21802144
Pedersen A, Zachariae R, Bovbjerg DH
Psychosom Med 2010 Oct;72(8):823-32. Epub 2010 Aug 17 doi: 10.1097/PSY.0b013e3181f1d003. PMID: 20716708
Sultan N, Nazareno J, Gregor J
Can J Gastroenterol 2008 Sep;22(9):761-6. doi: 10.1155/2008/821385. PMID: 18818790Free PMC Article
Graham V, Lasserson T, Rowe BH
Cochrane Database Syst Rev 2001;(3):CD002741. doi: 10.1002/14651858.CD002741. PMID: 11687022

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