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Ampulla of Vater carcinoma

MedGen UID:
120461
•Concept ID:
C0262401
•
Neoplastic Process
Synonyms: AMPCA; Ampulla of Vater Cancer; ampulla of Vater cancer; Ampulla of Vater Carcinoma; ampulla of Vater carcinoma; ampullary cancer; Ampullary carcinoma; Ampullary Carcinoma; ampullary carcinoma; Ampulloma; Carcinoma of ampulla of Vater; carcinoma of ampulla of vater; carcinoma of hepatopancreatic ampulla; carcinoma of the ampulla of vater; Carcinoma of the ampulla of Vater; hepatopancreatic ampulla carcinoma
SNOMED CT: Carcinoma of ampulla of Vater (254609000); Ampullary carcinoma (254609000)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
HPO: HP:0031524
Monarch Initiative: MONDO:0017590
Orphanet: ORPHA300557

Definition

A carcinoma originating in the ampulla of Vater (also known as the hepatopancreatic duct), which is formed by the union of the pancreatic duct and the common bile duct. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAmpulla of Vater carcinoma
Follow this link to review classifications for Ampulla of Vater carcinoma in Orphanet.

Professional guidelines

PubMed

Proposed indications for limited resection of early ampulla of Vater carcinoma: clinico-histopathological criteria to confirm cure.
Aiura K, Hibi T, Fujisaki H, Kitago M, Tanabe M, Kawachi S, Itano O, Shinoda M, Yagi H, Masugi Y, Sakamoto M, Kitagawa Y
J Hepatobiliary Pancreat Sci 2012 Nov;19(6):707-16. doi: 10.1007/s00534-011-0492-4. PMID: 22203456Free PMC Article

Recent clinical studies

Etiology

Prognostic Impact of Indicators of Systemic Inflammation and the Nutritional Status of Patients with Resected Carcinoma of the Ampulla of Vater: A Single-Center Retrospective Study.
Shimizu Y, Ashida R, Sugiura T, Okamura Y, Ito T, Yamamoto Y, Ohgi K, Otsuka S, Notsu A, Uesaka K
World J Surg 2022 Jan;46(1):246-258. Epub 2021 Oct 18 doi: 10.1007/s00268-021-06346-3. PMID: 34661701
Adjuvant Chemotherapy for Resected Ampulla of Vater Carcinoma: Retrospective Analysis of 646 Patients.
Kim JH, Jeong JH, Ryoo BY, Kim KP, Chang HM, Oh D, Song TJ, Lee SS, Seo DW, Lee SK, Kim MH, Park Y, Kwon JW, Hwang DW, Lee JH, Lee W, Kim SC, Yoo C, Song KB
Cancer Res Treat 2021 Apr;53(2):424-435. Epub 2020 Nov 9 doi: 10.4143/crt.2020.953. PMID: 33171024Free PMC Article
The Prognostic Relevance of the Number and Location of Positive Lymph Nodes for Ampulla of Vater Carcinoma.
Matsui S, Yamamoto Y, Sugiura T, Okamura Y, Ito T, Ashida R, Ohgi K, Imamura T, Uesaka K
World J Surg 2021 Jan;45(1):270-278. Epub 2020 Sep 9 doi: 10.1007/s00268-020-05770-1. PMID: 32909124
Perineural Invasion is a Strong Prognostic Moderator in Ampulla of Vater Carcinoma: A Meta-analysis.
Luchini C, Veronese N, Nottegar A, Riva G, Pilati C, Mafficini A, Stubbs B, Simbolo M, Mombello A, Corbo V, Cheng L, Yachida S, Wood LD, Lawlor RT, Salvia R, Scarpa A
Pancreas 2019 Jan;48(1):70-76. doi: 10.1097/MPA.0000000000001194. PMID: 30451797
Ampulla of Vater carcinoma in real-world clinical practice: a case series.
Giuliani J, Piacentini P, Bonetti A
Tumori 2015 Jun 25;101(3):e75-8. doi: 10.5301/tj.5000267. PMID: 25908045

