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Eosinophilic gastritis

MedGen UID:
120598
Concept ID:
C0267154
Disease or Syndrome
Synonyms: Eosinophilic Gastritis; eosinophilic gastritis; Eosinophilic infiltration in the stomach mucosa
SNOMED CT: Eosinophilic gastritis (66329006)
 
HPO: HP:0410147
Monarch Initiative: MONDO:0002840

Definition

Infiltration of eosinophils in the stomach mucosa, that is diagnosed by an upper endoscopy and microscopy that shows more than 20 eosinophils per high-power field in association with peripheral eosinophilia and the absence of secondary cause of eosinophilia. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEosinophilic gastritis

Conditions with this feature

Hyper-IgE recurrent infection syndrome 1, autosomal dominant
MedGen UID:
1648470
Concept ID:
C4721531
Disease or Syndrome
STAT3 hyper IgE syndrome (STAT3-HIES) is a primary immune deficiency syndrome characterized by elevated serum IgE, eczema, and recurrent skin and respiratory tract infections, together with several nonimmune features. This disorder typically manifests in the newborn period with a rash (often diagnosed as eosinophilic pustulosis) that subsequently evolves into an eczematoid dermatitis. Recurrent staphylococcal skin boils and bacterial pneumonias usually manifest in the first years of life. Pneumatoceles and bronchiectasis often result from aberrant healing of pneumonias. Mucocutaneous candidiasis is common. Nonimmune features may include retained primary teeth, scoliosis, bone fractures following minimal trauma, joint hyperextensibility, and characteristic facial appearance, which typically emerges in adolescence. Vascular abnormalities have been described and include middle-sized artery tortuosity and aneurysms, with infrequent clinical sequelae of myocardial infarction and subarachnoid hemorrhage. Gastrointestinal (GI) manifestations include gastroesophageal reflux disease, esophageal dysmotility, and spontaneous intestinal perforations (some of which are associated with diverticuli). Fungal infections of the GI tract (typically histoplasmosis, Cryptococcus, and Coccidioides) also occur infrequently. Survival is typically into adulthood, with most individuals now living into or past the sixth decade. Most deaths are associated with gram-negative (Pseudomonas) or filamentous fungal pneumonias resulting in hemoptysis. Lymphomas occur at an increased frequency.

Professional guidelines

PubMed

Patel N, Goyal A, Thaker A, Troendle D, Parrish C
J Pediatr Gastroenterol Nutr 2022 Aug 1;75(2):192-195. Epub 2022 Jun 6 doi: 10.1097/MPG.0000000000003512. PMID: 35666881
Dellon ES, Gonsalves N, Abonia JP, Alexander JA, Arva NC, Atkins D, Attwood SE, Auth MKH, Bailey DD, Biederman L, Blanchard C, Bonis PA, Bose P, Bredenoord AJ, Chang JW, Chehade M, Collins MH, Di Lorenzo C, Dias JA, Dohil R, Dupont C, Falk GW, Ferreira CT, Fox AT, Genta RM, Greuter T, Gupta SK, Hirano I, Hiremath GS, Horsley-Silva JL, Ishihara S, Ishimura N, Jensen ET, Gutiérrez-Junquera C, Katzka DA, Khoury P, Kinoshita Y, Kliewer KL, Koletzko S, Leung J, Liacouras CA, Lucendo AJ, Martin LJ, McGowan EC, Menard-Katcher C, Metz DC, Miller TL, Moawad FJ, Muir AB, Mukkada VA, Murch S, Nhu QM, Nomura I, Nurko S, Ohtsuka Y, Oliva S, Orel R, Papadopoulou A, Patel DA, Pesek RD, Peterson KA, Philpott H, Putnam PE, Richter JE, Rosen R, Ruffner MA, Safroneeva E, Schreiner P, Schoepfer A, Schroeder SR, Shah N, Souza RF, Spechler SJ, Spergel JM, Straumann A, Talley NJ, Thapar N, Vandenplas Y, Venkatesh RD, Vieira MC, von Arnim U, Walker MM, Wechsler JB, Wershil BK, Wright BL, Yamada Y, Yang GY, Zevit N, Rothenberg ME, Furuta GT, Aceves SS
Clin Gastroenterol Hepatol 2022 Nov;20(11):2474-2484.e3. Epub 2022 Feb 16 doi: 10.1016/j.cgh.2022.02.017. PMID: 35181570Free PMC Article
Bobrova VI, Horobets AO, Proshchenko JI, Levadna LO, Selska ZV
Wiad Lek 2021;74(7):1722-1727. PMID: 34459778

