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Yaws

MedGen UID:
12186
•Concept ID:
C0043388
•
Disease or Syndrome
Synonyms: Endemic treponematoses; Frambesia; Frambesia tropica; Treponema pertenue infection
SNOMED CT: Yaws (70647001); Frambesia (70647001); Pian (70647001); Buba (70647001); Infection by Treponema pertenue (70647001)
 
Monarch Initiative: MONDO:0006019

Definition

An endemic, infectious, nonvenereal disease in humans that presents mainly in children younger than 15 years. The disease occurs primarily in warm, humid, tropical areas of Africa, Asia, South America, and Oceania, among poor rural populations where conditions of overcrowding and poor sanitation prevail. Infection with Treponema pertenue, a subspecies of Treponema pallidum, causes the disease. [from NCI]

Professional guidelines

PubMed

Mass Treatment with Single-Dose Azithromycin for Yaws.
Tepper M, Whitehead J, Maher M
N Engl J Med 2016 Sep 15;375(11):1093-4. doi: 10.1056/NEJMc1503442. PMID: 27626527
New treatment schemes for yaws: the path toward eradication.
Mitjà O, Hays R, Rinaldi AC, McDermott R, Bassat Q
Clin Infect Dis 2012 Aug;55(3):406-12. Epub 2012 May 18 doi: 10.1093/cid/cis444. PMID: 22610931
Oral azithromycin for treatment of yaws.
Mabey D
Lancet 2012 Jan 28;379(9813):295-7. Epub 2012 Jan 11 doi: 10.1016/S0140-6736(11)61842-4. PMID: 22240406

Recent clinical studies

Etiology

Scientific literature on neglected tropical diseases: a bibliometric analysis.
Tebano G, Vanino E, Muratori P, Cristini F
Pathog Glob Health 2024 Mar;118(2):91-98. Epub 2023 Aug 22 doi: 10.1080/20477724.2023.2250619. PMID: 37606248Free PMC Article
Yaws, Haemophilus ducreyi, and Other Bacterial Causes of Cutaneous Ulcer Disease in the South Pacific Islands.
G-Beiras C, Ubals M, Corbacho-Monné M, Vall-Mayans M, Mitjà O
Dermatol Clin 2021 Jan;39(1):15-22. Epub 2020 Oct 31 doi: 10.1016/j.det.2020.08.002. PMID: 33228858
Modeling Treatment Strategies to Inform Yaws Eradication.
Holmes A, Tildesley MJ, Solomon AW, Mabey DCW, Sokana O, Marks M, Dyson L
Emerg Infect Dis 2020 Nov;26(11):2685-2693. doi: 10.3201/eid2611.191491. PMID: 33079046Free PMC Article
Hand Infections: Epidemiology and Public Health Burden.
Gundlach BK, Sasor SE, Chung KC
Hand Clin 2020 Aug;36(3):275-283. doi: 10.1016/j.hcl.2020.03.001. PMID: 32586453Free PMC Article
Syphilis in the United States.
Shockman S, Buescher LS, Stone SP
Clin Dermatol 2014 Mar-Apr;32(2):213-8. doi: 10.1016/j.clindermatol.2013.08.005. PMID: 24559556

Diagnosis

Yaws: towards the WHO eradication target.
Marks M
Trans R Soc Trop Med Hyg 2016 Jun;110(6):319-20. Epub 2016 Jun 6 doi: 10.1093/trstmh/trw032. PMID: 27268712Free PMC Article
Trachoma and Yaws: Common Ground?
Solomon AW, Marks M, Martin DL, Mikhailov A, Flueckiger RM, Mitjà O, Asiedu K, Jannin J, Engels D, Mabey DC
PLoS Negl Trop Dis 2015 Dec;9(12):e0004071. Epub 2015 Dec 3 doi: 10.1371/journal.pntd.0004071. PMID: 26633176Free PMC Article
Syphilis in the United States.
Shockman S, Buescher LS, Stone SP
Clin Dermatol 2014 Mar-Apr;32(2):213-8. doi: 10.1016/j.clindermatol.2013.08.005. PMID: 24559556
History of syphilis.
Rothschild BM
Clin Infect Dis 2005 May 15;40(10):1454-63. Epub 2005 Apr 1 doi: 10.1086/429626. PMID: 15844068
Yaws again.
Br Med J 1980 Oct 25;281(6248):1090-1. PMID: 7427596Free PMC Article

Therapy

Hand Infections: Epidemiology and Public Health Burden.
Gundlach BK, Sasor SE, Chung KC
Hand Clin 2020 Aug;36(3):275-283. doi: 10.1016/j.hcl.2020.03.001. PMID: 32586453Free PMC Article
Opportunities for Integrated Control of Neglected Tropical Diseases That Affect the Skin.
Engelman D, Fuller LC, Solomon AW, McCarthy JS, Hay RJ, Lammie PJ, Steer AC
Trends Parasitol 2016 Nov;32(11):843-854. Epub 2016 Sep 13 doi: 10.1016/j.pt.2016.08.005. PMID: 27638231
Yaws: towards the WHO eradication target.
Marks M
Trans R Soc Trop Med Hyg 2016 Jun;110(6):319-20. Epub 2016 Jun 6 doi: 10.1093/trstmh/trw032. PMID: 27268712Free PMC Article
Trachoma and Yaws: Common Ground?
Solomon AW, Marks M, Martin DL, Mikhailov A, Flueckiger RM, Mitjà O, Asiedu K, Jannin J, Engels D, Mabey DC
PLoS Negl Trop Dis 2015 Dec;9(12):e0004071. Epub 2015 Dec 3 doi: 10.1371/journal.pntd.0004071. PMID: 26633176Free PMC Article
Yaws again.
Br Med J 1980 Oct 25;281(6248):1090-1. PMID: 7427596Free PMC Article

