U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Vasovagal syncope

MedGen UID:
12060
Concept ID:
C0042420
Disease or Syndrome
Synonyms: Faint, Neurally Mediated; Faints, Neurally Mediated; Neurally Mediated Faint; Neurally Mediated Faints; Neurocardiogenic Syncope; Neurocardiogenic Syncopes; Neurogenic Syncope; Neurogenic Syncopes; Syncope, Neurocardiogenic; Syncope, Neurogenic; Syncope, Vasodepressor; Syncope, Vasovagal; Syncope, Vasovagal, Neurally-Mediated; Syncopes, Neurocardiogenic; Syncopes, Neurogenic; Syncopes, Vasodepressor; Syncopes, Vasovagal; Vasodepressor Syncope; Vasodepressor Syncopes; Vasovagal Syncope; Vasovagal Syncopes
SNOMED CT: Vasovagal syncope (398665005); Vaso vagal episode (398665005); Vasodepressor syncope (398665005); Neurally-mediated syncope (398665005); Vasovagal attack (398665005); Gower's syndrome (398665005)
 
HPO: HP:0012668

Definition

An autonomic reflex response to emotional or orthostatic stress, which is characterized by paradoxical hypotension and bradycardia. [from NCI]

Professional guidelines

PubMed

Ballantyne BA, Letourneau-Shesaf S, Raj SR
Auton Neurosci 2021 Dec;236:102904. Epub 2021 Nov 4 doi: 10.1016/j.autneu.2021.102904. PMID: 34763249
Ali M, Pachon Maetos JC, Kichloo A, Masudi S, Grubb BP, Kanjwal K
Pacing Clin Electrophysiol 2021 Dec;44(12):2100-2108. Epub 2021 Nov 23 doi: 10.1111/pace.14402. PMID: 34748224
Kenny RA, McNicholas T
QJM 2016 Dec;109(12):767-773. Epub 2016 Jun 23 doi: 10.1093/qjmed/hcw089. PMID: 27340222

Recent clinical studies

Etiology

Piotrowski R, Baran J, Sikorska A, Krynski T, Kulakowski P
JACC Clin Electrophysiol 2023 Jan;9(1):85-95. Epub 2022 Aug 28 doi: 10.1016/j.jacep.2022.08.011. PMID: 36114133
Sheldon R, Faris P, Tang A, Ayala-Paredes F, Guzman J, Marquez M, Morillo CA, Krahn AD, Kus T, Ritchie D, Safdar S, Maxey C, Raj SR; POST 4 investigators
Ann Intern Med 2021 Oct;174(10):1349-1356. Epub 2021 Aug 3 doi: 10.7326/M20-5415. PMID: 34339231
Romano S, Branz L, Fondrieschi L, Minuz P
High Blood Press Cardiovasc Prev 2019 Aug;26(4):273-281. Epub 2019 Jul 11 doi: 10.1007/s40292-019-00327-3. PMID: 31297720
Sheldon R
Prog Cardiovasc Dis 2013 Jan-Feb;55(4):390-5. doi: 10.1016/j.pcad.2012.10.011. PMID: 23472776
Brignole M
Ital Heart J 2005 Mar;6(3):249-55. PMID: 15875516

Diagnosis

Aksu T, Gupta D, D'Avila A, Morillo CA
J Cardiovasc Electrophysiol 2022 Oct;33(10):2205-2212. Epub 2022 Apr 9 doi: 10.1111/jce.15480. PMID: 35362165
Ali M, Pachon Maetos JC, Kichloo A, Masudi S, Grubb BP, Kanjwal K
Pacing Clin Electrophysiol 2021 Dec;44(12):2100-2108. Epub 2021 Nov 23 doi: 10.1111/pace.14402. PMID: 34748224
Romano S, Branz L, Fondrieschi L, Minuz P
High Blood Press Cardiovasc Prev 2019 Aug;26(4):273-281. Epub 2019 Jul 11 doi: 10.1007/s40292-019-00327-3. PMID: 31297720
Jardine DL, Wieling W, Brignole M, Lenders JWM, Sutton R, Stewart J
Heart Rhythm 2018 Jun;15(6):921-929. Epub 2017 Dec 12 doi: 10.1016/j.hrthm.2017.12.013. PMID: 29246828Free PMC Article
Kenny RA, McNicholas T
QJM 2016 Dec;109(12):767-773. Epub 2016 Jun 23 doi: 10.1093/qjmed/hcw089. PMID: 27340222

Therapy

Hatoum T, Raj S, Sheldon RS
Intern Emerg Med 2023 Jan;18(1):23-30. Epub 2022 Sep 18 doi: 10.1007/s11739-022-03102-w. PMID: 36117230
Piotrowski R, Baran J, Sikorska A, Krynski T, Kulakowski P
JACC Clin Electrophysiol 2023 Jan;9(1):85-95. Epub 2022 Aug 28 doi: 10.1016/j.jacep.2022.08.011. PMID: 36114133
Aksu T, Gupta D, D'Avila A, Morillo CA
J Cardiovasc Electrophysiol 2022 Oct;33(10):2205-2212. Epub 2022 Apr 9 doi: 10.1111/jce.15480. PMID: 35362165
Ballantyne BA, Letourneau-Shesaf S, Raj SR
Auton Neurosci 2021 Dec;236:102904. Epub 2021 Nov 4 doi: 10.1016/j.autneu.2021.102904. PMID: 34763249
Sheldon R, Faris P, Tang A, Ayala-Paredes F, Guzman J, Marquez M, Morillo CA, Krahn AD, Kus T, Ritchie D, Safdar S, Maxey C, Raj SR; POST 4 investigators
Ann Intern Med 2021 Oct;174(10):1349-1356. Epub 2021 Aug 3 doi: 10.7326/M20-5415. PMID: 34339231