Recent clinical studies

Etiology

Marasco G, Visaggi P, Vassallo M, Fiocca M, Cremon C, Barbaro MR, De Bortoli N, Bellini M, Stanghellini V, Savarino EV, Barbara G
Int J Mol Sci 2023 Oct 13;24(20) doi: 10.3390/ijms242015165. PMID: 37894846Free PMC Article
Kliewer KL, Murray-Petzold C, Collins MH, Abonia JP, Bolton SM, DiTommaso LA, Martin LJ, Zhang X, Mukkada VA, Putnam PE, Kellner ES, Devonshire AL, Schwartz JT, Kunnathur VA, Rosenberg CE, Lyles JL, Shoda T, Klion AD, Rothenberg ME
Lancet Gastroenterol Hepatol 2023 Sep;8(9):803-815. Epub 2023 Jun 16 doi: 10.1016/S2468-1253(23)00145-0. PMID: 37336228Free PMC Article
Dellon ES, Peterson KA, Murray JA, Falk GW, Gonsalves N, Chehade M, Genta RM, Leung J, Khoury P, Klion AD, Hazan S, Vaezi M, Bledsoe AC, Durrani SR, Wang C, Shaw C, Chang AT, Singh B, Kamboj AP, Rasmussen HS, Rothenberg ME, Hirano I
N Engl J Med 2020 Oct 22;383(17):1624-1634. doi: 10.1056/NEJMoa2012047. PMID: 33085861Free PMC Article
Licari A, Votto M, D'Auria E, Castagnoli R, Caimmi SME, Marseglia GL
Curr Pediatr Rev 2020;16(2):106-114. doi: 10.2174/1573396315666191022154432. PMID: 31642786
Gonsalves N
Clin Rev Allergy Immunol 2019 Oct;57(2):272-285. doi: 10.1007/s12016-019-08732-1. PMID: 30903439

Diagnosis

Dellon ES, Gonsalves N, Abonia JP, Alexander JA, Arva NC, Atkins D, Attwood SE, Auth MKH, Bailey DD, Biederman L, Blanchard C, Bonis PA, Bose P, Bredenoord AJ, Chang JW, Chehade M, Collins MH, Di Lorenzo C, Dias JA, Dohil R, Dupont C, Falk GW, Ferreira CT, Fox AT, Genta RM, Greuter T, Gupta SK, Hirano I, Hiremath GS, Horsley-Silva JL, Ishihara S, Ishimura N, Jensen ET, Gutiérrez-Junquera C, Katzka DA, Khoury P, Kinoshita Y, Kliewer KL, Koletzko S, Leung J, Liacouras CA, Lucendo AJ, Martin LJ, McGowan EC, Menard-Katcher C, Metz DC, Miller TL, Moawad FJ, Muir AB, Mukkada VA, Murch S, Nhu QM, Nomura I, Nurko S, Ohtsuka Y, Oliva S, Orel R, Papadopoulou A, Patel DA, Pesek RD, Peterson KA, Philpott H, Putnam PE, Richter JE, Rosen R, Ruffner MA, Safroneeva E, Schreiner P, Schoepfer A, Schroeder SR, Shah N, Souza RF, Spechler SJ, Spergel JM, Straumann A, Talley NJ, Thapar N, Vandenplas Y, Venkatesh RD, Vieira MC, von Arnim U, Walker MM, Wechsler JB, Wershil BK, Wright BL, Yamada Y, Yang GY, Zevit N, Rothenberg ME, Furuta GT, Aceves SS
Clin Gastroenterol Hepatol 2022 Nov;20(11):2474-2484.e3. Epub 2022 Feb 16 doi: 10.1016/j.cgh.2022.02.017. PMID: 35181570Free PMC Article
Chen PH, Anderson L, Zhang K, Weiss GA
Curr Gastroenterol Rep 2021 Jul 30;23(8):13. doi: 10.1007/s11894-021-00809-2. PMID: 34331146
Licari A, Votto M, D'Auria E, Castagnoli R, Caimmi SME, Marseglia GL
Curr Pediatr Rev 2020;16(2):106-114. doi: 10.2174/1573396315666191022154432. PMID: 31642786
Gonsalves N
Clin Rev Allergy Immunol 2019 Oct;57(2):272-285. doi: 10.1007/s12016-019-08732-1. PMID: 30903439
Zhang M, Li Y
J Gastroenterol Hepatol 2017 Jan;32(1):64-72. doi: 10.1111/jgh.13463. PMID: 27253425