Diagnosis

The Prognostic Relevance of Preoperative CEA and CA19-9 for Ampulla of Vater Carcinoma.
Matsui S, Yamamoto Y, Okamura Y, Ito T, Ashida R, Ohgi K, Yamada M, Otsuka S, Uesaka K, Sugiura T
Anticancer Res 2022 Jun;42(6):3169-3176. doi: 10.21873/anticanres.15806. PMID: 35641260
Ampullary carcinoma-A genetic perspective.
Jayaramayya K, Balachandar V, Santhy KS
Mutat Res Rev Mutat Res 2018 Apr-Jun;776:10-22. Epub 2018 Mar 17 doi: 10.1016/j.mrrev.2018.03.002. PMID: 29807574
Ampulla of Vater Carcinoma: Sequencing Analysis Identifies TP53 Status as a Novel Independent Prognostic Factor and Potentially Actionable ERBB, PI3K, and WNT Pathways Gene Mutations.
Mafficini A, Amato E, Cataldo I, Rusev BC, Bertoncello L, Corbo V, Simbolo M, Luchini C, Fassan M, Cantù C, Salvia R, Marchegiani G, Tortora G, Lawlor RT, Bassi C, Scarpa A
Ann Surg 2018 Jan;267(1):149-156. doi: 10.1097/SLA.0000000000001999. PMID: 27611608
Ampulla of Vater carcinoma in real-world clinical practice: a case series.
Giuliani J, Piacentini P, Bonetti A
Tumori 2015 Jun 25;101(3):e75-8. doi: 10.5301/tj.5000267. PMID: 25908045
The clinicopathologic and immunohistochemical characteristics of ampulla of Vater carcinoma: the intestinal type is associated with a better prognosis.
Roh YH, Kim YH, Lee HW, Kim SJ, Roh MS, Jeong JS, Jung GJ
Hepatogastroenterology 2007 Sep;54(78):1641-4. PMID: 18019683

Therapy

Influence of bile contamination for patients who undergo pancreaticoduodenectomy after biliary drainage.
Okano K, Suzuki Y
World J Gastroenterol 2019 Dec 21;25(47):6847-6856. doi: 10.3748/wjg.v25.i47.6847. PMID: 31885425Free PMC Article
Ampulla of Vater carcinoma in real-world clinical practice: a case series.
Giuliani J, Piacentini P, Bonetti A
Tumori 2015 Jun 25;101(3):e75-8. doi: 10.5301/tj.5000267. PMID: 25908045
A phase I and pharmacokinetic study of oxaliplatin and bortezomib: activity, but dose-limiting neurotoxicity.
Kobrinsky B, Joseph SO, Muggia F, Liebes L, Beric A, Malankar A, Ivy P, Hochster H
Cancer Chemother Pharmacol 2013 Nov;72(5):1073-8. Epub 2013 Sep 19 doi: 10.1007/s00280-013-2295-6. PMID: 24048674
Gemcitabine-based versus fluoropyrimidine-based chemotherapy with or without platinum in unresectable biliary tract cancer: a retrospective study.
Kim MJ, Oh DY, Lee SH, Kim DW, Im SA, Kim TY, Heo DS, Bang YJ
BMC Cancer 2008 Dec 18;8:374. doi: 10.1186/1471-2407-8-374. PMID: 19091129Free PMC Article
Prognostic relevance of lymph node ratio and number of resected nodes after curative resection of ampulla of Vater carcinoma.
Falconi M, Crippa S, Domínguez I, Barugola G, Capelli P, Marcucci S, Beghelli S, Scarpa A, Bassi C, Pederzoli P
Ann Surg Oncol 2008 Nov;15(11):3178-86. Epub 2008 Aug 20 doi: 10.1245/s10434-008-0099-4. PMID: 18712568

Prognosis

The Prognostic Relevance of Preoperative CEA and CA19-9 for Ampulla of Vater Carcinoma.
Matsui S, Yamamoto Y, Okamura Y, Ito T, Ashida R, Ohgi K, Yamada M, Otsuka S, Uesaka K, Sugiura T
Anticancer Res 2022 Jun;42(6):3169-3176. doi: 10.21873/anticanres.15806. PMID: 35641260
Adjuvant Chemotherapy for Resected Ampulla of Vater Carcinoma: Retrospective Analysis of 646 Patients.
Kim JH, Jeong JH, Ryoo BY, Kim KP, Chang HM, Oh D, Song TJ, Lee SS, Seo DW, Lee SK, Kim MH, Park Y, Kwon JW, Hwang DW, Lee JH, Lee W, Kim SC, Yoo C, Song KB
Cancer Res Treat 2021 Apr;53(2):424-435. Epub 2020 Nov 9 doi: 10.4143/crt.2020.953. PMID: 33171024Free PMC Article
Role of systemic inflammation in predicting the prognosis of ampulla of Vater carcinoma.
Seo HK, Hwang DW, Lee JH, Song KB, Shin SH, Kwon J, Lee YJ, Kim SC
Surg Oncol 2019 Jun;29:33-40. Epub 2019 Feb 15 doi: 10.1016/j.suronc.2019.02.006. PMID: 31196491
Ampullary carcinoma-A genetic perspective.
Jayaramayya K, Balachandar V, Santhy KS
Mutat Res Rev Mutat Res 2018 Apr-Jun;776:10-22. Epub 2018 Mar 17 doi: 10.1016/j.mrrev.2018.03.002. PMID: 29807574
Analysis of pancreatoduodenectomy.
O'Brien PH, Mincey KH
J Surg Oncol 1985 Jan;28(1):50-8. doi: 10.1002/jso.2930280113. PMID: 3968888