Prognosis

Li HX, Gao L, Yuan Y
World J Pediatr 2021 Feb;17(1):58-62. Epub 2020 May 13 doi: 10.1007/s12519-020-00367-z. PMID: 32405708
Stewart JM, Boris JR, Chelimsky G, Fischer PR, Fortunato JE, Grubb BP, Heyer GL, Jarjour IT, Medow MS, Numan MT, Pianosi PT, Singer W, Tarbell S, Chelimsky TC; Pediatric Writing Group of the American Autonomic Society
Pediatrics 2018 Jan;141(1) Epub 2017 Dec 8 doi: 10.1542/peds.2017-1673. PMID: 29222399Free PMC Article
Shen WK, Sheldon RS, Benditt DG, Cohen MI, Forman DE, Goldberger ZD, Grubb BP, Hamdan MH, Krahn AD, Link MS, Olshansky B, Raj SR, Sandhu RK, Sorajja D, Sun BC, Yancy CW
Circulation 2017 Aug 1;136(5):e60-e122. Epub 2017 Mar 9 doi: 10.1161/CIR.0000000000000499. PMID: 28280231
Alboni P, Holz A, Brignole M
Heart 2013 Jul;99(13):904-8. Epub 2013 Jan 2 doi: 10.1136/heartjnl-2012-303220. PMID: 23286970
Soteriades ES, Evans JC, Larson MG, Chen MH, Chen L, Benjamin EJ, Levy D
N Engl J Med 2002 Sep 19;347(12):878-85. doi: 10.1056/NEJMoa012407. PMID: 12239256

Clinical prediction guides

Karemaker JM
Biol Psychol 2022 Jul;172:108378. Epub 2022 Jun 7 doi: 10.1016/j.biopsycho.2022.108378. PMID: 35688294
Zimmermann T, du Fay de Lavallaz J, Nestelberger T, Gualandro DM, Lopez-Ayala P, Badertscher P, Widmer V, Shrestha S, Strebel I, Glarner N, Diebold M, Miró Ò, Christ M, Cullen L, Than M, Martin-Sanchez FJ, Di Somma S, Peacock WF, Keller DI, Bilici M, Costabel JP, Kühne M, Breidthardt T, Thiruganasambandamoorthy V, Mueller C; BASEL IX Investigators†, Belkin M, Leu K, Lohrmann J, Boeddinghaus J, Twerenbold R, Koechlin L, Walter JE, Amrein M, Wussler D, Freese M, Puelacher C, Kawecki D, Morawiec B, Salgado E, Martinez-Nadal G, Inostroza CIF, Mandrión JB, Poepping I, Rentsch K, von Eckardstein A, Buser A, Greenslade J, Reichlin T, Bürgler F
Ann Intern Med 2022 Jun;175(6):783-794. Epub 2022 Apr 26 doi: 10.7326/M21-2313. PMID: 35467933
Sheldon R, Faris P, Tang A, Ayala-Paredes F, Guzman J, Marquez M, Morillo CA, Krahn AD, Kus T, Ritchie D, Safdar S, Maxey C, Raj SR; POST 4 investigators
Ann Intern Med 2021 Oct;174(10):1349-1356. Epub 2021 Aug 3 doi: 10.7326/M20-5415. PMID: 34339231
Shen WK, Sheldon RS, Benditt DG, Cohen MI, Forman DE, Goldberger ZD, Grubb BP, Hamdan MH, Krahn AD, Link MS, Olshansky B, Raj SR, Sandhu RK, Sorajja D, Sun BC, Yancy CW
Circulation 2017 Aug 1;136(5):e60-e122. Epub 2017 Mar 9 doi: 10.1161/CIR.0000000000000499. PMID: 28280231
Alboni P, Holz A, Brignole M
Heart 2013 Jul;99(13):904-8. Epub 2013 Jan 2 doi: 10.1136/heartjnl-2012-303220. PMID: 23286970

Recent systematic reviews

Khalaji A, Behnoush AH, Tajdini M
Clin Cardiol 2023 Jul;46(7):721-728. Epub 2023 May 24 doi: 10.1002/clc.24035. PMID: 37226313Free PMC Article
Abdelazeem B, Abbas KS, Manasrah N, Amin MA, Mohammed SM, Mostafa MR
Complement Ther Clin Pract 2022 Aug;48:101579. Epub 2022 Apr 4 doi: 10.1016/j.ctcp.2022.101579. PMID: 35390588
Lei LY, Raj SR, Sheldon RS
Europace 2022 Jul 21;24(7):1171-1178. doi: 10.1093/europace/euab323. PMID: 35025999Free PMC Article
Veazie S, Peterson K, Ansari Y, Chung KA, Gibbons CH, Raj SR, Helfand M
Cochrane Database Syst Rev 2021 May 17;5(5):CD012868. doi: 10.1002/14651858.CD012868.pub2. PMID: 34000076Free PMC Article
Albassam OT, Redelmeier RJ, Shadowitz S, Husain AM, Simel D, Etchells EE
JAMA 2019 Jun 25;321(24):2448-2457. doi: 10.1001/jama.2019.8001. PMID: 31237649

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...