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Pertussis

MedGen UID:
12159
Concept ID:
C0043167
Disease or Syndrome
Synonym: Bordetella pertussis infection
SNOMED CT: Pertussis (27836007); Infection due to Bordetella pertussis (27836007); Whooping cough (27836007); WC - Whooping cough (27836007)
 
Monarch Initiative: MONDO:0005077
Orphanet: ORPHA1489

Definition

A rare bacterial infectious disease characterized by severe coughing paroxysms with inspiratory whooping and posttussive vomiting, caused by infection with <i>Bordetella pertussis</i>. After a variable incubation time, the clinical course progresses through a catarrhal stage with sore throat, nasal congestion, rhinorrhea, and mild progressive dry cough, a paroxysmal stage with the typical paroxysmal coughing, and finally convalescence. Disease duration is usually 2-3 months, often with milder presentation in adolescents and adults than in infants and children. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPertussis
Follow this link to review classifications for Pertussis in Orphanet.

Professional guidelines

PubMed

Kilgore PE, Salim AM, Zervos MJ, Schmitt HJ
Clin Microbiol Rev 2016 Jul;29(3):449-86. doi: 10.1128/CMR.00083-15. PMID: 27029594Free PMC Article
Albert RH
Am Fam Physician 2010 Dec 1;82(11):1345-50. PMID: 21121518
Braman SS
Chest 2006 Jan;129(1 Suppl):138S-146S. doi: 10.1378/chest.129.1_suppl.138S. PMID: 16428703

Recent clinical studies

Etiology

Regan AK, Moore HC, Binks MJ, McHugh L, Blyth CC, Pereira G, Lust K, Sarna M, Andrews R, Foo D, Effler PV, Lambert S, Van Buynder P
Pediatrics 2023 Nov 1;152(5) doi: 10.1542/peds.2023-062664. PMID: 37807881Free PMC Article
Macina D, Mathur S, Dvaretskaya M, Ekhtiari S, Hayat P, Montmerle M, Daluwatte C
Hum Vaccin Immunother 2023 Dec 31;19(1):2208514. doi: 10.1080/21645515.2023.2208514. PMID: 37171153Free PMC Article
Kline JM, Smith EA, Zavala A
Am Fam Physician 2021 Aug 1;104(2):186-192. PMID: 34383446
Dash N, Verma S
Indian J Pediatr 2018 Jan;85(1):53-59. Epub 2017 Jun 16 doi: 10.1007/s12098-017-2393-2. PMID: 28623456
Kilgore PE, Salim AM, Zervos MJ, Schmitt HJ
Clin Microbiol Rev 2016 Jul;29(3):449-86. doi: 10.1128/CMR.00083-15. PMID: 27029594Free PMC Article

Diagnosis

Yılmaz Çolak Ç, Tefon Öztürk BE
Pathog Glob Health 2023 Jun;117(4):342-355. Epub 2022 Sep 1 doi: 10.1080/20477724.2022.2117937. PMID: 36047634Free PMC Article
Kline JM, Smith EA, Zavala A
Am Fam Physician 2021 Aug 1;104(2):186-192. PMID: 34383446
Nguyen VTN, Simon L
Prim Care 2018 Sep;45(3):423-431. doi: 10.1016/j.pop.2018.05.003. PMID: 30115332
Nieves DJ, Heininger U
Microbiol Spectr 2016 Jun;4(3) doi: 10.1128/microbiolspec.EI10-0008-2015. PMID: 27337481
Spector TB, Maziarz EK
Med Clin North Am 2013 Jul;97(4):537-52, ix. Epub 2013 Apr 17 doi: 10.1016/j.mcna.2013.02.004. PMID: 23809713

Therapy

Boisnard F, Manson C, Serradell L, Macina D
Expert Rev Vaccines 2023 Jan-Dec;22(1):1196-1213. Epub 2023 Dec 6 doi: 10.1080/14760584.2023.2280236. PMID: 37936265
Callegaro A, Curran D, Matthews S
Pharm Stat 2020 Sep;19(5):636-645. Epub 2020 Mar 27 doi: 10.1002/pst.2020. PMID: 32220002Free PMC Article
Abdullahi LH, Kagina BM, Ndze VN, Hussey GD, Wiysonge CS
Cochrane Database Syst Rev 2020 Jan 17;1(1):CD011895. doi: 10.1002/14651858.CD011895.pub2. PMID: 31978259Free PMC Article
Munoz FM, Bond NH, Maccato M, Pinell P, Hammill HA, Swamy GK, Walter EB, Jackson LA, Englund JA, Edwards MS, Healy CM, Petrie CR, Ferreira J, Goll JB, Baker CJ
JAMA 2014 May 7;311(17):1760-9. doi: 10.1001/jama.2014.3633. PMID: 24794369Free PMC Article
Frampton JE
Paediatr Drugs 2011 Dec 1;13(6):401-15. doi: 10.2165/11207740-000000000-00000. PMID: 21999652