Clinical prediction guides

Prognostic Impact of Indicators of Systemic Inflammation and the Nutritional Status of Patients with Resected Carcinoma of the Ampulla of Vater: A Single-Center Retrospective Study.
Shimizu Y, Ashida R, Sugiura T, Okamura Y, Ito T, Yamamoto Y, Ohgi K, Otsuka S, Notsu A, Uesaka K
World J Surg 2022 Jan;46(1):246-258. Epub 2021 Oct 18 doi: 10.1007/s00268-021-06346-3. PMID: 34661701
Adjuvant Chemotherapy for Resected Ampulla of Vater Carcinoma: Retrospective Analysis of 646 Patients.
Kim JH, Jeong JH, Ryoo BY, Kim KP, Chang HM, Oh D, Song TJ, Lee SS, Seo DW, Lee SK, Kim MH, Park Y, Kwon JW, Hwang DW, Lee JH, Lee W, Kim SC, Yoo C, Song KB
Cancer Res Treat 2021 Apr;53(2):424-435. Epub 2020 Nov 9 doi: 10.4143/crt.2020.953. PMID: 33171024Free PMC Article
Role of systemic inflammation in predicting the prognosis of ampulla of Vater carcinoma.
Seo HK, Hwang DW, Lee JH, Song KB, Shin SH, Kwon J, Lee YJ, Kim SC
Surg Oncol 2019 Jun;29:33-40. Epub 2019 Feb 15 doi: 10.1016/j.suronc.2019.02.006. PMID: 31196491
Ampulla of Vater Carcinoma: Sequencing Analysis Identifies TP53 Status as a Novel Independent Prognostic Factor and Potentially Actionable ERBB, PI3K, and WNT Pathways Gene Mutations.
Mafficini A, Amato E, Cataldo I, Rusev BC, Bertoncello L, Corbo V, Simbolo M, Luchini C, Fassan M, Cantù C, Salvia R, Marchegiani G, Tortora G, Lawlor RT, Bassi C, Scarpa A
Ann Surg 2018 Jan;267(1):149-156. doi: 10.1097/SLA.0000000000001999. PMID: 27611608
Ampulla of Vater carcinoma in real-world clinical practice: a case series.
Giuliani J, Piacentini P, Bonetti A
Tumori 2015 Jun 25;101(3):e75-8. doi: 10.5301/tj.5000267. PMID: 25908045

Recent systematic reviews

The clinical implication of minimally invasive versus open pancreatoduodenectomy for non-pancreatic periampullary cancer: a systematic review and individual patient data meta-analysis.
Uijterwijk BA, Kasai M, Lemmers DHL, Chinnusamy P, van Hilst J, Ielpo B, Wei K, Song KB, Kim SC, Klompmaker S, Jang JY, Herremans KM, Bencini L, Coratti A, Mazzola M, Menon KV, Goh BKP, Qin R, Besselink MG, Abu Hilal M; International Study Group on non-pancreatic periAmpullary CAncer (ISGACA)
Langenbecks Arch Surg 2023 Aug 15;408(1):311. doi: 10.1007/s00423-023-03047-4. PMID: 37581763Free PMC Article
Perineural Invasion is a Strong Prognostic Moderator in Ampulla of Vater Carcinoma: A Meta-analysis.
Luchini C, Veronese N, Nottegar A, Riva G, Pilati C, Mafficini A, Stubbs B, Simbolo M, Mombello A, Corbo V, Cheng L, Yachida S, Wood LD, Lawlor RT, Salvia R, Scarpa A
Pancreas 2019 Jan;48(1):70-76. doi: 10.1097/MPA.0000000000001194. PMID: 30451797

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