U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hemophilic arthropathy

MedGen UID:
120487
•Concept ID:
C0263725
•
Disease or Syndrome
Synonyms: arthropathy in haemophilia; Arthropathy in hemophilia; arthropathy in hemophilia; Hemophilic arthritis; Hemophilic Arthritis; hemophilic arthritis; hemophilic arthropathy
SNOMED CT: Arthropathy in hemophilia (80813006); Hemophilic arthritis (80813006); Hemophilic arthropathy (80813006)
 
Monarch Initiative: MONDO:0043240

Definition

A form of arthritis that affects hemophiliacs, which is characterized by bleeding into the joint space. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHemophilic arthropathy

Professional guidelines

PubMed

Treatment with radiosynoviorthesis in hemophilic patients with and without inhibitor.
Tena-Sanabria ME, Rojas-Sato YF, Castañeda-Resendiz JC, Fuentes-Herrera G, Álvarez-Martínez FA, Tena-Gonzalez YI, Núñez-Enríquez JC
BMC Pediatr 2020 Apr 20;20(1):173. doi: 10.1186/s12887-020-02071-3. PMID: 32312235Free PMC Article
Curcumin: hopeful treatment of hemophilic arthropathy via inhibition of inflammation and angiogenesis.
Norooznezhad F, Rodriguez-Merchan EC, Asadi S, Norooznezhad AH
Expert Rev Hematol 2020 Jan;13(1):5-11. Epub 2019 Oct 30 doi: 10.1080/17474086.2020.1685867. PMID: 31657968
Management of Hemophilic Arthropathy of the Ankle.
Rodriguez-Merchan EC
Cardiovasc Hematol Disord Drug Targets 2017;17(2):111-118. doi: 10.2174/1871529X17666170908110758. PMID: 28891453

Recent clinical studies

Etiology

Hemophilic arthropathy: Current knowledge and future perspectives.
Gualtierotti R, Solimeno LP, Peyvandi F
J Thromb Haemost 2021 Sep;19(9):2112-2121. Epub 2021 Jul 27 doi: 10.1111/jth.15444. PMID: 34197690Free PMC Article
A history of prophylaxis in haemophilia.
Moreno MM, Cuesta-Barriuso R
Blood Coagul Fibrinolysis 2019 Mar;30(2):55-57. doi: 10.1097/MBC.0000000000000783. PMID: 30507712
Inhibitors in Hemophilia B.
Santoro C, Quintavalle G, Castaman G, Baldacci E, Ferretti A, Riccardi F, Tagliaferri A
Semin Thromb Hemost 2018 Sep;44(6):578-589. Epub 2018 Jun 20 doi: 10.1055/s-0038-1660817. PMID: 29925096
Cytokines in the pathogenesis of hemophilic arthropathy.
Wojdasiewicz P, Poniatowski ŁA, Nauman P, Mandat T, Paradowska-Gorycka A, Romanowska-Próchnicka K, Szukiewicz D, Kotela A, Kubaszewski Ł, Kotela I, Kurkowska-Jastrzębska I, Gasik R
Cytokine Growth Factor Rev 2018 Feb;39:71-91. Epub 2017 Nov 13 doi: 10.1016/j.cytogfr.2017.11.003. PMID: 29153709
Current role for radioisotope synovectomy.
André V, Dalibard V, Dernis E, Varin S, Cormier G
Joint Bone Spine 2018 May;85(3):295-299. Epub 2017 Jun 23 doi: 10.1016/j.jbspin.2017.06.002. PMID: 28652100