Therapy

Marasco G, Visaggi P, Vassallo M, Fiocca M, Cremon C, Barbaro MR, De Bortoli N, Bellini M, Stanghellini V, Savarino EV, Barbara G
Int J Mol Sci 2023 Oct 13;24(20) doi: 10.3390/ijms242015165. PMID: 37894846Free PMC Article
Chen PH, Anderson L, Zhang K, Weiss GA
Curr Gastroenterol Rep 2021 Jul 30;23(8):13. doi: 10.1007/s11894-021-00809-2. PMID: 34331146
Dellon ES, Peterson KA, Murray JA, Falk GW, Gonsalves N, Chehade M, Genta RM, Leung J, Khoury P, Klion AD, Hazan S, Vaezi M, Bledsoe AC, Durrani SR, Wang C, Shaw C, Chang AT, Singh B, Kamboj AP, Rasmussen HS, Rothenberg ME, Hirano I
N Engl J Med 2020 Oct 22;383(17):1624-1634. doi: 10.1056/NEJMoa2012047. PMID: 33085861Free PMC Article
Gonsalves N
Clin Rev Allergy Immunol 2019 Oct;57(2):272-285. doi: 10.1007/s12016-019-08732-1. PMID: 30903439
Zhang M, Li Y
J Gastroenterol Hepatol 2017 Jan;32(1):64-72. doi: 10.1111/jgh.13463. PMID: 27253425

Prognosis

Nagahara A, Shiotani A, Iijima K, Kamada T, Fujiwara Y, Kasugai K, Kato M, Higuchi K
Dig Endosc 2022 Jan;34(1):63-72. Epub 2021 Apr 22 doi: 10.1111/den.13982. PMID: 33772880
Bobrova VI, Horobets AO, Proshchenko JI, Levadna LO, Selska ZV
Wiad Lek 2021;74(7):1722-1727. PMID: 34459778
Chehade M, Kamboj AP, Atkins D, Gehman LT
J Allergy Clin Immunol Pract 2021 May;9(5):2050-2059.e20. Epub 2021 Jan 10 doi: 10.1016/j.jaip.2020.12.054. PMID: 33440255
Egritas Gurkan O, Ozturk H, Karagol HIE, Ceylan K, Duztas DT, Ekinci O, Sari S, Dalgic B, Bakirtas A
J Pediatr Gastroenterol Nutr 2021 Feb 1;72(2):294-299. doi: 10.1097/MPG.0000000000002925. PMID: 32868666
Licari A, Votto M, D'Auria E, Castagnoli R, Caimmi SME, Marseglia GL
Curr Pediatr Rev 2020;16(2):106-114. doi: 10.2174/1573396315666191022154432. PMID: 31642786