Prognosis

Macina D, Mathur S, Dvaretskaya M, Ekhtiari S, Hayat P, Montmerle M, Daluwatte C
Hum Vaccin Immunother 2023 Dec 31;19(1):2208514. doi: 10.1080/21645515.2023.2208514. PMID: 37171153Free PMC Article
Benn CS, Fisker AB, Rieckmann A, Sørup S, Aaby P
Lancet Infect Dis 2020 Oct;20(10):e274-e283. Epub 2020 Jul 6 doi: 10.1016/S1473-3099(19)30742-X. PMID: 32645296
Martinón-Torres F, Heininger U, Thomson A, Wirsing von König CH
Expert Rev Vaccines 2018 Apr;17(4):289-297. Epub 2018 Mar 12 doi: 10.1080/14760584.2018.1445530. PMID: 29482390
Berghella V, Buchanan E, Pereira L, Baxter JK
Obstet Gynecol Surv 2010 Feb;65(2):119-31. doi: 10.1097/OGX.0b013e3181d0c358. PMID: 20100361
Black S
Pediatr Infect Dis J 1997 Apr;16(4 Suppl):S85-9. doi: 10.1097/00006454-199704001-00003. PMID: 9109162

Clinical prediction guides

Regan AK, Moore HC, Binks MJ, McHugh L, Blyth CC, Pereira G, Lust K, Sarna M, Andrews R, Foo D, Effler PV, Lambert S, Van Buynder P
Pediatrics 2023 Nov 1;152(5) doi: 10.1542/peds.2023-062664. PMID: 37807881Free PMC Article
Daluwatte C, Dvaretskaya M, Ekhtiari S, Hayat P, Montmerle M, Mathur S, Macina D
Hum Vaccin Immunother 2023 Dec 31;19(1):2209455. doi: 10.1080/21645515.2023.2209455. PMID: 37171155Free PMC Article
Macina D, Mathur S, Dvaretskaya M, Ekhtiari S, Hayat P, Montmerle M, Daluwatte C
Hum Vaccin Immunother 2023 Dec 31;19(1):2208514. doi: 10.1080/21645515.2023.2208514. PMID: 37171153Free PMC Article
Yılmaz Çolak Ç, Tefon Öztürk BE
Pathog Glob Health 2023 Jun;117(4):342-355. Epub 2022 Sep 1 doi: 10.1080/20477724.2022.2117937. PMID: 36047634Free PMC Article
Callegaro A, Curran D, Matthews S
Pharm Stat 2020 Sep;19(5):636-645. Epub 2020 Mar 27 doi: 10.1002/pst.2020. PMID: 32220002Free PMC Article

Recent systematic reviews

O'Grady NP, Alexander E, Alhazzani W, Alshamsi F, Cuellar-Rodriguez J, Jefferson BK, Kalil AC, Pastores SM, Patel R, van Duin D, Weber DJ, Deresinski S
Crit Care Med 2023 Nov 1;51(11):1570-1586. Epub 2023 Oct 12 doi: 10.1097/CCM.0000000000006022. PMID: 37902340
Gidengil C, Goetz MB, Newberry S, Maglione M, Hall O, Larkin J, Motala A, Hempel S
Vaccine 2021 Jun 23;39(28):3696-3716. Epub 2021 May 25 doi: 10.1016/j.vaccine.2021.03.079. PMID: 34049735
Leidner AJ, Murthy N, Chesson HW, Biggerstaff M, Stoecker C, Harris AM, Acosta A, Dooling K, Bridges CB
Vaccine 2019 Jan 7;37(2):226-234. Epub 2018 Dec 4 doi: 10.1016/j.vaccine.2018.11.056. PMID: 30527660Free PMC Article
Jarrett C, Wilson R, O'Leary M, Eckersberger E, Larson HJ; SAGE Working Group on Vaccine Hesitancy
Vaccine 2015 Aug 14;33(34):4180-90. Epub 2015 Apr 18 doi: 10.1016/j.vaccine.2015.04.040. PMID: 25896377
Kramer A, Schwebke I, Kampf G
BMC Infect Dis 2006 Aug 16;6:130. doi: 10.1186/1471-2334-6-130. PMID: 16914034Free PMC Article

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