Diagnosis

Soft Tissue Pathology.
Shane AM, Reeves CL, Nguyen GB, Ferrise TD, Calaj PM
Clin Podiatr Med Surg 2023 Jul;40(3):381-395. Epub 2023 Apr 28 doi: 10.1016/j.cpm.2023.02.003. PMID: 37236677
Hemophilic arthropathy: Current knowledge and future perspectives.
Gualtierotti R, Solimeno LP, Peyvandi F
J Thromb Haemost 2021 Sep;19(9):2112-2121. Epub 2021 Jul 27 doi: 10.1111/jth.15444. PMID: 34197690Free PMC Article
The Progression of Hemophilic Arthropathy: The Role of Biomarkers.
Pasta G, Annunziata S, Polizzi A, Caliogna L, Jannelli E, Minen A, Mosconi M, Benazzo F, Di Minno MND
Int J Mol Sci 2020 Oct 2;21(19) doi: 10.3390/ijms21197292. PMID: 33023246Free PMC Article
Hemophilic Arthropathy.
Nacca CR, Harris AP, Tuttle JR
Orthopedics 2017 Nov 1;40(6):e940-e946. Epub 2017 Jun 30 doi: 10.3928/01477447-20170619-05. PMID: 28662249
Advances and challenges in hemophilic arthropathy.
Wyseure T, Mosnier LO, von Drygalski A
Semin Hematol 2016 Jan;53(1):10-9. Epub 2015 Oct 26 doi: 10.1053/j.seminhematol.2015.10.005. PMID: 26805902Free PMC Article

Therapy

Hemophilic arthropathy: how to diagnose subclinical bleeding early and how to orthopedically treat a damaged joint.
Rodriguez-Merchan EC
Expert Rev Hematol 2023 Jul-Dec;16(9):651-658. Epub 2023 Jul 4 doi: 10.1080/17474086.2023.2232547. PMID: 37392151
Curcumin: hopeful treatment of hemophilic arthropathy via inhibition of inflammation and angiogenesis.
Norooznezhad F, Rodriguez-Merchan EC, Asadi S, Norooznezhad AH
Expert Rev Hematol 2020 Jan;13(1):5-11. Epub 2019 Oct 30 doi: 10.1080/17474086.2020.1685867. PMID: 31657968
A history of prophylaxis in haemophilia.
Moreno MM, Cuesta-Barriuso R
Blood Coagul Fibrinolysis 2019 Mar;30(2):55-57. doi: 10.1097/MBC.0000000000000783. PMID: 30507712
Inhibitors in Hemophilia B.
Santoro C, Quintavalle G, Castaman G, Baldacci E, Ferretti A, Riccardi F, Tagliaferri A
Semin Thromb Hemost 2018 Sep;44(6):578-589. Epub 2018 Jun 20 doi: 10.1055/s-0038-1660817. PMID: 29925096
Hemophilic arthropathy.
Luck JV Jr, Silva M, Rodriguez-Merchan EC, Ghalambor N, Zahiri CA, Finn RS
J Am Acad Orthop Surg 2004 Jul-Aug;12(4):234-45. doi: 10.5435/00124635-200407000-00004. PMID: 15473675

Prognosis

Cytokines in the pathogenesis of hemophilic arthropathy.
Wojdasiewicz P, Poniatowski ŁA, Nauman P, Mandat T, Paradowska-Gorycka A, Romanowska-Próchnicka K, Szukiewicz D, Kotela A, Kubaszewski Ł, Kotela I, Kurkowska-Jastrzębska I, Gasik R
Cytokine Growth Factor Rev 2018 Feb;39:71-91. Epub 2017 Nov 13 doi: 10.1016/j.cytogfr.2017.11.003. PMID: 29153709
Current role for radioisotope synovectomy.
André V, Dalibard V, Dernis E, Varin S, Cormier G
Joint Bone Spine 2018 May;85(3):295-299. Epub 2017 Jun 23 doi: 10.1016/j.jbspin.2017.06.002. PMID: 28652100
Pathophysiology of hemophilic arthropathy and potential targets for therapy.
Pulles AE, Mastbergen SC, Schutgens RE, Lafeber FP, van Vulpen LF
Pharmacol Res 2017 Jan;115:192-199. Epub 2016 Nov 24 doi: 10.1016/j.phrs.2016.11.032. PMID: 27890816
Advances and challenges in hemophilic arthropathy.
Wyseure T, Mosnier LO, von Drygalski A
Semin Hematol 2016 Jan;53(1):10-9. Epub 2015 Oct 26 doi: 10.1053/j.seminhematol.2015.10.005. PMID: 26805902Free PMC Article
Synovium and cartilage biomarkers in hemophilic arthropathy.
Rodriguez-Merchan EC
Expert Rev Hematol 2016;9(4):409-14. Epub 2016 Feb 3 doi: 10.1586/17474086.2016.1141674. PMID: 26761216