Clinical prediction guides

Greuter T, Katzka D
Immunol Allergy Clin North Am 2024 May;44(2):357-368. Epub 2024 Feb 13 doi: 10.1016/j.iac.2024.01.007. PMID: 38575229
Kliewer KL, Murray-Petzold C, Collins MH, Abonia JP, Bolton SM, DiTommaso LA, Martin LJ, Zhang X, Mukkada VA, Putnam PE, Kellner ES, Devonshire AL, Schwartz JT, Kunnathur VA, Rosenberg CE, Lyles JL, Shoda T, Klion AD, Rothenberg ME
Lancet Gastroenterol Hepatol 2023 Sep;8(9):803-815. Epub 2023 Jun 16 doi: 10.1016/S2468-1253(23)00145-0. PMID: 37336228Free PMC Article
Furuta GT, Fillon SA, Williamson KM, Robertson CE, Stevens MJ, Aceves SS, Arva NC, Chehade M, Collins MH, Davis CM, Dellon ES, Falk GW, Gonsalves N, Gupta SK, Hirano I, Khoury P, Leung J, Martin LJ, Menard-Katcher P, Mukkada VA, Peterson K, Spergel JM, Wechsler JB, Yang GY, Rothenberg ME, Harris JK
J Pediatr Gastroenterol Nutr 2023 Mar 1;76(3):347-354. Epub 2022 Dec 16 doi: 10.1097/MPG.0000000000003685. PMID: 36525669Free PMC Article
Allen-Brady K, Colletier KJ, Woller S, Eliason K, Uchida AM, Ro G, Newman M, Peterson KA
Am J Gastroenterol 2023 Feb 1;118(2):263-268. Epub 2022 Sep 21 doi: 10.14309/ajg.0000000000002021. PMID: 36148824Free PMC Article
Dellon ES, Peterson KA, Murray JA, Falk GW, Gonsalves N, Chehade M, Genta RM, Leung J, Khoury P, Klion AD, Hazan S, Vaezi M, Bledsoe AC, Durrani SR, Wang C, Shaw C, Chang AT, Singh B, Kamboj AP, Rasmussen HS, Rothenberg ME, Hirano I
N Engl J Med 2020 Oct 22;383(17):1624-1634. doi: 10.1056/NEJMoa2012047. PMID: 33085861Free PMC Article

Recent systematic reviews

Bel Imam M, Stikas CV, Guha P, Chawes BL, Chu D, Greenhawt M, Khaleva E, Munblit D, Nekliudov N, van de Veen W, Schoos AM; Core Outcome Measures for Food Allergy (COMFA) consortium
Clin Exp Allergy 2023 May;53(5):526-535. Epub 2023 Mar 7 doi: 10.1111/cea.14304. PMID: 36880564
Assa A, Borrelli O, Broekaert I, Saccomani MD, Dolinsek J, Martin-de-Carpi J, Mas E, Miele E, Sila S, Thomson M, Tzivinikos C, Benninga MA; Gastrointestinal Committee of ESPGHAN
J Pediatr Gastroenterol Nutr 2022 May 1;74(5):956-967. Epub 2022 Feb 16 doi: 10.1097/MPG.0000000000003414. PMID: 35175996
Licari A, Votto M, Scudeller L, De Silvestri A, Rebuffi C, Cianferoni A, Marseglia GL
J Allergy Clin Immunol Pract 2020 Jun;8(6):1994-2003.e2. Epub 2020 Feb 28 doi: 10.1016/j.jaip.2020.01.060. PMID: 32061717
Lecouffe-Desprets M, Groh M, Bour B, Le Jeunne C, Puéchal X
Joint Bone Spine 2016 Oct;83(5):479-84. Epub 2015 Dec 19 doi: 10.1016/j.jbspin.2015.11.006. PMID: 26709253

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