Prognosis

Modeling Treatment Strategies to Inform Yaws Eradication.
Holmes A, Tildesley MJ, Solomon AW, Mabey DCW, Sokana O, Marks M, Dyson L
Emerg Infect Dis 2020 Nov;26(11):2685-2693. doi: 10.3201/eid2611.191491. PMID: 33079046Free PMC Article
Hand Infections: Epidemiology and Public Health Burden.
Gundlach BK, Sasor SE, Chung KC
Hand Clin 2020 Aug;36(3):275-283. doi: 10.1016/j.hcl.2020.03.001. PMID: 32586453Free PMC Article
Syphilis in the United States.
Shockman S, Buescher LS, Stone SP
Clin Dermatol 2014 Mar-Apr;32(2):213-8. doi: 10.1016/j.clindermatol.2013.08.005. PMID: 24559556
Outcome predictors in treatment of yaws.
Mitjà O, Hays R, Ipai A, Gubaila D, Lelngei F, Kirara M, Paru R, Bassat Q
Emerg Infect Dis 2011 Jun;17(6):1083-5. doi: 10.3201/eid/1706.101575. PMID: 21749808Free PMC Article
The return of yaws.
Asiedu K
Bull World Health Organ 2008 Jul;86(7):507-8. doi: 10.2471/blt.08.040708. PMID: 18670660Free PMC Article

Clinical prediction guides

Detection of cutaneous leishmaniasis in three communities of Oti Region, Ghana.
Akuffo R, Sanchez C, Chicharro C, Carrillo E, Attram N, Mosore MT, Yeboah C, Kotey NK, Boakye D, Ruiz-Postigo JA, Moreno J, Wilson M, Sarfo B, Anto F
PLoS Negl Trop Dis 2021 May;15(5):e0009416. Epub 2021 May 24 doi: 10.1371/journal.pntd.0009416. PMID: 34029326Free PMC Article
Outcome predictors in treatment of yaws.
Mitjà O, Hays R, Ipai A, Gubaila D, Lelngei F, Kirara M, Paru R, Bassat Q
Emerg Infect Dis 2011 Jun;17(6):1083-5. doi: 10.3201/eid/1706.101575. PMID: 21749808Free PMC Article
Yaws in the Solomon Islands.
Fegan D, Glennon M, Macbride-Stewart G, Moore T
J Trop Med Hyg 1990 Feb;93(1):52-7. PMID: 2304133
Potential for development of antibiotic resistance in pathogenic treponemes.
Stapleton JT, Stamm LV, Bassford PJ Jr
Rev Infect Dis 1985 May-Jun;7 Suppl 2:S314-7. doi: 10.1093/clinids/7-supplement_2.s314. PMID: 3892635
CLINICAL AND PATHOLOGICAL OBSERVATIONS ON JAMAICAN NEUROPATHY; A REPORT ON 206 CASES.
MONTGOMERY RD, CRUICKSHANK EK, ROBERTSON WB, MCMENEMEY WH
Brain 1964 Sep;87:425-62. doi: 10.1093/brain/87.3.425. PMID: 14215171

Recent systematic reviews

Improved rapid diagnostic tests to detect syphilis and yaws: a systematic review and meta-analysis.
Zhang Y, Goh SM, Mello MB, Baggaley RC, Wi T, Johnson CC, Asiedu KB, Marks M, Pham MD, Fairley CK, Chow EPF, Mitjà O, Toskin I, Ballard RC, Ong JJ
Sex Transm Infect 2022 Dec;98(8):608-616. Epub 2022 Sep 30 doi: 10.1136/sextrans-2022-055546. PMID: 36180209Free PMC Article
Secondary Effects from Mass Azithromycin Administration: A Systematic Review and Meta-analysis.
Li J, Xiong T, Yue Y, Choonara I, Qazi S, Tang J, Shi J, Wang H, Qu Y, Mu D
Am J Trop Med Hyg 2022 Oct 12;107(4):904-911. Epub 2022 Aug 15 doi: 10.4269/ajtmh.22-0134. PMID: 35970284Free PMC Article
Mobile Health Strategies to Tackle Skin Neglected Tropical Diseases With Recommendations From Innovative Experiences: Systematic Review.
Carrion C, Robles N, Sola-Morales O, Aymerich M, Ruiz Postigo JA
JMIR Mhealth Uhealth 2020 Dec 31;8(12):e22478. doi: 10.2196/22478. PMID: 33382382Free PMC Article
Epidemiological situation of yaws in the Americas: A systematic review in the context of a regional elimination goal.
Zoni AC, Saboyá-Díaz MI, Castellanos LG, Nicholls RS, Blaya-Novakova V
PLoS Negl Trop Dis 2019 Feb;13(2):e0007125. Epub 2019 Feb 25 doi: 10.1371/journal.pntd.0007125. PMID: 30802249Free PMC Article
Global epidemiology of yaws: a systematic review.
Mitjà O, Marks M, Konan DJ, Ayelo G, Gonzalez-Beiras C, Boua B, Houinei W, Kobara Y, Tabah EN, Nsiire A, Obvala D, Taleo F, Djupuri R, Zaixing Z, Utzinger J, Vestergaard LS, Bassat Q, Asiedu K
Lancet Glob Health 2015 Jun;3(6):e324-31. doi: 10.1016/S2214-109X(15)00011-X. PMID: 26001576Free PMC Article

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