Clinical prediction guides

What is the Effect of Bevacizumab on Cartilage and Synovium in a Rabbit Model of Hemophilic Arthropathy?
Mert L, Bilgiç B, Şenol BK, Zülfikar OB, Durmaz H, Polat G
Clin Orthop Relat Res 2023 Aug 1;481(8):1634-1647. Epub 2023 Apr 10 doi: 10.1097/CORR.0000000000002628. PMID: 37036937Free PMC Article
The Correlation Between the HEAD-US-C Score and HJHS in Hemophilic Arthropathy of the Knee.
Fang Y, Guo Y, Qin T, Luan Y, Zhang C
J Ultrasound Med 2023 Apr;42(4):859-868. Epub 2022 Aug 3 doi: 10.1002/jum.16072. PMID: 35920366
Pathophysiology of hemophilic arthropathy and potential targets for therapy.
Pulles AE, Mastbergen SC, Schutgens RE, Lafeber FP, van Vulpen LF
Pharmacol Res 2017 Jan;115:192-199. Epub 2016 Nov 24 doi: 10.1016/j.phrs.2016.11.032. PMID: 27890816
Advances and challenges in hemophilic arthropathy.
Wyseure T, Mosnier LO, von Drygalski A
Semin Hematol 2016 Jan;53(1):10-9. Epub 2015 Oct 26 doi: 10.1053/j.seminhematol.2015.10.005. PMID: 26805902Free PMC Article
Synovium and cartilage biomarkers in hemophilic arthropathy.
Rodriguez-Merchan EC
Expert Rev Hematol 2016;9(4):409-14. Epub 2016 Feb 3 doi: 10.1586/17474086.2016.1141674. PMID: 26761216

Recent systematic reviews

The Efficacy of Physical Therapy Modalities in Patients With Hemophilia: A Systematic Review of Randomized Controlled Trials With Meta-analysis.
Elshennawy S, Zahreldin AA, Mortada H, Hozien M, Youssef ASA, Galal A, Shahien M, Elfeky A, Elaraby A, Hamed M
Arch Phys Med Rehabil 2023 Mar;104(3):475-489. Epub 2022 Jul 19 doi: 10.1016/j.apmr.2022.05.023. PMID: 35868453
The fear for adverse bleeding and cardiovascular events in hemophilia patients using (non-)selective non-steroidal anti-inflammatory drugs: A systematic review reporting on safety.
van Bergen EDP, Monnikhof M, Lafeber FPJG, Schutgens REG, Mastbergen SC, van Vulpen LFD
Blood Rev 2022 Nov;56:100987. Epub 2022 Jun 24 doi: 10.1016/j.blre.2022.100987. PMID: 35779986
Total Knee Arthroplasty in Hemophilia: Survivorship and Outcomes-A Systematic Review and Meta-Analysis.
Fenelon C, Murphy EP, Fahey EJ, Murphy RP, O'Connell NM, Queally JM
J Arthroplasty 2022 Mar;37(3):581-592.e1. Epub 2021 Oct 28 doi: 10.1016/j.arth.2021.10.015. PMID: 34756977
Biochemical marker research in hemophilic arthropathy: A systematic review.
van Bergen EDP, van Vulpen LFD, Schutgens REG, Mastbergen SC, Lafeber FPJG
Blood Rev 2021 May;47:100781. Epub 2020 Nov 22 doi: 10.1016/j.blre.2020.100781. PMID: 33277057
Synovium and cartilage biomarkers in hemophilic arthropathy.
Rodriguez-Merchan EC
Expert Rev Hematol 2016;9(4):409-14. Epub 2016 Feb 3 doi: 10.1586/17474086.2016.1141674. PMID: 26761216

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...